Amino acid dipepetide frequency for Hyaloscypha bicolor E

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.889AlaAla: 7.889 ± 0.045
1.127AlaCys: 1.127 ± 0.012
3.669AlaAsp: 3.669 ± 0.022
4.799AlaGlu: 4.799 ± 0.029
3.21AlaPhe: 3.21 ± 0.022
5.493AlaGly: 5.493 ± 0.035
1.603AlaHis: 1.603 ± 0.014
4.557AlaIle: 4.557 ± 0.026
4.039AlaLys: 4.039 ± 0.025
7.608AlaLeu: 7.608 ± 0.044
1.854AlaMet: 1.854 ± 0.015
2.874AlaAsn: 2.874 ± 0.02
4.244AlaPro: 4.244 ± 0.029
3.027AlaGln: 3.027 ± 0.023
4.442AlaArg: 4.442 ± 0.027
6.847AlaSer: 6.847 ± 0.036
5.017AlaThr: 5.017 ± 0.027
5.005AlaVal: 5.005 ± 0.026
1.174AlaTrp: 1.174 ± 0.012
2.08AlaTyr: 2.08 ± 0.017
0.0AlaXaa: 0.0 ± 0.0
Cys
0.963CysAla: 0.963 ± 0.013
0.347CysCys: 0.347 ± 0.008
0.687CysAsp: 0.687 ± 0.011
0.689CysGlu: 0.689 ± 0.01
0.653CysPhe: 0.653 ± 0.01
1.103CysGly: 1.103 ± 0.014
0.377CysHis: 0.377 ± 0.007
0.831CysIle: 0.831 ± 0.012
0.624CysLys: 0.624 ± 0.009
1.443CysLeu: 1.443 ± 0.016
0.3CysMet: 0.3 ± 0.006
0.493CysAsn: 0.493 ± 0.009
0.747CysPro: 0.747 ± 0.011
0.534CysGln: 0.534 ± 0.009
0.82CysArg: 0.82 ± 0.011
1.127CysSer: 1.127 ± 0.012
0.809CysThr: 0.809 ± 0.011
0.836CysVal: 0.836 ± 0.012
0.267CysTrp: 0.267 ± 0.007
0.417CysTyr: 0.417 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
3.98AspAla: 3.98 ± 0.025
0.679AspCys: 0.679 ± 0.009
3.455AspAsp: 3.455 ± 0.032
4.164AspGlu: 4.164 ± 0.032
2.298AspPhe: 2.298 ± 0.017
3.892AspGly: 3.892 ± 0.024
1.164AspHis: 1.164 ± 0.011
3.161AspIle: 3.161 ± 0.02
2.236AspLys: 2.236 ± 0.018
4.986AspLeu: 4.986 ± 0.026
1.177AspMet: 1.177 ± 0.013
1.846AspAsn: 1.846 ± 0.016
3.155AspPro: 3.155 ± 0.023
1.736AspGln: 1.736 ± 0.016
2.756AspArg: 2.756 ± 0.022
3.932AspSer: 3.932 ± 0.025
2.735AspThr: 2.735 ± 0.019
3.347AspVal: 3.347 ± 0.023
0.891AspTrp: 0.891 ± 0.012
1.494AspTyr: 1.494 ± 0.016
0.0AspXaa: 0.0 ± 0.0
Glu
5.188GluAla: 5.188 ± 0.03
0.714GluCys: 0.714 ± 0.009
4.007GluAsp: 4.007 ± 0.028
5.485GluGlu: 5.485 ± 0.043
2.071GluPhe: 2.071 ± 0.016
4.005GluGly: 4.005 ± 0.025
1.349GluHis: 1.349 ± 0.016
3.399GluIle: 3.399 ± 0.024
3.972GluLys: 3.972 ± 0.027
5.276GluLeu: 5.276 ± 0.033
1.533GluMet: 1.533 ± 0.014
2.44GluAsn: 2.44 ± 0.02
2.561GluPro: 2.561 ± 0.021
2.288GluGln: 2.288 ± 0.021
3.985GluArg: 3.985 ± 0.032
4.236GluSer: 4.236 ± 0.026
3.363GluThr: 3.363 ± 0.022
3.769GluVal: 3.769 ± 0.023
0.965GluTrp: 0.965 ± 0.01
1.694GluTyr: 1.694 ± 0.015
0.0GluXaa: 0.0 ± 0.0
Phe
3.083PheAla: 3.083 ± 0.02
0.659PheCys: 0.659 ± 0.009
2.276PheAsp: 2.276 ± 0.018
2.358PheGlu: 2.358 ± 0.017
1.732PhePhe: 1.732 ± 0.019
3.069PheGly: 3.069 ± 0.029
0.921PheHis: 0.921 ± 0.01
1.989PheIle: 1.989 ± 0.018
1.709PheLys: 1.709 ± 0.017
3.764PheLeu: 3.764 ± 0.02
0.802PheMet: 0.802 ± 0.009
1.541PheAsn: 1.541 ± 0.016
2.103PhePro: 2.103 ± 0.019
1.521PheGln: 1.521 ± 0.014
2.049PheArg: 2.049 ± 0.016
3.252PheSer: 3.252 ± 0.023
2.291PheThr: 2.291 ± 0.015
2.47PheVal: 2.47 ± 0.02
0.723PheTrp: 0.723 ± 0.011
1.144PheTyr: 1.144 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
5.057GlyAla: 5.057 ± 0.035
1.014GlyCys: 1.014 ± 0.013
3.499GlyAsp: 3.499 ± 0.021
3.875GlyGlu: 3.875 ± 0.022
2.936GlyPhe: 2.936 ± 0.024
5.791GlyGly: 5.791 ± 0.047
1.655GlyHis: 1.655 ± 0.019
3.821GlyIle: 3.821 ± 0.027
3.805GlyLys: 3.805 ± 0.028
6.183GlyLeu: 6.183 ± 0.035
1.68GlyMet: 1.68 ± 0.015
2.754GlyAsn: 2.754 ± 0.023
3.216GlyPro: 3.216 ± 0.022
2.463GlyGln: 2.463 ± 0.021
4.049GlyArg: 4.049 ± 0.025
5.698GlySer: 5.698 ± 0.029
4.051GlyThr: 4.051 ± 0.026
4.369GlyVal: 4.369 ± 0.03
1.239GlyTrp: 1.239 ± 0.015
2.149GlyTyr: 2.149 ± 0.019
0.0GlyXaa: 0.0 ± 0.0
His
1.658HisAla: 1.658 ± 0.016
0.391HisCys: 0.391 ± 0.008
1.2HisAsp: 1.2 ± 0.013
1.311HisGlu: 1.311 ± 0.013
0.977HisPhe: 0.977 ± 0.012
1.65HisGly: 1.65 ± 0.016
0.796HisHis: 0.796 ± 0.013
1.262HisIle: 1.262 ± 0.013
0.948HisLys: 0.948 ± 0.012
2.279HisLeu: 2.279 ± 0.018
0.478HisMet: 0.478 ± 0.007
0.871HisAsn: 0.871 ± 0.011
1.602HisPro: 1.602 ± 0.016
0.945HisGln: 0.945 ± 0.011
1.445HisArg: 1.445 ± 0.016
1.843HisSer: 1.843 ± 0.019
1.286HisThr: 1.286 ± 0.012
1.32HisVal: 1.32 ± 0.013
0.374HisTrp: 0.374 ± 0.007
0.69HisTyr: 0.69 ± 0.01
0.0HisXaa: 0.0 ± 0.0
Ile
4.352IleAla: 4.352 ± 0.026
0.905IleCys: 0.905 ± 0.011
2.907IleAsp: 2.907 ± 0.022
3.131IleGlu: 3.131 ± 0.022
2.309IlePhe: 2.309 ± 0.019
3.451IleGly: 3.451 ± 0.024
1.24IleHis: 1.24 ± 0.014
2.916IleIle: 2.916 ± 0.023
2.444IleLys: 2.444 ± 0.02
5.119IleLeu: 5.119 ± 0.028
1.082IleMet: 1.082 ± 0.012
1.999IleAsn: 1.999 ± 0.017
3.227IlePro: 3.227 ± 0.02
2.063IleGln: 2.063 ± 0.016
2.909IleArg: 2.909 ± 0.02
4.336IleSer: 4.336 ± 0.024
3.12IleThr: 3.12 ± 0.022
3.268IleVal: 3.268 ± 0.022
0.857IleTrp: 0.857 ± 0.01
1.612IleTyr: 1.612 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
4.262LysAla: 4.262 ± 0.028
0.614LysCys: 0.614 ± 0.009
2.846LysAsp: 2.846 ± 0.023
3.702LysGlu: 3.702 ± 0.028
1.67LysPhe: 1.67 ± 0.014
3.296LysGly: 3.296 ± 0.022
1.175LysHis: 1.175 ± 0.011
2.628LysIle: 2.628 ± 0.022
3.479LysLys: 3.479 ± 0.033
4.303LysLeu: 4.303 ± 0.031
1.117LysMet: 1.117 ± 0.012
1.856LysAsn: 1.856 ± 0.015
2.664LysPro: 2.664 ± 0.023
1.81LysGln: 1.81 ± 0.018
3.405LysArg: 3.405 ± 0.023
3.761LysSer: 3.761 ± 0.024
2.969LysThr: 2.969 ± 0.021
2.975LysVal: 2.975 ± 0.022
0.774LysTrp: 0.774 ± 0.011
1.477LysTyr: 1.477 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
7.679LeuAla: 7.679 ± 0.034
1.387LeuCys: 1.387 ± 0.015
5.062LeuAsp: 5.062 ± 0.028
5.804LeuGlu: 5.804 ± 0.033
3.498LeuPhe: 3.498 ± 0.026
6.182LeuGly: 6.182 ± 0.033
2.305LeuHis: 2.305 ± 0.021
4.302LeuIle: 4.302 ± 0.025
4.575LeuLys: 4.575 ± 0.029
8.925LeuLeu: 8.925 ± 0.047
1.806LeuMet: 1.806 ± 0.016
3.307LeuAsn: 3.307 ± 0.021
5.553LeuPro: 5.553 ± 0.029
3.935LeuGln: 3.935 ± 0.025
5.634LeuArg: 5.634 ± 0.032
7.56LeuSer: 7.56 ± 0.039
4.914LeuThr: 4.914 ± 0.028
5.502LeuVal: 5.502 ± 0.031
1.369LeuTrp: 1.369 ± 0.015
2.423LeuTyr: 2.423 ± 0.019
0.0LeuXaa: 0.0 ± 0.0
Met
2.167MetAla: 2.167 ± 0.016
0.259MetCys: 0.259 ± 0.005
1.244MetAsp: 1.244 ± 0.012
1.338MetGlu: 1.338 ± 0.013
0.796MetPhe: 0.796 ± 0.01
1.496MetGly: 1.496 ± 0.016
0.46MetHis: 0.46 ± 0.009
1.059MetIle: 1.059 ± 0.012
1.129MetLys: 1.129 ± 0.013
1.859MetLeu: 1.859 ± 0.018
0.571MetMet: 0.571 ± 0.01
0.835MetAsn: 0.835 ± 0.011
1.198MetPro: 1.198 ± 0.014
0.828MetGln: 0.828 ± 0.013
1.242MetArg: 1.242 ± 0.014
1.842MetSer: 1.842 ± 0.015
1.262MetThr: 1.262 ± 0.014
1.318MetVal: 1.318 ± 0.013
0.287MetTrp: 0.287 ± 0.006
0.517MetTyr: 0.517 ± 0.008
0.0MetXaa: 0.0 ± 0.0
Asn
3.045AsnAla: 3.045 ± 0.018
0.527AsnCys: 0.527 ± 0.009
1.893AsnAsp: 1.893 ± 0.015
2.082AsnGlu: 2.082 ± 0.017
1.581AsnPhe: 1.581 ± 0.015
3.164AsnGly: 3.164 ± 0.028
0.891AsnHis: 0.891 ± 0.01
2.28AsnIle: 2.28 ± 0.019
1.584AsnLys: 1.584 ± 0.015
3.568AsnLeu: 3.568 ± 0.023
0.833AsnMet: 0.833 ± 0.01
1.585AsnAsn: 1.585 ± 0.017
2.482AsnPro: 2.482 ± 0.021
1.392AsnGln: 1.392 ± 0.015
1.931AsnArg: 1.931 ± 0.016
3.079AsnSer: 3.079 ± 0.022
2.349AsnThr: 2.349 ± 0.02
2.288AsnVal: 2.288 ± 0.019
0.638AsnTrp: 0.638 ± 0.01
1.124AsnTyr: 1.124 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
4.605ProAla: 4.605 ± 0.029
0.587ProCys: 0.587 ± 0.011
2.858ProAsp: 2.858 ± 0.02
3.582ProGlu: 3.582 ± 0.025
2.115ProPhe: 2.115 ± 0.018
3.749ProGly: 3.749 ± 0.025
1.269ProHis: 1.269 ± 0.016
2.717ProIle: 2.717 ± 0.019
2.772ProLys: 2.772 ± 0.023
4.875ProLeu: 4.875 ± 0.028
1.025ProMet: 1.025 ± 0.012
2.293ProAsn: 2.293 ± 0.019
4.797ProPro: 4.797 ± 0.053
2.377ProGln: 2.377 ± 0.024
3.273ProArg: 3.273 ± 0.024
5.764ProSer: 5.764 ± 0.038
3.893ProThr: 3.893 ± 0.027
3.222ProVal: 3.222 ± 0.022
0.762ProTrp: 0.762 ± 0.01
1.491ProTyr: 1.491 ± 0.016
0.0ProXaa: 0.0 ± 0.0
Gln
3.158GlnAla: 3.158 ± 0.026
0.511GlnCys: 0.511 ± 0.01
1.957GlnAsp: 1.957 ± 0.014
2.429GlnGlu: 2.429 ± 0.018
1.342GlnPhe: 1.342 ± 0.015
2.333GlnGly: 2.333 ± 0.022
1.024GlnHis: 1.024 ± 0.013
2.036GlnIle: 2.036 ± 0.015
2.001GlnLys: 2.001 ± 0.018
3.385GlnLeu: 3.385 ± 0.02
0.85GlnMet: 0.85 ± 0.012
1.691GlnAsn: 1.691 ± 0.017
2.269GlnPro: 2.269 ± 0.023
2.103GlnGln: 2.103 ± 0.032
2.495GlnArg: 2.495 ± 0.018
3.021GlnSer: 3.021 ± 0.022
2.269GlnThr: 2.269 ± 0.018
2.171GlnVal: 2.171 ± 0.018
0.585GlnTrp: 0.585 ± 0.009
1.165GlnTyr: 1.165 ± 0.013
0.0GlnXaa: 0.0 ± 0.0
Arg
4.221ArgAla: 4.221 ± 0.024
0.808ArgCys: 0.808 ± 0.01
3.143ArgAsp: 3.143 ± 0.027
3.848ArgGlu: 3.848 ± 0.028
2.118ArgPhe: 2.118 ± 0.017
3.733ArgGly: 3.733 ± 0.025
1.473ArgHis: 1.473 ± 0.016
3.038ArgIle: 3.038 ± 0.019
3.564ArgLys: 3.564 ± 0.024
5.361ArgLeu: 5.361 ± 0.032
1.312ArgMet: 1.312 ± 0.012
2.315ArgAsn: 2.315 ± 0.02
3.184ArgPro: 3.184 ± 0.026
2.437ArgGln: 2.437 ± 0.021
4.69ArgArg: 4.69 ± 0.03
4.57ArgSer: 4.57 ± 0.028
3.241ArgThr: 3.241 ± 0.02
3.242ArgVal: 3.242 ± 0.022
0.967ArgTrp: 0.967 ± 0.011
1.619ArgTyr: 1.619 ± 0.014
0.0ArgXaa: 0.0 ± 0.0
Ser
6.166SerAla: 6.166 ± 0.032
1.06SerCys: 1.06 ± 0.014
3.908SerAsp: 3.908 ± 0.025
4.156SerGlu: 4.156 ± 0.024
3.236SerPhe: 3.236 ± 0.022
5.581SerGly: 5.581 ± 0.03
1.915SerHis: 1.915 ± 0.016
4.385SerIle: 4.385 ± 0.025
3.991SerLys: 3.991 ± 0.029
7.455SerLeu: 7.455 ± 0.035
1.774SerMet: 1.774 ± 0.016
3.266SerAsn: 3.266 ± 0.027
5.369SerPro: 5.369 ± 0.04
3.256SerGln: 3.256 ± 0.024
4.929SerArg: 4.929 ± 0.032
8.788SerSer: 8.788 ± 0.054
5.856SerThr: 5.856 ± 0.033
4.43SerVal: 4.43 ± 0.026
1.259SerTrp: 1.259 ± 0.013
2.185SerTyr: 2.185 ± 0.016
0.0SerXaa: 0.0 ± 0.0
Thr
4.973ThrAla: 4.973 ± 0.026
0.854ThrCys: 0.854 ± 0.011
2.582ThrAsp: 2.582 ± 0.021
3.054ThrGlu: 3.054 ± 0.022
2.493ThrPhe: 2.493 ± 0.018
4.083ThrGly: 4.083 ± 0.028
1.269ThrHis: 1.269 ± 0.014
3.388ThrIle: 3.388 ± 0.023
2.786ThrLys: 2.786 ± 0.018
5.461ThrLeu: 5.461 ± 0.029
1.187ThrMet: 1.187 ± 0.011
2.272ThrAsn: 2.272 ± 0.018
4.162ThrPro: 4.162 ± 0.032
2.091ThrGln: 2.091 ± 0.019
3.077ThrArg: 3.077 ± 0.019
5.573ThrSer: 5.573 ± 0.035
4.316ThrThr: 4.316 ± 0.031
3.569ThrVal: 3.569 ± 0.023
0.908ThrTrp: 0.908 ± 0.01
1.66ThrTyr: 1.66 ± 0.017
0.0ThrXaa: 0.0 ± 0.0
Val
4.915ValAla: 4.915 ± 0.027
0.893ValCys: 0.893 ± 0.012
3.452ValAsp: 3.452 ± 0.026
3.95ValGlu: 3.95 ± 0.024
2.519ValPhe: 2.519 ± 0.017
4.076ValGly: 4.076 ± 0.03
1.313ValHis: 1.313 ± 0.013
3.041ValIle: 3.041 ± 0.022
3.012ValLys: 3.012 ± 0.021
5.696ValLeu: 5.696 ± 0.032
1.313ValMet: 1.313 ± 0.015
2.187ValAsn: 2.187 ± 0.02
3.345ValPro: 3.345 ± 0.02
2.275ValGln: 2.275 ± 0.018
3.193ValArg: 3.193 ± 0.021
4.462ValSer: 4.462 ± 0.023
3.377ValThr: 3.377 ± 0.023
4.259ValVal: 4.259 ± 0.026
0.937ValTrp: 0.937 ± 0.011
1.693ValTyr: 1.693 ± 0.015
0.0ValXaa: 0.0 ± 0.0
Trp
1.168TrpAla: 1.168 ± 0.013
0.224TrpCys: 0.224 ± 0.005
0.904TrpAsp: 0.904 ± 0.011
0.952TrpGlu: 0.952 ± 0.01
0.595TrpPhe: 0.595 ± 0.009
1.069TrpGly: 1.069 ± 0.012
0.376TrpHis: 0.376 ± 0.007
0.921TrpIle: 0.921 ± 0.013
0.917TrpLys: 0.917 ± 0.011
1.423TrpLeu: 1.423 ± 0.012
0.413TrpMet: 0.413 ± 0.007
0.708TrpAsn: 0.708 ± 0.01
0.658TrpPro: 0.658 ± 0.01
0.577TrpGln: 0.577 ± 0.008
0.977TrpArg: 0.977 ± 0.013
1.132TrpSer: 1.132 ± 0.016
0.985TrpThr: 0.985 ± 0.012
0.983TrpVal: 0.983 ± 0.012
0.305TrpTrp: 0.305 ± 0.007
0.469TrpTyr: 0.469 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.029TyrAla: 2.029 ± 0.017
0.504TyrCys: 0.504 ± 0.009
1.534TyrAsp: 1.534 ± 0.016
1.591TyrGlu: 1.591 ± 0.015
1.304TyrPhe: 1.304 ± 0.014
2.091TyrGly: 2.091 ± 0.019
0.748TyrHis: 0.748 ± 0.01
1.518TyrIle: 1.518 ± 0.013
1.197TyrLys: 1.197 ± 0.012
2.752TyrLeu: 2.752 ± 0.022
0.603TyrMet: 0.603 ± 0.008
1.185TyrAsn: 1.185 ± 0.013
1.488TyrPro: 1.488 ± 0.017
1.137TyrGln: 1.137 ± 0.012
1.585TyrArg: 1.585 ± 0.013
2.141TyrSer: 2.141 ± 0.017
1.652TyrThr: 1.652 ± 0.016
1.567TyrVal: 1.567 ± 0.012
0.476TyrTrp: 0.476 ± 0.008
0.93TyrTyr: 0.93 ± 0.011
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18616 proteins (7838171 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski