Amino acid dipepetide frequency for Gordonia phage Angelique

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.794AlaAla: 16.794 ± 1.74
1.278AlaCys: 1.278 ± 0.325
7.91AlaAsp: 7.91 ± 0.624
7.241AlaGlu: 7.241 ± 0.617
3.164AlaPhe: 3.164 ± 0.69
9.736AlaGly: 9.736 ± 0.884
2.13AlaHis: 2.13 ± 0.429
4.99AlaIle: 4.99 ± 0.488
4.32AlaLys: 4.32 ± 0.568
8.397AlaLeu: 8.397 ± 0.624
3.468AlaMet: 3.468 ± 0.845
4.077AlaAsn: 4.077 ± 0.732
5.476AlaPro: 5.476 ± 0.622
4.746AlaGln: 4.746 ± 0.778
7.424AlaArg: 7.424 ± 0.674
6.815AlaSer: 6.815 ± 0.719
7.545AlaThr: 7.545 ± 0.601
7.241AlaVal: 7.241 ± 0.728
2.13AlaTrp: 2.13 ± 0.293
1.704AlaTyr: 1.704 ± 0.289
0.0AlaXaa: 0.0 ± 0.0
Cys
0.913CysAla: 0.913 ± 0.22
0.122CysCys: 0.122 ± 0.071
0.73CysAsp: 0.73 ± 0.274
0.608CysGlu: 0.608 ± 0.191
0.183CysPhe: 0.183 ± 0.106
1.156CysGly: 1.156 ± 0.311
0.243CysHis: 0.243 ± 0.133
0.243CysIle: 0.243 ± 0.127
0.122CysLys: 0.122 ± 0.092
0.426CysLeu: 0.426 ± 0.15
0.122CysMet: 0.122 ± 0.076
0.122CysAsn: 0.122 ± 0.089
0.487CysPro: 0.487 ± 0.185
0.426CysGln: 0.426 ± 0.157
0.852CysArg: 0.852 ± 0.242
0.426CysSer: 0.426 ± 0.155
0.426CysThr: 0.426 ± 0.151
0.669CysVal: 0.669 ± 0.218
0.487CysTrp: 0.487 ± 0.233
0.426CysTyr: 0.426 ± 0.153
0.0CysXaa: 0.0 ± 0.0
Asp
7.789AspAla: 7.789 ± 0.582
0.426AspCys: 0.426 ± 0.122
5.051AspAsp: 5.051 ± 0.733
3.773AspGlu: 3.773 ± 0.518
1.704AspPhe: 1.704 ± 0.313
7.059AspGly: 7.059 ± 0.638
1.947AspHis: 1.947 ± 0.338
3.286AspIle: 3.286 ± 0.396
1.095AspLys: 1.095 ± 0.206
7.363AspLeu: 7.363 ± 0.688
0.913AspMet: 0.913 ± 0.221
1.825AspAsn: 1.825 ± 0.307
5.111AspPro: 5.111 ± 0.554
2.495AspGln: 2.495 ± 0.443
6.024AspArg: 6.024 ± 0.637
3.042AspSer: 3.042 ± 0.552
3.651AspThr: 3.651 ± 0.472
5.355AspVal: 5.355 ± 0.527
1.521AspTrp: 1.521 ± 0.38
1.339AspTyr: 1.339 ± 0.36
0.0AspXaa: 0.0 ± 0.0
Glu
5.172GluAla: 5.172 ± 0.528
0.426GluCys: 0.426 ± 0.177
3.103GluAsp: 3.103 ± 0.442
2.434GluGlu: 2.434 ± 0.397
2.191GluPhe: 2.191 ± 0.448
3.225GluGly: 3.225 ± 0.435
1.339GluHis: 1.339 ± 0.326
3.103GluIle: 3.103 ± 0.599
1.947GluLys: 1.947 ± 0.364
5.233GluLeu: 5.233 ± 0.607
1.521GluMet: 1.521 ± 0.325
1.46GluAsn: 1.46 ± 0.276
2.921GluPro: 2.921 ± 0.455
1.947GluGln: 1.947 ± 0.296
4.32GluArg: 4.32 ± 0.548
4.199GluSer: 4.199 ± 0.466
2.434GluThr: 2.434 ± 0.308
4.807GluVal: 4.807 ± 0.547
0.913GluTrp: 0.913 ± 0.241
1.278GluTyr: 1.278 ± 0.264
0.0GluXaa: 0.0 ± 0.0
Phe
2.434PheAla: 2.434 ± 0.363
0.243PheCys: 0.243 ± 0.119
3.103PheAsp: 3.103 ± 0.484
1.4PheGlu: 1.4 ± 0.335
0.608PhePhe: 0.608 ± 0.202
3.468PheGly: 3.468 ± 0.549
0.548PheHis: 0.548 ± 0.213
1.156PheIle: 1.156 ± 0.236
0.852PheLys: 0.852 ± 0.194
2.191PheLeu: 2.191 ± 0.369
0.426PheMet: 0.426 ± 0.185
0.669PheAsn: 0.669 ± 0.198
1.156PhePro: 1.156 ± 0.264
0.852PheGln: 0.852 ± 0.234
1.886PheArg: 1.886 ± 0.273
1.4PheSer: 1.4 ± 0.3
1.947PheThr: 1.947 ± 0.372
2.373PheVal: 2.373 ± 0.333
0.73PheTrp: 0.73 ± 0.244
0.608PheTyr: 0.608 ± 0.175
0.0PheXaa: 0.0 ± 0.0
Gly
8.58GlyAla: 8.58 ± 1.144
0.852GlyCys: 0.852 ± 0.305
6.207GlyAsp: 6.207 ± 0.567
4.259GlyGlu: 4.259 ± 0.538
2.982GlyPhe: 2.982 ± 0.436
8.945GlyGly: 8.945 ± 1.392
1.339GlyHis: 1.339 ± 0.353
4.259GlyIle: 4.259 ± 0.623
3.347GlyLys: 3.347 ± 0.388
6.024GlyLeu: 6.024 ± 0.79
1.339GlyMet: 1.339 ± 0.339
2.738GlyAsn: 2.738 ± 0.471
4.625GlyPro: 4.625 ± 0.44
3.59GlyGln: 3.59 ± 0.48
7.119GlyArg: 7.119 ± 0.676
5.537GlySer: 5.537 ± 0.826
5.355GlyThr: 5.355 ± 0.659
6.024GlyVal: 6.024 ± 0.508
2.069GlyTrp: 2.069 ± 0.348
2.312GlyTyr: 2.312 ± 0.334
0.0GlyXaa: 0.0 ± 0.0
His
2.13HisAla: 2.13 ± 0.35
0.608HisCys: 0.608 ± 0.247
1.521HisAsp: 1.521 ± 0.411
0.974HisGlu: 0.974 ± 0.188
0.243HisPhe: 0.243 ± 0.117
1.825HisGly: 1.825 ± 0.4
0.73HisHis: 0.73 ± 0.17
0.852HisIle: 0.852 ± 0.207
0.608HisLys: 0.608 ± 0.144
1.582HisLeu: 1.582 ± 0.288
0.183HisMet: 0.183 ± 0.115
0.548HisAsn: 0.548 ± 0.162
1.034HisPro: 1.034 ± 0.292
0.974HisGln: 0.974 ± 0.292
1.582HisArg: 1.582 ± 0.329
0.974HisSer: 0.974 ± 0.293
1.46HisThr: 1.46 ± 0.262
1.095HisVal: 1.095 ± 0.278
0.487HisTrp: 0.487 ± 0.192
0.791HisTyr: 0.791 ± 0.174
0.0HisXaa: 0.0 ± 0.0
Ile
5.781IleAla: 5.781 ± 0.556
0.243IleCys: 0.243 ± 0.119
3.834IleAsp: 3.834 ± 0.49
3.529IleGlu: 3.529 ± 0.614
1.156IlePhe: 1.156 ± 0.271
3.894IleGly: 3.894 ± 0.524
0.791IleHis: 0.791 ± 0.258
1.46IleIle: 1.46 ± 0.33
0.913IleLys: 0.913 ± 0.344
3.408IleLeu: 3.408 ± 0.386
0.304IleMet: 0.304 ± 0.13
1.4IleAsn: 1.4 ± 0.299
3.103IlePro: 3.103 ± 0.396
1.765IleGln: 1.765 ± 0.365
3.955IleArg: 3.955 ± 0.4
2.373IleSer: 2.373 ± 0.356
3.468IleThr: 3.468 ± 0.492
2.495IleVal: 2.495 ± 0.449
0.487IleTrp: 0.487 ± 0.192
0.913IleTyr: 0.913 ± 0.243
0.0IleXaa: 0.0 ± 0.0
Lys
3.834LysAla: 3.834 ± 0.462
0.243LysCys: 0.243 ± 0.138
1.886LysAsp: 1.886 ± 0.408
1.034LysGlu: 1.034 ± 0.222
0.913LysPhe: 0.913 ± 0.258
2.13LysGly: 2.13 ± 0.368
0.669LysHis: 0.669 ± 0.189
1.947LysIle: 1.947 ± 0.357
1.339LysLys: 1.339 ± 0.392
2.86LysLeu: 2.86 ± 0.377
0.548LysMet: 0.548 ± 0.181
1.095LysAsn: 1.095 ± 0.273
1.886LysPro: 1.886 ± 0.447
0.974LysGln: 0.974 ± 0.257
2.617LysArg: 2.617 ± 0.37
2.312LysSer: 2.312 ± 0.315
2.373LysThr: 2.373 ± 0.352
2.495LysVal: 2.495 ± 0.387
0.548LysTrp: 0.548 ± 0.19
0.913LysTyr: 0.913 ± 0.211
0.0LysXaa: 0.0 ± 0.0
Leu
10.831LeuAla: 10.831 ± 0.691
0.548LeuCys: 0.548 ± 0.193
6.45LeuAsp: 6.45 ± 0.945
4.077LeuGlu: 4.077 ± 0.605
2.251LeuPhe: 2.251 ± 0.349
6.815LeuGly: 6.815 ± 0.653
1.278LeuHis: 1.278 ± 0.287
3.894LeuIle: 3.894 ± 0.546
2.251LeuLys: 2.251 ± 0.484
4.503LeuLeu: 4.503 ± 0.42
1.582LeuMet: 1.582 ± 0.277
2.495LeuAsn: 2.495 ± 0.452
4.442LeuPro: 4.442 ± 0.542
3.408LeuGln: 3.408 ± 0.415
4.381LeuArg: 4.381 ± 0.672
4.442LeuSer: 4.442 ± 0.434
6.146LeuThr: 6.146 ± 0.568
4.746LeuVal: 4.746 ± 0.702
1.886LeuTrp: 1.886 ± 0.411
1.095LeuTyr: 1.095 ± 0.263
0.0LeuXaa: 0.0 ± 0.0
Met
2.617MetAla: 2.617 ± 0.367
0.365MetCys: 0.365 ± 0.144
0.852MetAsp: 0.852 ± 0.176
0.913MetGlu: 0.913 ± 0.211
0.304MetPhe: 0.304 ± 0.135
1.339MetGly: 1.339 ± 0.419
0.426MetHis: 0.426 ± 0.167
0.365MetIle: 0.365 ± 0.128
0.791MetLys: 0.791 ± 0.231
1.643MetLeu: 1.643 ± 0.272
0.243MetMet: 0.243 ± 0.151
0.852MetAsn: 0.852 ± 0.186
1.278MetPro: 1.278 ± 0.286
0.852MetGln: 0.852 ± 0.436
1.643MetArg: 1.643 ± 0.316
1.886MetSer: 1.886 ± 0.321
2.495MetThr: 2.495 ± 0.344
0.974MetVal: 0.974 ± 0.249
0.365MetTrp: 0.365 ± 0.167
0.365MetTyr: 0.365 ± 0.151
0.0MetXaa: 0.0 ± 0.0
Asn
4.381AsnAla: 4.381 ± 0.808
0.243AsnCys: 0.243 ± 0.115
1.643AsnAsp: 1.643 ± 0.255
1.643AsnGlu: 1.643 ± 0.313
0.852AsnPhe: 0.852 ± 0.249
3.347AsnGly: 3.347 ± 0.506
1.034AsnHis: 1.034 ± 0.344
0.791AsnIle: 0.791 ± 0.203
0.852AsnLys: 0.852 ± 0.193
2.617AsnLeu: 2.617 ± 0.477
0.487AsnMet: 0.487 ± 0.128
0.73AsnAsn: 0.73 ± 0.258
2.191AsnPro: 2.191 ± 0.387
1.4AsnGln: 1.4 ± 0.377
2.434AsnArg: 2.434 ± 0.37
2.251AsnSer: 2.251 ± 0.309
1.825AsnThr: 1.825 ± 0.412
1.947AsnVal: 1.947 ± 0.267
0.852AsnTrp: 0.852 ± 0.185
0.548AsnTyr: 0.548 ± 0.186
0.0AsnXaa: 0.0 ± 0.0
Pro
5.598ProAla: 5.598 ± 0.596
0.669ProCys: 0.669 ± 0.278
4.929ProAsp: 4.929 ± 0.609
3.955ProGlu: 3.955 ± 0.502
1.217ProPhe: 1.217 ± 0.264
4.807ProGly: 4.807 ± 0.472
1.034ProHis: 1.034 ± 0.31
2.495ProIle: 2.495 ± 0.502
2.312ProLys: 2.312 ± 0.409
3.408ProLeu: 3.408 ± 0.496
0.852ProMet: 0.852 ± 0.227
2.069ProAsn: 2.069 ± 0.384
3.347ProPro: 3.347 ± 0.506
1.825ProGln: 1.825 ± 0.287
3.834ProArg: 3.834 ± 0.564
3.042ProSer: 3.042 ± 0.489
3.103ProThr: 3.103 ± 0.518
4.381ProVal: 4.381 ± 0.634
1.339ProTrp: 1.339 ± 0.337
1.217ProTyr: 1.217 ± 0.196
0.0ProXaa: 0.0 ± 0.0
Gln
4.138GlnAla: 4.138 ± 0.77
0.061GlnCys: 0.061 ± 0.069
1.886GlnAsp: 1.886 ± 0.228
1.217GlnGlu: 1.217 ± 0.203
1.46GlnPhe: 1.46 ± 0.315
2.617GlnGly: 2.617 ± 0.679
0.548GlnHis: 0.548 ± 0.163
2.008GlnIle: 2.008 ± 0.347
1.339GlnLys: 1.339 ± 0.376
3.955GlnLeu: 3.955 ± 0.504
0.791GlnMet: 0.791 ± 0.208
1.095GlnAsn: 1.095 ± 0.348
2.251GlnPro: 2.251 ± 0.377
2.251GlnGln: 2.251 ± 0.761
2.921GlnArg: 2.921 ± 0.455
2.495GlnSer: 2.495 ± 0.484
2.434GlnThr: 2.434 ± 0.366
2.677GlnVal: 2.677 ± 0.445
0.974GlnTrp: 0.974 ± 0.267
0.913GlnTyr: 0.913 ± 0.2
0.0GlnXaa: 0.0 ± 0.0
Arg
7.302ArgAla: 7.302 ± 0.67
0.974ArgCys: 0.974 ± 0.345
4.503ArgAsp: 4.503 ± 0.509
4.32ArgGlu: 4.32 ± 0.656
2.495ArgPhe: 2.495 ± 0.338
4.503ArgGly: 4.503 ± 0.577
1.704ArgHis: 1.704 ± 0.383
3.651ArgIle: 3.651 ± 0.586
3.347ArgLys: 3.347 ± 0.448
6.328ArgLeu: 6.328 ± 0.604
2.373ArgMet: 2.373 ± 0.418
3.042ArgAsn: 3.042 ± 0.376
4.138ArgPro: 4.138 ± 0.593
2.556ArgGln: 2.556 ± 0.411
6.389ArgArg: 6.389 ± 0.869
3.529ArgSer: 3.529 ± 0.437
4.32ArgThr: 4.32 ± 0.407
4.929ArgVal: 4.929 ± 0.584
1.582ArgTrp: 1.582 ± 0.273
2.434ArgTyr: 2.434 ± 0.447
0.0ArgXaa: 0.0 ± 0.0
Ser
7.85SerAla: 7.85 ± 0.855
0.061SerCys: 0.061 ± 0.066
3.529SerAsp: 3.529 ± 0.437
3.042SerGlu: 3.042 ± 0.462
1.46SerPhe: 1.46 ± 0.254
7.119SerGly: 7.119 ± 0.868
1.156SerHis: 1.156 ± 0.214
2.617SerIle: 2.617 ± 0.401
1.643SerLys: 1.643 ± 0.343
4.138SerLeu: 4.138 ± 0.414
1.4SerMet: 1.4 ± 0.28
1.643SerAsn: 1.643 ± 0.262
2.191SerPro: 2.191 ± 0.277
2.251SerGln: 2.251 ± 0.354
3.894SerArg: 3.894 ± 0.498
2.982SerSer: 2.982 ± 0.436
4.077SerThr: 4.077 ± 0.579
3.955SerVal: 3.955 ± 0.384
1.156SerTrp: 1.156 ± 0.267
1.643SerTyr: 1.643 ± 0.305
0.0SerXaa: 0.0 ± 0.0
Thr
8.032ThrAla: 8.032 ± 0.789
0.608ThrCys: 0.608 ± 0.2
4.746ThrAsp: 4.746 ± 0.585
3.042ThrGlu: 3.042 ± 0.461
1.765ThrPhe: 1.765 ± 0.365
6.267ThrGly: 6.267 ± 0.689
1.034ThrHis: 1.034 ± 0.243
3.834ThrIle: 3.834 ± 0.493
1.765ThrLys: 1.765 ± 0.28
5.598ThrLeu: 5.598 ± 0.45
1.217ThrMet: 1.217 ± 0.271
2.251ThrAsn: 2.251 ± 0.307
3.408ThrPro: 3.408 ± 0.644
1.704ThrGln: 1.704 ± 0.397
4.625ThrArg: 4.625 ± 0.559
3.955ThrSer: 3.955 ± 0.541
4.564ThrThr: 4.564 ± 0.717
5.476ThrVal: 5.476 ± 0.707
1.156ThrTrp: 1.156 ± 0.211
1.4ThrTyr: 1.4 ± 0.319
0.0ThrXaa: 0.0 ± 0.0
Val
8.215ValAla: 8.215 ± 0.668
0.73ValCys: 0.73 ± 0.2
6.328ValAsp: 6.328 ± 0.718
4.503ValGlu: 4.503 ± 0.669
2.008ValPhe: 2.008 ± 0.313
5.72ValGly: 5.72 ± 0.552
1.217ValHis: 1.217 ± 0.294
2.799ValIle: 2.799 ± 0.522
1.947ValLys: 1.947 ± 0.297
4.746ValLeu: 4.746 ± 0.52
1.582ValMet: 1.582 ± 0.366
2.495ValAsn: 2.495 ± 0.383
4.564ValPro: 4.564 ± 0.601
2.434ValGln: 2.434 ± 0.415
4.685ValArg: 4.685 ± 0.484
3.894ValSer: 3.894 ± 0.422
5.659ValThr: 5.659 ± 0.661
5.781ValVal: 5.781 ± 0.748
0.913ValTrp: 0.913 ± 0.181
0.913ValTyr: 0.913 ± 0.194
0.0ValXaa: 0.0 ± 0.0
Trp
2.251TrpAla: 2.251 ± 0.426
0.183TrpCys: 0.183 ± 0.107
1.095TrpAsp: 1.095 ± 0.248
0.791TrpGlu: 0.791 ± 0.194
0.548TrpPhe: 0.548 ± 0.248
1.886TrpGly: 1.886 ± 0.372
0.548TrpHis: 0.548 ± 0.281
0.974TrpIle: 0.974 ± 0.243
0.852TrpLys: 0.852 ± 0.209
1.825TrpLeu: 1.825 ± 0.312
0.669TrpMet: 0.669 ± 0.174
0.73TrpAsn: 0.73 ± 0.205
0.73TrpPro: 0.73 ± 0.232
0.852TrpGln: 0.852 ± 0.222
1.825TrpArg: 1.825 ± 0.31
1.034TrpSer: 1.034 ± 0.243
1.278TrpThr: 1.278 ± 0.269
1.582TrpVal: 1.582 ± 0.27
0.73TrpTrp: 0.73 ± 0.242
0.365TrpTyr: 0.365 ± 0.11
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.947TyrAla: 1.947 ± 0.305
0.304TyrCys: 0.304 ± 0.153
1.521TyrAsp: 1.521 ± 0.221
1.217TyrGlu: 1.217 ± 0.241
0.548TyrPhe: 0.548 ± 0.172
1.643TyrGly: 1.643 ± 0.249
0.487TyrHis: 0.487 ± 0.22
0.548TyrIle: 0.548 ± 0.22
0.974TyrLys: 0.974 ± 0.226
1.278TyrLeu: 1.278 ± 0.278
0.487TyrMet: 0.487 ± 0.136
0.73TyrAsn: 0.73 ± 0.162
1.095TyrPro: 1.095 ± 0.336
0.73TyrGln: 0.73 ± 0.227
2.008TyrArg: 2.008 ± 0.423
1.217TyrSer: 1.217 ± 0.261
1.886TyrThr: 1.886 ± 0.369
2.13TyrVal: 2.13 ± 0.414
0.426TyrTrp: 0.426 ± 0.174
0.487TyrTyr: 0.487 ± 0.18
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (16435 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski