Amino acid dipepetide frequency for Candidatus Parvarchaeum acidiphilum ARMAN-4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.215AlaAla: 4.215 ± 0.2
0.511AlaCys: 0.511 ± 0.048
2.931AlaAsp: 2.931 ± 0.118
3.602AlaGlu: 3.602 ± 0.131
3.294AlaPhe: 3.294 ± 0.144
4.063AlaGly: 4.063 ± 0.144
0.65AlaHis: 0.65 ± 0.06
5.794AlaIle: 5.794 ± 0.158
4.287AlaLys: 4.287 ± 0.162
5.794AlaLeu: 5.794 ± 0.184
1.288AlaMet: 1.288 ± 0.072
2.961AlaAsn: 2.961 ± 0.132
1.723AlaPro: 1.723 ± 0.11
1.368AlaGln: 1.368 ± 0.087
1.82AlaArg: 1.82 ± 0.1
4.122AlaSer: 4.122 ± 0.166
2.77AlaThr: 2.77 ± 0.112
4.519AlaVal: 4.519 ± 0.168
0.346AlaTrp: 0.346 ± 0.043
2.618AlaTyr: 2.618 ± 0.12
0.0AlaXaa: 0.0 ± 0.0
Cys
0.443CysAla: 0.443 ± 0.046
0.084CysCys: 0.084 ± 0.024
0.367CysAsp: 0.367 ± 0.038
0.355CysGlu: 0.355 ± 0.039
0.253CysPhe: 0.253 ± 0.035
0.756CysGly: 0.756 ± 0.067
0.089CysHis: 0.089 ± 0.02
0.524CysIle: 0.524 ± 0.047
0.545CysLys: 0.545 ± 0.044
0.465CysLeu: 0.465 ± 0.046
0.156CysMet: 0.156 ± 0.023
0.486CysAsn: 0.486 ± 0.061
0.334CysPro: 0.334 ± 0.04
0.131CysGln: 0.131 ± 0.023
0.258CysArg: 0.258 ± 0.032
0.752CysSer: 0.752 ± 0.066
0.351CysThr: 0.351 ± 0.063
0.363CysVal: 0.363 ± 0.041
0.03CysTrp: 0.03 ± 0.012
0.249CysTyr: 0.249 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
2.542AspAla: 2.542 ± 0.102
0.317AspCys: 0.317 ± 0.036
1.96AspAsp: 1.96 ± 0.097
3.29AspGlu: 3.29 ± 0.11
2.83AspPhe: 2.83 ± 0.107
2.669AspGly: 2.669 ± 0.125
0.443AspHis: 0.443 ± 0.041
5.435AspIle: 5.435 ± 0.186
5.195AspLys: 5.195 ± 0.19
5.076AspLeu: 5.076 ± 0.172
1.081AspMet: 1.081 ± 0.07
2.863AspAsn: 2.863 ± 0.095
1.66AspPro: 1.66 ± 0.093
0.853AspGln: 0.853 ± 0.062
1.605AspArg: 1.605 ± 0.103
3.683AspSer: 3.683 ± 0.114
2.226AspThr: 2.226 ± 0.097
2.851AspVal: 2.851 ± 0.114
0.313AspTrp: 0.313 ± 0.037
2.656AspTyr: 2.656 ± 0.112
0.0AspXaa: 0.0 ± 0.0
Glu
3.598GluAla: 3.598 ± 0.131
0.308GluCys: 0.308 ± 0.037
3.281GluAsp: 3.281 ± 0.151
5.199GluGlu: 5.199 ± 0.192
2.859GluPhe: 2.859 ± 0.121
3.239GluGly: 3.239 ± 0.111
0.781GluHis: 0.781 ± 0.062
6.259GluIle: 6.259 ± 0.197
7.513GluLys: 7.513 ± 0.25
5.862GluLeu: 5.862 ± 0.19
1.398GluMet: 1.398 ± 0.083
4.274GluAsn: 4.274 ± 0.148
1.368GluPro: 1.368 ± 0.063
1.394GluGln: 1.394 ± 0.096
2.576GluArg: 2.576 ± 0.124
3.754GluSer: 3.754 ± 0.141
2.716GluThr: 2.716 ± 0.096
3.501GluVal: 3.501 ± 0.137
0.342GluTrp: 0.342 ± 0.04
2.568GluTyr: 2.568 ± 0.107
0.0GluXaa: 0.0 ± 0.0
Phe
2.787PheAla: 2.787 ± 0.125
0.376PheCys: 0.376 ± 0.043
2.45PheAsp: 2.45 ± 0.1
2.462PheGlu: 2.462 ± 0.094
2.686PhePhe: 2.686 ± 0.152
3.459PheGly: 3.459 ± 0.139
0.608PheHis: 0.608 ± 0.05
5.148PheIle: 5.148 ± 0.166
3.721PheLys: 3.721 ± 0.165
5.051PheLeu: 5.051 ± 0.197
1.111PheMet: 1.111 ± 0.07
3.556PheAsn: 3.556 ± 0.123
1.478PhePro: 1.478 ± 0.086
1.047PheGln: 1.047 ± 0.072
1.541PheArg: 1.541 ± 0.101
5.026PheSer: 5.026 ± 0.189
2.572PheThr: 2.572 ± 0.133
3.298PheVal: 3.298 ± 0.111
0.355PheTrp: 0.355 ± 0.039
2.399PheTyr: 2.399 ± 0.108
0.0PheXaa: 0.0 ± 0.0
Gly
3.438GlyAla: 3.438 ± 0.156
0.422GlyCys: 0.422 ± 0.048
2.627GlyAsp: 2.627 ± 0.119
3.404GlyGlu: 3.404 ± 0.144
3.425GlyPhe: 3.425 ± 0.127
3.835GlyGly: 3.835 ± 0.143
0.836GlyHis: 0.836 ± 0.059
6.525GlyIle: 6.525 ± 0.185
5.921GlyLys: 5.921 ± 0.193
5.853GlyLeu: 5.853 ± 0.182
1.584GlyMet: 1.584 ± 0.087
3.501GlyAsn: 3.501 ± 0.142
1.444GlyPro: 1.444 ± 0.077
1.575GlyGln: 1.575 ± 0.079
2.116GlyArg: 2.116 ± 0.094
4.844GlySer: 4.844 ± 0.211
3.273GlyThr: 3.273 ± 0.14
4.004GlyVal: 4.004 ± 0.132
0.591GlyTrp: 0.591 ± 0.05
3.062GlyTyr: 3.062 ± 0.111
0.0GlyXaa: 0.0 ± 0.0
His
0.71HisAla: 0.71 ± 0.055
0.127HisCys: 0.127 ± 0.021
0.494HisAsp: 0.494 ± 0.047
0.659HisGlu: 0.659 ± 0.059
0.667HisPhe: 0.667 ± 0.057
0.878HisGly: 0.878 ± 0.061
0.16HisHis: 0.16 ± 0.027
1.03HisIle: 1.03 ± 0.071
0.887HisLys: 0.887 ± 0.063
1.09HisLeu: 1.09 ± 0.074
0.228HisMet: 0.228 ± 0.033
0.629HisAsn: 0.629 ± 0.047
0.524HisPro: 0.524 ± 0.05
0.232HisGln: 0.232 ± 0.036
0.452HisArg: 0.452 ± 0.041
1.052HisSer: 1.052 ± 0.063
0.532HisThr: 0.532 ± 0.047
0.802HisVal: 0.802 ± 0.06
0.084HisTrp: 0.084 ± 0.019
0.562HisTyr: 0.562 ± 0.048
0.0HisXaa: 0.0 ± 0.0
Ile
6.221IleAla: 6.221 ± 0.207
0.629IleCys: 0.629 ± 0.049
5.296IleAsp: 5.296 ± 0.181
5.685IleGlu: 5.685 ± 0.188
4.574IlePhe: 4.574 ± 0.149
5.735IleGly: 5.735 ± 0.193
1.047IleHis: 1.047 ± 0.063
9.084IleIle: 9.084 ± 0.272
9.173IleLys: 9.173 ± 0.245
8.075IleLeu: 8.075 ± 0.232
2.006IleMet: 2.006 ± 0.085
6.698IleAsn: 6.698 ± 0.19
3.412IlePro: 3.412 ± 0.134
1.824IleGln: 1.824 ± 0.088
2.825IleArg: 2.825 ± 0.114
7.965IleSer: 7.965 ± 0.211
5.009IleThr: 5.009 ± 0.144
5.241IleVal: 5.241 ± 0.156
0.481IleTrp: 0.481 ± 0.049
3.193IleTyr: 3.193 ± 0.136
0.0IleXaa: 0.0 ± 0.0
Lys
4.865LysAla: 4.865 ± 0.167
0.625LysCys: 0.625 ± 0.061
5.347LysAsp: 5.347 ± 0.195
8.231LysGlu: 8.231 ± 0.275
3.518LysPhe: 3.518 ± 0.139
4.945LysGly: 4.945 ± 0.156
1.005LysHis: 1.005 ± 0.07
8.476LysIle: 8.476 ± 0.254
9.08LysLys: 9.08 ± 0.281
7.648LysLeu: 7.648 ± 0.2
2.331LysMet: 2.331 ± 0.116
6.259LysAsn: 6.259 ± 0.193
2.433LysPro: 2.433 ± 0.1
2.205LysGln: 2.205 ± 0.103
3.67LysArg: 3.67 ± 0.144
5.355LysSer: 5.355 ± 0.16
4.405LysThr: 4.405 ± 0.138
5.33LysVal: 5.33 ± 0.175
0.528LysTrp: 0.528 ± 0.05
3.467LysTyr: 3.467 ± 0.119
0.0LysXaa: 0.0 ± 0.0
Leu
5.406LeuAla: 5.406 ± 0.171
0.545LeuCys: 0.545 ± 0.053
5.013LeuAsp: 5.013 ± 0.16
5.537LeuGlu: 5.537 ± 0.174
4.831LeuPhe: 4.831 ± 0.19
5.6LeuGly: 5.6 ± 0.18
1.056LeuHis: 1.056 ± 0.072
8.202LeuIle: 8.202 ± 0.241
8.447LeuLys: 8.447 ± 0.212
8.81LeuLeu: 8.81 ± 0.251
2.027LeuMet: 2.027 ± 0.092
6.128LeuAsn: 6.128 ± 0.192
3.725LeuPro: 3.725 ± 0.131
2.116LeuGln: 2.116 ± 0.096
3.108LeuArg: 3.108 ± 0.141
9.186LeuSer: 9.186 ± 0.227
4.51LeuThr: 4.51 ± 0.167
5.634LeuVal: 5.634 ± 0.164
0.595LeuTrp: 0.595 ± 0.051
3.7LeuTyr: 3.7 ± 0.123
0.0LeuXaa: 0.0 ± 0.0
Met
1.402MetAla: 1.402 ± 0.082
0.169MetCys: 0.169 ± 0.026
1.301MetAsp: 1.301 ± 0.09
1.782MetGlu: 1.782 ± 0.105
1.047MetPhe: 1.047 ± 0.067
1.297MetGly: 1.297 ± 0.074
0.443MetHis: 0.443 ± 0.044
1.651MetIle: 1.651 ± 0.092
1.892MetLys: 1.892 ± 0.09
2.293MetLeu: 2.293 ± 0.104
0.469MetMet: 0.469 ± 0.045
1.326MetAsn: 1.326 ± 0.073
1.064MetPro: 1.064 ± 0.067
0.862MetGln: 0.862 ± 0.065
0.655MetArg: 0.655 ± 0.058
1.525MetSer: 1.525 ± 0.086
0.904MetThr: 0.904 ± 0.065
1.495MetVal: 1.495 ± 0.081
0.144MetTrp: 0.144 ± 0.024
0.693MetTyr: 0.693 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.708AsnAla: 3.708 ± 0.129
0.503AsnCys: 0.503 ± 0.061
2.817AsnAsp: 2.817 ± 0.125
4.118AsnGlu: 4.118 ± 0.13
3.045AsnPhe: 3.045 ± 0.12
4.654AsnGly: 4.654 ± 0.195
0.6AsnHis: 0.6 ± 0.05
5.545AsnIle: 5.545 ± 0.169
5.782AsnLys: 5.782 ± 0.157
6.204AsnLeu: 6.204 ± 0.208
1.313AsnMet: 1.313 ± 0.064
3.987AsnAsn: 3.987 ± 0.156
2.445AsnPro: 2.445 ± 0.122
1.639AsnGln: 1.639 ± 0.079
1.719AsnArg: 1.719 ± 0.084
5.596AsnSer: 5.596 ± 0.283
3.015AsnThr: 3.015 ± 0.121
3.936AsnVal: 3.936 ± 0.15
0.452AsnTrp: 0.452 ± 0.038
3.049AsnTyr: 3.049 ± 0.132
0.0AsnXaa: 0.0 ± 0.0
Pro
1.694ProAla: 1.694 ± 0.095
0.148ProCys: 0.148 ± 0.026
1.444ProAsp: 1.444 ± 0.08
2.129ProGlu: 2.129 ± 0.103
2.145ProPhe: 2.145 ± 0.096
1.867ProGly: 1.867 ± 0.093
0.384ProHis: 0.384 ± 0.044
2.804ProIle: 2.804 ± 0.108
2.386ProLys: 2.386 ± 0.101
3.066ProLeu: 3.066 ± 0.125
0.684ProMet: 0.684 ± 0.055
2.078ProAsn: 2.078 ± 0.105
1.081ProPro: 1.081 ± 0.08
0.845ProGln: 0.845 ± 0.071
0.815ProArg: 0.815 ± 0.062
3.383ProSer: 3.383 ± 0.196
1.74ProThr: 1.74 ± 0.094
2.297ProVal: 2.297 ± 0.101
0.253ProTrp: 0.253 ± 0.036
1.394ProTyr: 1.394 ± 0.082
0.004ProXaa: 0.004 ± 0.005
Gln
1.368GlnAla: 1.368 ± 0.091
0.144GlnCys: 0.144 ± 0.023
1.073GlnAsp: 1.073 ± 0.064
1.541GlnGlu: 1.541 ± 0.081
0.967GlnPhe: 0.967 ± 0.079
1.284GlnGly: 1.284 ± 0.077
0.275GlnHis: 0.275 ± 0.031
2.074GlnIle: 2.074 ± 0.092
2.027GlnLys: 2.027 ± 0.111
2.074GlnLeu: 2.074 ± 0.11
0.646GlnMet: 0.646 ± 0.048
1.656GlnAsn: 1.656 ± 0.101
0.76GlnPro: 0.76 ± 0.066
0.9GlnGln: 0.9 ± 0.071
0.938GlnArg: 0.938 ± 0.064
1.782GlnSer: 1.782 ± 0.108
1.174GlnThr: 1.174 ± 0.068
1.461GlnVal: 1.461 ± 0.072
0.156GlnTrp: 0.156 ± 0.031
1.026GlnTyr: 1.026 ± 0.066
0.0GlnXaa: 0.0 ± 0.0
Arg
1.651ArgAla: 1.651 ± 0.09
0.232ArgCys: 0.232 ± 0.03
1.736ArgAsp: 1.736 ± 0.1
2.327ArgGlu: 2.327 ± 0.133
1.715ArgPhe: 1.715 ± 0.089
1.85ArgGly: 1.85 ± 0.09
0.536ArgHis: 0.536 ± 0.05
3.058ArgIle: 3.058 ± 0.128
3.298ArgLys: 3.298 ± 0.138
3.303ArgLeu: 3.303 ± 0.141
0.828ArgMet: 0.828 ± 0.063
1.9ArgAsn: 1.9 ± 0.101
0.971ArgPro: 0.971 ± 0.078
0.781ArgGln: 0.781 ± 0.066
1.664ArgArg: 1.664 ± 0.101
2.04ArgSer: 2.04 ± 0.1
1.385ArgThr: 1.385 ± 0.086
2.031ArgVal: 2.031 ± 0.096
0.283ArgTrp: 0.283 ± 0.037
1.525ArgTyr: 1.525 ± 0.076
0.0ArgXaa: 0.0 ± 0.0
Ser
5.081SerAla: 5.081 ± 0.206
0.6SerCys: 0.6 ± 0.078
3.687SerAsp: 3.687 ± 0.136
4.021SerGlu: 4.021 ± 0.113
4.81SerPhe: 4.81 ± 0.189
5.44SerGly: 5.44 ± 0.226
0.849SerHis: 0.849 ± 0.057
7.733SerIle: 7.733 ± 0.18
6.837SerLys: 6.837 ± 0.178
7.822SerLeu: 7.822 ± 0.23
1.879SerMet: 1.879 ± 0.095
5.326SerAsn: 5.326 ± 0.259
2.454SerPro: 2.454 ± 0.143
2.078SerGln: 2.078 ± 0.108
2.42SerArg: 2.42 ± 0.109
7.707SerSer: 7.707 ± 0.435
4.396SerThr: 4.396 ± 0.232
4.92SerVal: 4.92 ± 0.175
0.541SerTrp: 0.541 ± 0.047
3.64SerTyr: 3.64 ± 0.16
0.0SerXaa: 0.0 ± 0.0
Thr
3.497ThrAla: 3.497 ± 0.134
0.346ThrCys: 0.346 ± 0.048
2.293ThrAsp: 2.293 ± 0.102
2.652ThrGlu: 2.652 ± 0.107
2.58ThrPhe: 2.58 ± 0.13
3.7ThrGly: 3.7 ± 0.144
0.697ThrHis: 0.697 ± 0.059
4.358ThrIle: 4.358 ± 0.173
3.573ThrLys: 3.573 ± 0.123
4.869ThrLeu: 4.869 ± 0.168
0.916ThrMet: 0.916 ± 0.067
2.745ThrAsn: 2.745 ± 0.15
1.917ThrPro: 1.917 ± 0.093
1.254ThrGln: 1.254 ± 0.07
1.364ThrArg: 1.364 ± 0.068
4.164ThrSer: 4.164 ± 0.187
2.661ThrThr: 2.661 ± 0.229
3.514ThrVal: 3.514 ± 0.138
0.308ThrTrp: 0.308 ± 0.04
2.002ThrTyr: 2.002 ± 0.14
0.0ThrXaa: 0.0 ± 0.0
Val
3.455ValAla: 3.455 ± 0.145
0.465ValCys: 0.465 ± 0.041
3.032ValAsp: 3.032 ± 0.139
3.248ValGlu: 3.248 ± 0.129
3.358ValPhe: 3.358 ± 0.123
3.695ValGly: 3.695 ± 0.115
0.705ValHis: 0.705 ± 0.061
6.326ValIle: 6.326 ± 0.181
5.11ValLys: 5.11 ± 0.163
5.942ValLeu: 5.942 ± 0.182
1.36ValMet: 1.36 ± 0.079
4.042ValAsn: 4.042 ± 0.145
2.133ValPro: 2.133 ± 0.09
1.09ValGln: 1.09 ± 0.067
1.846ValArg: 1.846 ± 0.104
5.393ValSer: 5.393 ± 0.17
3.07ValThr: 3.07 ± 0.134
3.852ValVal: 3.852 ± 0.139
0.359ValTrp: 0.359 ± 0.045
3.087ValTyr: 3.087 ± 0.113
0.0ValXaa: 0.0 ± 0.0
Trp
0.389TrpAla: 0.389 ± 0.038
0.068TrpCys: 0.068 ± 0.017
0.346TrpAsp: 0.346 ± 0.043
0.38TrpGlu: 0.38 ± 0.041
0.321TrpPhe: 0.321 ± 0.042
0.393TrpGly: 0.393 ± 0.038
0.131TrpHis: 0.131 ± 0.022
0.532TrpIle: 0.532 ± 0.045
0.503TrpLys: 0.503 ± 0.052
0.752TrpLeu: 0.752 ± 0.05
0.16TrpMet: 0.16 ± 0.023
0.422TrpAsn: 0.422 ± 0.052
0.266TrpPro: 0.266 ± 0.034
0.211TrpGln: 0.211 ± 0.031
0.3TrpArg: 0.3 ± 0.038
0.363TrpSer: 0.363 ± 0.042
0.313TrpThr: 0.313 ± 0.039
0.452TrpVal: 0.452 ± 0.044
0.156TrpTrp: 0.156 ± 0.025
0.266TrpTyr: 0.266 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.209TyrAla: 2.209 ± 0.118
0.372TyrCys: 0.372 ± 0.044
2.053TyrAsp: 2.053 ± 0.093
2.171TyrGlu: 2.171 ± 0.106
2.205TyrPhe: 2.205 ± 0.1
2.923TyrGly: 2.923 ± 0.12
0.503TyrHis: 0.503 ± 0.05
3.615TyrIle: 3.615 ± 0.118
3.548TyrLys: 3.548 ± 0.143
4.126TyrLeu: 4.126 ± 0.152
0.942TyrMet: 0.942 ± 0.066
3.29TyrAsn: 3.29 ± 0.167
1.449TyrPro: 1.449 ± 0.077
0.921TyrGln: 0.921 ± 0.066
1.423TyrArg: 1.423 ± 0.093
4.548TyrSer: 4.548 ± 0.164
2.39TyrThr: 2.39 ± 0.101
2.065TyrVal: 2.065 ± 0.105
0.405TyrTrp: 0.405 ± 0.045
1.985TyrTyr: 1.985 ± 0.104
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.004XaaTyr: 0.004 ± 0.005
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 911 proteins (236784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski