Amino acid dipepetide frequency for Lactococcus allomyrinae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.945AlaAla: 5.945 ± 0.145
0.419AlaCys: 0.419 ± 0.024
4.164AlaAsp: 4.164 ± 0.073
4.866AlaGlu: 4.866 ± 0.103
3.209AlaPhe: 3.209 ± 0.072
5.658AlaGly: 5.658 ± 0.101
1.482AlaHis: 1.482 ± 0.047
5.598AlaIle: 5.598 ± 0.108
5.044AlaLys: 5.044 ± 0.099
7.68AlaLeu: 7.68 ± 0.115
1.904AlaMet: 1.904 ± 0.059
3.265AlaAsn: 3.265 ± 0.071
2.221AlaPro: 2.221 ± 0.062
3.264AlaGln: 3.264 ± 0.079
2.823AlaArg: 2.823 ± 0.072
4.589AlaSer: 4.589 ± 0.104
4.651AlaThr: 4.651 ± 0.099
5.264AlaVal: 5.264 ± 0.094
0.716AlaTrp: 0.716 ± 0.032
2.474AlaTyr: 2.474 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.342CysAla: 0.342 ± 0.023
0.051CysCys: 0.051 ± 0.009
0.291CysAsp: 0.291 ± 0.02
0.336CysGlu: 0.336 ± 0.02
0.226CysPhe: 0.226 ± 0.018
0.5CysGly: 0.5 ± 0.026
0.117CysHis: 0.117 ± 0.015
0.28CysIle: 0.28 ± 0.021
0.223CysLys: 0.223 ± 0.022
0.467CysLeu: 0.467 ± 0.031
0.096CysMet: 0.096 ± 0.011
0.205CysAsn: 0.205 ± 0.017
0.214CysPro: 0.214 ± 0.017
0.193CysGln: 0.193 ± 0.017
0.18CysArg: 0.18 ± 0.016
0.3CysSer: 0.3 ± 0.021
0.23CysThr: 0.23 ± 0.019
0.28CysVal: 0.28 ± 0.023
0.052CysTrp: 0.052 ± 0.008
0.189CysTyr: 0.189 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.421AspAla: 3.421 ± 0.081
0.28AspCys: 0.28 ± 0.02
2.798AspAsp: 2.798 ± 0.071
4.79AspGlu: 4.79 ± 0.089
3.508AspPhe: 3.508 ± 0.083
3.855AspGly: 3.855 ± 0.079
0.745AspHis: 0.745 ± 0.034
3.82AspIle: 3.82 ± 0.079
4.261AspLys: 4.261 ± 0.09
5.167AspLeu: 5.167 ± 0.092
1.255AspMet: 1.255 ± 0.046
2.539AspAsn: 2.539 ± 0.069
1.324AspPro: 1.324 ± 0.054
1.142AspGln: 1.142 ± 0.04
1.792AspArg: 1.792 ± 0.045
3.003AspSer: 3.003 ± 0.069
2.754AspThr: 2.754 ± 0.078
3.535AspVal: 3.535 ± 0.075
0.726AspTrp: 0.726 ± 0.03
2.505AspTyr: 2.505 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
4.91GluAla: 4.91 ± 0.097
0.302GluCys: 0.302 ± 0.02
3.003GluAsp: 3.003 ± 0.067
5.012GluGlu: 5.012 ± 0.113
3.061GluPhe: 3.061 ± 0.056
3.159GluGly: 3.159 ± 0.07
1.398GluHis: 1.398 ± 0.048
5.99GluIle: 5.99 ± 0.099
6.167GluLys: 6.167 ± 0.112
6.941GluLeu: 6.941 ± 0.122
1.905GluMet: 1.905 ± 0.05
4.695GluAsn: 4.695 ± 0.085
1.524GluPro: 1.524 ± 0.054
3.07GluGln: 3.07 ± 0.074
3.032GluArg: 3.032 ± 0.079
3.334GluSer: 3.334 ± 0.079
3.487GluThr: 3.487 ± 0.068
4.485GluVal: 4.485 ± 0.084
0.535GluTrp: 0.535 ± 0.029
2.043GluTyr: 2.043 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.669PheAla: 3.669 ± 0.081
0.262PheCys: 0.262 ± 0.02
3.316PheAsp: 3.316 ± 0.076
3.476PheGlu: 3.476 ± 0.072
2.197PhePhe: 2.197 ± 0.061
3.606PheGly: 3.606 ± 0.086
0.773PheHis: 0.773 ± 0.033
3.595PheIle: 3.595 ± 0.083
2.514PheLys: 2.514 ± 0.061
4.571PheLeu: 4.571 ± 0.092
1.163PheMet: 1.163 ± 0.041
2.288PheAsn: 2.288 ± 0.052
1.675PhePro: 1.675 ± 0.052
1.484PheGln: 1.484 ± 0.045
1.576PheArg: 1.576 ± 0.043
3.601PheSer: 3.601 ± 0.073
2.812PheThr: 2.812 ± 0.065
3.541PheVal: 3.541 ± 0.078
0.592PheTrp: 0.592 ± 0.032
1.839PheTyr: 1.839 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
4.901GlyAla: 4.901 ± 0.116
0.35GlyCys: 0.35 ± 0.026
3.059GlyAsp: 3.059 ± 0.076
3.976GlyGlu: 3.976 ± 0.084
3.523GlyPhe: 3.523 ± 0.075
4.598GlyGly: 4.598 ± 0.119
1.25GlyHis: 1.25 ± 0.042
5.286GlyIle: 5.286 ± 0.092
4.855GlyLys: 4.855 ± 0.093
6.3GlyLeu: 6.3 ± 0.1
1.717GlyMet: 1.717 ± 0.048
3.236GlyAsn: 3.236 ± 0.101
1.284GlyPro: 1.284 ± 0.044
2.513GlyGln: 2.513 ± 0.07
2.507GlyArg: 2.507 ± 0.058
3.955GlySer: 3.955 ± 0.104
4.442GlyThr: 4.442 ± 0.124
4.85GlyVal: 4.85 ± 0.097
0.856GlyTrp: 0.856 ± 0.038
2.652GlyTyr: 2.652 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.185HisAla: 1.185 ± 0.04
0.123HisCys: 0.123 ± 0.013
1.062HisAsp: 1.062 ± 0.045
1.281HisGlu: 1.281 ± 0.048
1.134HisPhe: 1.134 ± 0.038
1.32HisGly: 1.32 ± 0.045
0.561HisHis: 0.561 ± 0.032
1.291HisIle: 1.291 ± 0.046
0.963HisLys: 0.963 ± 0.038
1.963HisLeu: 1.963 ± 0.054
0.398HisMet: 0.398 ± 0.023
0.69HisAsn: 0.69 ± 0.033
0.907HisPro: 0.907 ± 0.036
0.851HisGln: 0.851 ± 0.034
0.755HisArg: 0.755 ± 0.03
1.043HisSer: 1.043 ± 0.042
0.913HisThr: 0.913 ± 0.039
1.047HisVal: 1.047 ± 0.039
0.205HisTrp: 0.205 ± 0.017
0.805HisTyr: 0.805 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
6.3IleAla: 6.3 ± 0.11
0.46IleCys: 0.46 ± 0.027
4.245IleAsp: 4.245 ± 0.08
4.945IleGlu: 4.945 ± 0.086
3.928IlePhe: 3.928 ± 0.09
5.088IleGly: 5.088 ± 0.103
1.323IleHis: 1.323 ± 0.044
5.656IleIle: 5.656 ± 0.121
4.75IleLys: 4.75 ± 0.089
7.458IleLeu: 7.458 ± 0.127
1.623IleMet: 1.623 ± 0.049
3.663IleAsn: 3.663 ± 0.076
2.959IlePro: 2.959 ± 0.071
2.45IleGln: 2.45 ± 0.061
2.503IleArg: 2.503 ± 0.068
5.297IleSer: 5.297 ± 0.089
4.479IleThr: 4.479 ± 0.083
5.074IleVal: 5.074 ± 0.083
0.671IleTrp: 0.671 ± 0.032
2.538IleTyr: 2.538 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
5.044LysAla: 5.044 ± 0.108
0.198LysCys: 0.198 ± 0.017
3.286LysAsp: 3.286 ± 0.072
4.833LysGlu: 4.833 ± 0.099
2.795LysPhe: 2.795 ± 0.067
3.453LysGly: 3.453 ± 0.071
1.079LysHis: 1.079 ± 0.038
5.963LysIle: 5.963 ± 0.099
5.84LysLys: 5.84 ± 0.101
6.168LysLeu: 6.168 ± 0.09
2.367LysMet: 2.367 ± 0.054
4.647LysAsn: 4.647 ± 0.085
1.881LysPro: 1.881 ± 0.056
2.604LysGln: 2.604 ± 0.064
2.907LysArg: 2.907 ± 0.069
4.132LysSer: 4.132 ± 0.074
4.224LysThr: 4.224 ± 0.081
4.644LysVal: 4.644 ± 0.085
0.642LysTrp: 0.642 ± 0.028
2.458LysTyr: 2.458 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
7.753LeuAla: 7.753 ± 0.113
0.439LeuCys: 0.439 ± 0.027
5.206LeuAsp: 5.206 ± 0.09
6.305LeuGlu: 6.305 ± 0.111
4.479LeuPhe: 4.479 ± 0.1
6.362LeuGly: 6.362 ± 0.101
1.583LeuHis: 1.583 ± 0.053
7.051LeuIle: 7.051 ± 0.127
6.17LeuLys: 6.17 ± 0.087
9.442LeuLeu: 9.442 ± 0.15
2.404LeuMet: 2.404 ± 0.055
4.442LeuAsn: 4.442 ± 0.084
4.056LeuPro: 4.056 ± 0.084
3.264LeuGln: 3.264 ± 0.07
3.651LeuArg: 3.651 ± 0.092
8.007LeuSer: 8.007 ± 0.122
6.995LeuThr: 6.995 ± 0.11
6.278LeuVal: 6.278 ± 0.096
0.824LeuTrp: 0.824 ± 0.037
2.86LeuTyr: 2.86 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
1.889MetAla: 1.889 ± 0.064
0.099MetCys: 0.099 ± 0.011
1.229MetAsp: 1.229 ± 0.042
1.382MetGlu: 1.382 ± 0.049
0.955MetPhe: 0.955 ± 0.038
1.6MetGly: 1.6 ± 0.049
0.39MetHis: 0.39 ± 0.024
2.039MetIle: 2.039 ± 0.06
2.129MetLys: 2.129 ± 0.053
2.25MetLeu: 2.25 ± 0.057
0.821MetMet: 0.821 ± 0.038
1.571MetAsn: 1.571 ± 0.044
0.901MetPro: 0.901 ± 0.036
0.823MetGln: 0.823 ± 0.038
1.036MetArg: 1.036 ± 0.04
1.655MetSer: 1.655 ± 0.043
1.949MetThr: 1.949 ± 0.048
1.571MetVal: 1.571 ± 0.046
0.185MetTrp: 0.185 ± 0.014
0.598MetTyr: 0.598 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.519AsnAla: 3.519 ± 0.081
0.226AsnCys: 0.226 ± 0.019
2.541AsnAsp: 2.541 ± 0.061
3.061AsnGlu: 3.061 ± 0.075
2.79AsnPhe: 2.79 ± 0.068
3.64AsnGly: 3.64 ± 0.084
1.163AsnHis: 1.163 ± 0.044
3.87AsnIle: 3.87 ± 0.074
3.067AsnLys: 3.067 ± 0.072
4.974AsnLeu: 4.974 ± 0.094
1.262AsnMet: 1.262 ± 0.05
2.466AsnAsn: 2.466 ± 0.08
2.52AsnPro: 2.52 ± 0.071
2.463AsnGln: 2.463 ± 0.062
1.947AsnArg: 1.947 ± 0.053
2.954AsnSer: 2.954 ± 0.083
2.79AsnThr: 2.79 ± 0.088
3.14AsnVal: 3.14 ± 0.072
0.659AsnTrp: 0.659 ± 0.036
2.062AsnTyr: 2.062 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
2.392ProAla: 2.392 ± 0.056
0.12ProCys: 0.12 ± 0.015
2.009ProAsp: 2.009 ± 0.055
2.933ProGlu: 2.933 ± 0.068
1.692ProPhe: 1.692 ± 0.053
1.645ProGly: 1.645 ± 0.048
0.675ProHis: 0.675 ± 0.029
2.35ProIle: 2.35 ± 0.057
2.31ProLys: 2.31 ± 0.059
3.101ProLeu: 3.101 ± 0.069
0.758ProMet: 0.758 ± 0.034
1.783ProAsn: 1.783 ± 0.05
0.598ProPro: 0.598 ± 0.028
1.186ProGln: 1.186 ± 0.044
1.011ProArg: 1.011 ± 0.033
2.148ProSer: 2.148 ± 0.068
2.221ProThr: 2.221 ± 0.069
2.469ProVal: 2.469 ± 0.063
0.32ProTrp: 0.32 ± 0.02
1.244ProTyr: 1.244 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
3.188GlnAla: 3.188 ± 0.07
0.114GlnCys: 0.114 ± 0.013
1.579GlnAsp: 1.579 ± 0.044
2.681GlnGlu: 2.681 ± 0.068
1.644GlnPhe: 1.644 ± 0.043
2.209GlnGly: 2.209 ± 0.064
0.646GlnHis: 0.646 ± 0.029
2.919GlnIle: 2.919 ± 0.06
3.027GlnLys: 3.027 ± 0.073
3.844GlnLeu: 3.844 ± 0.078
1.053GlnMet: 1.053 ± 0.039
2.167GlnAsn: 2.167 ± 0.067
1.167GlnPro: 1.167 ± 0.038
1.638GlnGln: 1.638 ± 0.057
1.363GlnArg: 1.363 ± 0.043
2.181GlnSer: 2.181 ± 0.063
2.269GlnThr: 2.269 ± 0.071
2.501GlnVal: 2.501 ± 0.068
0.373GlnTrp: 0.373 ± 0.027
1.272GlnTyr: 1.272 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.592ArgAla: 2.592 ± 0.067
0.182ArgCys: 0.182 ± 0.019
1.947ArgAsp: 1.947 ± 0.057
3.081ArgGlu: 3.081 ± 0.08
1.876ArgPhe: 1.876 ± 0.052
2.276ArgGly: 2.276 ± 0.059
0.763ArgHis: 0.763 ± 0.032
2.731ArgIle: 2.731 ± 0.064
2.864ArgLys: 2.864 ± 0.061
3.739ArgLeu: 3.739 ± 0.085
1.065ArgMet: 1.065 ± 0.043
1.772ArgAsn: 1.772 ± 0.044
1.164ArgPro: 1.164 ± 0.038
1.608ArgGln: 1.608 ± 0.041
1.863ArgArg: 1.863 ± 0.058
1.809ArgSer: 1.809 ± 0.049
1.974ArgThr: 1.974 ± 0.056
2.552ArgVal: 2.552 ± 0.064
0.358ArgTrp: 0.358 ± 0.022
1.474ArgTyr: 1.474 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.734SerAla: 4.734 ± 0.11
0.3SerCys: 0.3 ± 0.026
3.548SerAsp: 3.548 ± 0.062
4.148SerGlu: 4.148 ± 0.087
3.114SerPhe: 3.114 ± 0.063
4.975SerGly: 4.975 ± 0.096
1.217SerHis: 1.217 ± 0.042
4.446SerIle: 4.446 ± 0.072
4.203SerLys: 4.203 ± 0.072
6.095SerLeu: 6.095 ± 0.093
1.394SerMet: 1.394 ± 0.045
3.156SerAsn: 3.156 ± 0.076
2.028SerPro: 2.028 ± 0.053
2.558SerGln: 2.558 ± 0.066
2.33SerArg: 2.33 ± 0.064
4.812SerSer: 4.812 ± 0.135
3.986SerThr: 3.986 ± 0.099
4.508SerVal: 4.508 ± 0.096
0.692SerTrp: 0.692 ± 0.03
2.251SerTyr: 2.251 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.785ThrAla: 4.785 ± 0.097
0.255ThrCys: 0.255 ± 0.021
3.783ThrAsp: 3.783 ± 0.072
3.725ThrGlu: 3.725 ± 0.08
2.86ThrPhe: 2.86 ± 0.047
4.595ThrGly: 4.595 ± 0.123
1.109ThrHis: 1.109 ± 0.042
4.464ThrIle: 4.464 ± 0.094
3.488ThrLys: 3.488 ± 0.07
5.92ThrLeu: 5.92 ± 0.102
1.229ThrMet: 1.229 ± 0.039
2.957ThrAsn: 2.957 ± 0.095
2.51ThrPro: 2.51 ± 0.069
2.31ThrGln: 2.31 ± 0.058
2.016ThrArg: 2.016 ± 0.05
4.027ThrSer: 4.027 ± 0.105
4.005ThrThr: 4.005 ± 0.124
4.318ThrVal: 4.318 ± 0.093
0.65ThrTrp: 0.65 ± 0.026
2.06ThrTyr: 2.06 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.589ValAla: 5.589 ± 0.092
0.342ValCys: 0.342 ± 0.023
3.501ValAsp: 3.501 ± 0.081
4.374ValGlu: 4.374 ± 0.096
2.946ValPhe: 2.946 ± 0.073
4.542ValGly: 4.542 ± 0.096
1.108ValHis: 1.108 ± 0.043
5.093ValIle: 5.093 ± 0.094
4.574ValLys: 4.574 ± 0.084
6.667ValLeu: 6.667 ± 0.109
1.615ValMet: 1.615 ± 0.045
3.275ValAsn: 3.275 ± 0.076
2.512ValPro: 2.512 ± 0.057
2.192ValGln: 2.192 ± 0.049
2.428ValArg: 2.428 ± 0.064
4.84ValSer: 4.84 ± 0.076
4.259ValThr: 4.259 ± 0.091
4.912ValVal: 4.912 ± 0.093
0.577ValTrp: 0.577 ± 0.031
2.257ValTyr: 2.257 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.62TrpAla: 0.62 ± 0.034
0.061TrpCys: 0.061 ± 0.009
0.51TrpAsp: 0.51 ± 0.026
0.609TrpGlu: 0.609 ± 0.031
0.53TrpPhe: 0.53 ± 0.027
0.693TrpGly: 0.693 ± 0.03
0.214TrpHis: 0.214 ± 0.018
0.756TrpIle: 0.756 ± 0.034
0.642TrpLys: 0.642 ± 0.031
1.174TrpLeu: 1.174 ± 0.045
0.269TrpMet: 0.269 ± 0.019
0.608TrpAsn: 0.608 ± 0.03
0.161TrpPro: 0.161 ± 0.018
0.528TrpGln: 0.528 ± 0.028
0.434TrpArg: 0.434 ± 0.024
0.645TrpSer: 0.645 ± 0.034
0.61TrpThr: 0.61 ± 0.032
0.591TrpVal: 0.591 ± 0.033
0.179TrpTrp: 0.179 ± 0.017
0.366TrpTyr: 0.366 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.461TyrAla: 2.461 ± 0.065
0.19TyrCys: 0.19 ± 0.017
2.147TyrAsp: 2.147 ± 0.062
2.239TyrGlu: 2.239 ± 0.064
2.085TyrPhe: 2.085 ± 0.048
2.337TyrGly: 2.337 ± 0.066
0.902TyrHis: 0.902 ± 0.039
2.211TyrIle: 2.211 ± 0.052
2.073TyrLys: 2.073 ± 0.052
3.651TyrLeu: 3.651 ± 0.075
0.77TyrMet: 0.77 ± 0.032
1.686TyrAsn: 1.686 ± 0.055
1.36TyrPro: 1.36 ± 0.055
1.693TyrGln: 1.693 ± 0.05
1.535TyrArg: 1.535 ± 0.047
2.162TyrSer: 2.162 ± 0.055
2.016TyrThr: 2.016 ± 0.057
2.043TyrVal: 2.043 ± 0.059
0.387TyrTrp: 0.387 ± 0.024
1.427TyrTyr: 1.427 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2440 proteins (725829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski