Amino acid dipepetide frequency for Human papillomavirus type 1 (Human papillomavirus type 1a)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.741AlaAla: 3.741 ± 1.291
0.0AlaCys: 0.0 ± 0.0
4.156AlaAsp: 4.156 ± 1.357
3.741AlaGlu: 3.741 ± 1.012
3.741AlaPhe: 3.741 ± 1.018
2.078AlaGly: 2.078 ± 0.787
0.416AlaHis: 0.416 ± 0.337
2.494AlaIle: 2.494 ± 0.852
2.909AlaLys: 2.909 ± 0.983
3.741AlaLeu: 3.741 ± 1.005
0.831AlaMet: 0.831 ± 0.713
1.663AlaAsn: 1.663 ± 0.662
3.325AlaPro: 3.325 ± 0.686
3.325AlaGln: 3.325 ± 1.016
4.156AlaArg: 4.156 ± 0.872
4.988AlaSer: 4.988 ± 0.702
3.741AlaThr: 3.741 ± 1.174
4.988AlaVal: 4.988 ± 1.215
0.416AlaTrp: 0.416 ± 0.413
2.909AlaTyr: 2.909 ± 0.934
0.0AlaXaa: 0.0 ± 0.0
Cys
1.247CysAla: 1.247 ± 0.663
0.831CysCys: 0.831 ± 0.477
0.0CysAsp: 0.0 ± 0.0
0.831CysGlu: 0.831 ± 0.588
0.416CysPhe: 0.416 ± 0.591
0.831CysGly: 0.831 ± 0.673
0.0CysHis: 0.0 ± 0.0
1.663CysIle: 1.663 ± 0.996
2.078CysLys: 2.078 ± 0.685
2.078CysLeu: 2.078 ± 1.751
0.0CysMet: 0.0 ± 0.0
1.247CysAsn: 1.247 ± 0.839
2.494CysPro: 2.494 ± 1.039
0.831CysGln: 0.831 ± 0.537
0.416CysArg: 0.416 ± 0.426
0.416CysSer: 0.416 ± 0.426
1.247CysThr: 1.247 ± 0.63
1.663CysVal: 1.663 ± 0.699
1.247CysTrp: 1.247 ± 0.677
0.416CysTyr: 0.416 ± 0.49
0.0CysXaa: 0.0 ± 0.0
Asp
3.741AspAla: 3.741 ± 0.964
1.247AspCys: 1.247 ± 0.677
2.494AspAsp: 2.494 ± 0.525
4.988AspGlu: 4.988 ± 2.261
2.078AspPhe: 2.078 ± 0.717
2.494AspGly: 2.494 ± 1.09
0.831AspHis: 0.831 ± 0.632
3.741AspIle: 3.741 ± 1.628
2.494AspLys: 2.494 ± 0.964
7.481AspLeu: 7.481 ± 2.042
0.416AspMet: 0.416 ± 0.374
4.572AspAsn: 4.572 ± 1.237
3.325AspPro: 3.325 ± 0.797
2.078AspGln: 2.078 ± 0.748
1.663AspArg: 1.663 ± 0.908
3.741AspSer: 3.741 ± 1.076
3.325AspThr: 3.325 ± 1.291
4.156AspVal: 4.156 ± 0.842
1.663AspTrp: 1.663 ± 0.607
1.663AspTyr: 1.663 ± 0.718
0.0AspXaa: 0.0 ± 0.0
Glu
3.325GluAla: 3.325 ± 0.869
0.416GluCys: 0.416 ± 0.337
5.403GluAsp: 5.403 ± 1.154
5.819GluGlu: 5.819 ± 2.053
2.078GluPhe: 2.078 ± 0.568
2.494GluGly: 2.494 ± 0.946
2.494GluHis: 2.494 ± 0.422
2.909GluIle: 2.909 ± 0.981
2.909GluLys: 2.909 ± 1.265
7.066GluLeu: 7.066 ± 1.964
1.247GluMet: 1.247 ± 0.577
4.156GluAsn: 4.156 ± 1.224
2.909GluPro: 2.909 ± 0.84
4.156GluGln: 4.156 ± 1.157
3.325GluArg: 3.325 ± 0.843
5.403GluSer: 5.403 ± 1.105
5.819GluThr: 5.819 ± 1.657
