Amino acid dipepetide frequency for Anaerostipes sp. 992a

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.991AlaAla: 5.991 ± 0.114
1.043AlaCys: 1.043 ± 0.041
3.958AlaAsp: 3.958 ± 0.079
4.518AlaGlu: 4.518 ± 0.083
3.0AlaPhe: 3.0 ± 0.071
5.521AlaGly: 5.521 ± 0.097
1.142AlaHis: 1.142 ± 0.039
5.472AlaIle: 5.472 ± 0.087
5.329AlaLys: 5.329 ± 0.092
5.935AlaLeu: 5.935 ± 0.09
2.369AlaMet: 2.369 ± 0.065
2.426AlaAsn: 2.426 ± 0.052
1.772AlaPro: 1.772 ± 0.049
2.261AlaGln: 2.261 ± 0.051
2.734AlaArg: 2.734 ± 0.068
3.788AlaSer: 3.788 ± 0.069
3.287AlaThr: 3.287 ± 0.075
5.71AlaVal: 5.71 ± 0.104
0.491AlaTrp: 0.491 ± 0.022
2.765AlaTyr: 2.765 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.914CysAla: 0.914 ± 0.041
0.261CysCys: 0.261 ± 0.018
0.87CysAsp: 0.87 ± 0.038
0.915CysGlu: 0.915 ± 0.033
0.652CysPhe: 0.652 ± 0.029
1.536CysGly: 1.536 ± 0.044
0.372CysHis: 0.372 ± 0.02
1.199CysIle: 1.199 ± 0.042
0.966CysLys: 0.966 ± 0.033
1.205CysLeu: 1.205 ± 0.04
0.528CysMet: 0.528 ± 0.023
0.583CysAsn: 0.583 ± 0.026
0.656CysPro: 0.656 ± 0.029
0.571CysGln: 0.571 ± 0.029
0.661CysArg: 0.661 ± 0.032
0.902CysSer: 0.902 ± 0.037
0.718CysThr: 0.718 ± 0.032
1.049CysVal: 1.049 ± 0.043
0.109CysTrp: 0.109 ± 0.013
0.606CysTyr: 0.606 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.775AspAla: 3.775 ± 0.071
0.887AspCys: 0.887 ± 0.03
2.845AspAsp: 2.845 ± 0.083
4.308AspGlu: 4.308 ± 0.082
2.553AspPhe: 2.553 ± 0.068
4.247AspGly: 4.247 ± 0.083
1.096AspHis: 1.096 ± 0.037
4.328AspIle: 4.328 ± 0.079
3.387AspLys: 3.387 ± 0.075
4.668AspLeu: 4.668 ± 0.088
1.977AspMet: 1.977 ± 0.048
1.873AspAsn: 1.873 ± 0.046
1.624AspPro: 1.624 ± 0.047
1.974AspGln: 1.974 ± 0.061
2.301AspArg: 2.301 ± 0.066
2.786AspSer: 2.786 ± 0.064
2.93AspThr: 2.93 ± 0.056
3.822AspVal: 3.822 ± 0.082
0.519AspTrp: 0.519 ± 0.027
2.855AspTyr: 2.855 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.628GluAla: 5.628 ± 0.1
0.938GluCys: 0.938 ± 0.037
4.454GluAsp: 4.454 ± 0.091
8.702GluGlu: 8.702 ± 0.142
2.639GluPhe: 2.639 ± 0.058
4.651GluGly: 4.651 ± 0.091
1.538GluHis: 1.538 ± 0.047
6.135GluIle: 6.135 ± 0.098
7.264GluLys: 7.264 ± 0.117
6.391GluLeu: 6.391 ± 0.094
2.624GluMet: 2.624 ± 0.062
3.623GluAsn: 3.623 ± 0.071
1.793GluPro: 1.793 ± 0.052
3.241GluGln: 3.241 ± 0.078
3.481GluArg: 3.481 ± 0.086
3.157GluSer: 3.157 ± 0.056
3.515GluThr: 3.515 ± 0.071
4.728GluVal: 4.728 ± 0.082
0.606GluTrp: 0.606 ± 0.025
3.412GluTyr: 3.412 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
2.737PheAla: 2.737 ± 0.062
0.819PheCys: 0.819 ± 0.03
2.396PheAsp: 2.396 ± 0.064
2.559PheGlu: 2.559 ± 0.063
1.946PhePhe: 1.946 ± 0.062
3.079PheGly: 3.079 ± 0.061
1.007PheHis: 1.007 ± 0.038
2.83PheIle: 2.83 ± 0.073
2.029PheLys: 2.029 ± 0.052
4.048PheLeu: 4.048 ± 0.086
1.168PheMet: 1.168 ± 0.038
1.331PheAsn: 1.331 ± 0.045
1.286PhePro: 1.286 ± 0.041
1.553PheGln: 1.553 ± 0.041
1.586PheArg: 1.586 ± 0.043
2.716PheSer: 2.716 ± 0.056
2.13PheThr: 2.13 ± 0.056
2.85PheVal: 2.85 ± 0.06
0.372PheTrp: 0.372 ± 0.022
1.792PheTyr: 1.792 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.693GlyAla: 4.693 ± 0.107
1.302GlyCys: 1.302 ± 0.042
3.288GlyAsp: 3.288 ± 0.073
4.67GlyGlu: 4.67 ± 0.075
3.065GlyPhe: 3.065 ± 0.065
4.724GlyGly: 4.724 ± 0.102
1.298GlyHis: 1.298 ± 0.051
6.72GlyIle: 6.72 ± 0.129
5.984GlyLys: 5.984 ± 0.09
5.53GlyLeu: 5.53 ± 0.091
2.608GlyMet: 2.608 ± 0.066
3.17GlyAsn: 3.17 ± 0.069
1.362GlyPro: 1.362 ± 0.048
2.149GlyGln: 2.149 ± 0.054
3.089GlyArg: 3.089 ± 0.06
3.912GlySer: 3.912 ± 0.073
4.163GlyThr: 4.163 ± 0.08
4.902GlyVal: 4.902 ± 0.093
0.696GlyTrp: 0.696 ± 0.034
3.319GlyTyr: 3.319 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.14HisAla: 1.14 ± 0.037
0.313HisCys: 0.313 ± 0.02
0.863HisAsp: 0.863 ± 0.036
1.151HisGlu: 1.151 ± 0.044
0.86HisPhe: 0.86 ± 0.034
1.517HisGly: 1.517 ± 0.04
0.48HisHis: 0.48 ± 0.04
1.541HisIle: 1.541 ± 0.047
1.142HisLys: 1.142 ± 0.037
1.739HisLeu: 1.739 ± 0.05
0.667HisMet: 0.667 ± 0.033
0.768HisAsn: 0.768 ± 0.03
1.012HisPro: 1.012 ± 0.038
0.626HisGln: 0.626 ± 0.029
0.821HisArg: 0.821 ± 0.032
1.026HisSer: 1.026 ± 0.037
1.041HisThr: 1.041 ± 0.04
1.139HisVal: 1.139 ± 0.033
0.16HisTrp: 0.16 ± 0.014
0.806HisTyr: 0.806 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.686IleAla: 5.686 ± 0.1
1.553IleCys: 1.553 ± 0.047
4.214IleAsp: 4.214 ± 0.07
5.338IleGlu: 5.338 ± 0.085
3.099IlePhe: 3.099 ± 0.069
5.687IleGly: 5.687 ± 0.095
1.547IleHis: 1.547 ± 0.046
5.646IleIle: 5.646 ± 0.105
4.996IleLys: 4.996 ± 0.081
7.501IleLeu: 7.501 ± 0.126
2.167IleMet: 2.167 ± 0.051
2.858IleAsn: 2.858 ± 0.069
3.318IlePro: 3.318 ± 0.07
2.869IleGln: 2.869 ± 0.059
3.699IleArg: 3.699 ± 0.073
5.06IleSer: 5.06 ± 0.096
4.458IleThr: 4.458 ± 0.091
5.138IleVal: 5.138 ± 0.1
0.631IleTrp: 0.631 ± 0.031
3.123IleTyr: 3.123 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
5.46LysAla: 5.46 ± 0.089
0.74LysCys: 0.74 ± 0.03
4.336LysAsp: 4.336 ± 0.084
8.452LysGlu: 8.452 ± 0.12
1.988LysPhe: 1.988 ± 0.057
4.721LysGly: 4.721 ± 0.08
1.168LysHis: 1.168 ± 0.038
5.602LysIle: 5.602 ± 0.099
7.995LysLys: 7.995 ± 0.123
5.673LysLeu: 5.673 ± 0.093
2.471LysMet: 2.471 ± 0.052
3.768LysAsn: 3.768 ± 0.082
2.085LysPro: 2.085 ± 0.051
2.783LysGln: 2.783 ± 0.065
3.478LysArg: 3.478 ± 0.074
3.615LysSer: 3.615 ± 0.085
3.918LysThr: 3.918 ± 0.079
4.893LysVal: 4.893 ± 0.081
0.617LysTrp: 0.617 ± 0.028
2.905LysTyr: 2.905 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
6.176LeuAla: 6.176 ± 0.094
1.359LeuCys: 1.359 ± 0.044
4.894LeuAsp: 4.894 ± 0.08
6.554LeuGlu: 6.554 ± 0.106
3.693LeuPhe: 3.693 ± 0.079
5.936LeuGly: 5.936 ± 0.1
1.558LeuHis: 1.558 ± 0.043
6.118LeuIle: 6.118 ± 0.101
6.627LeuLys: 6.627 ± 0.101
8.073LeuLeu: 8.073 ± 0.134
2.731LeuMet: 2.731 ± 0.058
3.621LeuAsn: 3.621 ± 0.063
3.322LeuPro: 3.322 ± 0.064
2.698LeuGln: 2.698 ± 0.058
3.421LeuArg: 3.421 ± 0.061
6.006LeuSer: 6.006 ± 0.107
4.753LeuThr: 4.753 ± 0.078
5.323LeuVal: 5.323 ± 0.091
0.739LeuTrp: 0.739 ± 0.033
3.161LeuTyr: 3.161 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.407MetAla: 2.407 ± 0.061
0.342MetCys: 0.342 ± 0.022
2.04MetAsp: 2.04 ± 0.052
2.984MetGlu: 2.984 ± 0.059
1.022MetPhe: 1.022 ± 0.035
2.172MetGly: 2.172 ± 0.06
0.49MetHis: 0.49 ± 0.026
2.617MetIle: 2.617 ± 0.061
3.097MetLys: 3.097 ± 0.072
2.716MetLeu: 2.716 ± 0.067
1.046MetMet: 1.046 ± 0.04
1.66MetAsn: 1.66 ± 0.043
1.105MetPro: 1.105 ± 0.039
0.989MetGln: 0.989 ± 0.031
1.214MetArg: 1.214 ± 0.043
1.651MetSer: 1.651 ± 0.045
1.807MetThr: 1.807 ± 0.043
2.116MetVal: 2.116 ± 0.056
0.207MetTrp: 0.207 ± 0.017
0.916MetTyr: 0.916 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
2.657AsnAla: 2.657 ± 0.061
0.626AsnCys: 0.626 ± 0.031
1.993AsnAsp: 1.993 ± 0.052
2.749AsnGlu: 2.749 ± 0.065
1.473AsnPhe: 1.473 ± 0.045
3.336AsnGly: 3.336 ± 0.072
1.013AsnHis: 1.013 ± 0.036
3.381AsnIle: 3.381 ± 0.07
2.692AsnLys: 2.692 ± 0.072
3.691AsnLeu: 3.691 ± 0.078
1.379AsnMet: 1.379 ± 0.044
1.59AsnAsn: 1.59 ± 0.049
1.937AsnPro: 1.937 ± 0.05
1.786AsnGln: 1.786 ± 0.047
1.983AsnArg: 1.983 ± 0.051
2.154AsnSer: 2.154 ± 0.055
2.084AsnThr: 2.084 ± 0.053
2.589AsnVal: 2.589 ± 0.054
0.324AsnTrp: 0.324 ± 0.019
1.782AsnTyr: 1.782 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
2.103ProAla: 2.103 ± 0.059
0.461ProCys: 0.461 ± 0.023
2.083ProAsp: 2.083 ± 0.051
3.191ProGlu: 3.191 ± 0.073
1.452ProPhe: 1.452 ± 0.048
2.172ProGly: 2.172 ± 0.063
0.586ProHis: 0.586 ± 0.027
2.33ProIle: 2.33 ± 0.063
2.113ProLys: 2.113 ± 0.05
2.582ProLeu: 2.582 ± 0.065
0.945ProMet: 0.945 ± 0.035
1.264ProAsn: 1.264 ± 0.045
0.665ProPro: 0.665 ± 0.035
0.955ProGln: 0.955 ± 0.032
0.972ProArg: 0.972 ± 0.035
1.749ProSer: 1.749 ± 0.045
1.595ProThr: 1.595 ± 0.048
2.742ProVal: 2.742 ± 0.059
0.264ProTrp: 0.264 ± 0.02
1.537ProTyr: 1.537 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.367GlnAla: 2.367 ± 0.06
0.449GlnCys: 0.449 ± 0.025
1.523GlnAsp: 1.523 ± 0.044
2.84GlnGlu: 2.84 ± 0.074
1.308GlnPhe: 1.308 ± 0.046
2.076GlnGly: 2.076 ± 0.056
0.569GlnHis: 0.569 ± 0.026
2.979GlnIle: 2.979 ± 0.061
3.273GlnLys: 3.273 ± 0.064
3.128GlnLeu: 3.128 ± 0.065
1.366GlnMet: 1.366 ± 0.04
1.501GlnAsn: 1.501 ± 0.046
0.914GlnPro: 0.914 ± 0.034
1.257GlnGln: 1.257 ± 0.045
1.455GlnArg: 1.455 ± 0.043
1.673GlnSer: 1.673 ± 0.051
1.678GlnThr: 1.678 ± 0.05
2.32GlnVal: 2.32 ± 0.064
0.407GlnTrp: 0.407 ± 0.024
1.667GlnTyr: 1.667 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.507ArgAla: 2.507 ± 0.052
0.632ArgCys: 0.632 ± 0.031
2.056ArgAsp: 2.056 ± 0.057
3.608ArgGlu: 3.608 ± 0.08
1.87ArgPhe: 1.87 ± 0.057
2.396ArgGly: 2.396 ± 0.06
0.729ArgHis: 0.729 ± 0.033
3.719ArgIle: 3.719 ± 0.063
3.875ArgLys: 3.875 ± 0.088
3.69ArgLeu: 3.69 ± 0.073
1.61ArgMet: 1.61 ± 0.047
2.039ArgAsn: 2.039 ± 0.057
1.267ArgPro: 1.267 ± 0.038
1.662ArgGln: 1.662 ± 0.048
2.174ArgArg: 2.174 ± 0.065
2.036ArgSer: 2.036 ± 0.052
2.113ArgThr: 2.113 ± 0.05
2.544ArgVal: 2.544 ± 0.057
0.393ArgTrp: 0.393 ± 0.024
1.91ArgTyr: 1.91 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
3.454SerAla: 3.454 ± 0.069
0.858SerCys: 0.858 ± 0.031
3.079SerAsp: 3.079 ± 0.057
3.446SerGlu: 3.446 ± 0.078
2.532SerPhe: 2.532 ± 0.06
4.585SerGly: 4.585 ± 0.08
1.061SerHis: 1.061 ± 0.036
4.498SerIle: 4.498 ± 0.088
3.842SerLys: 3.842 ± 0.073
4.737SerLeu: 4.737 ± 0.076
1.939SerMet: 1.939 ± 0.053
2.448SerAsn: 2.448 ± 0.067
1.651SerPro: 1.651 ± 0.049
1.91SerGln: 1.91 ± 0.062
2.561SerArg: 2.561 ± 0.066
3.659SerSer: 3.659 ± 0.104
2.666SerThr: 2.666 ± 0.064
3.939SerVal: 3.939 ± 0.071
0.501SerTrp: 0.501 ± 0.028
2.583SerTyr: 2.583 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
4.034ThrAla: 4.034 ± 0.096
0.721ThrCys: 0.721 ± 0.033
2.886ThrAsp: 2.886 ± 0.062
3.528ThrGlu: 3.528 ± 0.076
2.081ThrPhe: 2.081 ± 0.058
4.384ThrGly: 4.384 ± 0.083
0.85ThrHis: 0.85 ± 0.036
4.448ThrIle: 4.448 ± 0.086
3.724ThrLys: 3.724 ± 0.08
4.46ThrLeu: 4.46 ± 0.077
1.496ThrMet: 1.496 ± 0.044
1.962ThrAsn: 1.962 ± 0.051
1.93ThrPro: 1.93 ± 0.053
1.379ThrGln: 1.379 ± 0.042
1.993ThrArg: 1.993 ± 0.049
2.951ThrSer: 2.951 ± 0.078
2.745ThrThr: 2.745 ± 0.075
4.1ThrVal: 4.1 ± 0.082
0.44ThrTrp: 0.44 ± 0.028
2.163ThrTyr: 2.163 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
4.643ValAla: 4.643 ± 0.104
1.185ValCys: 1.185 ± 0.037
3.84ValAsp: 3.84 ± 0.07
4.881ValGlu: 4.881 ± 0.095
2.901ValPhe: 2.901 ± 0.064
4.233ValGly: 4.233 ± 0.085
1.146ValHis: 1.146 ± 0.038
5.44ValIle: 5.44 ± 0.095
4.854ValLys: 4.854 ± 0.065
6.356ValLeu: 6.356 ± 0.098
2.039ValMet: 2.039 ± 0.056
2.668ValAsn: 2.668 ± 0.053
2.427ValPro: 2.427 ± 0.062
1.938ValGln: 1.938 ± 0.05
2.747ValArg: 2.747 ± 0.061
4.398ValSer: 4.398 ± 0.078
4.1ValThr: 4.1 ± 0.096
4.874ValVal: 4.874 ± 0.098
0.573ValTrp: 0.573 ± 0.028
2.676ValTyr: 2.676 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.466TrpAla: 0.466 ± 0.023
0.143TrpCys: 0.143 ± 0.016
0.491TrpAsp: 0.491 ± 0.027
0.664TrpGlu: 0.664 ± 0.028
0.338TrpPhe: 0.338 ± 0.02
0.581TrpGly: 0.581 ± 0.028
0.137TrpHis: 0.137 ± 0.012
0.725TrpIle: 0.725 ± 0.03
0.911TrpLys: 0.911 ± 0.039
0.75TrpLeu: 0.75 ± 0.032
0.353TrpMet: 0.353 ± 0.023
0.474TrpAsn: 0.474 ± 0.025
0.173TrpPro: 0.173 ± 0.017
0.324TrpGln: 0.324 ± 0.026
0.314TrpArg: 0.314 ± 0.019
0.421TrpSer: 0.421 ± 0.025
0.349TrpThr: 0.349 ± 0.022
0.434TrpVal: 0.434 ± 0.025
0.07TrpTrp: 0.07 ± 0.01
0.334TrpTyr: 0.334 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.675TyrAla: 2.675 ± 0.065
0.64TyrCys: 0.64 ± 0.029
2.648TyrAsp: 2.648 ± 0.062
3.464TyrGlu: 3.464 ± 0.074
1.762TyrPhe: 1.762 ± 0.052
3.093TyrGly: 3.093 ± 0.055
1.023TyrHis: 1.023 ± 0.04
2.861TyrIle: 2.861 ± 0.06
2.566TyrLys: 2.566 ± 0.066
3.89TyrLeu: 3.89 ± 0.083
1.115TyrMet: 1.115 ± 0.038
1.592TyrAsn: 1.592 ± 0.042
1.46TyrPro: 1.46 ± 0.043
1.824TyrGln: 1.824 ± 0.055
2.144TyrArg: 2.144 ± 0.059
2.29TyrSer: 2.29 ± 0.058
2.227TyrThr: 2.227 ± 0.061
2.706TyrVal: 2.706 ± 0.054
0.333TyrTrp: 0.333 ± 0.023
2.158TyrTyr: 2.158 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2529 proteins (795659 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski