Amino acid dipepetide frequency for Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.884AlaAla: 6.884 ± 1.067
0.725AlaCys: 0.725 ± 0.242
5.556AlaAsp: 5.556 ± 0.708
4.106AlaGlu: 4.106 ± 0.749
3.623AlaPhe: 3.623 ± 0.531
3.744AlaGly: 3.744 ± 0.585
1.329AlaHis: 1.329 ± 0.384
4.71AlaIle: 4.71 ± 0.812
3.623AlaLys: 3.623 ± 0.976
7.005AlaLeu: 7.005 ± 1.054
1.932AlaMet: 1.932 ± 0.297
3.502AlaAsn: 3.502 ± 0.736
5.314AlaPro: 5.314 ± 0.822
5.435AlaGln: 5.435 ± 0.466
5.556AlaArg: 5.556 ± 0.81
6.039AlaSer: 6.039 ± 0.776
3.986AlaThr: 3.986 ± 0.438
4.227AlaVal: 4.227 ± 0.816
0.725AlaTrp: 0.725 ± 0.327
2.053AlaTyr: 2.053 ± 0.212
0.0AlaXaa: 0.0 ± 0.0
Cys
0.845CysAla: 0.845 ± 0.223
0.121CysCys: 0.121 ± 0.094
0.362CysAsp: 0.362 ± 0.25
0.966CysGlu: 0.966 ± 0.325
0.725CysPhe: 0.725 ± 0.296
0.362CysGly: 0.362 ± 0.27
0.362CysHis: 0.362 ± 0.143
0.845CysIle: 0.845 ± 0.414
0.121CysLys: 0.121 ± 0.108
1.57CysLeu: 1.57 ± 0.416
0.966CysMet: 0.966 ± 0.589
0.362CysAsn: 0.362 ± 0.182
1.087CysPro: 1.087 ± 0.289
0.604CysGln: 0.604 ± 0.203
0.725CysArg: 0.725 ± 0.184
1.329CysSer: 1.329 ± 0.282
0.604CysThr: 0.604 ± 0.216
0.845CysVal: 0.845 ± 0.322
0.121CysTrp: 0.121 ± 0.094
0.604CysTyr: 0.604 ± 0.251
0.0CysXaa: 0.0 ± 0.0
Asp
6.28AspAla: 6.28 ± 0.673
0.725AspCys: 0.725 ± 0.341
5.072AspAsp: 5.072 ± 0.866
3.865AspGlu: 3.865 ± 0.742
1.812AspPhe: 1.812 ± 0.495
4.71AspGly: 4.71 ± 0.781
1.329AspHis: 1.329 ± 0.318
3.14AspIle: 3.14 ± 0.388
2.295AspLys: 2.295 ± 0.462
5.797AspLeu: 5.797 ± 0.778
1.691AspMet: 1.691 ± 0.354
1.329AspAsn: 1.329 ± 0.472
3.865AspPro: 3.865 ± 0.583
2.295AspGln: 2.295 ± 0.435
3.14AspArg: 3.14 ± 0.649
4.348AspSer: 4.348 ± 0.644
2.657AspThr: 2.657 ± 0.796
7.126AspVal: 7.126 ± 1.373
0.845AspTrp: 0.845 ± 0.281
2.295AspTyr: 2.295 ± 0.538
0.0AspXaa: 0.0 ± 0.0
Glu
3.502GluAla: 3.502 ± 0.594
0.604GluCys: 0.604 ± 0.273
1.691GluAsp: 1.691 ± 0.38
1.449GluGlu: 1.449 ± 0.329
1.087GluPhe: 1.087 ± 0.295
2.053GluGly: 2.053 ± 0.361
0.966GluHis: 0.966 ± 0.199
3.019GluIle: 3.019 ± 0.597
2.899GluLys: 2.899 ± 0.691
6.039GluLeu: 6.039 ± 1.138
1.208GluMet: 1.208 ± 0.34
0.845GluAsn: 0.845 ± 0.353
1.932GluPro: 1.932 ± 0.337
2.415GluGln: 2.415 ± 0.591
2.174GluArg: 2.174 ± 0.645
3.019GluSer: 3.019 ± 0.602
3.14GluThr: 3.14 ± 0.633
3.502GluVal: 3.502 ± 0.521
0.966GluTrp: 0.966 ± 0.349
1.208GluTyr: 1.208 ± 0.251
0.0GluXaa: 0.0 ± 0.0
Phe
1.449PheAla: 1.449 ± 0.211
0.362PheCys: 0.362 ± 0.21
2.174PheAsp: 2.174 ± 0.425
1.329PheGlu: 1.329 ± 0.26
1.208PhePhe: 1.208 ± 0.45
3.14PheGly: 3.14 ± 0.629
0.121PheHis: 0.121 ± 0.134
2.174PheIle: 2.174 ± 0.413
2.053PheLys: 2.053 ± 0.463
2.536PheLeu: 2.536 ± 0.567
1.57PheMet: 1.57 ± 0.419
1.57PheAsn: 1.57 ± 0.267
1.57PhePro: 1.57 ± 0.347
2.174PheGln: 2.174 ± 0.426
1.449PheArg: 1.449 ± 0.433
3.744PheSer: 3.744 ± 0.694
2.415PheThr: 2.415 ± 0.306
2.778PheVal: 2.778 ± 0.649
0.362PheTrp: 0.362 ± 0.149
0.845PheTyr: 0.845 ± 0.429
0.0PheXaa: 0.0 ± 0.0
Gly
4.952GlyAla: 4.952 ± 0.98
0.604GlyCys: 0.604 ± 0.186
3.744GlyAsp: 3.744 ± 0.876
2.174GlyGlu: 2.174 ± 0.609
2.415GlyPhe: 2.415 ± 0.439
3.019GlyGly: 3.019 ± 0.797
1.57GlyHis: 1.57 ± 0.43
2.778GlyIle: 2.778 ± 0.364
2.053GlyLys: 2.053 ± 0.334
5.314GlyLeu: 5.314 ± 1.41
1.812GlyMet: 1.812 ± 0.408
2.899GlyAsn: 2.899 ± 0.604
1.812GlyPro: 1.812 ± 0.53
1.57GlyGln: 1.57 ± 0.45
3.744GlyArg: 3.744 ± 0.565
3.14GlySer: 3.14 ± 0.444
2.174GlyThr: 2.174 ± 0.493
5.676GlyVal: 5.676 ± 0.708
1.449GlyTrp: 1.449 ± 0.3
1.932GlyTyr: 1.932 ± 0.369
0.0GlyXaa: 0.0 ± 0.0
His
2.053HisAla: 2.053 ± 0.539
0.242HisCys: 0.242 ± 0.165
1.812HisAsp: 1.812 ± 0.343
0.725HisGlu: 0.725 ± 0.227
0.362HisPhe: 0.362 ± 0.189
1.329HisGly: 1.329 ± 0.353
0.966HisHis: 0.966 ± 0.327
0.845HisIle: 0.845 ± 0.352
0.483HisLys: 0.483 ± 0.196
1.932HisLeu: 1.932 ± 0.33
0.483HisMet: 0.483 ± 0.225
0.725HisAsn: 0.725 ± 0.244
0.845HisPro: 0.845 ± 0.2
0.725HisGln: 0.725 ± 0.297
1.087HisArg: 1.087 ± 0.335
1.57HisSer: 1.57 ± 0.411
1.691HisThr: 1.691 ± 0.551
1.449HisVal: 1.449 ± 0.365
0.121HisTrp: 0.121 ± 0.108
0.604HisTyr: 0.604 ± 0.3
0.0HisXaa: 0.0 ± 0.0
Ile
4.348IleAla: 4.348 ± 0.75
1.087IleCys: 1.087 ± 0.322
4.348IleAsp: 4.348 ± 0.602
2.295IleGlu: 2.295 ± 0.475
1.329IlePhe: 1.329 ± 0.462
2.899IleGly: 2.899 ± 0.849
1.329IleHis: 1.329 ± 0.409
2.415IleIle: 2.415 ± 0.61
2.174IleLys: 2.174 ± 0.38
3.502IleLeu: 3.502 ± 0.55
2.415IleMet: 2.415 ± 0.424
2.536IleAsn: 2.536 ± 0.213
4.348IlePro: 4.348 ± 0.679
3.019IleGln: 3.019 ± 0.55
2.899IleArg: 2.899 ± 0.51
6.039IleSer: 6.039 ± 0.822
4.469IleThr: 4.469 ± 0.688
3.382IleVal: 3.382 ± 0.335
0.121IleTrp: 0.121 ± 0.094
1.691IleTyr: 1.691 ± 0.306
0.0IleXaa: 0.0 ± 0.0
Lys
2.415LysAla: 2.415 ± 0.632
0.483LysCys: 0.483 ± 0.289
1.932LysAsp: 1.932 ± 0.348
1.329LysGlu: 1.329 ± 0.412
0.725LysPhe: 0.725 ± 0.259
2.295LysGly: 2.295 ± 0.328
1.087LysHis: 1.087 ± 0.232
2.657LysIle: 2.657 ± 0.596
0.966LysLys: 0.966 ± 0.385
3.986LysLeu: 3.986 ± 0.715
0.845LysMet: 0.845 ± 0.3
1.57LysAsn: 1.57 ± 0.398
1.812LysPro: 1.812 ± 0.413
1.449LysGln: 1.449 ± 0.564
2.657LysArg: 2.657 ± 0.533
3.019LysSer: 3.019 ± 0.531
2.536LysThr: 2.536 ± 0.482
2.657LysVal: 2.657 ± 0.915
1.087LysTrp: 1.087 ± 0.267
2.174LysTyr: 2.174 ± 0.517
0.0LysXaa: 0.0 ± 0.0
Leu
7.729LeuAla: 7.729 ± 0.737
1.449LeuCys: 1.449 ± 0.283
7.246LeuAsp: 7.246 ± 0.812
6.28LeuGlu: 6.28 ± 0.888
3.14LeuPhe: 3.14 ± 0.554
3.261LeuGly: 3.261 ± 0.816
1.449LeuHis: 1.449 ± 0.498
3.382LeuIle: 3.382 ± 0.568
2.778LeuLys: 2.778 ± 0.588
7.85LeuLeu: 7.85 ± 0.912
4.106LeuMet: 4.106 ± 0.889
4.227LeuAsn: 4.227 ± 0.807
5.314LeuPro: 5.314 ± 0.787
4.831LeuGln: 4.831 ± 0.713
7.488LeuArg: 7.488 ± 0.858
9.662LeuSer: 9.662 ± 1.074
5.918LeuThr: 5.918 ± 0.809
6.159LeuVal: 6.159 ± 0.467
0.966LeuTrp: 0.966 ± 0.306
2.415LeuTyr: 2.415 ± 0.518
0.0LeuXaa: 0.0 ± 0.0
Met
2.415MetAla: 2.415 ± 0.456
0.362MetCys: 0.362 ± 0.164
1.691MetAsp: 1.691 ± 0.535
1.449MetGlu: 1.449 ± 0.564
0.966MetPhe: 0.966 ± 0.277
1.329MetGly: 1.329 ± 0.516
0.725MetHis: 0.725 ± 0.38
2.174MetIle: 2.174 ± 0.458
1.208MetLys: 1.208 ± 0.419
3.14MetLeu: 3.14 ± 0.62
1.087MetMet: 1.087 ± 0.455
1.932MetAsn: 1.932 ± 0.529
1.449MetPro: 1.449 ± 0.395
1.449MetGln: 1.449 ± 0.393
1.812MetArg: 1.812 ± 0.387
2.415MetSer: 2.415 ± 0.358
3.14MetThr: 3.14 ± 0.208
1.691MetVal: 1.691 ± 0.538
0.362MetTrp: 0.362 ± 0.186
1.57MetTyr: 1.57 ± 0.241
0.0MetXaa: 0.0 ± 0.0
Asn
2.536AsnAla: 2.536 ± 0.421
0.966AsnCys: 0.966 ± 0.405
2.415AsnAsp: 2.415 ± 0.413
1.57AsnGlu: 1.57 ± 0.293
1.449AsnPhe: 1.449 ± 0.414
2.536AsnGly: 2.536 ± 0.447
0.845AsnHis: 0.845 ± 0.354
2.053AsnIle: 2.053 ± 0.524
0.604AsnLys: 0.604 ± 0.221
3.382AsnLeu: 3.382 ± 0.963
0.725AsnMet: 0.725 ± 0.238
1.932AsnAsn: 1.932 ± 0.62
1.932AsnPro: 1.932 ± 0.422
2.295AsnGln: 2.295 ± 0.51
2.536AsnArg: 2.536 ± 0.448
2.899AsnSer: 2.899 ± 0.608
2.657AsnThr: 2.657 ± 0.544
4.106AsnVal: 4.106 ± 0.596
1.087AsnTrp: 1.087 ± 0.389
1.449AsnTyr: 1.449 ± 0.375
0.0AsnXaa: 0.0 ± 0.0
Pro
3.744ProAla: 3.744 ± 0.539
0.121ProCys: 0.121 ± 0.107
3.986ProAsp: 3.986 ± 0.404
2.053ProGlu: 2.053 ± 0.679
2.778ProPhe: 2.778 ± 0.591
3.14ProGly: 3.14 ± 0.533
0.966ProHis: 0.966 ± 0.326
3.382ProIle: 3.382 ± 0.653
1.932ProLys: 1.932 ± 0.802
5.797ProLeu: 5.797 ± 0.78
2.174ProMet: 2.174 ± 0.751
2.657ProAsn: 2.657 ± 0.401
3.019ProPro: 3.019 ± 0.815
2.053ProGln: 2.053 ± 0.332
2.536ProArg: 2.536 ± 0.764
4.227ProSer: 4.227 ± 0.532
4.348ProThr: 4.348 ± 0.662
3.14ProVal: 3.14 ± 0.447
0.966ProTrp: 0.966 ± 0.285
1.812ProTyr: 1.812 ± 0.355
0.0ProXaa: 0.0 ± 0.0
Gln
4.589GlnAla: 4.589 ± 0.973
0.725GlnCys: 0.725 ± 0.197
1.449GlnAsp: 1.449 ± 0.264
1.329GlnGlu: 1.329 ± 0.422
1.932GlnPhe: 1.932 ± 0.62
2.174GlnGly: 2.174 ± 0.543
0.845GlnHis: 0.845 ± 0.298
3.744GlnIle: 3.744 ± 0.447
1.329GlnLys: 1.329 ± 0.413
6.763GlnLeu: 6.763 ± 0.808
1.208GlnMet: 1.208 ± 0.265
2.053GlnAsn: 2.053 ± 0.409
1.691GlnPro: 1.691 ± 0.285
2.174GlnGln: 2.174 ± 0.529
2.657GlnArg: 2.657 ± 0.615
3.986GlnSer: 3.986 ± 0.761
2.295GlnThr: 2.295 ± 0.527
2.657GlnVal: 2.657 ± 0.404
0.845GlnTrp: 0.845 ± 0.227
2.415GlnTyr: 2.415 ± 0.634
0.0GlnXaa: 0.0 ± 0.0
Arg
3.865ArgAla: 3.865 ± 0.781
0.725ArgCys: 0.725 ± 0.22
3.502ArgAsp: 3.502 ± 0.763
3.019ArgGlu: 3.019 ± 0.514
2.415ArgPhe: 2.415 ± 0.412
2.657ArgGly: 2.657 ± 0.366
1.208ArgHis: 1.208 ± 0.392
3.744ArgIle: 3.744 ± 0.695
3.019ArgLys: 3.019 ± 0.953
5.072ArgLeu: 5.072 ± 1.323
2.174ArgMet: 2.174 ± 0.51
1.449ArgAsn: 1.449 ± 0.336
2.295ArgPro: 2.295 ± 0.608
3.019ArgGln: 3.019 ± 0.398
2.295ArgArg: 2.295 ± 0.539
4.589ArgSer: 4.589 ± 0.709
2.899ArgThr: 2.899 ± 0.477
5.193ArgVal: 5.193 ± 0.861
1.087ArgTrp: 1.087 ± 0.324
2.295ArgTyr: 2.295 ± 0.675
0.0ArgXaa: 0.0 ± 0.0
Ser
8.696SerAla: 8.696 ± 0.841
1.208SerCys: 1.208 ± 0.286
5.556SerAsp: 5.556 ± 0.675
2.657SerGlu: 2.657 ± 0.478
2.536SerPhe: 2.536 ± 0.309
5.556SerGly: 5.556 ± 0.824
1.329SerHis: 1.329 ± 0.365
5.676SerIle: 5.676 ± 0.769
2.536SerLys: 2.536 ± 0.757
9.058SerLeu: 9.058 ± 1.238
1.932SerMet: 1.932 ± 0.364
2.536SerAsn: 2.536 ± 0.587
4.589SerPro: 4.589 ± 0.511
2.657SerGln: 2.657 ± 0.328
4.71SerArg: 4.71 ± 0.649
8.333SerSer: 8.333 ± 1.092
4.831SerThr: 4.831 ± 0.615
5.314SerVal: 5.314 ± 0.641
0.966SerTrp: 0.966 ± 0.349
3.019SerTyr: 3.019 ± 0.448
0.0SerXaa: 0.0 ± 0.0
Thr
4.589ThrAla: 4.589 ± 0.659
0.725ThrCys: 0.725 ± 0.217
2.899ThrAsp: 2.899 ± 0.444
3.261ThrGlu: 3.261 ± 0.929
1.812ThrPhe: 1.812 ± 0.39
3.623ThrGly: 3.623 ± 0.575
1.087ThrHis: 1.087 ± 0.256
3.502ThrIle: 3.502 ± 0.66
2.536ThrLys: 2.536 ± 0.352
5.797ThrLeu: 5.797 ± 0.799
2.415ThrMet: 2.415 ± 0.466
2.174ThrAsn: 2.174 ± 0.787
4.106ThrPro: 4.106 ± 0.794
3.502ThrGln: 3.502 ± 0.66
3.14ThrArg: 3.14 ± 0.615
5.918ThrSer: 5.918 ± 0.995
3.14ThrThr: 3.14 ± 0.664
3.865ThrVal: 3.865 ± 0.699
1.329ThrTrp: 1.329 ± 0.451
1.932ThrTyr: 1.932 ± 0.355
0.0ThrXaa: 0.0 ± 0.0
Val
5.918ValAla: 5.918 ± 1.159
1.329ValCys: 1.329 ± 0.368
6.039ValAsp: 6.039 ± 1.196
2.053ValGlu: 2.053 ± 0.413
2.536ValPhe: 2.536 ± 0.439
4.106ValGly: 4.106 ± 0.294
1.449ValHis: 1.449 ± 0.365
3.14ValIle: 3.14 ± 0.695
3.382ValLys: 3.382 ± 0.847
6.643ValLeu: 6.643 ± 0.914
1.812ValMet: 1.812 ± 0.497
3.502ValAsn: 3.502 ± 0.484
5.072ValPro: 5.072 ± 1.053
2.295ValGln: 2.295 ± 0.613
4.227ValArg: 4.227 ± 0.638
6.522ValSer: 6.522 ± 0.975
5.072ValThr: 5.072 ± 0.967
6.039ValVal: 6.039 ± 0.975
0.845ValTrp: 0.845 ± 0.291
1.691ValTyr: 1.691 ± 0.558
0.0ValXaa: 0.0 ± 0.0
Trp
0.725TrpAla: 0.725 ± 0.342
0.483TrpCys: 0.483 ± 0.196
0.966TrpAsp: 0.966 ± 0.282
0.483TrpGlu: 0.483 ± 0.184
0.362TrpPhe: 0.362 ± 0.248
1.087TrpGly: 1.087 ± 0.349
0.362TrpHis: 0.362 ± 0.173
1.57TrpIle: 1.57 ± 0.42
0.483TrpLys: 0.483 ± 0.185
1.449TrpLeu: 1.449 ± 0.274
0.604TrpMet: 0.604 ± 0.299
0.362TrpAsn: 0.362 ± 0.173
0.845TrpPro: 0.845 ± 0.3
0.725TrpGln: 0.725 ± 0.26
0.362TrpArg: 0.362 ± 0.175
0.604TrpSer: 0.604 ± 0.27
1.449TrpThr: 1.449 ± 0.43
1.087TrpVal: 1.087 ± 0.251
0.0TrpTrp: 0.0 ± 0.0
0.725TrpTyr: 0.725 ± 0.354
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.536TyrAla: 2.536 ± 0.533
0.483TyrCys: 0.483 ± 0.271
2.174TyrAsp: 2.174 ± 0.508
1.329TyrGlu: 1.329 ± 0.316
1.812TyrPhe: 1.812 ± 0.326
1.812TyrGly: 1.812 ± 0.393
0.725TyrHis: 0.725 ± 0.269
1.691TyrIle: 1.691 ± 0.405
1.208TyrLys: 1.208 ± 0.348
3.14TyrLeu: 3.14 ± 0.711
1.087TyrMet: 1.087 ± 0.282
1.812TyrAsn: 1.812 ± 0.488
1.932TyrPro: 1.932 ± 0.522
2.174TyrGln: 2.174 ± 0.298
1.329TyrArg: 1.329 ± 0.394
2.295TyrSer: 2.295 ± 0.464
1.932TyrThr: 1.932 ± 0.284
2.778TyrVal: 2.778 ± 0.463
0.483TyrTrp: 0.483 ± 0.178
1.449TyrTyr: 1.449 ± 0.225
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (8281 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski