Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA259E17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.951AlaAla: 3.951 ± 0.197
0.689AlaCys: 0.689 ± 0.063
3.282AlaAsp: 3.282 ± 0.142
5.949AlaGlu: 5.949 ± 0.187
2.162AlaPhe: 2.162 ± 0.122
4.85AlaGly: 4.85 ± 0.192
1.021AlaHis: 1.021 ± 0.073
4.024AlaIle: 4.024 ± 0.166
3.493AlaLys: 3.493 ± 0.153
5.918AlaLeu: 5.918 ± 0.196
1.568AlaMet: 1.568 ± 0.111
1.547AlaAsn: 1.547 ± 0.092
2.115AlaPro: 2.115 ± 0.102
1.378AlaGln: 1.378 ± 0.089
3.803AlaArg: 3.803 ± 0.153
3.709AlaSer: 3.709 ± 0.158
2.846AlaThr: 2.846 ± 0.131
4.55AlaVal: 4.55 ± 0.17
0.789AlaTrp: 0.789 ± 0.067
1.631AlaTyr: 1.631 ± 0.1
0.0AlaXaa: 0.0 ± 0.0
Cys
0.463CysAla: 0.463 ± 0.053
0.163CysCys: 0.163 ± 0.031
0.573CysAsp: 0.573 ± 0.064
0.805CysGlu: 0.805 ± 0.067
0.368CysPhe: 0.368 ± 0.047
1.168CysGly: 1.168 ± 0.086
0.221CysHis: 0.221 ± 0.034
0.442CysIle: 0.442 ± 0.054
0.5CysLys: 0.5 ± 0.049
0.815CysLeu: 0.815 ± 0.077
0.284CysMet: 0.284 ± 0.034
0.3CysAsn: 0.3 ± 0.043
0.752CysPro: 0.752 ± 0.078
0.305CysGln: 0.305 ± 0.041
0.589CysArg: 0.589 ± 0.048
0.689CysSer: 0.689 ± 0.06
0.384CysThr: 0.384 ± 0.053
0.647CysVal: 0.647 ± 0.063
0.163CysTrp: 0.163 ± 0.026
0.279CysTyr: 0.279 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
3.088AspAla: 3.088 ± 0.14
0.642AspCys: 0.642 ± 0.058
2.762AspAsp: 2.762 ± 0.115
5.997AspGlu: 5.997 ± 0.175
2.898AspPhe: 2.898 ± 0.131
3.751AspGly: 3.751 ± 0.141
1.063AspHis: 1.063 ± 0.077
3.929AspIle: 3.929 ± 0.172
3.272AspLys: 3.272 ± 0.143
6.812AspLeu: 6.812 ± 0.206
1.231AspMet: 1.231 ± 0.094
1.583AspAsn: 1.583 ± 0.118
3.004AspPro: 3.004 ± 0.129
1.205AspGln: 1.205 ± 0.077
3.64AspArg: 3.64 ± 0.143
3.488AspSer: 3.488 ± 0.137
2.204AspThr: 2.204 ± 0.112
4.356AspVal: 4.356 ± 0.147
1.005AspTrp: 1.005 ± 0.083
2.341AspTyr: 2.341 ± 0.11
0.0AspXaa: 0.0 ± 0.0
Glu
6.37GluAla: 6.37 ± 0.187
0.863GluCys: 0.863 ± 0.065
6.523GluAsp: 6.523 ± 0.224
13.477GluGlu: 13.477 ± 0.359
3.246GluPhe: 3.246 ± 0.121
7.48GluGly: 7.48 ± 0.224
1.452GluHis: 1.452 ± 0.095
7.575GluIle: 7.575 ± 0.231
10.7GluLys: 10.7 ± 0.297
8.816GluLeu: 8.816 ± 0.221
2.678GluMet: 2.678 ± 0.108
5.471GluAsn: 5.471 ± 0.18
2.941GluPro: 2.941 ± 0.111
1.594GluGln: 1.594 ± 0.09
6.591GluArg: 6.591 ± 0.198
5.381GluSer: 5.381 ± 0.173
4.503GluThr: 4.503 ± 0.159
6.996GluVal: 6.996 ± 0.226
1.141GluTrp: 1.141 ± 0.073
2.662GluTyr: 2.662 ± 0.139
0.0GluXaa: 0.0 ± 0.0
Phe
2.041PheAla: 2.041 ± 0.115
0.51PheCys: 0.51 ± 0.046
2.514PheAsp: 2.514 ± 0.112
3.714PheGlu: 3.714 ± 0.128
1.873PhePhe: 1.873 ± 0.123
3.177PheGly: 3.177 ± 0.148
0.8PheHis: 0.8 ± 0.065
1.878PheIle: 1.878 ± 0.108
2.03PheLys: 2.03 ± 0.107
4.245PheLeu: 4.245 ± 0.193
0.789PheMet: 0.789 ± 0.059
1.236PheAsn: 1.236 ± 0.081
1.678PhePro: 1.678 ± 0.1
1.042PheGln: 1.042 ± 0.078
2.173PheArg: 2.173 ± 0.108
3.114PheSer: 3.114 ± 0.123
1.673PheThr: 1.673 ± 0.099
2.514PheVal: 2.514 ± 0.124
0.526PheTrp: 0.526 ± 0.054
1.215PheTyr: 1.215 ± 0.082
0.0PheXaa: 0.0 ± 0.0
Gly
4.461GlyAla: 4.461 ± 0.189
0.684GlyCys: 0.684 ± 0.07
4.203GlyAsp: 4.203 ± 0.168
7.649GlyGlu: 7.649 ± 0.23
2.956GlyPhe: 2.956 ± 0.149
5.765GlyGly: 5.765 ± 0.222
1.168GlyHis: 1.168 ± 0.095
5.187GlyIle: 5.187 ± 0.165
5.844GlyLys: 5.844 ± 0.178
6.223GlyLeu: 6.223 ± 0.191
1.81GlyMet: 1.81 ± 0.093
2.688GlyAsn: 2.688 ± 0.125
2.257GlyPro: 2.257 ± 0.117
1.573GlyGln: 1.573 ± 0.091
4.792GlyArg: 4.792 ± 0.152
4.824GlySer: 4.824 ± 0.159
3.603GlyThr: 3.603 ± 0.149
5.281GlyVal: 5.281 ± 0.176
1.047GlyTrp: 1.047 ± 0.074
2.441GlyTyr: 2.441 ± 0.134
0.0GlyXaa: 0.0 ± 0.0
His
0.915HisAla: 0.915 ± 0.074
0.252HisCys: 0.252 ± 0.032
1.021HisAsp: 1.021 ± 0.073
1.399HisGlu: 1.399 ± 0.087
0.742HisPhe: 0.742 ± 0.068
1.378HisGly: 1.378 ± 0.095
0.41HisHis: 0.41 ± 0.053
1.073HisIle: 1.073 ± 0.079
0.873HisLys: 0.873 ± 0.06
1.699HisLeu: 1.699 ± 0.095
0.247HisMet: 0.247 ± 0.035
0.494HisAsn: 0.494 ± 0.056
1.205HisPro: 1.205 ± 0.088
0.516HisGln: 0.516 ± 0.054
1.026HisArg: 1.026 ± 0.079
1.215HisSer: 1.215 ± 0.083
0.757HisThr: 0.757 ± 0.061
1.11HisVal: 1.11 ± 0.074
0.179HisTrp: 0.179 ± 0.029
0.594HisTyr: 0.594 ± 0.056
0.0HisXaa: 0.0 ± 0.0
Ile
4.308IleAla: 4.308 ± 0.179
0.705IleCys: 0.705 ± 0.052
4.082IleAsp: 4.082 ± 0.154
6.665IleGlu: 6.665 ± 0.191
2.741IlePhe: 2.741 ± 0.138
4.824IleGly: 4.824 ± 0.162
1.305IleHis: 1.305 ± 0.085
3.509IleIle: 3.509 ± 0.154
3.682IleLys: 3.682 ± 0.147
5.965IleLeu: 5.965 ± 0.216
1.042IleMet: 1.042 ± 0.081
2.025IleAsn: 2.025 ± 0.103
3.256IlePro: 3.256 ± 0.146
1.741IleGln: 1.741 ± 0.111
3.882IleArg: 3.882 ± 0.131
4.866IleSer: 4.866 ± 0.173
2.898IleThr: 2.898 ± 0.126
4.203IleVal: 4.203 ± 0.154
0.626IleTrp: 0.626 ± 0.059
1.773IleTyr: 1.773 ± 0.106
0.0IleXaa: 0.0 ± 0.0
Lys
4.198LysAla: 4.198 ± 0.156
0.642LysCys: 0.642 ± 0.053
3.94LysAsp: 3.94 ± 0.147
8.075LysGlu: 8.075 ± 0.242
2.62LysPhe: 2.62 ± 0.142
4.755LysGly: 4.755 ± 0.167
0.936LysHis: 0.936 ± 0.069
5.881LysIle: 5.881 ± 0.213
6.47LysLys: 6.47 ± 0.215
6.16LysLeu: 6.16 ± 0.227
1.736LysMet: 1.736 ± 0.081
3.472LysAsn: 3.472 ± 0.143
2.278LysPro: 2.278 ± 0.108
1.362LysGln: 1.362 ± 0.093
4.592LysArg: 4.592 ± 0.185
4.592LysSer: 4.592 ± 0.159
3.503LysThr: 3.503 ± 0.129
4.755LysVal: 4.755 ± 0.148
0.884LysTrp: 0.884 ± 0.067
2.125LysTyr: 2.125 ± 0.106
0.0LysXaa: 0.0 ± 0.0
Leu
5.844LeuAla: 5.844 ± 0.197
0.815LeuCys: 0.815 ± 0.058
5.855LeuAsp: 5.855 ± 0.184
10.863LeuGlu: 10.863 ± 0.293
3.293LeuPhe: 3.293 ± 0.169
6.649LeuGly: 6.649 ± 0.23
1.536LeuHis: 1.536 ± 0.095
5.076LeuIle: 5.076 ± 0.167
6.954LeuLys: 6.954 ± 0.226
7.938LeuLeu: 7.938 ± 0.272
1.883LeuMet: 1.883 ± 0.101
3.303LeuAsn: 3.303 ± 0.14
3.924LeuPro: 3.924 ± 0.154
2.173LeuGln: 2.173 ± 0.124
5.881LeuArg: 5.881 ± 0.185
6.649LeuSer: 6.649 ± 0.182
4.461LeuThr: 4.461 ± 0.154
5.844LeuVal: 5.844 ± 0.19
0.915LeuTrp: 0.915 ± 0.075
2.32LeuTyr: 2.32 ± 0.128
0.0LeuXaa: 0.0 ± 0.0
Met
1.515MetAla: 1.515 ± 0.088
0.121MetCys: 0.121 ± 0.023
1.357MetAsp: 1.357 ± 0.102
2.53MetGlu: 2.53 ± 0.116
0.673MetPhe: 0.673 ± 0.061
1.673MetGly: 1.673 ± 0.089
0.268MetHis: 0.268 ± 0.039
1.415MetIle: 1.415 ± 0.093
1.931MetLys: 1.931 ± 0.076
1.689MetLeu: 1.689 ± 0.104
0.484MetMet: 0.484 ± 0.055
0.873MetAsn: 0.873 ± 0.066
0.973MetPro: 0.973 ± 0.076
0.494MetGln: 0.494 ± 0.048
1.383MetArg: 1.383 ± 0.088
1.42MetSer: 1.42 ± 0.083
0.999MetThr: 0.999 ± 0.068
1.525MetVal: 1.525 ± 0.097
0.2MetTrp: 0.2 ± 0.033
0.442MetTyr: 0.442 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
1.904AsnAla: 1.904 ± 0.099
0.416AsnCys: 0.416 ± 0.045
1.426AsnAsp: 1.426 ± 0.093
2.977AsnGlu: 2.977 ± 0.121
1.636AsnPhe: 1.636 ± 0.111
2.304AsnGly: 2.304 ± 0.111
0.773AsnHis: 0.773 ± 0.06
2.351AsnIle: 2.351 ± 0.121
2.041AsnLys: 2.041 ± 0.119
4.292AsnLeu: 4.292 ± 0.154
0.752AsnMet: 0.752 ± 0.063
1.078AsnAsn: 1.078 ± 0.077
2.436AsnPro: 2.436 ± 0.128
1.073AsnGln: 1.073 ± 0.072
2.336AsnArg: 2.336 ± 0.117
2.493AsnSer: 2.493 ± 0.123
1.52AsnThr: 1.52 ± 0.092
2.557AsnVal: 2.557 ± 0.132
0.663AsnTrp: 0.663 ± 0.075
1.389AsnTyr: 1.389 ± 0.097
0.0AsnXaa: 0.0 ± 0.0
Pro
2.02ProAla: 2.02 ± 0.092
0.337ProCys: 0.337 ± 0.044
3.025ProAsp: 3.025 ± 0.146
4.955ProGlu: 4.955 ± 0.182
1.583ProPhe: 1.583 ± 0.086
2.967ProGly: 2.967 ± 0.139
0.768ProHis: 0.768 ± 0.061
2.341ProIle: 2.341 ± 0.102
2.725ProLys: 2.725 ± 0.117
3.703ProLeu: 3.703 ± 0.154
0.831ProMet: 0.831 ± 0.063
1.504ProAsn: 1.504 ± 0.089
2.304ProPro: 2.304 ± 0.114
1.068ProGln: 1.068 ± 0.078
2.146ProArg: 2.146 ± 0.099
3.093ProSer: 3.093 ± 0.129
1.978ProThr: 1.978 ± 0.099
2.888ProVal: 2.888 ± 0.138
0.5ProTrp: 0.5 ± 0.053
1.426ProTyr: 1.426 ± 0.091
0.0ProXaa: 0.0 ± 0.0
Gln
1.494GlnAla: 1.494 ± 0.088
0.168GlnCys: 0.168 ± 0.028
1.231GlnAsp: 1.231 ± 0.072
2.441GlnGlu: 2.441 ± 0.121
0.826GlnPhe: 0.826 ± 0.064
1.578GlnGly: 1.578 ± 0.092
0.352GlnHis: 0.352 ± 0.041
1.778GlnIle: 1.778 ± 0.096
1.946GlnLys: 1.946 ± 0.1
1.794GlnLeu: 1.794 ± 0.101
0.605GlnMet: 0.605 ± 0.055
1.005GlnAsn: 1.005 ± 0.073
0.757GlnPro: 0.757 ± 0.067
0.379GlnGln: 0.379 ± 0.056
1.504GlnArg: 1.504 ± 0.099
1.199GlnSer: 1.199 ± 0.074
1.189GlnThr: 1.189 ± 0.08
1.525GlnVal: 1.525 ± 0.1
0.184GlnTrp: 0.184 ± 0.033
0.589GlnTyr: 0.589 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
3.835ArgAla: 3.835 ± 0.155
0.494ArgCys: 0.494 ± 0.048
3.335ArgAsp: 3.335 ± 0.13
7.154ArgGlu: 7.154 ± 0.204
2.13ArgPhe: 2.13 ± 0.112
4.65ArgGly: 4.65 ± 0.157
0.863ArgHis: 0.863 ± 0.062
4.329ArgIle: 4.329 ± 0.163
6.007ArgLys: 6.007 ± 0.198
4.945ArgLeu: 4.945 ± 0.182
1.483ArgMet: 1.483 ± 0.085
2.472ArgAsn: 2.472 ± 0.104
2.062ArgPro: 2.062 ± 0.089
1.22ArgGln: 1.22 ± 0.082
4.371ArgArg: 4.371 ± 0.178
3.614ArgSer: 3.614 ± 0.135
2.919ArgThr: 2.919 ± 0.155
4.014ArgVal: 4.014 ± 0.142
0.868ArgTrp: 0.868 ± 0.08
1.678ArgTyr: 1.678 ± 0.096
0.0ArgXaa: 0.0 ± 0.0
Ser
3.719SerAla: 3.719 ± 0.178
0.673SerCys: 0.673 ± 0.062
4.061SerAsp: 4.061 ± 0.153
6.791SerGlu: 6.791 ± 0.175
2.862SerPhe: 2.862 ± 0.124
5.418SerGly: 5.418 ± 0.179
1.147SerHis: 1.147 ± 0.078
4.04SerIle: 4.04 ± 0.154
4.25SerLys: 4.25 ± 0.163
6.191SerLeu: 6.191 ± 0.173
1.389SerMet: 1.389 ± 0.087
2.199SerAsn: 2.199 ± 0.118
3.051SerPro: 3.051 ± 0.126
1.81SerGln: 1.81 ± 0.094
3.993SerArg: 3.993 ± 0.147
4.582SerSer: 4.582 ± 0.19
2.846SerThr: 2.846 ± 0.123
4.082SerVal: 4.082 ± 0.139
0.852SerTrp: 0.852 ± 0.067
1.957SerTyr: 1.957 ± 0.09
0.0SerXaa: 0.0 ± 0.0
Thr
2.956ThrAla: 2.956 ± 0.135
0.5ThrCys: 0.5 ± 0.053
2.378ThrAsp: 2.378 ± 0.103
4.177ThrGlu: 4.177 ± 0.153
1.867ThrPhe: 1.867 ± 0.103
3.893ThrGly: 3.893 ± 0.165
0.921ThrHis: 0.921 ± 0.068
2.909ThrIle: 2.909 ± 0.13
2.699ThrLys: 2.699 ± 0.123
4.466ThrLeu: 4.466 ± 0.155
0.921ThrMet: 0.921 ± 0.061
1.415ThrAsn: 1.415 ± 0.08
2.241ThrPro: 2.241 ± 0.113
0.999ThrGln: 0.999 ± 0.075
2.425ThrArg: 2.425 ± 0.116
3.214ThrSer: 3.214 ± 0.138
2.246ThrThr: 2.246 ± 0.132
3.488ThrVal: 3.488 ± 0.144
0.563ThrTrp: 0.563 ± 0.051
1.42ThrTyr: 1.42 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
4.082ValAla: 4.082 ± 0.175
0.747ValCys: 0.747 ± 0.064
4.298ValAsp: 4.298 ± 0.154
7.033ValGlu: 7.033 ± 0.192
2.488ValPhe: 2.488 ± 0.12
5.124ValGly: 5.124 ± 0.181
1.299ValHis: 1.299 ± 0.087
3.835ValIle: 3.835 ± 0.153
4.782ValLys: 4.782 ± 0.174
6.191ValLeu: 6.191 ± 0.21
1.31ValMet: 1.31 ± 0.089
2.257ValAsn: 2.257 ± 0.116
3.067ValPro: 3.067 ± 0.128
1.547ValGln: 1.547 ± 0.084
4.15ValArg: 4.15 ± 0.122
4.829ValSer: 4.829 ± 0.159
3.23ValThr: 3.23 ± 0.149
4.519ValVal: 4.519 ± 0.163
0.821ValTrp: 0.821 ± 0.067
1.757ValTyr: 1.757 ± 0.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.637TrpAla: 0.637 ± 0.06
0.137TrpCys: 0.137 ± 0.024
0.621TrpAsp: 0.621 ± 0.062
1.063TrpGlu: 1.063 ± 0.078
0.542TrpPhe: 0.542 ± 0.056
0.715TrpGly: 0.715 ± 0.065
0.179TrpHis: 0.179 ± 0.034
0.936TrpIle: 0.936 ± 0.071
1.32TrpLys: 1.32 ± 0.084
1.063TrpLeu: 1.063 ± 0.084
0.358TrpMet: 0.358 ± 0.049
0.652TrpAsn: 0.652 ± 0.064
0.405TrpPro: 0.405 ± 0.048
0.279TrpGln: 0.279 ± 0.041
0.984TrpArg: 0.984 ± 0.072
0.805TrpSer: 0.805 ± 0.064
0.584TrpThr: 0.584 ± 0.066
0.752TrpVal: 0.752 ± 0.062
0.263TrpTrp: 0.263 ± 0.041
0.352TrpTyr: 0.352 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.473TyrAla: 1.473 ± 0.076
0.352TyrCys: 0.352 ± 0.042
1.783TyrAsp: 1.783 ± 0.084
2.746TyrGlu: 2.746 ± 0.117
1.236TyrPhe: 1.236 ± 0.083
2.336TyrGly: 2.336 ± 0.108
0.626TyrHis: 0.626 ± 0.061
1.589TyrIle: 1.589 ± 0.092
1.457TyrLys: 1.457 ± 0.093
3.251TyrLeu: 3.251 ± 0.14
0.563TyrMet: 0.563 ± 0.058
0.847TyrAsn: 0.847 ± 0.07
1.457TyrPro: 1.457 ± 0.09
0.789TyrGln: 0.789 ± 0.071
2.183TyrArg: 2.183 ± 0.113
2.136TyrSer: 2.136 ± 0.124
1.352TyrThr: 1.352 ± 0.078
1.757TyrVal: 1.757 ± 0.103
0.458TyrTrp: 0.458 ± 0.043
0.989TyrTyr: 0.989 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 891 proteins (190103 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski