Amino acid dipepetide frequency for Hyunsoonleella pacifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.611AlaAla: 3.611 ± 0.066	0.529AlaCys: 0.529 ± 0.021	3.124AlaAsp: 3.124 ± 0.061	3.667AlaGlu: 3.667 ± 0.066	3.198AlaPhe: 3.198 ± 0.057	3.705AlaGly: 3.705 ± 0.073	1.069AlaHis: 1.069 ± 0.031	5.39AlaIle: 5.39 ± 0.077	4.625AlaLys: 4.625 ± 0.067	6.16AlaLeu: 6.16 ± 0.082	1.324AlaMet: 1.324 ± 0.035	3.541AlaAsn: 3.541 ± 0.055	1.879AlaPro: 1.879 ± 0.048	2.215AlaGln: 2.215 ± 0.047	1.842AlaArg: 1.842 ± 0.042	4.216AlaSer: 4.216 ± 0.068	3.564AlaThr: 3.564 ± 0.073	3.745AlaVal: 3.745 ± 0.067	0.58AlaTrp: 0.58 ± 0.022	2.466AlaTyr: 2.466 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.441CysAla: 0.441 ± 0.02	0.115CysCys: 0.115 ± 0.009	0.475CysAsp: 0.475 ± 0.022	0.483CysGlu: 0.483 ± 0.023	0.473CysPhe: 0.473 ± 0.023	0.595CysGly: 0.595 ± 0.025	0.196CysHis: 0.196 ± 0.015	0.643CysIle: 0.643 ± 0.025	0.529CysLys: 0.529 ± 0.023	0.653CysLeu: 0.653 ± 0.02	0.139CysMet: 0.139 ± 0.011	0.451CysAsn: 0.451 ± 0.022	0.325CysPro: 0.325 ± 0.018	0.18CysGln: 0.18 ± 0.012	0.195CysArg: 0.195 ± 0.012	0.608CysSer: 0.608 ± 0.026	0.448CysThr: 0.448 ± 0.025	0.426CysVal: 0.426 ± 0.02	0.07CysTrp: 0.07 ± 0.007	0.335CysTyr: 0.335 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.899AspAla: 3.899 ± 0.066	0.415AspCys: 0.415 ± 0.019	3.454AspAsp: 3.454 ± 0.07	3.768AspGlu: 3.768 ± 0.066	3.69AspPhe: 3.69 ± 0.055	3.858AspGly: 3.858 ± 0.088	0.751AspHis: 0.751 ± 0.024	5.131AspIle: 5.131 ± 0.065	4.285AspLys: 4.285 ± 0.075	5.289AspLeu: 5.289 ± 0.079	1.139AspMet: 1.139 ± 0.035	3.774AspAsn: 3.774 ± 0.055	1.552AspPro: 1.552 ± 0.049	1.23AspGln: 1.23 ± 0.035	1.765AspArg: 1.765 ± 0.04	3.31AspSer: 3.31 ± 0.053	3.143AspThr: 3.143 ± 0.056	4.032AspVal: 4.032 ± 0.056	0.744AspTrp: 0.744 ± 0.024	2.936AspTyr: 2.936 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.438GluAla: 4.438 ± 0.08	0.363GluCys: 0.363 ± 0.018	3.974GluAsp: 3.974 ± 0.066	4.445GluGlu: 4.445 ± 0.076	3.017GluPhe: 3.017 ± 0.048	3.623GluGly: 3.623 ± 0.061	1.167GluHis: 1.167 ± 0.032	5.214GluIle: 5.214 ± 0.073	5.25GluLys: 5.25 ± 0.084	5.893GluLeu: 5.893 ± 0.068	1.273GluMet: 1.273 ± 0.032	4.627GluAsn: 4.627 ± 0.075	1.472GluPro: 1.472 ± 0.032	2.173GluGln: 2.173 ± 0.051	2.418GluArg: 2.418 ± 0.056	3.418GluSer: 3.418 ± 0.05	3.895GluThr: 3.895 ± 0.055	4.225GluVal: 4.225 ± 0.059	0.591GluTrp: 0.591 ± 0.02	2.325GluTyr: 2.325 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.694PheAla: 2.694 ± 0.049	0.443PheCys: 0.443 ± 0.022	3.341PheAsp: 3.341 ± 0.066	3.47PheGlu: 3.47 ± 0.055	2.688PhePhe: 2.688 ± 0.058	3.535PheGly: 3.535 ± 0.069	0.805PheHis: 0.805 ± 0.023	3.932PheIle: 3.932 ± 0.058	4.22PheLys: 4.22 ± 0.077	4.672PheLeu: 4.672 ± 0.069	1.02PheMet: 1.02 ± 0.033	3.828PheAsn: 3.828 ± 0.074	1.625PhePro: 1.625 ± 0.033	1.551PheGln: 1.551 ± 0.036	1.613PheArg: 1.613 ± 0.036	4.134PheSer: 4.134 ± 0.059	3.145PheThr: 3.145 ± 0.059	2.961PheVal: 2.961 ± 0.05	0.583PheTrp: 0.583 ± 0.023	2.148PheTyr: 2.148 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.019GlyAla: 4.019 ± 0.071	0.632GlyCys: 0.632 ± 0.03	3.458GlyAsp: 3.458 ± 0.062	3.379GlyGlu: 3.379 ± 0.062	3.622GlyPhe: 3.622 ± 0.058	4.407GlyGly: 4.407 ± 0.08	1.045GlyHis: 1.045 ± 0.032	5.264GlyIle: 5.264 ± 0.074	4.916GlyLys: 4.916 ± 0.078	5.625GlyLeu: 5.625 ± 0.08	1.407GlyMet: 1.407 ± 0.036	4.064GlyAsn: 4.064 ± 0.075	1.333GlyPro: 1.333 ± 0.038	1.789GlyGln: 1.789 ± 0.033	2.032GlyArg: 2.032 ± 0.046	3.837GlySer: 3.837 ± 0.068	3.943GlyThr: 3.943 ± 0.097	4.393GlyVal: 4.393 ± 0.064	0.814GlyTrp: 0.814 ± 0.034	2.827GlyTyr: 2.827 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	0.918HisAla: 0.918 ± 0.024	0.165HisCys: 0.165 ± 0.013	0.855HisAsp: 0.855 ± 0.029	0.987HisGlu: 0.987 ± 0.031	1.103HisPhe: 1.103 ± 0.033	1.065HisGly: 1.065 ± 0.028	0.47HisHis: 0.47 ± 0.024	1.518HisIle: 1.518 ± 0.033	1.357HisLys: 1.357 ± 0.039	1.732HisLeu: 1.732 ± 0.039	0.294HisMet: 0.294 ± 0.016	1.089HisAsn: 1.089 ± 0.029	0.814HisPro: 0.814 ± 0.029	0.657HisGln: 0.657 ± 0.025	0.622HisArg: 0.622 ± 0.02	1.017HisSer: 1.017 ± 0.032	0.958HisThr: 0.958 ± 0.029	0.962HisVal: 0.962 ± 0.026	0.229HisTrp: 0.229 ± 0.016	0.875HisTyr: 0.875 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.436IleAla: 5.436 ± 0.073	0.659IleCys: 0.659 ± 0.026	5.226IleAsp: 5.226 ± 0.065	5.716IleGlu: 5.716 ± 0.076	3.522IlePhe: 3.522 ± 0.064	5.064IleGly: 5.064 ± 0.074	1.37IleHis: 1.37 ± 0.037	6.302IleIle: 6.302 ± 0.102	6.152IleLys: 6.152 ± 0.082	7.041IleLeu: 7.041 ± 0.11	1.37IleMet: 1.37 ± 0.036	5.288IleAsn: 5.288 ± 0.075	3.192IlePro: 3.192 ± 0.054	2.47IleGln: 2.47 ± 0.048	2.468IleArg: 2.468 ± 0.049	5.963IleSer: 5.963 ± 0.086	5.216IleThr: 5.216 ± 0.088	4.915IleVal: 4.915 ± 0.075	0.721IleTrp: 0.721 ± 0.025	2.955IleTyr: 2.955 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	5.126LysAla: 5.126 ± 0.084	0.35LysCys: 0.35 ± 0.017	4.831LysAsp: 4.831 ± 0.079	5.53LysGlu: 5.53 ± 0.085	3.041LysPhe: 3.041 ± 0.05	4.52LysGly: 4.52 ± 0.066	1.678LysHis: 1.678 ± 0.043	6.012LysIle: 6.012 ± 0.085	6.778LysLys: 6.778 ± 0.11	7.045LysLeu: 7.045 ± 0.088	1.724LysMet: 1.724 ± 0.043	5.305LysAsn: 5.305 ± 0.081	2.64LysPro: 2.64 ± 0.05	2.969LysGln: 2.969 ± 0.068	3.129LysArg: 3.129 ± 0.06	4.88LysSer: 4.88 ± 0.071	5.238LysThr: 5.238 ± 0.078	4.702LysVal: 4.702 ± 0.072	0.829LysTrp: 0.829 ± 0.028	3.2LysTyr: 3.2 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.233LeuAla: 5.233 ± 0.072	0.739LeuCys: 0.739 ± 0.025	5.219LeuAsp: 5.219 ± 0.062	6.139LeuGlu: 6.139 ± 0.07	4.83LeuPhe: 4.83 ± 0.084	5.691LeuGly: 5.691 ± 0.077	1.542LeuHis: 1.542 ± 0.038	6.922LeuIle: 6.922 ± 0.108	8.209LeuLys: 8.209 ± 0.113	8.279LeuLeu: 8.279 ± 0.119	1.85LeuMet: 1.85 ± 0.04	6.276LeuAsn: 6.276 ± 0.088	3.383LeuPro: 3.383 ± 0.06	3.045LeuGln: 3.045 ± 0.051	3.108LeuArg: 3.108 ± 0.055	6.684LeuSer: 6.684 ± 0.082	4.866LeuThr: 4.866 ± 0.058	5.477LeuVal: 5.477 ± 0.076	0.858LeuTrp: 0.858 ± 0.03	3.26LeuTyr: 3.26 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.411MetAla: 1.411 ± 0.032	0.154MetCys: 0.154 ± 0.011	1.018MetAsp: 1.018 ± 0.031	1.131MetGlu: 1.131 ± 0.03	0.855MetPhe: 0.855 ± 0.027	1.183MetGly: 1.183 ± 0.034	0.394MetHis: 0.394 ± 0.019	1.39MetIle: 1.39 ± 0.033	1.961MetLys: 1.961 ± 0.039	1.824MetLeu: 1.824 ± 0.035	0.498MetMet: 0.498 ± 0.021	1.16MetAsn: 1.16 ± 0.027	0.778MetPro: 0.778 ± 0.025	0.768MetGln: 0.768 ± 0.023	0.749MetArg: 0.749 ± 0.023	1.37MetSer: 1.37 ± 0.032	1.004MetThr: 1.004 ± 0.028	1.224MetVal: 1.224 ± 0.036	0.166MetTrp: 0.166 ± 0.013	0.737MetTyr: 0.737 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.964AsnAla: 3.964 ± 0.063	0.547AsnCys: 0.547 ± 0.024	3.697AsnAsp: 3.697 ± 0.068	3.843AsnGlu: 3.843 ± 0.056	3.317AsnPhe: 3.317 ± 0.06	4.364AsnGly: 4.364 ± 0.086	1.115AsnHis: 1.115 ± 0.03	5.571AsnIle: 5.571 ± 0.074	4.687AsnLys: 4.687 ± 0.075	5.72AsnLeu: 5.72 ± 0.083	1.258AsnMet: 1.258 ± 0.037	4.695AsnAsn: 4.695 ± 0.099	2.803AsnPro: 2.803 ± 0.059	2.127AsnGln: 2.127 ± 0.045	2.29AsnArg: 2.29 ± 0.053	4.286AsnSer: 4.286 ± 0.074	4.49AsnThr: 4.49 ± 0.086	3.681AsnVal: 3.681 ± 0.061	0.822AsnTrp: 0.822 ± 0.025	3.174AsnTyr: 3.174 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.646ProAla: 1.646 ± 0.041	0.234ProCys: 0.234 ± 0.016	2.046ProAsp: 2.046 ± 0.043	2.827ProGlu: 2.827 ± 0.049	1.852ProPhe: 1.852 ± 0.04	1.715ProGly: 1.715 ± 0.038	0.577ProHis: 0.577 ± 0.023	2.697ProIle: 2.697 ± 0.046	2.684ProLys: 2.684 ± 0.052	2.81ProLeu: 2.81 ± 0.052	0.622ProMet: 0.622 ± 0.022	2.448ProAsn: 2.448 ± 0.054	0.807ProPro: 0.807 ± 0.03	1.065ProGln: 1.065 ± 0.027	0.949ProArg: 0.949 ± 0.026	2.194ProSer: 2.194 ± 0.048	1.845ProThr: 1.845 ± 0.048	2.176ProVal: 2.176 ± 0.048	0.352ProTrp: 0.352 ± 0.019	1.378ProTyr: 1.378 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.752GlnAla: 1.752 ± 0.04	0.188GlnCys: 0.188 ± 0.012	1.674GlnAsp: 1.674 ± 0.041	2.082GlnGlu: 2.082 ± 0.045	1.655GlnPhe: 1.655 ± 0.034	1.798GlnGly: 1.798 ± 0.04	0.657GlnHis: 0.657 ± 0.024	2.704GlnIle: 2.704 ± 0.056	2.61GlnLys: 2.61 ± 0.051	3.324GlnLeu: 3.324 ± 0.055	0.693GlnMet: 0.693 ± 0.025	2.189GlnAsn: 2.189 ± 0.047	1.054GlnPro: 1.054 ± 0.026	1.314GlnGln: 1.314 ± 0.036	1.185GlnArg: 1.185 ± 0.036	1.862GlnSer: 1.862 ± 0.039	1.876GlnThr: 1.876 ± 0.044	1.826GlnVal: 1.826 ± 0.039	0.367GlnTrp: 0.367 ± 0.016	1.336GlnTyr: 1.336 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.013ArgAla: 2.013 ± 0.046	0.208ArgCys: 0.208 ± 0.013	1.855ArgAsp: 1.855 ± 0.04	2.017ArgGlu: 2.017 ± 0.048	1.918ArgPhe: 1.918 ± 0.044	1.948ArgGly: 1.948 ± 0.045	0.657ArgHis: 0.657 ± 0.024	2.887ArgIle: 2.887 ± 0.049	2.686ArgLys: 2.686 ± 0.051	3.26ArgLeu: 3.26 ± 0.057	0.764ArgMet: 0.764 ± 0.024	2.078ArgAsn: 2.078 ± 0.049	1.07ArgPro: 1.07 ± 0.031	1.078ArgGln: 1.078 ± 0.033	1.331ArgArg: 1.331 ± 0.042	1.834ArgSer: 1.834 ± 0.042	1.848ArgThr: 1.848 ± 0.042	2.058ArgVal: 2.058 ± 0.044	0.4ArgTrp: 0.4 ± 0.017	1.506ArgTyr: 1.506 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.578SerAla: 3.578 ± 0.055	0.693SerCys: 0.693 ± 0.023	3.552SerAsp: 3.552 ± 0.057	4.138SerGlu: 4.138 ± 0.054	3.809SerPhe: 3.809 ± 0.066	4.717SerGly: 4.717 ± 0.083	1.136SerHis: 1.136 ± 0.031	5.63SerIle: 5.63 ± 0.076	5.499SerLys: 5.499 ± 0.083	5.903SerLeu: 5.903 ± 0.069	1.168SerMet: 1.168 ± 0.029	4.432SerAsn: 4.432 ± 0.078	1.942SerPro: 1.942 ± 0.044	2.136SerGln: 2.136 ± 0.043	2.123SerArg: 2.123 ± 0.05	4.467SerSer: 4.467 ± 0.08	3.721SerThr: 3.721 ± 0.059	3.898SerVal: 3.898 ± 0.058	0.776SerTrp: 0.776 ± 0.027	2.842SerTyr: 2.842 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.457ThrAla: 3.457 ± 0.059	0.396ThrCys: 0.396 ± 0.024	3.497ThrAsp: 3.497 ± 0.066	3.364ThrGlu: 3.364 ± 0.057	3.253ThrPhe: 3.253 ± 0.057	3.989ThrGly: 3.989 ± 0.08	1.045ThrHis: 1.045 ± 0.029	5.242ThrIle: 5.242 ± 0.066	4.222ThrLys: 4.222 ± 0.063	5.592ThrLeu: 5.592 ± 0.07	0.947ThrMet: 0.947 ± 0.029	3.656ThrAsn: 3.656 ± 0.067	2.523ThrPro: 2.523 ± 0.056	1.93ThrGln: 1.93 ± 0.039	1.695ThrArg: 1.695 ± 0.038	4.246ThrSer: 4.246 ± 0.078	3.758ThrThr: 3.758 ± 0.083	3.799ThrVal: 3.799 ± 0.086	0.644ThrTrp: 0.644 ± 0.029	2.591ThrTyr: 2.591 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	3.829ValAla: 3.829 ± 0.06	0.528ValCys: 0.528 ± 0.022	3.81ValAsp: 3.81 ± 0.062	3.882ValGlu: 3.882 ± 0.056	3.553ValPhe: 3.553 ± 0.054	3.729ValGly: 3.729 ± 0.06	0.953ValHis: 0.953 ± 0.026	4.848ValIle: 4.848 ± 0.07	4.588ValLys: 4.588 ± 0.065	6.001ValLeu: 6.001 ± 0.085	1.243ValMet: 1.243 ± 0.032	3.83ValAsn: 3.83 ± 0.062	2.036ValPro: 2.036 ± 0.05	1.548ValGln: 1.548 ± 0.032	1.91ValArg: 1.91 ± 0.041	4.48ValSer: 4.48 ± 0.061	3.644ValThr: 3.644 ± 0.079	4.117ValVal: 4.117 ± 0.071	0.579ValTrp: 0.579 ± 0.023	2.378ValTyr: 2.378 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.558TrpAla: 0.558 ± 0.021	0.112TrpCys: 0.112 ± 0.009	0.663TrpAsp: 0.663 ± 0.028	0.688TrpGlu: 0.688 ± 0.026	0.568TrpPhe: 0.568 ± 0.024	0.668TrpGly: 0.668 ± 0.027	0.249TrpHis: 0.249 ± 0.014	0.75TrpIle: 0.75 ± 0.026	0.826TrpLys: 0.826 ± 0.032	1.003TrpLeu: 1.003 ± 0.031	0.295TrpMet: 0.295 ± 0.015	0.719TrpAsn: 0.719 ± 0.025	0.243TrpPro: 0.243 ± 0.015	0.416TrpGln: 0.416 ± 0.02	0.403TrpArg: 0.403 ± 0.02	0.687TrpSer: 0.687 ± 0.027	0.654TrpThr: 0.654 ± 0.032	0.636TrpVal: 0.636 ± 0.026	0.179TrpTrp: 0.179 ± 0.013	0.496TrpTyr: 0.496 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.425TyrAla: 2.425 ± 0.05	0.311TyrCys: 0.311 ± 0.015	2.395TyrAsp: 2.395 ± 0.052	2.245TyrGlu: 2.245 ± 0.043	2.442TyrPhe: 2.442 ± 0.039	2.633TyrGly: 2.633 ± 0.051	0.809TyrHis: 0.809 ± 0.027	2.997TyrIle: 2.997 ± 0.054	3.442TyrLys: 3.442 ± 0.051	3.783TyrLeu: 3.783 ± 0.064	0.747TyrMet: 0.747 ± 0.023	3.003TyrAsn: 3.003 ± 0.056	1.456TyrPro: 1.456 ± 0.032	1.488TyrGln: 1.488 ± 0.045	1.589TyrArg: 1.589 ± 0.037	2.668TyrSer: 2.668 ± 0.058	2.59TyrThr: 2.59 ± 0.053	2.232TyrVal: 2.232 ± 0.036	0.508TyrTrp: 0.508 ± 0.022	1.941TyrTyr: 1.941 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3449 proteins (1242761 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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