Amino acid dipepetide frequency for Zygosaccharomyces parabailii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.161AlaAla: 5.161 ± 0.06	0.809AlaCys: 0.809 ± 0.014	3.033AlaAsp: 3.033 ± 0.026	3.769AlaGlu: 3.769 ± 0.033	2.457AlaPhe: 2.457 ± 0.022	3.642AlaGly: 3.642 ± 0.039	1.364AlaHis: 1.364 ± 0.018	3.597AlaIle: 3.597 ± 0.032	4.086AlaLys: 4.086 ± 0.039	6.021AlaLeu: 6.021 ± 0.045	1.412AlaMet: 1.412 ± 0.016	2.942AlaAsn: 2.942 ± 0.026	2.899AlaPro: 2.899 ± 0.045	2.741AlaGln: 2.741 ± 0.043	3.039AlaArg: 3.039 ± 0.027	5.539AlaSer: 5.539 ± 0.059	3.77AlaThr: 3.77 ± 0.037	3.908AlaVal: 3.908 ± 0.026	0.553AlaTrp: 0.553 ± 0.011	1.809AlaTyr: 1.809 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.746CysAla: 0.746 ± 0.015	0.314CysCys: 0.314 ± 0.008	0.716CysAsp: 0.716 ± 0.012	0.687CysGlu: 0.687 ± 0.012	0.7CysPhe: 0.7 ± 0.012	0.942CysGly: 0.942 ± 0.018	0.367CysHis: 0.367 ± 0.009	0.905CysIle: 0.905 ± 0.015	0.8CysLys: 0.8 ± 0.012	1.372CysLeu: 1.372 ± 0.018	0.307CysMet: 0.307 ± 0.009	0.624CysAsn: 0.624 ± 0.012	0.582CysPro: 0.582 ± 0.014	0.496CysGln: 0.496 ± 0.011	0.649CysArg: 0.649 ± 0.013	1.138CysSer: 1.138 ± 0.017	0.664CysThr: 0.664 ± 0.015	0.934CysVal: 0.934 ± 0.015	0.183CysTrp: 0.183 ± 0.006	0.551CysTyr: 0.551 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	3.414AspAla: 3.414 ± 0.031	0.712AspCys: 0.712 ± 0.014	3.974AspAsp: 3.974 ± 0.049	4.86AspGlu: 4.86 ± 0.048	2.618AspPhe: 2.618 ± 0.027	3.026AspGly: 3.026 ± 0.032	1.161AspHis: 1.161 ± 0.017	3.445AspIle: 3.445 ± 0.037	3.232AspLys: 3.232 ± 0.029	5.467AspLeu: 5.467 ± 0.037	1.203AspMet: 1.203 ± 0.016	2.613AspAsn: 2.613 ± 0.026	2.613AspPro: 2.613 ± 0.026	1.971AspGln: 1.971 ± 0.023	2.351AspArg: 2.351 ± 0.023	4.591AspSer: 4.591 ± 0.034	2.812AspThr: 2.812 ± 0.023	3.675AspVal: 3.675 ± 0.03	0.665AspTrp: 0.665 ± 0.012	2.065AspTyr: 2.065 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	3.965GluAla: 3.965 ± 0.037	0.704GluCys: 0.704 ± 0.014	4.445GluAsp: 4.445 ± 0.043	6.433GluGlu: 6.433 ± 0.064	2.705GluPhe: 2.705 ± 0.027	3.185GluGly: 3.185 ± 0.025	1.464GluHis: 1.464 ± 0.021	3.833GluIle: 3.833 ± 0.034	4.97GluLys: 4.97 ± 0.051	6.83GluLeu: 6.83 ± 0.047	1.539GluMet: 1.539 ± 0.02	3.781GluAsn: 3.781 ± 0.034	2.33GluPro: 2.33 ± 0.028	3.069GluGln: 3.069 ± 0.029	3.378GluArg: 3.378 ± 0.03	4.951GluSer: 4.951 ± 0.045	3.477GluThr: 3.477 ± 0.036	3.783GluVal: 3.783 ± 0.031	0.664GluTrp: 0.664 ± 0.013	2.21GluTyr: 2.21 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	2.659PheAla: 2.659 ± 0.026	0.61PheCys: 0.61 ± 0.012	2.602PheAsp: 2.602 ± 0.026	2.861PheGlu: 2.861 ± 0.025	2.093PhePhe: 2.093 ± 0.028	2.693PheGly: 2.693 ± 0.037	1.051PheHis: 1.051 ± 0.017	2.381PheIle: 2.381 ± 0.026	2.691PheLys: 2.691 ± 0.023	4.196PheLeu: 4.196 ± 0.034	0.918PheMet: 0.918 ± 0.015	2.126PheAsn: 2.126 ± 0.021	1.821PhePro: 1.821 ± 0.022	1.853PheGln: 1.853 ± 0.019	1.795PheArg: 1.795 ± 0.021	3.456PheSer: 3.456 ± 0.034	2.322PheThr: 2.322 ± 0.024	2.777PheVal: 2.777 ± 0.026	0.523PheTrp: 0.523 ± 0.011	1.614PheTyr: 1.614 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	3.539GlyAla: 3.539 ± 0.034	0.827GlyCys: 0.827 ± 0.015	3.053GlyAsp: 3.053 ± 0.028	3.289GlyGlu: 3.289 ± 0.029	2.52GlyPhe: 2.52 ± 0.026	3.992GlyGly: 3.992 ± 0.055	1.288GlyHis: 1.288 ± 0.019	3.372GlyIle: 3.372 ± 0.03	3.74GlyLys: 3.74 ± 0.033	4.961GlyLeu: 4.961 ± 0.039	1.122GlyMet: 1.122 ± 0.019	2.774GlyAsn: 2.774 ± 0.026	2.039GlyPro: 2.039 ± 0.027	1.959GlyGln: 1.959 ± 0.023	2.578GlyArg: 2.578 ± 0.025	5.402GlySer: 5.402 ± 0.063	3.239GlyThr: 3.239 ± 0.033	3.56GlyVal: 3.56 ± 0.029	0.645GlyTrp: 0.645 ± 0.013	1.964GlyTyr: 1.964 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.303HisAla: 1.303 ± 0.015	0.37HisCys: 0.37 ± 0.01	1.223HisAsp: 1.223 ± 0.016	1.434HisGlu: 1.434 ± 0.019	1.036HisPhe: 1.036 ± 0.015	1.372HisGly: 1.372 ± 0.019	0.771HisHis: 0.771 ± 0.019	1.298HisIle: 1.298 ± 0.017	1.288HisLys: 1.288 ± 0.016	2.331HisLeu: 2.331 ± 0.023	0.483HisMet: 0.483 ± 0.011	1.076HisAsn: 1.076 ± 0.014	1.143HisPro: 1.143 ± 0.018	0.982HisGln: 0.982 ± 0.019	1.263HisArg: 1.263 ± 0.017	1.969HisSer: 1.969 ± 0.024	1.14HisThr: 1.14 ± 0.015	1.375HisVal: 1.375 ± 0.018	0.304HisTrp: 0.304 ± 0.008	0.851HisTyr: 0.851 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.502IleAla: 3.502 ± 0.027	0.873IleCys: 0.873 ± 0.016	3.316IleAsp: 3.316 ± 0.027	3.48IleGlu: 3.48 ± 0.035	2.588IlePhe: 2.588 ± 0.03	2.908IleGly: 2.908 ± 0.028	1.227IleHis: 1.227 ± 0.016	3.121IleIle: 3.121 ± 0.029	3.631IleLys: 3.631 ± 0.029	5.49IleLeu: 5.49 ± 0.039	1.224IleMet: 1.224 ± 0.017	2.719IleAsn: 2.719 ± 0.024	2.936IlePro: 2.936 ± 0.032	2.063IleGln: 2.063 ± 0.023	2.681IleArg: 2.681 ± 0.026	4.88IleSer: 4.88 ± 0.038	3.147IleThr: 3.147 ± 0.028	3.604IleVal: 3.604 ± 0.029	0.645IleTrp: 0.645 ± 0.012	1.947IleTyr: 1.947 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.591LysAla: 3.591 ± 0.031	0.822LysCys: 0.822 ± 0.016	3.666LysAsp: 3.666 ± 0.032	4.825LysGlu: 4.825 ± 0.047	2.799LysPhe: 2.799 ± 0.026	3.07LysGly: 3.07 ± 0.026	1.519LysHis: 1.519 ± 0.018	3.838LysIle: 3.838 ± 0.03	5.564LysLys: 5.564 ± 0.051	6.679LysLeu: 6.679 ± 0.046	1.472LysMet: 1.472 ± 0.017	3.549LysAsn: 3.549 ± 0.029	2.832LysPro: 2.832 ± 0.028	2.777LysGln: 2.777 ± 0.027	3.99LysArg: 3.99 ± 0.034	5.005LysSer: 5.005 ± 0.035	3.392LysThr: 3.392 ± 0.031	3.842LysVal: 3.842 ± 0.03	0.762LysTrp: 0.762 ± 0.014	2.427LysTyr: 2.427 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	6.209LeuAla: 6.209 ± 0.039	1.476LeuCys: 1.476 ± 0.019	5.485LeuAsp: 5.485 ± 0.041	6.601LeuGlu: 6.601 ± 0.048	4.084LeuPhe: 4.084 ± 0.032	5.008LeuGly: 5.008 ± 0.038	2.29LeuHis: 2.29 ± 0.022	5.022LeuIle: 5.022 ± 0.041	6.975LeuLys: 6.975 ± 0.043	9.944LeuLeu: 9.944 ± 0.069	2.028LeuMet: 2.028 ± 0.019	4.822LeuAsn: 4.822 ± 0.039	4.844LeuPro: 4.844 ± 0.033	4.9LeuGln: 4.9 ± 0.041	5.027LeuArg: 5.027 ± 0.036	8.087LeuSer: 8.087 ± 0.043	5.037LeuThr: 5.037 ± 0.034	5.667LeuVal: 5.667 ± 0.038	1.034LeuTrp: 1.034 ± 0.016	3.085LeuTyr: 3.085 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.596MetAla: 1.596 ± 0.019	0.3MetCys: 0.3 ± 0.008	1.352MetAsp: 1.352 ± 0.019	1.372MetGlu: 1.372 ± 0.016	0.901MetPhe: 0.901 ± 0.013	1.308MetGly: 1.308 ± 0.018	0.436MetHis: 0.436 ± 0.009	1.184MetIle: 1.184 ± 0.016	1.342MetLys: 1.342 ± 0.016	2.048MetLeu: 2.048 ± 0.022	0.545MetMet: 0.545 ± 0.013	1.045MetAsn: 1.045 ± 0.015	0.951MetPro: 0.951 ± 0.015	0.891MetGln: 0.891 ± 0.015	1.027MetArg: 1.027 ± 0.018	2.08MetSer: 2.08 ± 0.021	1.116MetThr: 1.116 ± 0.016	1.325MetVal: 1.325 ± 0.016	0.229MetTrp: 0.229 ± 0.005	0.601MetTyr: 0.601 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.142AsnAla: 3.142 ± 0.032	0.684AsnCys: 0.684 ± 0.012	2.891AsnAsp: 2.891 ± 0.029	3.339AsnGlu: 3.339 ± 0.029	2.246AsnPhe: 2.246 ± 0.022	3.154AsnGly: 3.154 ± 0.032	1.091AsnHis: 1.091 ± 0.015	2.818AsnIle: 2.818 ± 0.027	3.106AsnLys: 3.106 ± 0.029	4.55AsnLeu: 4.55 ± 0.036	1.092AsnMet: 1.092 ± 0.014	2.734AsnAsn: 2.734 ± 0.033	2.276AsnPro: 2.276 ± 0.027	1.783AsnGln: 1.783 ± 0.019	2.129AsnArg: 2.129 ± 0.022	4.475AsnSer: 4.475 ± 0.039	2.606AsnThr: 2.606 ± 0.025	3.17AsnVal: 3.17 ± 0.027	0.603AsnTrp: 0.603 ± 0.012	1.791AsnTyr: 1.791 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	2.894ProAla: 2.894 ± 0.043	0.449ProCys: 0.449 ± 0.012	2.255ProAsp: 2.255 ± 0.021	3.243ProGlu: 3.243 ± 0.028	1.865ProPhe: 1.865 ± 0.022	2.361ProGly: 2.361 ± 0.029	1.104ProHis: 1.104 ± 0.016	2.42ProIle: 2.42 ± 0.027	2.736ProLys: 2.736 ± 0.025	4.451ProLeu: 4.451 ± 0.035	0.911ProMet: 0.911 ± 0.017	2.086ProAsn: 2.086 ± 0.023	2.826ProPro: 2.826 ± 0.053	2.302ProGln: 2.302 ± 0.03	2.158ProArg: 2.158 ± 0.023	4.415ProSer: 4.415 ± 0.075	2.694ProThr: 2.694 ± 0.032	2.859ProVal: 2.859 ± 0.029	0.532ProTrp: 0.532 ± 0.02	1.383ProTyr: 1.383 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	2.529GlnAla: 2.529 ± 0.037	0.511GlnCys: 0.511 ± 0.01	2.297GlnAsp: 2.297 ± 0.026	3.32GlnGlu: 3.32 ± 0.034	1.764GlnPhe: 1.764 ± 0.021	2.162GlnGly: 2.162 ± 0.026	1.057GlnHis: 1.057 ± 0.018	2.212GlnIle: 2.212 ± 0.024	2.71GlnLys: 2.71 ± 0.027	4.62GlnLeu: 4.62 ± 0.036	0.94GlnMet: 0.94 ± 0.014	2.064GlnAsn: 2.064 ± 0.021	1.839GlnPro: 1.839 ± 0.031	3.46GlnGln: 3.46 ± 0.096	2.466GlnArg: 2.466 ± 0.025	3.156GlnSer: 3.156 ± 0.031	1.972GlnThr: 1.972 ± 0.02	2.519GlnVal: 2.519 ± 0.023	0.495GlnTrp: 0.495 ± 0.011	1.387GlnTyr: 1.387 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	2.859ArgAla: 2.859 ± 0.026	0.713ArgCys: 0.713 ± 0.014	2.726ArgAsp: 2.726 ± 0.024	3.354ArgGlu: 3.354 ± 0.026	2.036ArgPhe: 2.036 ± 0.021	2.599ArgGly: 2.599 ± 0.027	1.204ArgHis: 1.204 ± 0.018	2.942ArgIle: 2.942 ± 0.028	3.764ArgLys: 3.764 ± 0.034	4.744ArgLeu: 4.744 ± 0.038	1.05ArgMet: 1.05 ± 0.015	2.562ArgAsn: 2.562 ± 0.023	2.067ArgPro: 2.067 ± 0.021	2.208ArgGln: 2.208 ± 0.025	3.482ArgArg: 3.482 ± 0.03	3.976ArgSer: 3.976 ± 0.034	2.549ArgThr: 2.549 ± 0.023	2.73ArgVal: 2.73 ± 0.026	0.556ArgTrp: 0.556 ± 0.012	1.663ArgTyr: 1.663 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	5.145SerAla: 5.145 ± 0.044	1.075SerCys: 1.075 ± 0.019	4.345SerAsp: 4.345 ± 0.038	4.865SerGlu: 4.865 ± 0.041	3.506SerPhe: 3.506 ± 0.03	5.034SerGly: 5.034 ± 0.062	1.968SerHis: 1.968 ± 0.023	4.664SerIle: 4.664 ± 0.038	5.645SerLys: 5.645 ± 0.042	8.332SerLeu: 8.332 ± 0.048	1.915SerMet: 1.915 ± 0.021	4.389SerAsn: 4.389 ± 0.039	4.028SerPro: 4.028 ± 0.042	3.81SerGln: 3.81 ± 0.032	4.17SerArg: 4.17 ± 0.035	10.34SerSer: 10.34 ± 0.289	5.373SerThr: 5.373 ± 0.087	4.976SerVal: 4.976 ± 0.065	0.909SerTrp: 0.909 ± 0.015	2.496SerTyr: 2.496 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	3.618ThrAla: 3.618 ± 0.03	0.691ThrCys: 0.691 ± 0.013	2.67ThrAsp: 2.67 ± 0.03	3.12ThrGlu: 3.12 ± 0.04	2.356ThrPhe: 2.356 ± 0.023	3.339ThrGly: 3.339 ± 0.043	1.172ThrHis: 1.172 ± 0.016	3.085ThrIle: 3.085 ± 0.028	3.434ThrLys: 3.434 ± 0.029	5.263ThrLeu: 5.263 ± 0.037	1.202ThrMet: 1.202 ± 0.015	2.693ThrAsn: 2.693 ± 0.031	3.078ThrPro: 3.078 ± 0.062	2.029ThrGln: 2.029 ± 0.022	2.527ThrArg: 2.527 ± 0.025	4.984ThrSer: 4.984 ± 0.062	3.562ThrThr: 3.562 ± 0.064	3.585ThrVal: 3.585 ± 0.032	0.593ThrTrp: 0.593 ± 0.021	1.61ThrTyr: 1.61 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.138ValAla: 4.138 ± 0.037	0.91ValCys: 0.91 ± 0.014	3.699ValAsp: 3.699 ± 0.031	4.107ValGlu: 4.107 ± 0.039	2.629ValPhe: 2.629 ± 0.028	3.39ValGly: 3.39 ± 0.034	1.356ValHis: 1.356 ± 0.018	3.442ValIle: 3.442 ± 0.028	3.88ValLys: 3.88 ± 0.033	5.94ValLeu: 5.94 ± 0.043	1.26ValMet: 1.26 ± 0.017	2.822ValAsn: 2.822 ± 0.026	3.155ValPro: 3.155 ± 0.051	2.336ValGln: 2.336 ± 0.024	2.847ValArg: 2.847 ± 0.025	5.024ValSer: 5.024 ± 0.033	3.495ValThr: 3.495 ± 0.054	4.214ValVal: 4.214 ± 0.041	0.667ValTrp: 0.667 ± 0.013	1.922ValTyr: 1.922 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.608TrpAla: 0.608 ± 0.013	0.246TrpCys: 0.246 ± 0.007	0.706TrpAsp: 0.706 ± 0.013	0.651TrpGlu: 0.651 ± 0.013	0.533TrpPhe: 0.533 ± 0.011	0.614TrpGly: 0.614 ± 0.013	0.252TrpHis: 0.252 ± 0.008	0.638TrpIle: 0.638 ± 0.014	0.825TrpLys: 0.825 ± 0.012	1.075TrpLeu: 1.075 ± 0.017	0.252TrpMet: 0.252 ± 0.008	0.601TrpAsn: 0.601 ± 0.011	0.353TrpPro: 0.353 ± 0.009	0.479TrpGln: 0.479 ± 0.011	0.62TrpArg: 0.62 ± 0.012	0.936TrpSer: 0.936 ± 0.018	0.54TrpThr: 0.54 ± 0.011	0.625TrpVal: 0.625 ± 0.018	0.173TrpTrp: 0.173 ± 0.006	0.413TrpTyr: 0.413 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.936TyrAla: 1.936 ± 0.024	0.582TyrCys: 0.582 ± 0.012	2.017TyrAsp: 2.017 ± 0.02	2.108TyrGlu: 2.108 ± 0.024	1.607TyrPhe: 1.607 ± 0.02	2.064TyrGly: 2.064 ± 0.022	0.873TyrHis: 0.873 ± 0.013	1.763TyrIle: 1.763 ± 0.023	2.001TyrLys: 2.001 ± 0.023	3.311TyrLeu: 3.311 ± 0.032	0.771TyrMet: 0.771 ± 0.013	1.659TyrAsn: 1.659 ± 0.019	1.33TyrPro: 1.33 ± 0.02	1.371TyrGln: 1.371 ± 0.019	1.607TyrArg: 1.607 ± 0.023	2.579TyrSer: 2.579 ± 0.035	1.704TyrThr: 1.704 ± 0.026	2.104TyrVal: 2.104 ± 0.031	0.402TyrTrp: 0.402 ± 0.011	1.345TyrTyr: 1.345 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9766 proteins (4869795 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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