Amino acid dipepetide frequency for Gordonia phage Yvonnetastic

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.668AlaAla: 8.668 ± 0.914
0.896AlaCys: 0.896 ± 0.198
5.789AlaAsp: 5.789 ± 0.413
6.269AlaGlu: 6.269 ± 0.487
2.495AlaPhe: 2.495 ± 0.25
6.269AlaGly: 6.269 ± 0.799
1.983AlaHis: 1.983 ± 0.258
4.574AlaIle: 4.574 ± 0.405
3.87AlaLys: 3.87 ± 0.347
7.644AlaLeu: 7.644 ± 0.633
2.111AlaMet: 2.111 ± 0.277
2.623AlaAsn: 2.623 ± 0.438
3.262AlaPro: 3.262 ± 0.27
3.422AlaGln: 3.422 ± 0.579
6.045AlaArg: 6.045 ± 0.53
3.454AlaSer: 3.454 ± 0.288
4.734AlaThr: 4.734 ± 0.513
5.885AlaVal: 5.885 ± 0.486
2.239AlaTrp: 2.239 ± 0.285
2.815AlaTyr: 2.815 ± 0.326
0.0AlaXaa: 0.0 ± 0.0
Cys
0.928CysAla: 0.928 ± 0.195
0.384CysCys: 0.384 ± 0.111
1.024CysAsp: 1.024 ± 0.226
0.896CysGlu: 0.896 ± 0.186
0.32CysPhe: 0.32 ± 0.09
1.823CysGly: 1.823 ± 0.356
0.448CysHis: 0.448 ± 0.146
0.48CysIle: 0.48 ± 0.127
0.64CysLys: 0.64 ± 0.214
0.96CysLeu: 0.96 ± 0.185
0.192CysMet: 0.192 ± 0.079
0.576CysAsn: 0.576 ± 0.13
0.672CysPro: 0.672 ± 0.151
0.768CysGln: 0.768 ± 0.16
0.992CysArg: 0.992 ± 0.227
1.119CysSer: 1.119 ± 0.24
0.736CysThr: 0.736 ± 0.203
0.736CysVal: 0.736 ± 0.179
0.416CysTrp: 0.416 ± 0.141
0.416CysTyr: 0.416 ± 0.134
0.0CysXaa: 0.0 ± 0.0
Asp
5.597AspAla: 5.597 ± 0.408
0.8AspCys: 0.8 ± 0.183
4.702AspAsp: 4.702 ± 0.592
5.661AspGlu: 5.661 ± 0.451
1.823AspPhe: 1.823 ± 0.235
5.437AspGly: 5.437 ± 0.493
2.207AspHis: 2.207 ± 0.308
3.358AspIle: 3.358 ± 0.326
2.719AspLys: 2.719 ± 0.273
5.757AspLeu: 5.757 ± 0.45
1.503AspMet: 1.503 ± 0.222
2.495AspAsn: 2.495 ± 0.284
4.158AspPro: 4.158 ± 0.375
2.239AspGln: 2.239 ± 0.272
4.254AspArg: 4.254 ± 0.326
3.454AspSer: 3.454 ± 0.317
3.39AspThr: 3.39 ± 0.317
3.678AspVal: 3.678 ± 0.333
2.367AspTrp: 2.367 ± 0.297
2.879AspTyr: 2.879 ± 0.356
0.0AspXaa: 0.0 ± 0.0
Glu
5.949GluAla: 5.949 ± 0.442
1.151GluCys: 1.151 ± 0.254
5.15GluAsp: 5.15 ± 0.421
5.086GluGlu: 5.086 ± 0.529
2.271GluPhe: 2.271 ± 0.282
4.958GluGly: 4.958 ± 0.447
1.695GluHis: 1.695 ± 0.217
3.039GluIle: 3.039 ± 0.316
3.358GluLys: 3.358 ± 0.305
7.548GluLeu: 7.548 ± 0.518
2.143GluMet: 2.143 ± 0.225
2.431GluAsn: 2.431 ± 0.322
2.847GluPro: 2.847 ± 0.401
2.879GluGln: 2.879 ± 0.297
4.318GluArg: 4.318 ± 0.343
3.55GluSer: 3.55 ± 0.293
3.646GluThr: 3.646 ± 0.266
5.15GluVal: 5.15 ± 0.41
1.727GluTrp: 1.727 ± 0.21
2.783GluTyr: 2.783 ± 0.357
0.0GluXaa: 0.0 ± 0.0
Phe
2.559PheAla: 2.559 ± 0.358
0.256PheCys: 0.256 ± 0.088
2.719PheAsp: 2.719 ± 0.281
2.015PheGlu: 2.015 ± 0.316
0.864PhePhe: 0.864 ± 0.216
2.335PheGly: 2.335 ± 0.302
0.928PheHis: 0.928 ± 0.19
1.567PheIle: 1.567 ± 0.24
0.672PheLys: 0.672 ± 0.178
2.175PheLeu: 2.175 ± 0.251
1.055PheMet: 1.055 ± 0.184
1.119PheAsn: 1.119 ± 0.158
1.215PhePro: 1.215 ± 0.169
0.608PheGln: 0.608 ± 0.13
1.759PheArg: 1.759 ± 0.208
1.823PheSer: 1.823 ± 0.225
2.079PheThr: 2.079 ± 0.277
1.631PheVal: 1.631 ± 0.207
0.48PheTrp: 0.48 ± 0.143
0.832PheTyr: 0.832 ± 0.163
0.0PheXaa: 0.0 ± 0.0
Gly
5.022GlyAla: 5.022 ± 0.593
1.439GlyCys: 1.439 ± 0.284
4.382GlyAsp: 4.382 ± 0.393
5.245GlyGlu: 5.245 ± 0.435
2.431GlyPhe: 2.431 ± 0.305
7.197GlyGly: 7.197 ± 0.68
1.599GlyHis: 1.599 ± 0.269
4.126GlyIle: 4.126 ± 0.336
3.486GlyLys: 3.486 ± 0.395
6.269GlyLeu: 6.269 ± 0.396
2.591GlyMet: 2.591 ± 0.393
2.623GlyAsn: 2.623 ± 0.245
3.838GlyPro: 3.838 ± 0.424
2.879GlyGln: 2.879 ± 0.332
5.086GlyArg: 5.086 ± 0.459
4.926GlySer: 4.926 ± 0.464
4.702GlyThr: 4.702 ± 0.566
6.109GlyVal: 6.109 ± 0.493
2.527GlyTrp: 2.527 ± 0.296
3.582GlyTyr: 3.582 ± 0.379
0.0GlyXaa: 0.0 ± 0.0
His
1.471HisAla: 1.471 ± 0.235
0.288HisCys: 0.288 ± 0.112
1.375HisAsp: 1.375 ± 0.228
1.599HisGlu: 1.599 ± 0.244
0.608HisPhe: 0.608 ± 0.122
1.919HisGly: 1.919 ± 0.299
0.608HisHis: 0.608 ± 0.139
1.343HisIle: 1.343 ± 0.199
1.024HisLys: 1.024 ± 0.193
2.399HisLeu: 2.399 ± 0.323
0.256HisMet: 0.256 ± 0.098
0.96HisAsn: 0.96 ± 0.2
1.535HisPro: 1.535 ± 0.212
0.928HisGln: 0.928 ± 0.211
1.791HisArg: 1.791 ± 0.208
1.343HisSer: 1.343 ± 0.211
1.535HisThr: 1.535 ± 0.207
1.823HisVal: 1.823 ± 0.25
0.544HisTrp: 0.544 ± 0.145
1.087HisTyr: 1.087 ± 0.203
0.0HisXaa: 0.0 ± 0.0
Ile
4.926IleAla: 4.926 ± 0.407
0.704IleCys: 0.704 ± 0.151
3.486IleAsp: 3.486 ± 0.331
4.254IleGlu: 4.254 ± 0.337
1.055IlePhe: 1.055 ± 0.184
3.742IleGly: 3.742 ± 0.306
1.471IleHis: 1.471 ± 0.206
2.719IleIle: 2.719 ± 0.364
2.239IleLys: 2.239 ± 0.254
3.198IleLeu: 3.198 ± 0.338
1.024IleMet: 1.024 ± 0.175
1.663IleAsn: 1.663 ± 0.211
2.527IlePro: 2.527 ± 0.325
1.855IleGln: 1.855 ± 0.256
3.039IleArg: 3.039 ± 0.351
2.943IleSer: 2.943 ± 0.419
3.294IleThr: 3.294 ± 0.268
3.358IleVal: 3.358 ± 0.307
1.087IleTrp: 1.087 ± 0.211
1.183IleTyr: 1.183 ± 0.221
0.0IleXaa: 0.0 ± 0.0
Lys
3.614LysAla: 3.614 ± 0.327
0.544LysCys: 0.544 ± 0.146
3.198LysAsp: 3.198 ± 0.262
2.495LysGlu: 2.495 ± 0.299
1.119LysPhe: 1.119 ± 0.172
3.103LysGly: 3.103 ± 0.29
1.343LysHis: 1.343 ± 0.223
1.919LysIle: 1.919 ± 0.231
2.911LysLys: 2.911 ± 0.361
3.614LysLeu: 3.614 ± 0.329
1.343LysMet: 1.343 ± 0.186
1.119LysAsn: 1.119 ± 0.164
2.815LysPro: 2.815 ± 0.285
1.823LysGln: 1.823 ± 0.264
3.55LysArg: 3.55 ± 0.294
2.783LysSer: 2.783 ± 0.291
2.175LysThr: 2.175 ± 0.273
3.134LysVal: 3.134 ± 0.273
1.471LysTrp: 1.471 ± 0.224
1.951LysTyr: 1.951 ± 0.258
0.0LysXaa: 0.0 ± 0.0
Leu
6.173LeuAla: 6.173 ± 0.467
1.151LeuCys: 1.151 ± 0.207
5.533LeuAsp: 5.533 ± 0.332
7.516LeuGlu: 7.516 ± 0.538
2.175LeuPhe: 2.175 ± 0.244
6.301LeuGly: 6.301 ± 0.498
1.535LeuHis: 1.535 ± 0.211
3.646LeuIle: 3.646 ± 0.319
3.454LeuLys: 3.454 ± 0.301
5.725LeuLeu: 5.725 ± 0.428
1.951LeuMet: 1.951 ± 0.307
3.198LeuAsn: 3.198 ± 0.332
3.358LeuPro: 3.358 ± 0.322
2.591LeuGln: 2.591 ± 0.322
5.086LeuArg: 5.086 ± 0.347
5.309LeuSer: 5.309 ± 0.382
3.71LeuThr: 3.71 ± 0.34
5.118LeuVal: 5.118 ± 0.361
1.343LeuTrp: 1.343 ± 0.255
2.623LeuTyr: 2.623 ± 0.343
0.0LeuXaa: 0.0 ± 0.0
Met
2.783MetAla: 2.783 ± 0.311
0.256MetCys: 0.256 ± 0.077
1.663MetAsp: 1.663 ± 0.273
1.119MetGlu: 1.119 ± 0.194
0.672MetPhe: 0.672 ± 0.131
1.727MetGly: 1.727 ± 0.264
0.288MetHis: 0.288 ± 0.091
1.087MetIle: 1.087 ± 0.175
1.024MetLys: 1.024 ± 0.182
1.151MetLeu: 1.151 ± 0.196
0.832MetMet: 0.832 ± 0.189
0.928MetAsn: 0.928 ± 0.195
1.599MetPro: 1.599 ± 0.26
0.576MetGln: 0.576 ± 0.135
1.343MetArg: 1.343 ± 0.192
3.039MetSer: 3.039 ± 0.368
2.207MetThr: 2.207 ± 0.254
1.791MetVal: 1.791 ± 0.221
0.512MetTrp: 0.512 ± 0.131
0.384MetTyr: 0.384 ± 0.116
0.0MetXaa: 0.0 ± 0.0
Asn
2.495AsnAla: 2.495 ± 0.27
0.608AsnCys: 0.608 ± 0.149
1.887AsnAsp: 1.887 ± 0.26
1.983AsnGlu: 1.983 ± 0.246
0.928AsnPhe: 0.928 ± 0.182
2.943AsnGly: 2.943 ± 0.346
0.832AsnHis: 0.832 ± 0.192
2.015AsnIle: 2.015 ± 0.256
1.791AsnLys: 1.791 ± 0.22
2.879AsnLeu: 2.879 ± 0.27
0.576AsnMet: 0.576 ± 0.124
1.439AsnAsn: 1.439 ± 0.218
3.071AsnPro: 3.071 ± 0.283
0.896AsnGln: 0.896 ± 0.202
2.591AsnArg: 2.591 ± 0.315
1.983AsnSer: 1.983 ± 0.241
1.535AsnThr: 1.535 ± 0.236
2.175AsnVal: 2.175 ± 0.252
0.64AsnTrp: 0.64 ± 0.125
1.024AsnTyr: 1.024 ± 0.206
0.0AsnXaa: 0.0 ± 0.0
Pro
3.678ProAla: 3.678 ± 0.375
0.992ProCys: 0.992 ± 0.197
3.87ProAsp: 3.87 ± 0.429
4.414ProGlu: 4.414 ± 0.413
1.599ProPhe: 1.599 ± 0.208
5.437ProGly: 5.437 ± 0.519
1.311ProHis: 1.311 ± 0.232
2.431ProIle: 2.431 ± 0.304
2.207ProLys: 2.207 ± 0.293
2.655ProLeu: 2.655 ± 0.309
0.928ProMet: 0.928 ± 0.171
1.567ProAsn: 1.567 ± 0.237
2.687ProPro: 2.687 ± 0.368
1.279ProGln: 1.279 ± 0.197
2.719ProArg: 2.719 ± 0.309
2.431ProSer: 2.431 ± 0.24
2.751ProThr: 2.751 ± 0.301
2.943ProVal: 2.943 ± 0.329
1.215ProTrp: 1.215 ± 0.225
1.855ProTyr: 1.855 ± 0.282
0.0ProXaa: 0.0 ± 0.0
Gln
3.71GlnAla: 3.71 ± 0.399
0.544GlnCys: 0.544 ± 0.188
1.823GlnAsp: 1.823 ± 0.26
1.919GlnGlu: 1.919 ± 0.284
1.087GlnPhe: 1.087 ± 0.2
2.911GlnGly: 2.911 ± 0.37
0.736GlnHis: 0.736 ± 0.16
1.951GlnIle: 1.951 ± 0.259
1.759GlnLys: 1.759 ± 0.253
3.55GlnLeu: 3.55 ± 0.377
1.343GlnMet: 1.343 ± 0.19
1.119GlnAsn: 1.119 ± 0.182
1.279GlnPro: 1.279 ± 0.191
2.303GlnGln: 2.303 ± 0.353
3.007GlnArg: 3.007 ± 0.315
1.759GlnSer: 1.759 ± 0.25
1.599GlnThr: 1.599 ± 0.234
2.911GlnVal: 2.911 ± 0.278
1.024GlnTrp: 1.024 ± 0.165
0.832GlnTyr: 0.832 ± 0.153
0.0GlnXaa: 0.0 ± 0.0
Arg
6.397ArgAla: 6.397 ± 0.524
0.96ArgCys: 0.96 ± 0.212
5.118ArgAsp: 5.118 ± 0.449
4.51ArgGlu: 4.51 ± 0.391
2.111ArgPhe: 2.111 ± 0.247
4.478ArgGly: 4.478 ± 0.354
1.599ArgHis: 1.599 ± 0.295
3.966ArgIle: 3.966 ± 0.346
3.262ArgLys: 3.262 ± 0.325
4.83ArgLeu: 4.83 ± 0.418
1.887ArgMet: 1.887 ± 0.279
2.271ArgAsn: 2.271 ± 0.278
2.815ArgPro: 2.815 ± 0.373
2.943ArgGln: 2.943 ± 0.341
5.629ArgArg: 5.629 ± 0.583
3.422ArgSer: 3.422 ± 0.391
3.294ArgThr: 3.294 ± 0.353
4.19ArgVal: 4.19 ± 0.35
1.695ArgTrp: 1.695 ± 0.227
2.367ArgTyr: 2.367 ± 0.347
0.0ArgXaa: 0.0 ± 0.0
Ser
4.414SerAla: 4.414 ± 0.423
0.672SerCys: 0.672 ± 0.16
3.934SerAsp: 3.934 ± 0.377
3.934SerGlu: 3.934 ± 0.291
1.823SerPhe: 1.823 ± 0.221
4.51SerGly: 4.51 ± 0.407
1.215SerHis: 1.215 ± 0.248
3.007SerIle: 3.007 ± 0.302
2.719SerLys: 2.719 ± 0.255
3.806SerLeu: 3.806 ± 0.353
1.567SerMet: 1.567 ± 0.245
2.079SerAsn: 2.079 ± 0.279
2.751SerPro: 2.751 ± 0.336
2.399SerGln: 2.399 ± 0.254
4.574SerArg: 4.574 ± 0.474
3.39SerSer: 3.39 ± 0.412
3.39SerThr: 3.39 ± 0.309
3.966SerVal: 3.966 ± 0.327
1.567SerTrp: 1.567 ± 0.25
2.239SerTyr: 2.239 ± 0.269
0.0SerXaa: 0.0 ± 0.0
Thr
5.405ThrAla: 5.405 ± 0.639
0.576ThrCys: 0.576 ± 0.149
3.614ThrAsp: 3.614 ± 0.335
3.454ThrGlu: 3.454 ± 0.342
2.111ThrPhe: 2.111 ± 0.254
4.958ThrGly: 4.958 ± 0.479
1.247ThrHis: 1.247 ± 0.234
2.463ThrIle: 2.463 ± 0.289
2.943ThrLys: 2.943 ± 0.348
3.678ThrLeu: 3.678 ± 0.325
1.119ThrMet: 1.119 ± 0.173
1.919ThrAsn: 1.919 ± 0.341
3.454ThrPro: 3.454 ± 0.368
2.015ThrGln: 2.015 ± 0.326
3.198ThrArg: 3.198 ± 0.291
3.358ThrSer: 3.358 ± 0.337
3.39ThrThr: 3.39 ± 0.384
3.838ThrVal: 3.838 ± 0.412
1.087ThrTrp: 1.087 ± 0.195
1.919ThrTyr: 1.919 ± 0.211
0.0ThrXaa: 0.0 ± 0.0
Val
6.621ValAla: 6.621 ± 0.519
1.087ValCys: 1.087 ± 0.233
4.862ValAsp: 4.862 ± 0.349
5.15ValGlu: 5.15 ± 0.541
1.311ValPhe: 1.311 ± 0.229
5.565ValGly: 5.565 ± 0.448
1.791ValHis: 1.791 ± 0.233
3.454ValIle: 3.454 ± 0.287
3.071ValLys: 3.071 ± 0.285
4.798ValLeu: 4.798 ± 0.354
1.151ValMet: 1.151 ± 0.189
2.271ValAsn: 2.271 ± 0.272
2.815ValPro: 2.815 ± 0.291
2.495ValGln: 2.495 ± 0.364
4.83ValArg: 4.83 ± 0.376
3.998ValSer: 3.998 ± 0.414
3.966ValThr: 3.966 ± 0.346
4.99ValVal: 4.99 ± 0.436
1.119ValTrp: 1.119 ± 0.183
2.015ValTyr: 2.015 ± 0.224
0.0ValXaa: 0.0 ± 0.0
Trp
2.079TrpAla: 2.079 ± 0.27
0.544TrpCys: 0.544 ± 0.162
1.759TrpAsp: 1.759 ± 0.237
1.759TrpGlu: 1.759 ± 0.235
0.8TrpPhe: 0.8 ± 0.162
1.567TrpGly: 1.567 ± 0.212
0.544TrpHis: 0.544 ± 0.128
1.247TrpIle: 1.247 ± 0.207
1.279TrpLys: 1.279 ± 0.197
2.207TrpLeu: 2.207 ± 0.279
0.672TrpMet: 0.672 ± 0.145
0.832TrpAsn: 0.832 ± 0.142
0.896TrpPro: 0.896 ± 0.179
0.928TrpGln: 0.928 ± 0.165
1.439TrpArg: 1.439 ± 0.207
1.887TrpSer: 1.887 ± 0.25
1.375TrpThr: 1.375 ± 0.206
1.567TrpVal: 1.567 ± 0.214
0.608TrpTrp: 0.608 ± 0.136
0.768TrpTyr: 0.768 ± 0.132
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.559TyrAla: 2.559 ± 0.287
0.672TyrCys: 0.672 ± 0.166
2.591TyrAsp: 2.591 ± 0.36
2.399TyrGlu: 2.399 ± 0.29
1.087TyrPhe: 1.087 ± 0.211
2.879TyrGly: 2.879 ± 0.305
1.055TyrHis: 1.055 ± 0.193
1.375TyrIle: 1.375 ± 0.202
1.599TyrLys: 1.599 ± 0.233
2.687TyrLeu: 2.687 ± 0.313
0.704TyrMet: 0.704 ± 0.167
1.055TyrAsn: 1.055 ± 0.179
1.375TyrPro: 1.375 ± 0.253
1.343TyrGln: 1.343 ± 0.216
2.495TyrArg: 2.495 ± 0.335
1.983TyrSer: 1.983 ± 0.257
2.239TyrThr: 2.239 ± 0.302
2.367TyrVal: 2.367 ± 0.321
1.087TyrTrp: 1.087 ± 0.199
1.279TyrTyr: 1.279 ± 0.216
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 198 proteins (31266 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski