Amino acid dipepetide frequency for Chimpanzee faeces associated microphage 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.997AlaAla: 8.997 ± 6.539
0.0AlaCys: 0.0 ± 0.0
6.228AlaAsp: 6.228 ± 1.622
3.46AlaGlu: 3.46 ± 2.905
1.384AlaPhe: 1.384 ± 0.975
4.152AlaGly: 4.152 ± 0.886
1.384AlaHis: 1.384 ± 1.271
2.076AlaIle: 2.076 ± 0.603
6.228AlaLys: 6.228 ± 4.55
4.844AlaLeu: 4.844 ± 1.197
0.692AlaMet: 0.692 ± 0.7
6.228AlaAsn: 6.228 ± 3.813
1.384AlaPro: 1.384 ± 0.918
2.768AlaGln: 2.768 ± 1.346
5.536AlaArg: 5.536 ± 1.557
8.304AlaSer: 8.304 ± 1.9
4.844AlaThr: 4.844 ± 1.171
2.768AlaVal: 2.768 ± 1.343
1.384AlaTrp: 1.384 ± 0.975
3.46AlaTyr: 3.46 ± 1.42
0.0AlaXaa: 0.0 ± 0.0
Cys
0.692CysAla: 0.692 ± 0.728
0.0CysCys: 0.0 ± 0.0
0.692CysAsp: 0.692 ± 0.923
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.692CysGly: 0.692 ± 0.728
0.0CysHis: 0.0 ± 0.0
1.384CysIle: 1.384 ± 1.237
0.0CysLys: 0.0 ± 0.0
0.692CysLeu: 0.692 ± 0.488
2.768CysMet: 2.768 ± 3.147
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.384CysArg: 1.384 ± 1.457
0.692CysSer: 0.692 ± 0.923
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.46AspAla: 3.46 ± 1.7
0.0AspCys: 0.0 ± 0.0
3.46AspAsp: 3.46 ± 1.232
4.844AspGlu: 4.844 ± 2.014
2.076AspPhe: 2.076 ± 0.881
1.384AspGly: 1.384 ± 1.07
1.384AspHis: 1.384 ± 0.975
3.46AspIle: 3.46 ± 1.916
3.46AspLys: 3.46 ± 1.109
4.152AspLeu: 4.152 ± 2.762
2.076AspMet: 2.076 ± 1.17
4.844AspAsn: 4.844 ± 1.46
0.692AspPro: 0.692 ± 0.488
0.692AspGln: 0.692 ± 0.728
2.768AspArg: 2.768 ± 1.141
8.304AspSer: 8.304 ± 2.002
3.46AspThr: 3.46 ± 1.05
4.152AspVal: 4.152 ± 1.745
0.692AspTrp: 0.692 ± 0.728
6.228AspTyr: 6.228 ± 1.908
0.0AspXaa: 0.0 ± 0.0
Glu
3.46GluAla: 3.46 ± 1.956
0.0GluCys: 0.0 ± 0.0
1.384GluAsp: 1.384 ± 0.918
2.076GluGlu: 2.076 ± 1.582
2.768GluPhe: 2.768 ± 2.141
0.692GluGly: 0.692 ± 0.488
2.076GluHis: 2.076 ± 0.871
2.076GluIle: 2.076 ± 1.28
2.768GluLys: 2.768 ± 1.331
4.152GluLeu: 4.152 ± 1.947
3.46GluMet: 3.46 ± 2.259
2.768GluAsn: 2.768 ± 0.968
2.076GluPro: 2.076 ± 1.582
2.076GluGln: 2.076 ± 1.284
2.768GluArg: 2.768 ± 1.688
3.46GluSer: 3.46 ± 1.537
4.152GluThr: 4.152 ± 1.334
4.844GluVal: 4.844 ± 1.418
1.384GluTrp: 1.384 ± 0.638
3.46GluTyr: 3.46 ± 1.646
0.0GluXaa: 0.0 ± 0.0
Phe
4.152PheAla: 4.152 ± 0.806
0.0PheCys: 0.0 ± 0.0
1.384PheAsp: 1.384 ± 0.975
0.692PheGlu: 0.692 ± 0.728
2.768PhePhe: 2.768 ± 0.94
3.46PheGly: 3.46 ± 1.21
0.0PheHis: 0.0 ± 0.0
0.692PheIle: 0.692 ± 0.488
1.384PheLys: 1.384 ± 1.059
0.692PheLeu: 0.692 ± 1.031
1.384PheMet: 1.384 ± 1.07
2.768PheAsn: 2.768 ± 1.71
1.384PhePro: 1.384 ± 0.638
2.076PheGln: 2.076 ± 0.603
2.076PheArg: 2.076 ± 1.463
0.0PheSer: 0.0 ± 0.0
5.536PheThr: 5.536 ± 1.76
3.46PheVal: 3.46 ± 1.232
1.384PheTrp: 1.384 ± 0.673
2.076PheTyr: 2.076 ± 0.603
0.0PheXaa: 0.0 ± 0.0
Gly
3.46GlyAla: 3.46 ± 2.642
0.692GlyCys: 0.692 ± 0.728
4.844GlyAsp: 4.844 ± 1.964
4.844GlyGlu: 4.844 ± 0.815
0.692GlyPhe: 0.692 ± 0.488
2.768GlyGly: 2.768 ± 1.343
0.692GlyHis: 0.692 ± 0.728
2.076GlyIle: 2.076 ± 0.998
4.844GlyLys: 4.844 ± 1.827
4.152GlyLeu: 4.152 ± 1.421
0.0GlyMet: 0.0 ± 0.0
4.844GlyAsn: 4.844 ± 0.95
0.692GlyPro: 0.692 ± 0.488
0.0GlyGln: 0.0 ± 0.0
2.076GlyArg: 2.076 ± 1.448
4.844GlySer: 4.844 ± 1.473
4.152GlyThr: 4.152 ± 2.359
4.152GlyVal: 4.152 ± 1.588
0.692GlyTrp: 0.692 ± 0.488
1.384GlyTyr: 1.384 ± 0.975
0.0GlyXaa: 0.0 ± 0.0
His
0.692HisAla: 0.692 ± 0.728
0.692HisCys: 0.692 ± 0.728
2.076HisAsp: 2.076 ± 0.871
0.692HisGlu: 0.692 ± 0.923
2.076HisPhe: 2.076 ± 0.944
0.692HisGly: 0.692 ± 0.488
1.384HisHis: 1.384 ± 0.638
0.0HisIle: 0.0 ± 0.0
0.692HisLys: 0.692 ± 0.728
0.692HisLeu: 0.692 ± 0.728
1.384HisMet: 1.384 ± 0.808
0.0HisAsn: 0.0 ± 0.0
0.692HisPro: 0.692 ± 0.7
0.692HisGln: 0.692 ± 0.7
0.0HisArg: 0.0 ± 0.0
1.384HisSer: 1.384 ± 1.362
0.692HisThr: 0.692 ± 0.488
1.384HisVal: 1.384 ± 1.07
0.692HisTrp: 0.692 ± 0.488
2.076HisTyr: 2.076 ± 1.28
0.0HisXaa: 0.0 ± 0.0
Ile
2.076IleAla: 2.076 ± 0.603
0.692IleCys: 0.692 ± 0.923
1.384IleAsp: 1.384 ± 0.975
1.384IleGlu: 1.384 ± 0.918
0.692IlePhe: 0.692 ± 1.031
6.92IleGly: 6.92 ± 1.047
0.692IleHis: 0.692 ± 0.923
2.076IleIle: 2.076 ± 0.998
1.384IleLys: 1.384 ± 0.638
5.536IleLeu: 5.536 ± 2.546
2.076IleMet: 2.076 ± 0.872
4.152IleAsn: 4.152 ± 1.175
3.46IlePro: 3.46 ± 2.438
2.768IleGln: 2.768 ± 1.501
2.076IleArg: 2.076 ± 1.915
4.844IleSer: 4.844 ± 2.336
3.46IleThr: 3.46 ± 1.423
2.076IleVal: 2.076 ± 0.998
0.692IleTrp: 0.692 ± 0.728
4.152IleTyr: 4.152 ± 1.341
0.0IleXaa: 0.0 ± 0.0
Lys
2.768LysAla: 2.768 ± 1.956
0.0LysCys: 0.0 ± 0.0
2.076LysAsp: 2.076 ± 0.915
6.228LysGlu: 6.228 ± 2.602
1.384LysPhe: 1.384 ± 1.457
2.768LysGly: 2.768 ± 0.664
0.0LysHis: 0.0 ± 0.0
3.46LysIle: 3.46 ± 2.656
4.844LysLys: 4.844 ± 3.052
6.92LysLeu: 6.92 ± 3.817
0.692LysMet: 0.692 ± 1.031
1.384LysAsn: 1.384 ± 0.873
0.692LysPro: 0.692 ± 0.488
0.692LysGln: 0.692 ± 0.728
2.768LysArg: 2.768 ± 2.119
5.536LysSer: 5.536 ± 1.522
4.152LysThr: 4.152 ± 1.657
2.768LysVal: 2.768 ± 0.94
0.0LysTrp: 0.0 ± 0.0
4.844LysTyr: 4.844 ± 1.802
0.0LysXaa: 0.0 ± 0.0
Leu
5.536LeuAla: 5.536 ± 2.365
1.384LeuCys: 1.384 ± 2.062
4.844LeuAsp: 4.844 ± 3.256
5.536LeuGlu: 5.536 ± 2.099
0.692LeuPhe: 0.692 ± 0.488
1.384LeuGly: 1.384 ± 0.975
2.076LeuHis: 2.076 ± 1.35
6.228LeuIle: 6.228 ± 5.805
6.228LeuLys: 6.228 ± 3.942
7.612LeuLeu: 7.612 ± 9.318
2.768LeuMet: 2.768 ± 1.471
6.228LeuAsn: 6.228 ± 2.496
6.92LeuPro: 6.92 ± 1.838
4.152LeuGln: 4.152 ± 1.711
3.46LeuArg: 3.46 ± 2.095
4.844LeuSer: 4.844 ± 1.762
3.46LeuThr: 3.46 ± 2.924
5.536LeuVal: 5.536 ± 1.776
0.0LeuTrp: 0.0 ± 0.0
4.844LeuTyr: 4.844 ± 1.199
0.0LeuXaa: 0.0 ± 0.0
Met
1.384MetAla: 1.384 ± 0.673
0.0MetCys: 0.0 ± 0.0
1.384MetAsp: 1.384 ± 0.673
0.692MetGlu: 0.692 ± 0.923
0.692MetPhe: 0.692 ± 0.923
0.692MetGly: 0.692 ± 0.488
0.692MetHis: 0.692 ± 0.488
0.692MetIle: 0.692 ± 0.728
0.692MetLys: 0.692 ± 0.728
2.768MetLeu: 2.768 ± 1.501
0.0MetMet: 0.0 ± 0.0
2.768MetAsn: 2.768 ± 1.346
1.384MetPro: 1.384 ± 0.943
2.076MetGln: 2.076 ± 1.199
2.768MetArg: 2.768 ± 2.927
2.768MetSer: 2.768 ± 1.156
0.0MetThr: 0.0 ± 0.0
2.768MetVal: 2.768 ± 1.886
0.0MetTrp: 0.0 ± 0.0
2.768MetTyr: 2.768 ± 1.956
0.0MetXaa: 0.0 ± 0.0
Asn
6.228AsnAla: 6.228 ± 3.046
0.0AsnCys: 0.0 ± 0.0
3.46AsnAsp: 3.46 ± 1.025
0.692AsnGlu: 0.692 ± 0.488
2.076AsnPhe: 2.076 ± 1.405
2.768AsnGly: 2.768 ± 1.71
1.384AsnHis: 1.384 ± 1.07
4.152AsnIle: 4.152 ± 2.925
4.844AsnLys: 4.844 ± 0.95
6.92AsnLeu: 6.92 ± 2.84
0.692AsnMet: 0.692 ± 0.488
2.076AsnAsn: 2.076 ± 0.944
2.768AsnPro: 2.768 ± 1.346
6.92AsnGln: 6.92 ± 3.854
4.152AsnArg: 4.152 ± 0.725
8.997AsnSer: 8.997 ± 1.838
4.152AsnThr: 4.152 ± 2.019
1.384AsnVal: 1.384 ± 0.975
1.384AsnTrp: 1.384 ± 0.873
2.076AsnTyr: 2.076 ± 1.405
0.0AsnXaa: 0.0 ± 0.0
Pro
1.384ProAla: 1.384 ± 0.975
2.076ProCys: 2.076 ± 2.157
4.152ProAsp: 4.152 ± 1.421
2.768ProGlu: 2.768 ± 1.982
2.076ProPhe: 2.076 ± 1.463
2.768ProGly: 2.768 ± 0.94
0.692ProHis: 0.692 ± 0.728
2.076ProIle: 2.076 ± 0.603
1.384ProLys: 1.384 ± 1.237
2.768ProLeu: 2.768 ± 1.222
2.076ProMet: 2.076 ± 1.463
1.384ProAsn: 1.384 ± 0.975
0.692ProPro: 0.692 ± 0.728
2.076ProGln: 2.076 ± 1.463
0.692ProArg: 0.692 ± 0.488
3.46ProSer: 3.46 ± 1.303
3.46ProThr: 3.46 ± 2.017
3.46ProVal: 3.46 ± 2.017
0.0ProTrp: 0.0 ± 0.0
1.384ProTyr: 1.384 ± 0.873
0.0ProXaa: 0.0 ± 0.0
Gln
4.152GlnAla: 4.152 ± 3.335
0.0GlnCys: 0.0 ± 0.0
2.076GlnAsp: 2.076 ± 1.405
1.384GlnGlu: 1.384 ± 0.943
0.692GlnPhe: 0.692 ± 0.7
2.076GlnGly: 2.076 ± 1.463
0.692GlnHis: 0.692 ± 0.7
3.46GlnIle: 3.46 ± 1.05
2.768GlnLys: 2.768 ± 1.015
4.152GlnLeu: 4.152 ± 1.909
0.692GlnMet: 0.692 ± 0.7
3.46GlnAsn: 3.46 ± 1.927
0.692GlnPro: 0.692 ± 0.488
1.384GlnGln: 1.384 ± 0.673
4.152GlnArg: 4.152 ± 1.396
1.384GlnSer: 1.384 ± 0.673
3.46GlnThr: 3.46 ± 1.109
1.384GlnVal: 1.384 ± 0.975
0.0GlnTrp: 0.0 ± 0.0
1.384GlnTyr: 1.384 ± 1.457
0.0GlnXaa: 0.0 ± 0.0
Arg
3.46ArgAla: 3.46 ± 1.129
1.384ArgCys: 1.384 ± 1.457
3.46ArgAsp: 3.46 ± 1.835
4.152ArgGlu: 4.152 ± 1.947
5.536ArgPhe: 5.536 ± 2.626
0.692ArgGly: 0.692 ± 0.488
0.0ArgHis: 0.0 ± 0.0
2.768ArgIle: 2.768 ± 1.466
2.076ArgLys: 2.076 ± 1.28
9.689ArgLeu: 9.689 ± 7.765
1.384ArgMet: 1.384 ± 0.975
4.152ArgAsn: 4.152 ± 1.175
4.152ArgPro: 4.152 ± 1.9
2.076ArgGln: 2.076 ± 1.445
4.152ArgArg: 4.152 ± 4.315
2.076ArgSer: 2.076 ± 1.463
1.384ArgThr: 1.384 ± 1.845
3.46ArgVal: 3.46 ± 1.163
0.0ArgTrp: 0.0 ± 0.0
2.768ArgTyr: 2.768 ± 1.26
0.0ArgXaa: 0.0 ± 0.0
Ser
7.612SerAla: 7.612 ± 2.486
1.384SerCys: 1.384 ± 0.918
2.768SerAsp: 2.768 ± 0.664
4.152SerGlu: 4.152 ± 3.163
4.152SerPhe: 4.152 ± 1.084
3.46SerGly: 3.46 ± 1.315
1.384SerHis: 1.384 ± 0.975
6.228SerIle: 6.228 ± 0.618
3.46SerLys: 3.46 ± 1.025
4.152SerLeu: 4.152 ± 0.806
3.46SerMet: 3.46 ± 3.026
8.304SerAsn: 8.304 ± 3.009
4.152SerPro: 4.152 ± 1.588
4.152SerGln: 4.152 ± 1.998
6.228SerArg: 6.228 ± 2.292
4.844SerSer: 4.844 ± 1.46
4.844SerThr: 4.844 ± 2.022
5.536SerVal: 5.536 ± 2.358
1.384SerTrp: 1.384 ± 0.975
1.384SerTyr: 1.384 ± 0.975
0.0SerXaa: 0.0 ± 0.0
Thr
4.844ThrAla: 4.844 ± 2.513
0.692ThrCys: 0.692 ± 0.728
4.844ThrAsp: 4.844 ± 2.625
2.768ThrGlu: 2.768 ± 1.501
0.692ThrPhe: 0.692 ± 0.7
6.92ThrGly: 6.92 ± 1.147
0.692ThrHis: 0.692 ± 0.923
2.076ThrIle: 2.076 ± 1.145
0.692ThrLys: 0.692 ± 1.031
5.536ThrLeu: 5.536 ± 3.518
0.0ThrMet: 0.0 ± 0.0
4.844ThrAsn: 4.844 ± 2.27
2.768ThrPro: 2.768 ± 1.71
1.384ThrGln: 1.384 ± 1.401
6.228ThrArg: 6.228 ± 2.7
8.304ThrSer: 8.304 ± 2.32
4.152ThrThr: 4.152 ± 2.359
0.692ThrVal: 0.692 ± 0.488
0.0ThrTrp: 0.0 ± 0.0
5.536ThrTyr: 5.536 ± 2.626
0.0ThrXaa: 0.0 ± 0.0
Val
4.844ValAla: 4.844 ± 2.817
0.0ValCys: 0.0 ± 0.0
4.844ValAsp: 4.844 ± 1.729
2.768ValGlu: 2.768 ± 2.735
1.384ValPhe: 1.384 ± 0.975
2.076ValGly: 2.076 ± 0.871
0.692ValHis: 0.692 ± 0.728
2.768ValIle: 2.768 ± 0.94
3.46ValLys: 3.46 ± 0.824
5.536ValLeu: 5.536 ± 3.661
0.692ValMet: 0.692 ± 0.488
3.46ValAsn: 3.46 ± 1.21
4.152ValPro: 4.152 ± 2.161
1.384ValGln: 1.384 ± 0.918
2.768ValArg: 2.768 ± 1.144
2.768ValSer: 2.768 ± 1.95
6.228ValThr: 6.228 ± 1.401
6.228ValVal: 6.228 ± 2.112
0.692ValTrp: 0.692 ± 0.488
1.384ValTyr: 1.384 ± 1.845
0.0ValXaa: 0.0 ± 0.0
Trp
1.384TrpAla: 1.384 ± 0.638
0.0TrpCys: 0.0 ± 0.0
0.692TrpAsp: 0.692 ± 0.728
0.692TrpGlu: 0.692 ± 0.488
0.692TrpPhe: 0.692 ± 0.488
0.692TrpGly: 0.692 ± 0.728
0.692TrpHis: 0.692 ± 0.488
2.076TrpIle: 2.076 ± 0.871
0.692TrpLys: 0.692 ± 0.7
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.692TrpArg: 0.692 ± 0.488
1.384TrpSer: 1.384 ± 0.673
0.692TrpThr: 0.692 ± 0.488
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.536TyrAla: 5.536 ± 0.756
0.0TyrCys: 0.0 ± 0.0
5.536TyrAsp: 5.536 ± 0.756
2.768TyrGlu: 2.768 ± 1.276
4.844TyrPhe: 4.844 ± 0.815
4.844TyrGly: 4.844 ± 1.802
2.076TyrHis: 2.076 ± 1.28
2.768TyrIle: 2.768 ± 0.664
2.076TyrLys: 2.076 ± 0.881
2.768TyrLeu: 2.768 ± 1.276
0.0TyrMet: 0.0 ± 0.0
3.46TyrAsn: 3.46 ± 1.025
2.076TyrPro: 2.076 ± 1.145
2.076TyrGln: 2.076 ± 0.944
2.076TyrArg: 2.076 ± 1.199
4.844TyrSer: 4.844 ± 0.649
1.384TyrThr: 1.384 ± 0.873
2.076TyrVal: 2.076 ± 0.944
0.0TyrTrp: 0.0 ± 0.0
3.46TyrTyr: 3.46 ± 0.996
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1446 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski