Amino acid dipepetide frequency for Wenzhouxiangella sp. W260

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.215AlaAla: 14.215 ± 0.155
1.17AlaCys: 1.17 ± 0.042
7.332AlaAsp: 7.332 ± 0.089
7.214AlaGlu: 7.214 ± 0.101
3.963AlaPhe: 3.963 ± 0.063
10.585AlaGly: 10.585 ± 0.121
2.187AlaHis: 2.187 ± 0.048
5.516AlaIle: 5.516 ± 0.071
2.314AlaLys: 2.314 ± 0.063
12.799AlaLeu: 12.799 ± 0.148
3.259AlaMet: 3.259 ± 0.063
3.007AlaAsn: 3.007 ± 0.06
5.167AlaPro: 5.167 ± 0.088
3.645AlaGln: 3.645 ± 0.065
8.229AlaArg: 8.229 ± 0.103
5.915AlaSer: 5.915 ± 0.081
5.924AlaThr: 5.924 ± 0.081
8.201AlaVal: 8.201 ± 0.101
2.296AlaTrp: 2.296 ± 0.056
2.474AlaTyr: 2.474 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.976CysAla: 0.976 ± 0.036
0.115CysCys: 0.115 ± 0.011
0.586CysAsp: 0.586 ± 0.033
0.539CysGlu: 0.539 ± 0.021
0.301CysPhe: 0.301 ± 0.017
0.866CysGly: 0.866 ± 0.033
0.286CysHis: 0.286 ± 0.021
0.336CysIle: 0.336 ± 0.017
0.179CysLys: 0.179 ± 0.014
0.823CysLeu: 0.823 ± 0.028
0.178CysMet: 0.178 ± 0.013
0.236CysAsn: 0.236 ± 0.015
0.448CysPro: 0.448 ± 0.026
0.292CysGln: 0.292 ± 0.02
0.63CysArg: 0.63 ± 0.027
0.484CysSer: 0.484 ± 0.018
0.449CysThr: 0.449 ± 0.025
0.616CysVal: 0.616 ± 0.025
0.124CysTrp: 0.124 ± 0.012
0.215CysTyr: 0.215 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.486AspAla: 7.486 ± 0.107
0.535AspCys: 0.535 ± 0.024
4.845AspAsp: 4.845 ± 0.082
4.214AspGlu: 4.214 ± 0.068
2.432AspPhe: 2.432 ± 0.049
6.429AspGly: 6.429 ± 0.103
1.468AspHis: 1.468 ± 0.039
3.547AspIle: 3.547 ± 0.057
1.4AspLys: 1.4 ± 0.039
6.075AspLeu: 6.075 ± 0.082
1.608AspMet: 1.608 ± 0.039
1.901AspAsn: 1.901 ± 0.044
3.802AspPro: 3.802 ± 0.063
2.122AspGln: 2.122 ± 0.047
4.512AspArg: 4.512 ± 0.07
3.1AspSer: 3.1 ± 0.066
3.476AspThr: 3.476 ± 0.062
4.4AspVal: 4.4 ± 0.063
1.37AspTrp: 1.37 ± 0.043
1.919AspTyr: 1.919 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
6.989GluAla: 6.989 ± 0.099
0.434GluCys: 0.434 ± 0.023
3.511GluAsp: 3.511 ± 0.054
3.06GluGlu: 3.06 ± 0.074
2.095GluPhe: 2.095 ± 0.05
4.532GluGly: 4.532 ± 0.075
1.431GluHis: 1.431 ± 0.036
2.973GluIle: 2.973 ± 0.06
1.88GluLys: 1.88 ± 0.045
6.49GluLeu: 6.49 ± 0.093
1.396GluMet: 1.396 ± 0.039
1.763GluAsn: 1.763 ± 0.036
3.252GluPro: 3.252 ± 0.058
2.742GluGln: 2.742 ± 0.061
5.059GluArg: 5.059 ± 0.085
3.323GluSer: 3.323 ± 0.06
3.391GluThr: 3.391 ± 0.052
4.094GluVal: 4.094 ± 0.067
1.001GluTrp: 1.001 ± 0.031
1.473GluTyr: 1.473 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.676PheAla: 3.676 ± 0.06
0.365PheCys: 0.365 ± 0.019
2.923PheAsp: 2.923 ± 0.061
2.613PheGlu: 2.613 ± 0.051
1.395PhePhe: 1.395 ± 0.042
3.471PheGly: 3.471 ± 0.059
0.815PheHis: 0.815 ± 0.027
1.735PheIle: 1.735 ± 0.04
0.831PheLys: 0.831 ± 0.03
3.166PheLeu: 3.166 ± 0.056
0.933PheMet: 0.933 ± 0.033
1.325PheAsn: 1.325 ± 0.041
1.512PhePro: 1.512 ± 0.038
1.119PheGln: 1.119 ± 0.034
2.392PheArg: 2.392 ± 0.045
2.414PheSer: 2.414 ± 0.052
2.092PheThr: 2.092 ± 0.042
2.457PheVal: 2.457 ± 0.045
0.583PheTrp: 0.583 ± 0.025
0.94PheTyr: 0.94 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
8.451GlyAla: 8.451 ± 0.104
0.851GlyCys: 0.851 ± 0.031
5.802GlyAsp: 5.802 ± 0.089
5.725GlyGlu: 5.725 ± 0.076
3.668GlyPhe: 3.668 ± 0.068
7.089GlyGly: 7.089 ± 0.104
2.074GlyHis: 2.074 ± 0.052
4.269GlyIle: 4.269 ± 0.066
2.594GlyLys: 2.594 ± 0.057
8.801GlyLeu: 8.801 ± 0.11
2.421GlyMet: 2.421 ± 0.056
2.653GlyAsn: 2.653 ± 0.065
3.352GlyPro: 3.352 ± 0.064
3.543GlyGln: 3.543 ± 0.061
5.791GlyArg: 5.791 ± 0.078
4.539GlySer: 4.539 ± 0.08
4.42GlyThr: 4.42 ± 0.083
6.426GlyVal: 6.426 ± 0.09
1.673GlyTrp: 1.673 ± 0.043
2.477GlyTyr: 2.477 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.315HisAla: 2.315 ± 0.052
0.255HisCys: 0.255 ± 0.016
1.489HisAsp: 1.489 ± 0.04
1.233HisGlu: 1.233 ± 0.036
0.888HisPhe: 0.888 ± 0.03
2.065HisGly: 2.065 ± 0.048
0.667HisHis: 0.667 ± 0.026
0.867HisIle: 0.867 ± 0.028
0.415HisLys: 0.415 ± 0.02
2.074HisLeu: 2.074 ± 0.045
0.443HisMet: 0.443 ± 0.019
0.534HisAsn: 0.534 ± 0.019
1.381HisPro: 1.381 ± 0.04
0.693HisGln: 0.693 ± 0.025
1.617HisArg: 1.617 ± 0.041
0.98HisSer: 0.98 ± 0.031
0.959HisThr: 0.959 ± 0.031
1.53HisVal: 1.53 ± 0.04
0.403HisTrp: 0.403 ± 0.021
0.724HisTyr: 0.724 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.376IleAla: 5.376 ± 0.08
0.396IleCys: 0.396 ± 0.02
3.767IleAsp: 3.767 ± 0.051
3.412IleGlu: 3.412 ± 0.059
1.361IlePhe: 1.361 ± 0.041
4.096IleGly: 4.096 ± 0.079
0.984IleHis: 0.984 ± 0.03
2.068IleIle: 2.068 ± 0.045
1.099IleLys: 1.099 ± 0.036
3.555IleLeu: 3.555 ± 0.061
0.843IleMet: 0.843 ± 0.032
1.562IleAsn: 1.562 ± 0.038
2.188IlePro: 2.188 ± 0.048
1.26IleGln: 1.26 ± 0.04
3.101IleArg: 3.101 ± 0.053
2.546IleSer: 2.546 ± 0.058
2.641IleThr: 2.641 ± 0.057
3.203IleVal: 3.203 ± 0.067
0.495IleTrp: 0.495 ± 0.019
1.103IleTyr: 1.103 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.052LysAla: 3.052 ± 0.083
0.155LysCys: 0.155 ± 0.014
1.336LysAsp: 1.336 ± 0.04
1.148LysGlu: 1.148 ± 0.039
0.759LysPhe: 0.759 ± 0.027
1.868LysGly: 1.868 ± 0.049
0.558LysHis: 0.558 ± 0.024
1.119LysIle: 1.119 ± 0.032
0.914LysLys: 0.914 ± 0.046
2.55LysLeu: 2.55 ± 0.057
0.584LysMet: 0.584 ± 0.024
0.701LysAsn: 0.701 ± 0.029
1.484LysPro: 1.484 ± 0.041
0.9LysGln: 0.9 ± 0.031
1.965LysArg: 1.965 ± 0.047
1.403LysSer: 1.403 ± 0.043
1.473LysThr: 1.473 ± 0.042
1.978LysVal: 1.978 ± 0.052
0.291LysTrp: 0.291 ± 0.016
0.612LysTyr: 0.612 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
13.999LeuAla: 13.999 ± 0.145
0.863LeuCys: 0.863 ± 0.029
7.354LeuAsp: 7.354 ± 0.091
6.469LeuGlu: 6.469 ± 0.086
3.694LeuPhe: 3.694 ± 0.065
8.549LeuGly: 8.549 ± 0.098
1.87LeuHis: 1.87 ± 0.045
3.288LeuIle: 3.288 ± 0.067
2.857LeuLys: 2.857 ± 0.064
10.2LeuLeu: 10.2 ± 0.128
2.163LeuMet: 2.163 ± 0.047
2.7LeuAsn: 2.7 ± 0.056
5.552LeuPro: 5.552 ± 0.09
3.231LeuGln: 3.231 ± 0.066
6.662LeuArg: 6.662 ± 0.094
5.633LeuSer: 5.633 ± 0.078
4.751LeuThr: 4.751 ± 0.083
8.681LeuVal: 8.681 ± 0.109
1.225LeuTrp: 1.225 ± 0.035
2.249LeuTyr: 2.249 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
3.089MetAla: 3.089 ± 0.06
0.154MetCys: 0.154 ± 0.012
1.449MetAsp: 1.449 ± 0.036
1.186MetGlu: 1.186 ± 0.035
0.719MetPhe: 0.719 ± 0.03
1.898MetGly: 1.898 ± 0.045
0.474MetHis: 0.474 ± 0.022
1.066MetIle: 1.066 ± 0.033
0.948MetLys: 0.948 ± 0.032
2.371MetLeu: 2.371 ± 0.049
0.584MetMet: 0.584 ± 0.025
0.999MetAsn: 0.999 ± 0.029
1.314MetPro: 1.314 ± 0.034
0.743MetGln: 0.743 ± 0.025
1.634MetArg: 1.634 ± 0.045
1.613MetSer: 1.613 ± 0.04
1.685MetThr: 1.685 ± 0.039
1.784MetVal: 1.784 ± 0.047
0.229MetTrp: 0.229 ± 0.015
0.408MetTyr: 0.408 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.172AsnAla: 3.172 ± 0.054
0.263AsnCys: 0.263 ± 0.017
1.833AsnAsp: 1.833 ± 0.045
1.544AsnGlu: 1.544 ± 0.043
0.981AsnPhe: 0.981 ± 0.032
2.738AsnGly: 2.738 ± 0.061
0.656AsnHis: 0.656 ± 0.026
1.471AsnIle: 1.471 ± 0.042
0.585AsnLys: 0.585 ± 0.028
2.784AsnLeu: 2.784 ± 0.051
0.634AsnMet: 0.634 ± 0.027
0.9AsnAsn: 0.9 ± 0.035
2.024AsnPro: 2.024 ± 0.047
0.936AsnGln: 0.936 ± 0.035
2.111AsnArg: 2.111 ± 0.046
1.336AsnSer: 1.336 ± 0.037
1.555AsnThr: 1.555 ± 0.042
2.083AsnVal: 2.083 ± 0.052
0.49AsnTrp: 0.49 ± 0.023
0.783AsnTyr: 0.783 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.253ProAla: 6.253 ± 0.105
0.332ProCys: 0.332 ± 0.023
3.983ProAsp: 3.983 ± 0.077
3.957ProGlu: 3.957 ± 0.061
1.805ProPhe: 1.805 ± 0.042
5.496ProGly: 5.496 ± 0.079
0.881ProHis: 0.881 ± 0.033
1.797ProIle: 1.797 ± 0.041
1.127ProLys: 1.127 ± 0.046
4.624ProLeu: 4.624 ± 0.078
1.31ProMet: 1.31 ± 0.033
1.369ProAsn: 1.369 ± 0.034
2.54ProPro: 2.54 ± 0.062
1.409ProGln: 1.409 ± 0.042
2.85ProArg: 2.85 ± 0.057
2.498ProSer: 2.498 ± 0.048
2.314ProThr: 2.314 ± 0.048
4.454ProVal: 4.454 ± 0.068
0.908ProTrp: 0.908 ± 0.03
1.174ProTyr: 1.174 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.935GlnAla: 4.935 ± 0.071
0.279GlnCys: 0.279 ± 0.018
1.827GlnAsp: 1.827 ± 0.045
1.362GlnGlu: 1.362 ± 0.039
1.182GlnPhe: 1.182 ± 0.035
2.668GlnGly: 2.668 ± 0.051
0.7GlnHis: 0.7 ± 0.027
1.126GlnIle: 1.126 ± 0.03
0.848GlnLys: 0.848 ± 0.033
3.743GlnLeu: 3.743 ± 0.068
0.824GlnMet: 0.824 ± 0.025
0.809GlnAsn: 0.809 ± 0.032
1.952GlnPro: 1.952 ± 0.041
1.379GlnGln: 1.379 ± 0.045
2.719GlnArg: 2.719 ± 0.06
1.862GlnSer: 1.862 ± 0.042
1.363GlnThr: 1.363 ± 0.036
3.062GlnVal: 3.062 ± 0.052
0.595GlnTrp: 0.595 ± 0.026
0.818GlnTyr: 0.818 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
7.286ArgAla: 7.286 ± 0.096
0.54ArgCys: 0.54 ± 0.024
4.531ArgAsp: 4.531 ± 0.073
4.669ArgGlu: 4.669 ± 0.084
2.959ArgPhe: 2.959 ± 0.058
4.742ArgGly: 4.742 ± 0.065
1.819ArgHis: 1.819 ± 0.047
3.235ArgIle: 3.235 ± 0.063
1.954ArgLys: 1.954 ± 0.052
7.878ArgLeu: 7.878 ± 0.112
1.782ArgMet: 1.782 ± 0.04
2.028ArgAsn: 2.028 ± 0.046
3.321ArgPro: 3.321 ± 0.053
2.993ArgGln: 2.993 ± 0.06
5.446ArgArg: 5.446 ± 0.08
3.318ArgSer: 3.318 ± 0.055
2.893ArgThr: 2.893 ± 0.059
5.646ArgVal: 5.646 ± 0.087
1.253ArgTrp: 1.253 ± 0.042
2.188ArgTyr: 2.188 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
5.907SerAla: 5.907 ± 0.095
0.456SerCys: 0.456 ± 0.028
3.161SerAsp: 3.161 ± 0.063
2.951SerGlu: 2.951 ± 0.06
1.963SerPhe: 1.963 ± 0.044
5.608SerGly: 5.608 ± 0.1
1.088SerHis: 1.088 ± 0.034
2.376SerIle: 2.376 ± 0.053
1.255SerLys: 1.255 ± 0.037
5.473SerLeu: 5.473 ± 0.085
1.398SerMet: 1.398 ± 0.041
1.496SerAsn: 1.496 ± 0.042
2.794SerPro: 2.794 ± 0.048
1.721SerGln: 1.721 ± 0.04
3.743SerArg: 3.743 ± 0.067
2.859SerSer: 2.859 ± 0.059
2.876SerThr: 2.876 ± 0.059
3.937SerVal: 3.937 ± 0.059
0.9SerTrp: 0.9 ± 0.031
1.296SerTyr: 1.296 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.901ThrAla: 5.901 ± 0.076
0.436ThrCys: 0.436 ± 0.024
3.173ThrAsp: 3.173 ± 0.07
2.781ThrGlu: 2.781 ± 0.056
1.892ThrPhe: 1.892 ± 0.047
5.191ThrGly: 5.191 ± 0.071
1.086ThrHis: 1.086 ± 0.035
2.399ThrIle: 2.399 ± 0.059
0.864ThrLys: 0.864 ± 0.029
5.967ThrLeu: 5.967 ± 0.096
1.088ThrMet: 1.088 ± 0.029
1.239ThrAsn: 1.239 ± 0.032
3.296ThrPro: 3.296 ± 0.058
1.47ThrGln: 1.47 ± 0.04
3.652ThrArg: 3.652 ± 0.057
2.541ThrSer: 2.541 ± 0.049
2.875ThrThr: 2.875 ± 0.064
4.271ThrVal: 4.271 ± 0.086
0.974ThrTrp: 0.974 ± 0.032
1.199ThrTyr: 1.199 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
8.386ValAla: 8.386 ± 0.107
0.675ValCys: 0.675 ± 0.027
5.153ValAsp: 5.153 ± 0.074
4.715ValGlu: 4.715 ± 0.072
2.936ValPhe: 2.936 ± 0.058
5.507ValGly: 5.507 ± 0.08
1.517ValHis: 1.517 ± 0.042
4.144ValIle: 4.144 ± 0.069
1.816ValLys: 1.816 ± 0.049
7.927ValLeu: 7.927 ± 0.084
1.963ValMet: 1.963 ± 0.051
2.383ValAsn: 2.383 ± 0.055
3.615ValPro: 3.615 ± 0.051
2.129ValGln: 2.129 ± 0.041
4.889ValArg: 4.889 ± 0.066
4.516ValSer: 4.516 ± 0.067
4.847ValThr: 4.847 ± 0.088
5.939ValVal: 5.939 ± 0.091
0.855ValTrp: 0.855 ± 0.029
1.776ValTyr: 1.776 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.448TrpAla: 1.448 ± 0.041
0.171TrpCys: 0.171 ± 0.014
0.845TrpAsp: 0.845 ± 0.029
0.684TrpGlu: 0.684 ± 0.026
0.701TrpPhe: 0.701 ± 0.027
1.083TrpGly: 1.083 ± 0.032
0.379TrpHis: 0.379 ± 0.02
0.713TrpIle: 0.713 ± 0.027
0.428TrpLys: 0.428 ± 0.022
2.114TrpLeu: 2.114 ± 0.047
0.4TrpMet: 0.4 ± 0.021
0.528TrpAsn: 0.528 ± 0.022
0.86TrpPro: 0.86 ± 0.031
0.704TrpGln: 0.704 ± 0.028
1.338TrpArg: 1.338 ± 0.041
1.035TrpSer: 1.035 ± 0.029
0.882TrpThr: 0.882 ± 0.033
1.301TrpVal: 1.301 ± 0.035
0.321TrpTrp: 0.321 ± 0.023
0.493TrpTyr: 0.493 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.501TyrAla: 2.501 ± 0.05
0.234TyrCys: 0.234 ± 0.017
1.743TyrAsp: 1.743 ± 0.052
1.415TyrGlu: 1.415 ± 0.041
1.063TyrPhe: 1.063 ± 0.037
2.139TyrGly: 2.139 ± 0.047
0.591TyrHis: 0.591 ± 0.024
1.011TyrIle: 1.011 ± 0.033
0.54TyrLys: 0.54 ± 0.023
2.571TyrLeu: 2.571 ± 0.045
0.533TyrMet: 0.533 ± 0.02
0.743TyrAsn: 0.743 ± 0.028
1.227TyrPro: 1.227 ± 0.041
1.023TyrGln: 1.023 ± 0.033
2.142TyrArg: 2.142 ± 0.051
1.346TyrSer: 1.346 ± 0.035
1.428TyrThr: 1.428 ± 0.04
1.628TyrVal: 1.628 ± 0.044
0.443TyrTrp: 0.443 ± 0.022
0.742TyrTyr: 0.742 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3042 proteins (1066961 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski