Amino acid dipepetide frequency for Bovine papular stomatitis virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.702AlaAla: 12.702 ± 0.863
2.503AlaCys: 2.503 ± 0.296
6.681AlaAsp: 6.681 ± 0.516
5.383AlaGlu: 5.383 ± 0.385
3.4AlaPhe: 3.4 ± 0.272
5.383AlaGly: 5.383 ± 0.431
2.078AlaHis: 2.078 ± 0.3
3.541AlaIle: 3.541 ± 0.272
2.951AlaLys: 2.951 ± 0.271
10.057AlaLeu: 10.057 ± 0.672
2.55AlaMet: 2.55 ± 0.291
2.503AlaAsn: 2.503 ± 0.21
4.958AlaPro: 4.958 ± 0.507
2.054AlaGln: 2.054 ± 0.238
8.074AlaArg: 8.074 ± 0.478
6.54AlaSer: 6.54 ± 0.413
5.123AlaThr: 5.123 ± 0.386
8.098AlaVal: 8.098 ± 0.536
0.614AlaTrp: 0.614 ± 0.132
2.172AlaTyr: 2.172 ± 0.213
0.0AlaXaa: 0.0 ± 0.0
Cys
2.196CysAla: 2.196 ± 0.261
0.779CysCys: 0.779 ± 0.148
1.605CysAsp: 1.605 ± 0.175
1.346CysGlu: 1.346 ± 0.153
0.85CysPhe: 0.85 ± 0.156
1.605CysGly: 1.605 ± 0.189
0.26CysHis: 0.26 ± 0.071
0.803CysIle: 0.803 ± 0.162
0.803CysLys: 0.803 ± 0.112
2.148CysLeu: 2.148 ± 0.297
0.755CysMet: 0.755 ± 0.131
0.826CysAsn: 0.826 ± 0.152
1.18CysPro: 1.18 ± 0.23
0.425CysGln: 0.425 ± 0.116
1.96CysArg: 1.96 ± 0.212
1.629CysSer: 1.629 ± 0.186
1.346CysThr: 1.346 ± 0.201
2.337CysVal: 2.337 ± 0.242
0.165CysTrp: 0.165 ± 0.056
0.708CysTyr: 0.708 ± 0.119
0.0CysXaa: 0.0 ± 0.0
Asp
7.696AspAla: 7.696 ± 0.497
1.133AspCys: 1.133 ± 0.192
4.132AspAsp: 4.132 ± 0.355
4.132AspGlu: 4.132 ± 0.288
2.951AspPhe: 2.951 ± 0.249
4.415AspGly: 4.415 ± 0.315
0.968AspHis: 0.968 ± 0.151
3.14AspIle: 3.14 ± 0.301
1.841AspLys: 1.841 ± 0.244
5.241AspLeu: 5.241 ± 0.321
2.196AspMet: 2.196 ± 0.231
1.96AspAsn: 1.96 ± 0.23
3.187AspPro: 3.187 ± 0.295
0.874AspGln: 0.874 ± 0.17
3.707AspArg: 3.707 ± 0.277
3.636AspSer: 3.636 ± 0.316
3.069AspThr: 3.069 ± 0.255
6.186AspVal: 6.186 ± 0.388
0.354AspTrp: 0.354 ± 0.101
1.511AspTyr: 1.511 ± 0.187
0.0AspXaa: 0.0 ± 0.0
Glu
4.675GluAla: 4.675 ± 0.286
1.086GluCys: 1.086 ± 0.2
3.801GluAsp: 3.801 ± 0.294
4.155GluGlu: 4.155 ± 0.368
2.715GluPhe: 2.715 ± 0.264
1.936GluGly: 1.936 ± 0.228
1.228GluHis: 1.228 ± 0.19
2.809GluIle: 2.809 ± 0.3
2.361GluLys: 2.361 ± 0.247
5.241GluLeu: 5.241 ± 0.339
1.865GluMet: 1.865 ± 0.199
2.148GluAsn: 2.148 ± 0.245
2.219GluPro: 2.219 ± 0.241
1.133GluGln: 1.133 ± 0.171
4.863GluArg: 4.863 ± 0.36
3.659GluSer: 3.659 ± 0.277
3.73GluThr: 3.73 ± 0.279
4.486GluVal: 4.486 ± 0.301
0.59GluTrp: 0.59 ± 0.097
2.196GluTyr: 2.196 ± 0.205
0.0GluXaa: 0.0 ± 0.0
Phe
3.872PheAla: 3.872 ± 0.284
1.11PheCys: 1.11 ± 0.178
3.046PheAsp: 3.046 ± 0.261
2.196PheGlu: 2.196 ± 0.277
2.266PhePhe: 2.266 ± 0.191
2.644PheGly: 2.644 ± 0.24
1.062PheHis: 1.062 ± 0.171
1.723PheIle: 1.723 ± 0.195
1.771PheLys: 1.771 ± 0.253
4.273PheLeu: 4.273 ± 0.332
1.228PheMet: 1.228 ± 0.144
1.841PheAsn: 1.841 ± 0.246
1.794PhePro: 1.794 ± 0.201
0.944PheGln: 0.944 ± 0.155
3.258PheArg: 3.258 ± 0.247
3.234PheSer: 3.234 ± 0.278
2.408PheThr: 2.408 ± 0.228
4.297PheVal: 4.297 ± 0.321
0.378PheTrp: 0.378 ± 0.129
1.11PheTyr: 1.11 ± 0.177
0.0PheXaa: 0.0 ± 0.0
Gly
6.847GlyAla: 6.847 ± 0.532
1.298GlyCys: 1.298 ± 0.172
3.187GlyAsp: 3.187 ± 0.256
2.479GlyGlu: 2.479 ± 0.266
2.148GlyPhe: 2.148 ± 0.199
4.037GlyGly: 4.037 ± 0.499
0.921GlyHis: 0.921 ± 0.123
2.644GlyIle: 2.644 ± 0.269
2.054GlyLys: 2.054 ± 0.247
3.565GlyLeu: 3.565 ± 0.31
1.535GlyMet: 1.535 ± 0.178
1.841GlyAsn: 1.841 ± 0.237
1.771GlyPro: 1.771 ± 0.197
0.874GlyGln: 0.874 ± 0.134
4.202GlyArg: 4.202 ± 0.299
4.084GlySer: 4.084 ± 0.294
3.164GlyThr: 3.164 ± 0.26
4.911GlyVal: 4.911 ± 0.312
0.354GlyTrp: 0.354 ± 0.09
1.605GlyTyr: 1.605 ± 0.202
0.0GlyXaa: 0.0 ± 0.0
His
2.172HisAla: 2.172 ± 0.252
0.378HisCys: 0.378 ± 0.09
1.204HisAsp: 1.204 ± 0.173
0.826HisGlu: 0.826 ± 0.127
0.921HisPhe: 0.921 ± 0.137
1.417HisGly: 1.417 ± 0.201
0.992HisHis: 0.992 ± 0.171
1.346HisIle: 1.346 ± 0.218
0.708HisLys: 0.708 ± 0.153
2.101HisLeu: 2.101 ± 0.233
0.803HisMet: 0.803 ± 0.132
0.897HisAsn: 0.897 ± 0.155
1.133HisPro: 1.133 ± 0.185
0.472HisGln: 0.472 ± 0.103
2.219HisArg: 2.219 ± 0.267
1.346HisSer: 1.346 ± 0.196
1.133HisThr: 1.133 ± 0.124
2.148HisVal: 2.148 ± 0.21
0.165HisTrp: 0.165 ± 0.054
0.59HisTyr: 0.59 ± 0.105
0.0HisXaa: 0.0 ± 0.0
Ile
3.234IleAla: 3.234 ± 0.307
0.968IleCys: 0.968 ± 0.158
2.455IleAsp: 2.455 ± 0.244
2.503IleGlu: 2.503 ± 0.193
2.337IlePhe: 2.337 ± 0.237
1.605IleGly: 1.605 ± 0.244
0.992IleHis: 0.992 ± 0.133
1.629IleIle: 1.629 ± 0.199
1.7IleLys: 1.7 ± 0.249
3.541IleLeu: 3.541 ± 0.345
1.346IleMet: 1.346 ± 0.237
2.101IleAsn: 2.101 ± 0.278
2.243IlePro: 2.243 ± 0.227
0.897IleGln: 0.897 ± 0.127
3.305IleArg: 3.305 ± 0.254
3.329IleSer: 3.329 ± 0.361
2.078IleThr: 2.078 ± 0.189
3.943IleVal: 3.943 ± 0.307
0.307IleTrp: 0.307 ± 0.085
1.228IleTyr: 1.228 ± 0.158
0.0IleXaa: 0.0 ± 0.0
Lys
2.266LysAla: 2.266 ± 0.224
0.59LysCys: 0.59 ± 0.12
1.936LysAsp: 1.936 ± 0.229
1.582LysGlu: 1.582 ± 0.204
1.346LysPhe: 1.346 ± 0.227
1.393LysGly: 1.393 ± 0.169
1.11LysHis: 1.11 ± 0.153
2.196LysIle: 2.196 ± 0.339
2.455LysLys: 2.455 ± 0.288
3.943LysLeu: 3.943 ± 0.271
0.992LysMet: 0.992 ± 0.16
1.7LysAsn: 1.7 ± 0.226
1.44LysPro: 1.44 ± 0.237
0.944LysGln: 0.944 ± 0.159
2.621LysArg: 2.621 ± 0.252
2.857LysSer: 2.857 ± 0.265
2.691LysThr: 2.691 ± 0.255
2.408LysVal: 2.408 ± 0.249
0.165LysTrp: 0.165 ± 0.076
1.676LysTyr: 1.676 ± 0.194
0.0LysXaa: 0.0 ± 0.0
Leu
8.334LeuAla: 8.334 ± 0.52
2.597LeuCys: 2.597 ± 0.261
5.831LeuAsp: 5.831 ± 0.352
5.265LeuGlu: 5.265 ± 0.376
4.486LeuPhe: 4.486 ± 0.368
4.722LeuGly: 4.722 ± 0.332
2.573LeuHis: 2.573 ± 0.331
3.329LeuIle: 3.329 ± 0.253
3.518LeuLys: 3.518 ± 0.287
10.128LeuLeu: 10.128 ± 0.623
2.998LeuMet: 2.998 ± 0.257
3.305LeuAsn: 3.305 ± 0.302
3.541LeuPro: 3.541 ± 0.264
2.196LeuGln: 2.196 ± 0.255
8.499LeuArg: 8.499 ± 0.528
6.847LeuSer: 6.847 ± 0.348
4.981LeuThr: 4.981 ± 0.406
8.782LeuVal: 8.782 ± 0.528
0.425LeuTrp: 0.425 ± 0.112
3.069LeuTyr: 3.069 ± 0.247
0.0LeuXaa: 0.0 ± 0.0
Met
2.762MetAla: 2.762 ± 0.289
0.496MetCys: 0.496 ± 0.1
2.29MetAsp: 2.29 ± 0.232
2.054MetGlu: 2.054 ± 0.236
1.346MetPhe: 1.346 ± 0.153
1.393MetGly: 1.393 ± 0.191
0.449MetHis: 0.449 ± 0.092
1.228MetIle: 1.228 ± 0.162
1.015MetLys: 1.015 ± 0.19
2.786MetLeu: 2.786 ± 0.26
0.59MetMet: 0.59 ± 0.11
0.874MetAsn: 0.874 ± 0.18
1.298MetPro: 1.298 ± 0.139
0.85MetGln: 0.85 ± 0.177
2.432MetArg: 2.432 ± 0.211
2.148MetSer: 2.148 ± 0.279
1.676MetThr: 1.676 ± 0.215
1.723MetVal: 1.723 ± 0.194
0.283MetTrp: 0.283 ± 0.089
1.133MetTyr: 1.133 ± 0.184
0.0MetXaa: 0.0 ± 0.0
Asn
3.376AsnAla: 3.376 ± 0.289
0.567AsnCys: 0.567 ± 0.13
1.582AsnAsp: 1.582 ± 0.221
1.747AsnGlu: 1.747 ± 0.206
1.7AsnPhe: 1.7 ± 0.198
1.771AsnGly: 1.771 ± 0.24
0.85AsnHis: 0.85 ± 0.142
2.007AsnIle: 2.007 ± 0.188
1.535AsnLys: 1.535 ± 0.218
2.786AsnLeu: 2.786 ± 0.326
1.039AsnMet: 1.039 ± 0.174
1.605AsnAsn: 1.605 ± 0.228
1.629AsnPro: 1.629 ± 0.181
0.637AsnGln: 0.637 ± 0.135
2.054AsnArg: 2.054 ± 0.245
2.597AsnSer: 2.597 ± 0.25
2.219AsnThr: 2.219 ± 0.235
3.541AsnVal: 3.541 ± 0.297
0.236AsnTrp: 0.236 ± 0.079
1.369AsnTyr: 1.369 ± 0.179
0.0AsnXaa: 0.0 ± 0.0
Pro
5.241ProAla: 5.241 ± 0.462
1.062ProCys: 1.062 ± 0.164
3.376ProAsp: 3.376 ± 0.255
3.541ProGlu: 3.541 ± 0.288
1.771ProPhe: 1.771 ± 0.196
2.88ProGly: 2.88 ± 0.297
1.062ProHis: 1.062 ± 0.187
1.251ProIle: 1.251 ± 0.148
1.204ProLys: 1.204 ± 0.184
4.415ProLeu: 4.415 ± 0.36
1.086ProMet: 1.086 ± 0.154
1.228ProAsn: 1.228 ± 0.165
3.612ProPro: 3.612 ± 0.379
1.204ProGln: 1.204 ± 0.186
3.282ProArg: 3.282 ± 0.225
3.258ProSer: 3.258 ± 0.294
2.432ProThr: 2.432 ± 0.29
4.415ProVal: 4.415 ± 0.369
0.331ProTrp: 0.331 ± 0.084
1.11ProTyr: 1.11 ± 0.147
0.0ProXaa: 0.0 ± 0.0
Gln
1.417GlnAla: 1.417 ± 0.213
0.519GlnCys: 0.519 ± 0.115
0.968GlnAsp: 0.968 ± 0.152
1.228GlnGlu: 1.228 ± 0.218
0.803GlnPhe: 0.803 ± 0.147
0.921GlnGly: 0.921 ± 0.129
0.732GlnHis: 0.732 ± 0.131
0.944GlnIle: 0.944 ± 0.157
0.755GlnLys: 0.755 ± 0.127
2.384GlnLeu: 2.384 ± 0.218
0.826GlnMet: 0.826 ± 0.122
0.637GlnAsn: 0.637 ± 0.104
0.992GlnPro: 0.992 ± 0.122
0.874GlnGln: 0.874 ± 0.182
1.865GlnArg: 1.865 ± 0.211
1.794GlnSer: 1.794 ± 0.233
1.629GlnThr: 1.629 ± 0.231
1.133GlnVal: 1.133 ± 0.163
0.189GlnTrp: 0.189 ± 0.07
0.614GlnTyr: 0.614 ± 0.109
0.0GlnXaa: 0.0 ± 0.0
Arg
7.98ArgAla: 7.98 ± 0.521
2.196ArgCys: 2.196 ± 0.258
4.084ArgAsp: 4.084 ± 0.332
4.58ArgGlu: 4.58 ± 0.306
3.612ArgPhe: 3.612 ± 0.3
3.895ArgGly: 3.895 ± 0.328
2.125ArgHis: 2.125 ± 0.223
3.352ArgIle: 3.352 ± 0.284
2.526ArgLys: 2.526 ± 0.233
7.791ArgLeu: 7.791 ± 0.394
2.479ArgMet: 2.479 ± 0.25
2.526ArgAsn: 2.526 ± 0.224
3.423ArgPro: 3.423 ± 0.307
2.148ArgGln: 2.148 ± 0.188
7.815ArgArg: 7.815 ± 0.519
5.43ArgSer: 5.43 ± 0.415
3.919ArgThr: 3.919 ± 0.313
7.46ArgVal: 7.46 ± 0.354
0.26ArgTrp: 0.26 ± 0.082
2.432ArgTyr: 2.432 ± 0.25
0.0ArgXaa: 0.0 ± 0.0
Ser
7.153SerAla: 7.153 ± 0.365
1.558SerCys: 1.558 ± 0.178
4.061SerAsp: 4.061 ± 0.315
3.73SerGlu: 3.73 ± 0.28
2.927SerPhe: 2.927 ± 0.23
3.801SerGly: 3.801 ± 0.321
1.298SerHis: 1.298 ± 0.194
3.116SerIle: 3.116 ± 0.333
2.786SerLys: 2.786 ± 0.25
6.799SerLeu: 6.799 ± 0.364
1.747SerMet: 1.747 ± 0.231
2.078SerAsn: 2.078 ± 0.235
3.589SerPro: 3.589 ± 0.313
1.417SerGln: 1.417 ± 0.193
5.572SerArg: 5.572 ± 0.457
6.115SerSer: 6.115 ± 0.731
4.061SerThr: 4.061 ± 0.471
6.304SerVal: 6.304 ± 0.364
0.472SerTrp: 0.472 ± 0.095
1.841SerTyr: 1.841 ± 0.191
0.0SerXaa: 0.0 ± 0.0
Thr
5.1ThrAla: 5.1 ± 0.402
1.11ThrCys: 1.11 ± 0.154
3.589ThrAsp: 3.589 ± 0.249
3.541ThrGlu: 3.541 ± 0.293
2.337ThrPhe: 2.337 ± 0.277
3.541ThrGly: 3.541 ± 0.302
1.369ThrHis: 1.369 ± 0.169
1.653ThrIle: 1.653 ± 0.175
1.841ThrLys: 1.841 ± 0.238
5.406ThrLeu: 5.406 ± 0.355
1.369ThrMet: 1.369 ± 0.207
1.841ThrAsn: 1.841 ± 0.189
4.179ThrPro: 4.179 ± 0.439
0.874ThrGln: 0.874 ± 0.131
3.848ThrArg: 3.848 ± 0.279
3.895ThrSer: 3.895 ± 0.411
3.612ThrThr: 3.612 ± 0.618
5.288ThrVal: 5.288 ± 0.382
0.378ThrTrp: 0.378 ± 0.085
1.676ThrTyr: 1.676 ± 0.188
0.0ThrXaa: 0.0 ± 0.0
Val
7.46ValAla: 7.46 ± 0.455
2.715ValCys: 2.715 ± 0.253
6.256ValAsp: 6.256 ± 0.364
4.769ValGlu: 4.769 ± 0.356
4.108ValPhe: 4.108 ± 0.362
3.707ValGly: 3.707 ± 0.302
2.148ValHis: 2.148 ± 0.227
3.14ValIle: 3.14 ± 0.254
3.258ValLys: 3.258 ± 0.35
9.066ValLeu: 9.066 ± 0.444
2.266ValMet: 2.266 ± 0.245
3.612ValAsn: 3.612 ± 0.262
4.108ValPro: 4.108 ± 0.294
1.771ValGln: 1.771 ± 0.217
7.767ValArg: 7.767 ± 0.493
5.784ValSer: 5.784 ± 0.406
5.052ValThr: 5.052 ± 0.37
7.909ValVal: 7.909 ± 0.419
0.661ValTrp: 0.661 ± 0.122
3.046ValTyr: 3.046 ± 0.243
0.0ValXaa: 0.0 ± 0.0
Trp
0.331TrpAla: 0.331 ± 0.083
0.212TrpCys: 0.212 ± 0.063
0.307TrpAsp: 0.307 ± 0.087
0.354TrpGlu: 0.354 ± 0.087
0.496TrpPhe: 0.496 ± 0.103
0.472TrpGly: 0.472 ± 0.135
0.071TrpHis: 0.071 ± 0.042
0.307TrpIle: 0.307 ± 0.084
0.165TrpLys: 0.165 ± 0.053
0.732TrpLeu: 0.732 ± 0.137
0.236TrpMet: 0.236 ± 0.07
0.165TrpAsn: 0.165 ± 0.079
0.307TrpPro: 0.307 ± 0.102
0.071TrpGln: 0.071 ± 0.043
0.661TrpArg: 0.661 ± 0.108
0.401TrpSer: 0.401 ± 0.093
0.661TrpThr: 0.661 ± 0.12
0.26TrpVal: 0.26 ± 0.072
0.142TrpTrp: 0.142 ± 0.088
0.354TrpTyr: 0.354 ± 0.101
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.55TyrAla: 2.55 ± 0.263
0.85TyrCys: 0.85 ± 0.135
1.936TyrAsp: 1.936 ± 0.182
1.487TyrGlu: 1.487 ± 0.199
1.936TyrPhe: 1.936 ± 0.205
1.983TyrGly: 1.983 ± 0.236
0.685TyrHis: 0.685 ± 0.109
1.582TyrIle: 1.582 ± 0.203
1.062TyrLys: 1.062 ± 0.177
3.022TyrLeu: 3.022 ± 0.25
0.897TyrMet: 0.897 ± 0.136
1.157TyrAsn: 1.157 ± 0.188
1.157TyrPro: 1.157 ± 0.159
0.567TyrGln: 0.567 ± 0.121
2.054TyrArg: 2.054 ± 0.196
1.841TyrSer: 1.841 ± 0.215
1.464TyrThr: 1.464 ± 0.144
2.975TyrVal: 2.975 ± 0.264
0.236TyrTrp: 0.236 ± 0.072
0.944TyrTyr: 0.944 ± 0.157
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 130 proteins (42358 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski