Amino acid dipepetide frequency for Naumannella halotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.099AlaAla: 18.099 ± 0.19	0.839AlaCys: 0.839 ± 0.029	8.681AlaAsp: 8.681 ± 0.105	9.983AlaGlu: 9.983 ± 0.122	3.226AlaPhe: 3.226 ± 0.061	11.93AlaGly: 11.93 ± 0.128	2.113AlaHis: 2.113 ± 0.048	5.214AlaIle: 5.214 ± 0.082	2.761AlaLys: 2.761 ± 0.075	12.322AlaLeu: 12.322 ± 0.127	2.852AlaMet: 2.852 ± 0.055	2.255AlaAsn: 2.255 ± 0.053	5.643AlaPro: 5.643 ± 0.085	3.901AlaGln: 3.901 ± 0.076	8.042AlaArg: 8.042 ± 0.116	5.828AlaSer: 5.828 ± 0.085	6.822AlaThr: 6.822 ± 0.1	10.806AlaVal: 10.806 ± 0.112	1.72AlaTrp: 1.72 ± 0.041	2.238AlaTyr: 2.238 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.824CysAla: 0.824 ± 0.031	0.115CysCys: 0.115 ± 0.01	0.437CysAsp: 0.437 ± 0.022	0.325CysGlu: 0.325 ± 0.02	0.204CysPhe: 0.204 ± 0.013	0.803CysGly: 0.803 ± 0.028	0.177CysHis: 0.177 ± 0.014	0.226CysIle: 0.226 ± 0.014	0.089CysLys: 0.089 ± 0.008	0.695CysLeu: 0.695 ± 0.022	0.101CysMet: 0.101 ± 0.01	0.127CysAsn: 0.127 ± 0.012	0.45CysPro: 0.45 ± 0.023	0.172CysGln: 0.172 ± 0.011	0.52CysArg: 0.52 ± 0.025	0.442CysSer: 0.442 ± 0.019	0.45CysThr: 0.45 ± 0.028	0.516CysVal: 0.516 ± 0.025	0.124CysTrp: 0.124 ± 0.013	0.139CysTyr: 0.139 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.026AspAla: 7.026 ± 0.1	0.355AspCys: 0.355 ± 0.02	4.207AspAsp: 4.207 ± 0.076	4.053AspGlu: 4.053 ± 0.077	1.781AspPhe: 1.781 ± 0.048	5.784AspGly: 5.784 ± 0.101	1.645AspHis: 1.645 ± 0.049	1.991AspIle: 1.991 ± 0.047	1.151AspLys: 1.151 ± 0.043	7.098AspLeu: 7.098 ± 0.089	0.802AspMet: 0.802 ± 0.024	1.194AspAsn: 1.194 ± 0.036	5.148AspPro: 5.148 ± 0.069	2.282AspGln: 2.282 ± 0.047	5.206AspArg: 5.206 ± 0.072	3.181AspSer: 3.181 ± 0.064	2.935AspThr: 2.935 ± 0.063	4.149AspVal: 4.149 ± 0.064	1.012AspTrp: 1.012 ± 0.031	1.356AspTyr: 1.356 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.986GluAla: 6.986 ± 0.099	0.349GluCys: 0.349 ± 0.021	2.788GluAsp: 2.788 ± 0.06	3.289GluGlu: 3.289 ± 0.065	1.822GluPhe: 1.822 ± 0.046	3.879GluGly: 3.879 ± 0.065	1.417GluHis: 1.417 ± 0.04	2.762GluIle: 2.762 ± 0.058	1.349GluLys: 1.349 ± 0.044	7.925GluLeu: 7.925 ± 0.096	0.953GluMet: 0.953 ± 0.035	1.225GluAsn: 1.225 ± 0.036	3.716GluPro: 3.716 ± 0.074	2.94GluGln: 2.94 ± 0.058	4.909GluArg: 4.909 ± 0.068	3.085GluSer: 3.085 ± 0.062	3.126GluThr: 3.126 ± 0.047	5.553GluVal: 5.553 ± 0.08	0.754GluTrp: 0.754 ± 0.031	1.071GluTyr: 1.071 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.806PheAla: 3.806 ± 0.063	0.274PheCys: 0.274 ± 0.015	2.385PheAsp: 2.385 ± 0.051	1.48PheGlu: 1.48 ± 0.037	0.942PhePhe: 0.942 ± 0.036	3.424PheGly: 3.424 ± 0.062	0.584PheHis: 0.584 ± 0.026	1.002PheIle: 1.002 ± 0.037	0.419PheLys: 0.419 ± 0.021	2.548PheLeu: 2.548 ± 0.058	0.417PheMet: 0.417 ± 0.021	0.686PheAsn: 0.686 ± 0.028	1.305PhePro: 1.305 ± 0.038	0.6PheGln: 0.6 ± 0.025	1.627PheArg: 1.627 ± 0.042	1.799PheSer: 1.799 ± 0.044	1.956PheThr: 1.956 ± 0.047	2.543PheVal: 2.543 ± 0.058	0.47PheTrp: 0.47 ± 0.021	0.578PheTyr: 0.578 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.624GlyAla: 9.624 ± 0.109	0.711GlyCys: 0.711 ± 0.029	4.936GlyAsp: 4.936 ± 0.078	5.421GlyGlu: 5.421 ± 0.079	3.049GlyPhe: 3.049 ± 0.065	7.654GlyGly: 7.654 ± 0.113	1.813GlyHis: 1.813 ± 0.039	4.289GlyIle: 4.289 ± 0.081	2.142GlyLys: 2.142 ± 0.052	9.352GlyLeu: 9.352 ± 0.124	2.104GlyMet: 2.104 ± 0.05	1.882GlyAsn: 1.882 ± 0.046	4.554GlyPro: 4.554 ± 0.067	3.04GlyGln: 3.04 ± 0.066	6.561GlyArg: 6.561 ± 0.095	5.91GlySer: 5.91 ± 0.104	5.629GlyThr: 5.629 ± 0.09	7.628GlyVal: 7.628 ± 0.1	1.823GlyTrp: 1.823 ± 0.041	2.228GlyTyr: 2.228 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.054HisAla: 2.054 ± 0.049	0.185HisCys: 0.185 ± 0.014	1.34HisAsp: 1.34 ± 0.044	0.988HisGlu: 0.988 ± 0.032	0.567HisPhe: 0.567 ± 0.026	1.94HisGly: 1.94 ± 0.048	0.644HisHis: 0.644 ± 0.031	0.628HisIle: 0.628 ± 0.024	0.298HisLys: 0.298 ± 0.021	2.067HisLeu: 2.067 ± 0.048	0.319HisMet: 0.319 ± 0.02	0.388HisAsn: 0.388 ± 0.02	1.595HisPro: 1.595 ± 0.039	0.648HisGln: 0.648 ± 0.022	1.918HisArg: 1.918 ± 0.046	1.01HisSer: 1.01 ± 0.033	1.043HisThr: 1.043 ± 0.038	1.308HisVal: 1.308 ± 0.03	0.335HisTrp: 0.335 ± 0.02	0.412HisTyr: 0.412 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.27IleAla: 6.27 ± 0.094	0.435IleCys: 0.435 ± 0.02	3.523IleAsp: 3.523 ± 0.064	2.75IleGlu: 2.75 ± 0.054	1.257IlePhe: 1.257 ± 0.038	5.027IleGly: 5.027 ± 0.074	0.652IleHis: 0.652 ± 0.027	1.859IleIle: 1.859 ± 0.042	0.833IleLys: 0.833 ± 0.031	3.154IleLeu: 3.154 ± 0.058	0.671IleMet: 0.671 ± 0.031	1.105IleAsn: 1.105 ± 0.034	2.153IlePro: 2.153 ± 0.045	0.864IleGln: 0.864 ± 0.031	2.685IleArg: 2.685 ± 0.051	2.67IleSer: 2.67 ± 0.053	3.073IleThr: 3.073 ± 0.066	3.734IleVal: 3.734 ± 0.077	0.551IleTrp: 0.551 ± 0.024	0.761IleTyr: 0.761 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.52LysAla: 2.52 ± 0.065	0.082LysCys: 0.082 ± 0.01	0.945LysAsp: 0.945 ± 0.04	1.023LysGlu: 1.023 ± 0.038	0.537LysPhe: 0.537 ± 0.024	1.478LysGly: 1.478 ± 0.039	0.412LysHis: 0.412 ± 0.02	1.066LysIle: 1.066 ± 0.042	0.812LysLys: 0.812 ± 0.05	2.05LysLeu: 2.05 ± 0.047	0.375LysMet: 0.375 ± 0.023	0.476LysAsn: 0.476 ± 0.024	1.228LysPro: 1.228 ± 0.042	0.837LysGln: 0.837 ± 0.029	1.426LysArg: 1.426 ± 0.039	1.212LysSer: 1.212 ± 0.043	1.153LysThr: 1.153 ± 0.04	1.897LysVal: 1.897 ± 0.042	0.212LysTrp: 0.212 ± 0.014	0.417LysTyr: 0.417 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.691LeuAla: 14.691 ± 0.156	0.669LeuCys: 0.669 ± 0.029	6.459LeuAsp: 6.459 ± 0.096	4.522LeuGlu: 4.522 ± 0.068	2.636LeuPhe: 2.636 ± 0.055	9.505LeuGly: 9.505 ± 0.115	1.839LeuHis: 1.839 ± 0.041	4.835LeuIle: 4.835 ± 0.084	1.583LeuLys: 1.583 ± 0.046	11.03LeuLeu: 11.03 ± 0.15	1.598LeuMet: 1.598 ± 0.042	2.029LeuAsn: 2.029 ± 0.043	6.013LeuPro: 6.013 ± 0.08	3.381LeuGln: 3.381 ± 0.064	7.58LeuArg: 7.58 ± 0.101	6.146LeuSer: 6.146 ± 0.082	6.377LeuThr: 6.377 ± 0.082	8.653LeuVal: 8.653 ± 0.093	1.253LeuTrp: 1.253 ± 0.037	1.449LeuTyr: 1.449 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.34MetAla: 2.34 ± 0.045	0.138MetCys: 0.138 ± 0.012	0.878MetAsp: 0.878 ± 0.032	0.739MetGlu: 0.739 ± 0.025	0.551MetPhe: 0.551 ± 0.023	1.347MetGly: 1.347 ± 0.04	0.339MetHis: 0.339 ± 0.019	1.261MetIle: 1.261 ± 0.041	0.462MetLys: 0.462 ± 0.023	1.843MetLeu: 1.843 ± 0.045	0.356MetMet: 0.356 ± 0.019	0.519MetAsn: 0.519 ± 0.025	1.077MetPro: 1.077 ± 0.038	0.593MetGln: 0.593 ± 0.027	1.266MetArg: 1.266 ± 0.036	1.556MetSer: 1.556 ± 0.04	1.563MetThr: 1.563 ± 0.034	1.589MetVal: 1.589 ± 0.04	0.189MetTrp: 0.189 ± 0.014	0.314MetTyr: 0.314 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.453AsnAla: 2.453 ± 0.057	0.166AsnCys: 0.166 ± 0.01	1.254AsnAsp: 1.254 ± 0.041	1.053AsnGlu: 1.053 ± 0.032	0.636AsnPhe: 0.636 ± 0.026	1.908AsnGly: 1.908 ± 0.047	0.449AsnHis: 0.449 ± 0.021	0.8AsnIle: 0.8 ± 0.03	0.434AsnLys: 0.434 ± 0.023	2.093AsnLeu: 2.093 ± 0.052	0.376AsnMet: 0.376 ± 0.02	0.499AsnAsn: 0.499 ± 0.025	1.667AsnPro: 1.667 ± 0.044	0.697AsnGln: 0.697 ± 0.028	1.558AsnArg: 1.558 ± 0.037	1.183AsnSer: 1.183 ± 0.035	1.192AsnThr: 1.192 ± 0.031	1.479AsnVal: 1.479 ± 0.042	0.377AsnTrp: 0.377 ± 0.02	0.506AsnTyr: 0.506 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.151ProAla: 7.151 ± 0.082	0.258ProCys: 0.258 ± 0.018	4.249ProAsp: 4.249 ± 0.062	4.445ProGlu: 4.445 ± 0.057	1.551ProPhe: 1.551 ± 0.041	5.75ProGly: 5.75 ± 0.08	1.067ProHis: 1.067 ± 0.032	2.127ProIle: 2.127 ± 0.046	1.211ProLys: 1.211 ± 0.036	4.757ProLeu: 4.757 ± 0.071	1.066ProMet: 1.066 ± 0.029	1.167ProAsn: 1.167 ± 0.038	2.818ProPro: 2.818 ± 0.069	1.985ProGln: 1.985 ± 0.043	3.482ProArg: 3.482 ± 0.068	3.45ProSer: 3.45 ± 0.089	3.656ProThr: 3.656 ± 0.088	5.146ProVal: 5.146 ± 0.09	0.883ProTrp: 0.883 ± 0.031	1.136ProTyr: 1.136 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.191GlnAla: 4.191 ± 0.081	0.172GlnCys: 0.172 ± 0.013	1.216GlnAsp: 1.216 ± 0.038	1.362GlnGlu: 1.362 ± 0.04	0.885GlnPhe: 0.885 ± 0.032	2.219GlnGly: 2.219 ± 0.052	0.676GlnHis: 0.676 ± 0.027	1.578GlnIle: 1.578 ± 0.044	0.593GlnLys: 0.593 ± 0.025	4.076GlnLeu: 4.076 ± 0.072	0.649GlnMet: 0.649 ± 0.028	0.669GlnAsn: 0.669 ± 0.028	2.085GlnPro: 2.085 ± 0.051	1.59GlnGln: 1.59 ± 0.046	2.943GlnArg: 2.943 ± 0.055	1.532GlnSer: 1.532 ± 0.043	1.956GlnThr: 1.956 ± 0.051	3.564GlnVal: 3.564 ± 0.058	0.572GlnTrp: 0.572 ± 0.023	0.564GlnTyr: 0.564 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.921ArgAla: 7.921 ± 0.123	0.484ArgCys: 0.484 ± 0.022	3.832ArgAsp: 3.832 ± 0.062	4.123ArgGlu: 4.123 ± 0.065	2.264ArgPhe: 2.264 ± 0.056	5.12ArgGly: 5.12 ± 0.078	1.604ArgHis: 1.604 ± 0.039	3.588ArgIle: 3.588 ± 0.064	1.599ArgLys: 1.599 ± 0.047	7.666ArgLeu: 7.666 ± 0.116	1.699ArgMet: 1.699 ± 0.042	1.565ArgAsn: 1.565 ± 0.041	4.153ArgPro: 4.153 ± 0.071	2.652ArgGln: 2.652 ± 0.051	7.163ArgArg: 7.163 ± 0.124	4.533ArgSer: 4.533 ± 0.085	4.585ArgThr: 4.585 ± 0.067	5.474ArgVal: 5.474 ± 0.075	1.361ArgTrp: 1.361 ± 0.037	1.561ArgTyr: 1.561 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	7.095SerAla: 7.095 ± 0.104	0.349SerCys: 0.349 ± 0.021	3.301SerAsp: 3.301 ± 0.059	3.39SerGlu: 3.39 ± 0.059	1.671SerPhe: 1.671 ± 0.042	6.203SerGly: 6.203 ± 0.106	0.935SerHis: 0.935 ± 0.034	2.446SerIle: 2.446 ± 0.045	1.155SerLys: 1.155 ± 0.035	5.196SerLeu: 5.196 ± 0.069	1.327SerMet: 1.327 ± 0.038	1.152SerAsn: 1.152 ± 0.035	3.403SerPro: 3.403 ± 0.077	1.675SerGln: 1.675 ± 0.042	3.942SerArg: 3.942 ± 0.065	3.534SerSer: 3.534 ± 0.074	3.63SerThr: 3.63 ± 0.066	4.684SerVal: 4.684 ± 0.07	0.922SerTrp: 0.922 ± 0.031	1.178SerTyr: 1.178 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.564ThrAla: 7.564 ± 0.09	0.398ThrCys: 0.398 ± 0.021	4.186ThrAsp: 4.186 ± 0.064	4.124ThrGlu: 4.124 ± 0.069	1.639ThrPhe: 1.639 ± 0.043	6.227ThrGly: 6.227 ± 0.102	1.082ThrHis: 1.082 ± 0.03	2.595ThrIle: 2.595 ± 0.056	1.201ThrLys: 1.201 ± 0.038	5.157ThrLeu: 5.157 ± 0.072	1.102ThrMet: 1.102 ± 0.035	1.234ThrAsn: 1.234 ± 0.039	3.796ThrPro: 3.796 ± 0.092	1.53ThrGln: 1.53 ± 0.039	3.518ThrArg: 3.518 ± 0.064	3.288ThrSer: 3.288 ± 0.062	3.758ThrThr: 3.758 ± 0.065	5.726ThrVal: 5.726 ± 0.094	0.898ThrTrp: 0.898 ± 0.033	1.153ThrTyr: 1.153 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.783ValAla: 10.783 ± 0.104	0.663ValCys: 0.663 ± 0.03	5.718ValAsp: 5.718 ± 0.074	5.185ValGlu: 5.185 ± 0.082	2.378ValPhe: 2.378 ± 0.056	7.174ValGly: 7.174 ± 0.108	1.573ValHis: 1.573 ± 0.037	4.537ValIle: 4.537 ± 0.073	1.482ValLys: 1.482 ± 0.038	9.081ValLeu: 9.081 ± 0.105	1.636ValMet: 1.636 ± 0.04	1.763ValAsn: 1.763 ± 0.049	4.662ValPro: 4.662 ± 0.073	2.364ValGln: 2.364 ± 0.049	5.815ValArg: 5.815 ± 0.074	4.773ValSer: 4.773 ± 0.068	5.325ValThr: 5.325 ± 0.086	8.28ValVal: 8.28 ± 0.095	1.038ValTrp: 1.038 ± 0.03	1.257ValTyr: 1.257 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.584TrpAla: 1.584 ± 0.042	0.141TrpCys: 0.141 ± 0.011	0.736TrpAsp: 0.736 ± 0.026	0.621TrpGlu: 0.621 ± 0.025	0.604TrpPhe: 0.604 ± 0.024	1.021TrpGly: 1.021 ± 0.032	0.302TrpHis: 0.302 ± 0.019	0.653TrpIle: 0.653 ± 0.029	0.27TrpLys: 0.27 ± 0.018	1.938TrpLeu: 1.938 ± 0.049	0.282TrpMet: 0.282 ± 0.018	0.404TrpAsn: 0.404 ± 0.02	0.807TrpPro: 0.807 ± 0.031	0.775TrpGln: 0.775 ± 0.029	1.209TrpArg: 1.209 ± 0.037	1.0TrpSer: 1.0 ± 0.034	0.913TrpThr: 0.913 ± 0.033	1.24TrpVal: 1.24 ± 0.035	0.389TrpTrp: 0.389 ± 0.023	0.31TrpTyr: 0.31 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.294TyrAla: 2.294 ± 0.05	0.157TyrCys: 0.157 ± 0.012	1.285TyrAsp: 1.285 ± 0.036	1.021TyrGlu: 1.021 ± 0.032	0.647TyrPhe: 0.647 ± 0.025	1.956TyrGly: 1.956 ± 0.057	0.365TyrHis: 0.365 ± 0.017	0.573TyrIle: 0.573 ± 0.024	0.315TyrLys: 0.315 ± 0.02	2.197TyrLeu: 2.197 ± 0.044	0.234TyrMet: 0.234 ± 0.016	0.44TyrAsn: 0.44 ± 0.02	1.083TyrPro: 1.083 ± 0.039	0.566TyrGln: 0.566 ± 0.028	1.577TyrArg: 1.577 ± 0.043	1.055TyrSer: 1.055 ± 0.034	1.032TyrThr: 1.032 ± 0.033	1.516TyrVal: 1.516 ± 0.044	0.314TyrTrp: 0.314 ± 0.016	0.447TyrTyr: 0.447 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3108 proteins (1020358 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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