4.988GluVal: 4.988 ± 1.467
0.831GluTrp: 0.831 ± 0.673
0.416GluTyr: 0.416 ± 0.374
0.0GluXaa: 0.0 ± 0.0
Phe
2.909PheAla: 2.909 ± 1.359
1.247PheCys: 1.247 ± 0.703
2.494PheAsp: 2.494 ± 0.994
2.078PheGlu: 2.078 ± 0.628
2.078PhePhe: 2.078 ± 0.938
2.078PheGly: 2.078 ± 0.65
0.831PheHis: 0.831 ± 0.448
2.078PheIle: 2.078 ± 0.442
2.494PheLys: 2.494 ± 1.609
6.234PheLeu: 6.234 ± 1.282
0.416PheMet: 0.416 ± 0.337
1.663PheAsn: 1.663 ± 1.071
1.663PhePro: 1.663 ± 0.557
1.247PheGln: 1.247 ± 0.339
2.078PheArg: 2.078 ± 0.667
1.663PheSer: 1.663 ± 0.778
2.494PheThr: 2.494 ± 0.422
1.663PheVal: 1.663 ± 1.044
1.663PheTrp: 1.663 ± 0.979
2.494PheTyr: 2.494 ± 1.471
0.0PheXaa: 0.0 ± 0.0
Gly
2.078GlyAla: 2.078 ± 0.564
1.247GlyCys: 1.247 ± 0.894
5.403GlyAsp: 5.403 ± 1.547
7.066GlyGlu: 7.066 ± 2.551
0.831GlyPhe: 0.831 ± 0.431
4.156GlyGly: 4.156 ± 1.597
1.663GlyHis: 1.663 ± 0.662
2.078GlyIle: 2.078 ± 1.39
2.494GlyLys: 2.494 ± 1.158
3.741GlyLeu: 3.741 ± 1.49
0.416GlyMet: 0.416 ± 0.374
2.494GlyAsn: 2.494 ± 1.153
1.247GlyPro: 1.247 ± 0.675
2.078GlyGln: 2.078 ± 1.239
3.325GlyArg: 3.325 ± 1.142
4.988GlySer: 4.988 ± 1.615
4.156GlyThr: 4.156 ± 0.844
3.741GlyVal: 3.741 ± 1.202
0.0GlyTrp: 0.0 ± 0.0
0.831GlyTyr: 0.831 ± 0.491
0.0GlyXaa: 0.0 ± 0.0
His
1.247HisAla: 1.247 ± 0.733
0.416HisCys: 0.416 ± 0.337
0.416HisAsp: 0.416 ± 0.413
0.831HisGlu: 0.831 ± 0.431
1.663HisPhe: 1.663 ± 0.571
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.416HisLys: 0.416 ± 0.337
1.247HisLeu: 1.247 ± 0.864
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.663HisPro: 1.663 ± 0.81
0.416HisGln: 0.416 ± 0.337
0.831HisArg: 0.831 ± 0.477
2.078HisSer: 2.078 ± 0.778
2.909HisThr: 2.909 ± 0.564
0.831HisVal: 0.831 ± 0.491
0.831HisTrp: 0.831 ± 0.466
0.416HisTyr: 0.416 ± 0.337
0.0HisXaa: 0.0 ± 0.0
Ile
3.741IleAla: 3.741 ± 1.8
1.247IleCys: 1.247 ± 0.686
3.325IleAsp: 3.325 ± 1.163
4.156IleGlu: 4.156 ± 1.236
2.909IlePhe: 2.909 ± 1.189
3.741IleGly: 3.741 ± 0.824
1.247IleHis: 1.247 ± 0.422
2.494IleIle: 2.494 ± 2.059
1.663IleLys: 1.663 ± 0.699
4.572IleLeu: 4.572 ± 1.318
0.831IleMet: 0.831 ± 0.433
1.247IleAsn: 1.247 ± 0.339
2.909IlePro: 2.909 ± 1.772
1.247IleGln: 1.247 ± 0.675
3.325IleArg: 3.325 ± 0.837
5.403IleSer: 5.403 ± 1.356
2.909IleThr: 2.909 ± 1.093
2.078IleVal: 2.078 ± 0.764
0.831IleTrp: 0.831 ± 0.729
0.831IleTyr: 0.831 ± 0.389
0.0IleXaa: 0.0 ± 0.0
Lys
3.325LysAla: 3.325 ± 0.935
1.663LysCys: 1.663 ± 0.496
3.325LysAsp: 3.325 ± 1.22
2.078LysGlu: 2.078 ± 0.976
2.494LysPhe: 2.494 ± 1.06
2.078LysGly: 2.078 ± 0.894
0.831LysHis: 0.831 ± 0.563
2.078LysIle: 2.078 ± 1.04
1.663LysLys: 1.663 ± 0.699
4.988LysLeu: 4.988 ± 1.515
0.416LysMet: 0.416 ± 0.508
2.494LysAsn: 2.494 ± 1.102
1.663LysPro: 1.663 ± 0.932
1.663LysGln: 1.663 ± 0.607
3.741LysArg: 3.741 ± 0.641
4.156LysSer: 4.156 ± 2.004
1.663LysThr: 1.663 ± 0.718
1.663LysVal: 1.663 ± 0.662
0.0LysTrp: 0.0 ± 0.0
1.247LysTyr: 1.247 ± 0.424
0.0LysXaa: 0.0 ± 0.0
Leu
4.572LeuAla: 4.572 ± 0.907
2.494LeuCys: 2.494 ± 1.007
7.897LeuAsp: 7.897 ± 1.546
9.144LeuGlu: 9.144 ± 1.653
5.403LeuPhe: 5.403 ± 1.508
7.481LeuGly: 7.481 ± 2.849
2.078LeuHis: 2.078 ± 0.737
3.741LeuIle: 3.741 ± 1.759
3.741LeuLys: 3.741 ± 1.451
11.638LeuLeu: 11.638 ± 3.013
1.247LeuMet: 1.247 ± 1.261
2.078LeuAsn: 2.078 ± 0.764
2.909LeuPro: 2.909 ± 0.639
6.65LeuGln: 6.65 ± 1.166
5.819LeuArg: 5.819 ± 0.848
7.481LeuSer: 7.481 ± 1.376
4.156LeuThr: 4.156 ± 1.037
5.819LeuVal: 5.819 ± 1.613
0.0LeuTrp: 0.0 ± 0.0
4.156LeuTyr: 4.156 ± 1.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.078MetAla: 2.078 ± 0.79
0.0MetCys: 0.0 ± 0.0
1.663MetAsp: 1.663 ± 1.081
0.416MetGlu: 0.416 ± 0.413
1.663MetPhe: 1.663 ± 0.928
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.831MetIle: 0.831 ± 0.431
0.416MetLys: 0.416 ± 0.374
0.831MetLeu: 0.831 ± 0.729
0.416MetMet: 0.416 ± 0.374
0.831MetAsn: 0.831 ± 0.466
0.416MetPro: 0.416 ± 0.49
0.0MetGln: 0.0 ± 0.0
1.247MetArg: 1.247 ± 0.677
2.078MetSer: 2.078 ± 0.886
0.416MetThr: 0.416 ± 0.374
2.494MetVal: 2.494 ± 0.525
0.0MetTrp: 0.0 ± 0.0
1.663MetTyr: 1.663 ± 0.598
0.0MetXaa: 0.0 ± 0.0
Asn
3.325AsnAla: 3.325 ± 1.045
0.416AsnCys: 0.416 ± 0.337
1.247AsnAsp: 1.247 ± 0.677
1.247AsnGlu: 1.247 ± 0.675
0.831AsnPhe: 0.831 ± 0.537
3.741AsnGly: 3.741 ± 0.84
1.247AsnHis: 1.247 ± 0.424
3.325AsnIle: 3.325 ± 1.222
2.494AsnLys: 2.494 ± 0.699
4.156AsnLeu: 4.156 ± 1.001
0.0AsnMet: 0.0 ± 0.0
2.078AsnAsn: 2.078 ± 0.717
2.909AsnPro: 2.909 ± 1.085
2.078AsnGln: 2.078 ± 1.075
2.494AsnArg: 2.494 ± 0.772
3.325AsnSer: 3.325 ± 0.976
2.909AsnThr: 2.909 ± 0.764
1.663AsnVal: 1.663 ± 0.607
0.831AsnTrp: 0.831 ± 0.673
2.078AsnTyr: 2.078 ± 0.977
0.0AsnXaa: 0.0 ± 0.0
Pro
2.909ProAla: 2.909 ± 0.878
0.831ProCys: 0.831 ± 0.477
1.663ProAsp: 1.663 ± 0.572
4.572ProGlu: 4.572 ± 1.89
1.247ProPhe: 1.247 ± 0.63
2.078ProGly: 2.078 ± 0.564
0.0ProHis: 0.0 ± 0.0
3.325ProIle: 3.325 ± 1.626
1.663ProLys: 1.663 ± 0.542
6.234ProLeu: 6.234 ± 1.986
0.416ProMet: 0.416 ± 0.475
2.909ProAsn: 2.909 ± 0.95
4.988ProPro: 4.988 ± 0.59
4.988ProGln: 4.988 ± 0.88
3.741ProArg: 3.741 ± 1.403
5.403ProSer: 5.403 ± 2.399
3.741ProThr: 3.741 ± 1.634
2.494ProVal: 2.494 ± 1.078
0.0ProTrp: 0.0 ± 0.0
2.494ProTyr: 2.494 ± 1.075
0.0ProXaa: 0.0 ± 0.0
Gln
2.078GlnAla: 2.078 ± 0.748
0.0GlnCys: 0.0 ± 0.0
3.741GlnAsp: 3.741 ± 0.73
4.156GlnGlu: 4.156 ± 1.605
1.247GlnPhe: 1.247 ± 0.424
2.494GlnGly: 2.494 ± 0.634
0.0GlnHis: 0.0 ± 0.0
1.247GlnIle: 1.247 ± 0.547
1.663GlnLys: 1.663 ± 0.896
6.65GlnLeu: 6.65 ± 1.263
2.909GlnMet: 2.909 ± 1.499
2.078GlnAsn: 2.078 ± 0.944
2.909GlnPro: 2.909 ± 1.059
4.156GlnGln: 4.156 ± 1.813
2.909GlnArg: 2.909 ± 0.979
2.909GlnSer: 2.909 ± 0.389
3.325GlnThr: 3.325 ± 0.636
3.325GlnVal: 3.325 ± 1.1
0.831GlnTrp: 0.831 ± 0.448
2.494GlnTyr: 2.494 ± 0.859
0.0GlnXaa: 0.0 ± 0.0
Arg
3.325ArgAla: 3.325 ± 1.43
1.247ArgCys: 1.247 ± 0.822
2.078ArgAsp: 2.078 ± 1.177
2.909ArgGlu: 2.909 ± 0.927
4.988ArgPhe: 4.988 ± 1.461
3.741ArgGly: 3.741 ± 1.326
1.663ArgHis: 1.663 ± 0.662
2.078ArgIle: 2.078 ± 0.564
5.403ArgLys: 5.403 ± 0.974
6.65ArgLeu: 6.65 ± 1.526
1.247ArgMet: 1.247 ± 0.737
1.247ArgAsn: 1.247 ± 0.517
4.156ArgPro: 4.156 ± 2.501
3.325ArgGln: 3.325 ± 1.219
6.234ArgArg: 6.234 ± 2.279
4.988ArgSer: 4.988 ± 1.595
4.156ArgThr: 4.156 ± 1.527
4.988ArgVal: 4.988 ± 1.727
0.0ArgTrp: 0.0 ± 0.0
1.247ArgTyr: 1.247 ± 0.677
0.0ArgXaa: 0.0 ± 0.0
Ser
3.325SerAla: 3.325 ± 0.608
1.663SerCys: 1.663 ± 0.793
4.572SerAsp: 4.572 ± 0.721
4.572SerGlu: 4.572 ± 0.76
2.909SerPhe: 2.909 ± 0.988
4.156SerGly: 4.156 ± 0.778
0.0SerHis: 0.0 ± 0.0
4.156SerIle: 4.156 ± 1.18
2.078SerLys: 2.078 ± 0.848
9.559SerLeu: 9.559 ± 1.366
3.325SerMet: 3.325 ± 0.894
5.403SerAsn: 5.403 ± 1.32
3.325SerPro: 3.325 ± 1.166
4.156SerGln: 4.156 ± 0.922
7.066SerArg: 7.066 ± 1.536
8.728SerSer: 8.728 ± 2.288
8.313SerThr: 8.313 ± 2.319
4.988SerVal: 4.988 ± 0.677
0.0SerTrp: 0.0 ± 0.0
2.078SerTyr: 2.078 ± 0.952
0.0SerXaa: 0.0 ± 0.0
Thr
4.988ThrAla: 4.988 ± 1.1
2.078ThrCys: 2.078 ± 0.568
3.741ThrAsp: 3.741 ± 0.932
4.572ThrGlu: 4.572 ± 1.094
1.247ThrPhe: 1.247 ± 0.759
2.494ThrGly: 2.494 ± 0.422
1.247ThrHis: 1.247 ± 0.339
4.572ThrIle: 4.572 ± 1.366
1.247ThrLys: 1.247 ± 0.677
2.909ThrLeu: 2.909 ± 0.975
0.416ThrMet: 0.416 ± 0.374
3.325ThrAsn: 3.325 ± 1.317
7.481ThrPro: 7.481 ± 2.878
2.909ThrGln: 2.909 ± 0.603
3.741ThrArg: 3.741 ± 1.42
6.65ThrSer: 6.65 ± 1.082
5.403ThrThr: 5.403 ± 1.294
5.403ThrVal: 5.403 ± 1.652
0.831ThrTrp: 0.831 ± 0.448
0.831ThrTyr: 0.831 ± 0.466
0.0ThrXaa: 0.0 ± 0.0
Val
2.909ValAla: 2.909 ± 1.127
0.831ValCys: 0.831 ± 0.557
2.494ValAsp: 2.494 ± 0.574
2.909ValGlu: 2.909 ± 1.179
2.909ValPhe: 2.909 ± 0.531
4.988ValGly: 4.988 ± 1.331
0.831ValHis: 0.831 ± 0.58
4.156ValIle: 4.156 ± 1.802
3.325ValLys: 3.325 ± 1.061
4.988ValLeu: 4.988 ± 1.721
1.247ValMet: 1.247 ± 0.811
0.831ValAsn: 0.831 ± 0.448
3.325ValPro: 3.325 ± 1.055
3.741ValGln: 3.741 ± 1.445
5.819ValArg: 5.819 ± 0.78
7.066ValSer: 7.066 ± 1.082
2.909ValThr: 2.909 ± 0.686
3.325ValVal: 3.325 ± 1.438
2.078ValTrp: 2.078 ± 0.687
2.078ValTyr: 2.078 ± 0.848
0.0ValXaa: 0.0 ± 0.0
Trp
0.416TrpAla: 0.416 ± 0.337
0.416TrpCys: 0.416 ± 0.591
0.831TrpAsp: 0.831 ± 0.448
0.416TrpGlu: 0.416 ± 0.374
0.416TrpPhe: 0.416 ± 0.337
1.247TrpGly: 1.247 ± 0.677
0.416TrpHis: 0.416 ± 0.413
0.831TrpIle: 0.831 ± 0.673
0.831TrpLys: 0.831 ± 0.673
1.247TrpLeu: 1.247 ± 0.733
0.416TrpMet: 0.416 ± 0.337
0.831TrpAsn: 0.831 ± 0.826
0.0TrpPro: 0.0 ± 0.0
0.831TrpGln: 0.831 ± 0.431
1.247TrpArg: 1.247 ± 0.592
0.831TrpSer: 0.831 ± 0.729
0.831TrpThr: 0.831 ± 0.466
0.416TrpVal: 0.416 ± 0.337
0.0TrpTrp: 0.0 ± 0.0
0.416TrpTyr: 0.416 ± 0.337
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.078TyrAla: 2.078 ± 0.857
1.663TyrCys: 1.663 ± 1.123
1.247TyrAsp: 1.247 ± 0.419
1.663TyrGlu: 1.663 ± 0.755
0.416TyrPhe: 0.416 ± 0.426
1.663TyrGly: 1.663 ± 0.731
0.416TyrHis: 0.416 ± 0.374
2.909TyrIle: 2.909 ± 1.24
1.663TyrLys: 1.663 ± 0.607
2.494TyrLeu: 2.494 ± 0.472
0.831TyrMet: 0.831 ± 0.673
1.247TyrAsn: 1.247 ± 0.674
2.078TyrPro: 2.078 ± 0.824
1.247TyrGln: 1.247 ± 0.592
2.494TyrArg: 2.494 ± 0.785
2.078TyrSer: 2.078 ± 0.442
1.663TyrThr: 1.663 ± 0.677
2.078TyrVal: 2.078 ± 0.442
0.831TyrTrp: 0.831 ± 0.726
2.909TyrTyr: 2.909 ± 1.122
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (2407 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski