Amino acid dipepetide frequency for Rheinheimera nanhaiensis E407-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.453AlaAla: 12.453 ± 0.143	1.037AlaCys: 1.037 ± 0.034	6.357AlaAsp: 6.357 ± 0.079	6.692AlaGlu: 6.692 ± 0.09	3.749AlaPhe: 3.749 ± 0.06	7.777AlaGly: 7.777 ± 0.117	1.763AlaHis: 1.763 ± 0.042	5.892AlaIle: 5.892 ± 0.084	4.807AlaLys: 4.807 ± 0.088	13.239AlaLeu: 13.239 ± 0.156	2.721AlaMet: 2.721 ± 0.046	3.804AlaAsn: 3.804 ± 0.06	3.742AlaPro: 3.742 ± 0.066	5.975AlaGln: 5.975 ± 0.092	4.824AlaArg: 4.824 ± 0.072	5.994AlaSer: 5.994 ± 0.074	4.883AlaThr: 4.883 ± 0.073	7.517AlaVal: 7.517 ± 0.097	1.085AlaTrp: 1.085 ± 0.031	2.658AlaTyr: 2.658 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.929CysAla: 0.929 ± 0.03	0.178CysCys: 0.178 ± 0.014	0.511CysAsp: 0.511 ± 0.023	0.405CysGlu: 0.405 ± 0.021	0.437CysPhe: 0.437 ± 0.02	0.817CysGly: 0.817 ± 0.028	0.301CysHis: 0.301 ± 0.017	0.494CysIle: 0.494 ± 0.022	0.318CysLys: 0.318 ± 0.017	0.941CysLeu: 0.941 ± 0.033	0.185CysMet: 0.185 ± 0.012	0.308CysAsn: 0.308 ± 0.015	0.445CysPro: 0.445 ± 0.021	0.651CysGln: 0.651 ± 0.028	0.577CysArg: 0.577 ± 0.024	0.742CysSer: 0.742 ± 0.027	0.436CysThr: 0.436 ± 0.02	0.544CysVal: 0.544 ± 0.022	0.18CysTrp: 0.18 ± 0.013	0.405CysTyr: 0.405 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.363AspAla: 5.363 ± 0.062	0.471AspCys: 0.471 ± 0.021	2.942AspAsp: 2.942 ± 0.065	3.147AspGlu: 3.147 ± 0.06	2.246AspPhe: 2.246 ± 0.045	3.889AspGly: 3.889 ± 0.083	0.858AspHis: 0.858 ± 0.033	3.803AspIle: 3.803 ± 0.063	2.879AspLys: 2.879 ± 0.063	4.651AspLeu: 4.651 ± 0.062	1.291AspMet: 1.291 ± 0.033	2.587AspAsn: 2.587 ± 0.053	1.873AspPro: 1.873 ± 0.042	1.694AspGln: 1.694 ± 0.043	1.947AspArg: 1.947 ± 0.035	3.473AspSer: 3.473 ± 0.063	2.782AspThr: 2.782 ± 0.056	3.439AspVal: 3.439 ± 0.056	0.952AspTrp: 0.952 ± 0.03	2.09AspTyr: 2.09 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.677GluAla: 4.677 ± 0.072	0.306GluCys: 0.306 ± 0.017	2.033GluAsp: 2.033 ± 0.049	2.088GluGlu: 2.088 ± 0.057	1.945GluPhe: 1.945 ± 0.043	2.711GluGly: 2.711 ± 0.049	1.511GluHis: 1.511 ± 0.037	2.614GluIle: 2.614 ± 0.053	2.352GluLys: 2.352 ± 0.057	7.026GluLeu: 7.026 ± 0.095	1.18GluMet: 1.18 ± 0.033	1.55GluAsn: 1.55 ± 0.037	2.165GluPro: 2.165 ± 0.043	5.169GluGln: 5.169 ± 0.088	3.127GluArg: 3.127 ± 0.055	2.025GluSer: 2.025 ± 0.047	2.17GluThr: 2.17 ± 0.05	3.537GluVal: 3.537 ± 0.059	0.471GluTrp: 0.471 ± 0.021	1.384GluTyr: 1.384 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.377PheAla: 4.377 ± 0.061	0.469PheCys: 0.469 ± 0.02	2.587PheAsp: 2.587 ± 0.049	1.854PheGlu: 1.854 ± 0.04	1.561PhePhe: 1.561 ± 0.045	3.032PheGly: 3.032 ± 0.061	0.726PheHis: 0.726 ± 0.027	2.346PheIle: 2.346 ± 0.048	1.514PheLys: 1.514 ± 0.04	3.015PheLeu: 3.015 ± 0.059	0.952PheMet: 0.952 ± 0.03	2.007PheAsn: 2.007 ± 0.04	1.249PhePro: 1.249 ± 0.034	1.139PheGln: 1.139 ± 0.03	1.543PheArg: 1.543 ± 0.035	3.546PheSer: 3.546 ± 0.058	2.158PheThr: 2.158 ± 0.047	2.713PheVal: 2.713 ± 0.053	0.549PheTrp: 0.549 ± 0.021	1.426PheTyr: 1.426 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.042GlyAla: 6.042 ± 0.09	0.831GlyCys: 0.831 ± 0.026	3.548GlyAsp: 3.548 ± 0.067	3.667GlyGlu: 3.667 ± 0.064	3.293GlyPhe: 3.293 ± 0.056	4.861GlyGly: 4.861 ± 0.096	1.447GlyHis: 1.447 ± 0.041	4.152GlyIle: 4.152 ± 0.058	3.623GlyLys: 3.623 ± 0.061	7.089GlyLeu: 7.089 ± 0.081	1.825GlyMet: 1.825 ± 0.043	2.572GlyAsn: 2.572 ± 0.076	1.779GlyPro: 1.779 ± 0.041	3.307GlyGln: 3.307 ± 0.065	3.388GlyArg: 3.388 ± 0.05	4.323GlySer: 4.323 ± 0.075	3.245GlyThr: 3.245 ± 0.066	5.0GlyVal: 5.0 ± 0.083	1.04GlyTrp: 1.04 ± 0.033	2.569GlyTyr: 2.569 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.798HisAla: 1.798 ± 0.037	0.322HisCys: 0.322 ± 0.019	1.008HisAsp: 1.008 ± 0.03	0.874HisGlu: 0.874 ± 0.03	1.102HisPhe: 1.102 ± 0.034	1.622HisGly: 1.622 ± 0.044	0.561HisHis: 0.561 ± 0.021	1.298HisIle: 1.298 ± 0.029	0.97HisLys: 0.97 ± 0.025	2.195HisLeu: 2.195 ± 0.039	0.423HisMet: 0.423 ± 0.021	0.926HisAsn: 0.926 ± 0.03	1.113HisPro: 1.113 ± 0.033	1.387HisGln: 1.387 ± 0.042	0.972HisArg: 0.972 ± 0.028	1.685HisSer: 1.685 ± 0.042	1.029HisThr: 1.029 ± 0.03	1.075HisVal: 1.075 ± 0.03	0.474HisTrp: 0.474 ± 0.018	1.002HisTyr: 1.002 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.265IleAla: 6.265 ± 0.084	0.579IleCys: 0.579 ± 0.024	3.34IleAsp: 3.34 ± 0.055	3.05IleGlu: 3.05 ± 0.055	1.687IlePhe: 1.687 ± 0.042	3.853IleGly: 3.853 ± 0.065	0.92IleHis: 0.92 ± 0.027	2.617IleIle: 2.617 ± 0.067	2.571IleLys: 2.571 ± 0.054	4.295IleLeu: 4.295 ± 0.079	1.031IleMet: 1.031 ± 0.031	2.525IleAsn: 2.525 ± 0.051	2.094IlePro: 2.094 ± 0.045	1.812IleGln: 1.812 ± 0.043	2.699IleArg: 2.699 ± 0.051	4.237IleSer: 4.237 ± 0.067	3.015IleThr: 3.015 ± 0.055	3.391IleVal: 3.391 ± 0.067	0.587IleTrp: 0.587 ± 0.025	1.47IleTyr: 1.47 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	5.152LysAla: 5.152 ± 0.088	0.243LysCys: 0.243 ± 0.017	2.061LysAsp: 2.061 ± 0.055	1.761LysGlu: 1.761 ± 0.055	1.248LysPhe: 1.248 ± 0.034	2.486LysGly: 2.486 ± 0.053	1.039LysHis: 1.039 ± 0.035	2.037LysIle: 2.037 ± 0.05	1.876LysLys: 1.876 ± 0.057	5.208LysLeu: 5.208 ± 0.072	0.943LysMet: 0.943 ± 0.032	1.411LysAsn: 1.411 ± 0.038	2.407LysPro: 2.407 ± 0.05	3.175LysGln: 3.175 ± 0.064	2.428LysArg: 2.428 ± 0.05	2.039LysSer: 2.039 ± 0.048	2.411LysThr: 2.411 ± 0.047	3.34LysVal: 3.34 ± 0.059	0.408LysTrp: 0.408 ± 0.021	1.09LysTyr: 1.09 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	14.024LeuAla: 14.024 ± 0.151	1.348LeuCys: 1.348 ± 0.039	5.7LeuAsp: 5.7 ± 0.074	5.176LeuGlu: 5.176 ± 0.075	4.202LeuPhe: 4.202 ± 0.082	7.09LeuGly: 7.09 ± 0.086	2.479LeuHis: 2.479 ± 0.046	5.427LeuIle: 5.427 ± 0.093	4.923LeuLys: 4.923 ± 0.086	15.063LeuLeu: 15.063 ± 0.227	2.594LeuMet: 2.594 ± 0.048	4.475LeuAsn: 4.475 ± 0.054	5.908LeuPro: 5.908 ± 0.086	7.188LeuGln: 7.188 ± 0.129	5.3LeuArg: 5.3 ± 0.069	8.752LeuSer: 8.752 ± 0.118	7.027LeuThr: 7.027 ± 0.095	7.422LeuVal: 7.422 ± 0.083	1.461LeuTrp: 1.461 ± 0.041	3.193LeuTyr: 3.193 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.69MetAla: 2.69 ± 0.048	0.142MetCys: 0.142 ± 0.011	0.921MetAsp: 0.921 ± 0.031	0.813MetGlu: 0.813 ± 0.03	0.73MetPhe: 0.73 ± 0.025	1.266MetGly: 1.266 ± 0.034	0.486MetHis: 0.486 ± 0.02	0.965MetIle: 0.965 ± 0.029	0.976MetLys: 0.976 ± 0.033	3.24MetLeu: 3.24 ± 0.061	0.53MetMet: 0.53 ± 0.022	0.693MetAsn: 0.693 ± 0.027	1.27MetPro: 1.27 ± 0.035	1.684MetGln: 1.684 ± 0.039	1.189MetArg: 1.189 ± 0.034	1.493MetSer: 1.493 ± 0.04	1.349MetThr: 1.349 ± 0.03	1.426MetVal: 1.426 ± 0.035	0.181MetTrp: 0.181 ± 0.012	0.497MetTyr: 0.497 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.639AsnAla: 3.639 ± 0.057	0.374AsnCys: 0.374 ± 0.019	1.89AsnAsp: 1.89 ± 0.055	1.71AsnGlu: 1.71 ± 0.038	1.38AsnPhe: 1.38 ± 0.036	2.871AsnGly: 2.871 ± 0.062	0.77AsnHis: 0.77 ± 0.028	2.074AsnIle: 2.074 ± 0.046	1.623AsnLys: 1.623 ± 0.041	3.707AsnLeu: 3.707 ± 0.057	0.875AsnMet: 0.875 ± 0.029	1.682AsnAsn: 1.682 ± 0.05	1.937AsnPro: 1.937 ± 0.043	1.906AsnGln: 1.906 ± 0.046	1.971AsnArg: 1.971 ± 0.043	2.549AsnSer: 2.549 ± 0.051	2.074AsnThr: 2.074 ± 0.038	2.214AsnVal: 2.214 ± 0.04	0.669AsnTrp: 0.669 ± 0.027	1.22AsnTyr: 1.22 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	5.199ProAla: 5.199 ± 0.07	0.351ProCys: 0.351 ± 0.019	2.756ProAsp: 2.756 ± 0.059	2.823ProGlu: 2.823 ± 0.049	1.607ProPhe: 1.607 ± 0.037	3.022ProGly: 3.022 ± 0.06	0.837ProHis: 0.837 ± 0.028	1.711ProIle: 1.711 ± 0.038	1.617ProLys: 1.617 ± 0.045	5.346ProLeu: 5.346 ± 0.084	0.937ProMet: 0.937 ± 0.029	1.324ProAsn: 1.324 ± 0.035	1.421ProPro: 1.421 ± 0.039	2.388ProGln: 2.388 ± 0.052	1.51ProArg: 1.51 ± 0.034	1.965ProSer: 1.965 ± 0.041	1.868ProThr: 1.868 ± 0.039	3.573ProVal: 3.573 ± 0.055	0.529ProTrp: 0.529 ± 0.022	1.375ProTyr: 1.375 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	6.443GlnAla: 6.443 ± 0.096	0.441GlnCys: 0.441 ± 0.021	2.327GlnAsp: 2.327 ± 0.048	1.846GlnGlu: 1.846 ± 0.045	2.246GlnPhe: 2.246 ± 0.043	3.536GlnGly: 3.536 ± 0.067	2.2GlnHis: 2.2 ± 0.048	2.564GlnIle: 2.564 ± 0.05	1.826GlnLys: 1.826 ± 0.043	9.711GlnLeu: 9.711 ± 0.172	1.184GlnMet: 1.184 ± 0.035	1.579GlnAsn: 1.579 ± 0.037	2.803GlnPro: 2.803 ± 0.068	8.35GlnGln: 8.35 ± 0.219	3.631GlnArg: 3.631 ± 0.07	3.141GlnSer: 3.141 ± 0.056	2.365GlnThr: 2.365 ± 0.048	3.67GlnVal: 3.67 ± 0.059	0.873GlnTrp: 0.873 ± 0.028	1.868GlnTyr: 1.868 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	4.133ArgAla: 4.133 ± 0.063	0.493ArgCys: 0.493 ± 0.022	2.561ArgAsp: 2.561 ± 0.051	2.606ArgGlu: 2.606 ± 0.056	2.496ArgPhe: 2.496 ± 0.046	2.752ArgGly: 2.752 ± 0.058	1.314ArgHis: 1.314 ± 0.033	2.817ArgIle: 2.817 ± 0.05	1.966ArgLys: 1.966 ± 0.047	6.427ArgLeu: 6.427 ± 0.096	1.132ArgMet: 1.132 ± 0.033	1.741ArgAsn: 1.741 ± 0.04	1.87ArgPro: 1.87 ± 0.041	3.53ArgGln: 3.53 ± 0.067	2.706ArgArg: 2.706 ± 0.054	2.855ArgSer: 2.855 ± 0.053	2.04ArgThr: 2.04 ± 0.049	3.014ArgVal: 3.014 ± 0.058	0.787ArgTrp: 0.787 ± 0.024	2.102ArgTyr: 2.102 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.986SerAla: 6.986 ± 0.102	0.703SerCys: 0.703 ± 0.029	3.274SerAsp: 3.274 ± 0.06	3.216SerGlu: 3.216 ± 0.055	2.69SerPhe: 2.69 ± 0.049	5.159SerGly: 5.159 ± 0.077	1.34SerHis: 1.34 ± 0.037	3.045SerIle: 3.045 ± 0.047	2.579SerLys: 2.579 ± 0.056	7.125SerLeu: 7.125 ± 0.091	1.344SerMet: 1.344 ± 0.036	2.158SerAsn: 2.158 ± 0.048	2.353SerPro: 2.353 ± 0.047	3.241SerGln: 3.241 ± 0.059	3.391SerArg: 3.391 ± 0.05	4.303SerSer: 4.303 ± 0.072	2.87SerThr: 2.87 ± 0.057	4.321SerVal: 4.321 ± 0.064	1.06SerTrp: 1.06 ± 0.027	2.143SerTyr: 2.143 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	5.963ThrAla: 5.963 ± 0.079	0.328ThrCys: 0.328 ± 0.016	3.095ThrAsp: 3.095 ± 0.06	3.385ThrGlu: 3.385 ± 0.053	1.511ThrPhe: 1.511 ± 0.041	3.973ThrGly: 3.973 ± 0.071	0.807ThrHis: 0.807 ± 0.025	2.336ThrIle: 2.336 ± 0.047	1.77ThrLys: 1.77 ± 0.037	6.443ThrLeu: 6.443 ± 0.081	0.914ThrMet: 0.914 ± 0.028	1.599ThrAsn: 1.599 ± 0.045	2.926ThrPro: 2.926 ± 0.055	2.327ThrGln: 2.327 ± 0.05	2.019ThrArg: 2.019 ± 0.042	2.649ThrSer: 2.649 ± 0.056	2.618ThrThr: 2.618 ± 0.05	3.82ThrVal: 3.82 ± 0.068	0.391ThrTrp: 0.391 ± 0.018	1.205ThrTyr: 1.205 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.272ValAla: 7.272 ± 0.102	0.649ValCys: 0.649 ± 0.027	3.325ValAsp: 3.325 ± 0.057	3.375ValGlu: 3.375 ± 0.058	2.639ValPhe: 2.639 ± 0.051	4.041ValGly: 4.041 ± 0.064	1.238ValHis: 1.238 ± 0.036	3.902ValIle: 3.902 ± 0.062	3.221ValLys: 3.221 ± 0.063	7.997ValLeu: 7.997 ± 0.106	1.713ValMet: 1.713 ± 0.041	2.755ValAsn: 2.755 ± 0.054	2.741ValPro: 2.741 ± 0.048	3.14ValGln: 3.14 ± 0.054	3.21ValArg: 3.21 ± 0.058	4.819ValSer: 4.819 ± 0.069	3.939ValThr: 3.939 ± 0.068	4.992ValVal: 4.992 ± 0.088	0.788ValTrp: 0.788 ± 0.027	1.852ValTyr: 1.852 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.898TrpAla: 0.898 ± 0.03	0.151TrpCys: 0.151 ± 0.011	0.525TrpAsp: 0.525 ± 0.022	0.345TrpGlu: 0.345 ± 0.018	0.655TrpPhe: 0.655 ± 0.026	0.7TrpGly: 0.7 ± 0.026	0.481TrpHis: 0.481 ± 0.02	0.472TrpIle: 0.472 ± 0.02	0.255TrpLys: 0.255 ± 0.015	2.293TrpLeu: 2.293 ± 0.052	0.242TrpMet: 0.242 ± 0.015	0.314TrpAsn: 0.314 ± 0.018	0.632TrpPro: 0.632 ± 0.025	1.826TrpGln: 1.826 ± 0.048	0.941TrpArg: 0.941 ± 0.031	0.614TrpSer: 0.614 ± 0.028	0.463TrpThr: 0.463 ± 0.022	0.776TrpVal: 0.776 ± 0.023	0.239TrpTrp: 0.239 ± 0.014	0.412TrpTyr: 0.412 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.664TyrAla: 2.664 ± 0.048	0.392TyrCys: 0.392 ± 0.019	1.612TyrAsp: 1.612 ± 0.05	1.208TyrGlu: 1.208 ± 0.038	1.338TyrPhe: 1.338 ± 0.031	2.142TyrGly: 2.142 ± 0.047	0.762TyrHis: 0.762 ± 0.03	1.472TyrIle: 1.472 ± 0.036	1.097TyrLys: 1.097 ± 0.042	3.742TyrLeu: 3.742 ± 0.061	0.524TyrMet: 0.524 ± 0.022	1.127TyrAsn: 1.127 ± 0.037	1.431TyrPro: 1.431 ± 0.035	2.714TyrGln: 2.714 ± 0.053	1.968TyrArg: 1.968 ± 0.042	2.096TyrSer: 2.096 ± 0.049	1.336TyrThr: 1.336 ± 0.039	1.823TyrVal: 1.823 ± 0.043	0.512TyrTrp: 0.512 ± 0.019	1.101TyrTyr: 1.101 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3730 proteins (1193890 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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