Human papillomavirus type 1 (Human papillomavirus type 1a)

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Mupapillomavirus; Mupapillomavirus 1

Average proteome isoelectric point is 6.16

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 8 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P06923|VE4_HPV1 Protein E4 OS=Human papillomavirus type 1 OX=10583 GN=E4 PE=3 SV=3
MM1 pKa = 7.81VGEE4 pKa = 4.4MPALKK9 pKa = 10.53DD10 pKa = 3.85LVLQLEE16 pKa = 4.44PSVLDD21 pKa = 3.7LDD23 pKa = 4.54LYY25 pKa = 10.95CYY27 pKa = 10.86EE28 pKa = 4.89EE29 pKa = 4.63VPPDD33 pKa = 4.61DD34 pKa = 4.09IEE36 pKa = 4.59EE37 pKa = 4.24EE38 pKa = 4.32LVSPQQPYY46 pKa = 10.83AVVASCAYY54 pKa = 10.03CEE56 pKa = 4.02KK57 pKa = 10.59LVRR60 pKa = 11.84LTVLADD66 pKa = 3.53HH67 pKa = 6.39SAIRR71 pKa = 11.84QLEE74 pKa = 4.01EE75 pKa = 3.65LLLRR79 pKa = 11.84SLNIVCPLCTLQRR92 pKa = 11.84QQ93 pKa = 3.52

Molecular weight: 10.5 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|Q84215|Q84215_HPV1 E8 protein OS=Human papillomavirus type 1 OX=10583 GN=E8 PE=4 SV=1
MM1 pKa = 7.54FYY3 pKa = 10.66CLVIFVIIFCLMLRR17 pKa = 11.84SCFLIILICILSGEE31 pKa = 4.66TIWCLDD37 pKa = 3.15AVKK40 pKa = 10.6GVLEE44 pKa = 4.12LLAYY48 pKa = 9.18WSLFYY53 pKa = 10.48IIRR56 pKa = 11.84SLMRR60 pKa = 11.84YY61 pKa = 9.29RR62 pKa = 11.84KK63 pKa = 9.63

Molecular weight: 7.53 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

8

0

8

2407

63

612

300.9

34.01

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.733 ± 0.392

1.994 ± 0.709

5.816 ± 0.406

6.813 ± 0.532

4.155 ± 0.602

5.401 ± 0.67

1.62 ± 0.159

5.069 ± 0.816

4.362 ± 0.836

9.846 ± 1.164

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.745 ± 0.342

4.238 ± 0.45

5.567 ± 0.932

5.11 ± 0.501

6.564 ± 0.703

8.434 ± 0.605

6.606 ± 0.8

6.273 ± 0.679

1.288 ± 0.39

3.365 ± 0.379
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski