Amino acid dipepetide frequency for Klebsiella phage K5-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.587AlaAla: 9.587 ± 1.158
0.645AlaCys: 0.645 ± 0.247
6.284AlaAsp: 6.284 ± 0.825
5.156AlaGlu: 5.156 ± 0.697
3.223AlaPhe: 3.223 ± 0.519
7.17AlaGly: 7.17 ± 1.089
1.209AlaHis: 1.209 ± 0.291
3.948AlaIle: 3.948 ± 0.441
6.204AlaLys: 6.204 ± 0.657
8.862AlaLeu: 8.862 ± 1.083
2.981AlaMet: 2.981 ± 0.579
4.109AlaAsn: 4.109 ± 0.528
2.981AlaPro: 2.981 ± 0.507
3.464AlaGln: 3.464 ± 0.645
5.156AlaArg: 5.156 ± 0.701
5.398AlaSer: 5.398 ± 0.597
3.787AlaThr: 3.787 ± 0.587
6.204AlaVal: 6.204 ± 0.733
1.289AlaTrp: 1.289 ± 0.312
3.464AlaTyr: 3.464 ± 0.465
0.0AlaXaa: 0.0 ± 0.0
Cys
0.564CysAla: 0.564 ± 0.235
0.161CysCys: 0.161 ± 0.129
0.564CysAsp: 0.564 ± 0.29
1.128CysGlu: 1.128 ± 0.362
0.403CysPhe: 0.403 ± 0.182
0.725CysGly: 0.725 ± 0.237
0.322CysHis: 0.322 ± 0.134
0.564CysIle: 0.564 ± 0.205
0.403CysLys: 0.403 ± 0.193
1.047CysLeu: 1.047 ± 0.362
0.0CysMet: 0.0 ± 0.0
0.242CysAsn: 0.242 ± 0.216
0.645CysPro: 0.645 ± 0.218
0.645CysGln: 0.645 ± 0.228
0.645CysArg: 0.645 ± 0.285
0.564CysSer: 0.564 ± 0.234
0.645CysThr: 0.645 ± 0.237
0.967CysVal: 0.967 ± 0.224
0.161CysTrp: 0.161 ± 0.103
0.403CysTyr: 0.403 ± 0.206
0.0CysXaa: 0.0 ± 0.0
Asp
5.479AspAla: 5.479 ± 0.658
0.564AspCys: 0.564 ± 0.247
4.753AspAsp: 4.753 ± 0.595
3.545AspGlu: 3.545 ± 0.576
2.9AspPhe: 2.9 ± 0.467
6.687AspGly: 6.687 ± 0.789
1.047AspHis: 1.047 ± 0.275
2.578AspIle: 2.578 ± 0.448
4.512AspLys: 4.512 ± 0.803
3.787AspLeu: 3.787 ± 0.621
2.175AspMet: 2.175 ± 0.451
2.498AspAsn: 2.498 ± 0.528
2.739AspPro: 2.739 ± 0.429
2.498AspGln: 2.498 ± 0.469
2.498AspArg: 2.498 ± 0.38
4.028AspSer: 4.028 ± 0.532
3.867AspThr: 3.867 ± 0.587
4.351AspVal: 4.351 ± 0.658
0.886AspTrp: 0.886 ± 0.303
1.934AspTyr: 1.934 ± 0.378
0.0AspXaa: 0.0 ± 0.0
Glu
7.896GluAla: 7.896 ± 0.865
0.564GluCys: 0.564 ± 0.26
4.27GluAsp: 4.27 ± 0.778
4.834GluGlu: 4.834 ± 0.9
2.578GluPhe: 2.578 ± 0.481
5.076GluGly: 5.076 ± 0.806
1.45GluHis: 1.45 ± 0.435
2.82GluIle: 2.82 ± 0.392
2.981GluLys: 2.981 ± 0.536
6.284GluLeu: 6.284 ± 0.793
1.37GluMet: 1.37 ± 0.485
1.853GluAsn: 1.853 ± 0.372
2.417GluPro: 2.417 ± 0.625
3.464GluGln: 3.464 ± 0.699
4.028GluArg: 4.028 ± 0.636
4.673GluSer: 4.673 ± 0.62
2.739GluThr: 2.739 ± 0.46
4.351GluVal: 4.351 ± 0.595
0.645GluTrp: 0.645 ± 0.208
2.981GluTyr: 2.981 ± 0.406
0.0GluXaa: 0.0 ± 0.0
Phe
2.417PheAla: 2.417 ± 0.429
0.322PheCys: 0.322 ± 0.167
2.82PheAsp: 2.82 ± 0.45
1.45PheGlu: 1.45 ± 0.36
0.806PhePhe: 0.806 ± 0.254
2.981PheGly: 2.981 ± 0.62
0.645PheHis: 0.645 ± 0.285
1.772PheIle: 1.772 ± 0.512
1.934PheLys: 1.934 ± 0.33
2.9PheLeu: 2.9 ± 0.497
0.967PheMet: 0.967 ± 0.227
2.256PheAsn: 2.256 ± 0.433
1.611PhePro: 1.611 ± 0.379
1.37PheGln: 1.37 ± 0.296
1.934PheArg: 1.934 ± 0.43
2.498PheSer: 2.498 ± 0.421
2.498PheThr: 2.498 ± 0.494
2.498PheVal: 2.498 ± 0.519
0.403PheTrp: 0.403 ± 0.157
0.967PheTyr: 0.967 ± 0.184
0.0PheXaa: 0.0 ± 0.0
Gly
7.734GlyAla: 7.734 ± 1.096
0.806GlyCys: 0.806 ± 0.311
5.72GlyAsp: 5.72 ± 0.61
5.559GlyGlu: 5.559 ± 0.675
3.062GlyPhe: 3.062 ± 0.458
6.365GlyGly: 6.365 ± 0.854
1.772GlyHis: 1.772 ± 0.435
4.673GlyIle: 4.673 ± 0.645
6.204GlyLys: 6.204 ± 0.711
6.526GlyLeu: 6.526 ± 0.75
1.531GlyMet: 1.531 ± 0.425
3.464GlyAsn: 3.464 ± 0.545
1.289GlyPro: 1.289 ± 0.311
2.9GlyGln: 2.9 ± 0.383
4.351GlyArg: 4.351 ± 0.35
5.559GlySer: 5.559 ± 0.649
4.834GlyThr: 4.834 ± 0.558
5.398GlyVal: 5.398 ± 0.755
1.531GlyTrp: 1.531 ± 0.415
3.142GlyTyr: 3.142 ± 0.458
0.0GlyXaa: 0.0 ± 0.0
His
1.531HisAla: 1.531 ± 0.3
0.564HisCys: 0.564 ± 0.181
1.45HisAsp: 1.45 ± 0.301
1.45HisGlu: 1.45 ± 0.385
0.645HisPhe: 0.645 ± 0.216
1.531HisGly: 1.531 ± 0.341
0.483HisHis: 0.483 ± 0.197
0.967HisIle: 0.967 ± 0.338
0.967HisLys: 0.967 ± 0.25
1.37HisLeu: 1.37 ± 0.376
0.483HisMet: 0.483 ± 0.181
0.403HisAsn: 0.403 ± 0.162
0.806HisPro: 0.806 ± 0.233
0.483HisGln: 0.483 ± 0.175
0.483HisArg: 0.483 ± 0.141
1.047HisSer: 1.047 ± 0.28
1.047HisThr: 1.047 ± 0.266
1.611HisVal: 1.611 ± 0.33
0.161HisTrp: 0.161 ± 0.093
1.128HisTyr: 1.128 ± 0.257
0.0HisXaa: 0.0 ± 0.0
Ile
3.787IleAla: 3.787 ± 0.418
0.725IleCys: 0.725 ± 0.206
3.303IleAsp: 3.303 ± 0.504
2.9IleGlu: 2.9 ± 0.446
0.806IlePhe: 0.806 ± 0.247
3.948IleGly: 3.948 ± 0.516
0.967IleHis: 0.967 ± 0.241
2.095IleIle: 2.095 ± 0.397
3.223IleLys: 3.223 ± 0.395
3.384IleLeu: 3.384 ± 0.482
0.967IleMet: 0.967 ± 0.307
2.659IleAsn: 2.659 ± 0.67
2.578IlePro: 2.578 ± 0.472
1.934IleGln: 1.934 ± 0.4
3.464IleArg: 3.464 ± 0.556
3.142IleSer: 3.142 ± 0.57
2.659IleThr: 2.659 ± 0.541
3.142IleVal: 3.142 ± 0.672
0.483IleTrp: 0.483 ± 0.192
1.45IleTyr: 1.45 ± 0.337
0.0IleXaa: 0.0 ± 0.0
Lys
7.332LysAla: 7.332 ± 1.131
0.564LysCys: 0.564 ± 0.22
3.464LysAsp: 3.464 ± 0.537
4.512LysGlu: 4.512 ± 0.65
2.498LysPhe: 2.498 ± 0.449
6.284LysGly: 6.284 ± 0.873
1.772LysHis: 1.772 ± 0.427
2.256LysIle: 2.256 ± 0.501
3.464LysLys: 3.464 ± 0.699
5.64LysLeu: 5.64 ± 0.748
2.014LysMet: 2.014 ± 0.399
2.498LysAsn: 2.498 ± 0.391
2.578LysPro: 2.578 ± 0.613
2.336LysGln: 2.336 ± 0.557
3.303LysArg: 3.303 ± 0.615
2.9LysSer: 2.9 ± 0.552
2.9LysThr: 2.9 ± 0.447
4.915LysVal: 4.915 ± 0.638
0.806LysTrp: 0.806 ± 0.317
1.772LysTyr: 1.772 ± 0.362
0.0LysXaa: 0.0 ± 0.0
Leu
8.057LeuAla: 8.057 ± 1.133
0.564LeuCys: 0.564 ± 0.234
4.753LeuAsp: 4.753 ± 0.562
6.848LeuGlu: 6.848 ± 0.932
2.578LeuPhe: 2.578 ± 0.414
5.559LeuGly: 5.559 ± 0.619
1.128LeuHis: 1.128 ± 0.298
3.464LeuIle: 3.464 ± 0.458
6.445LeuLys: 6.445 ± 0.734
6.123LeuLeu: 6.123 ± 0.742
2.336LeuMet: 2.336 ± 0.315
4.028LeuAsn: 4.028 ± 0.53
3.142LeuPro: 3.142 ± 0.451
3.142LeuGln: 3.142 ± 0.562
5.398LeuArg: 5.398 ± 0.604
5.479LeuSer: 5.479 ± 0.712
4.753LeuThr: 4.753 ± 0.684
4.351LeuVal: 4.351 ± 0.62
1.289LeuTrp: 1.289 ± 0.363
2.739LeuTyr: 2.739 ± 0.449
0.0LeuXaa: 0.0 ± 0.0
Met
3.303MetAla: 3.303 ± 0.425
0.161MetCys: 0.161 ± 0.117
1.611MetAsp: 1.611 ± 0.349
1.209MetGlu: 1.209 ± 0.291
0.886MetPhe: 0.886 ± 0.248
1.611MetGly: 1.611 ± 0.285
0.483MetHis: 0.483 ± 0.217
1.128MetIle: 1.128 ± 0.29
1.289MetLys: 1.289 ± 0.272
2.578MetLeu: 2.578 ± 0.448
0.645MetMet: 0.645 ± 0.219
0.806MetAsn: 0.806 ± 0.211
0.806MetPro: 0.806 ± 0.224
2.175MetGln: 2.175 ± 0.395
1.047MetArg: 1.047 ± 0.264
1.45MetSer: 1.45 ± 0.364
2.417MetThr: 2.417 ± 0.422
1.37MetVal: 1.37 ± 0.382
0.0MetTrp: 0.0 ± 0.0
0.564MetTyr: 0.564 ± 0.178
0.0MetXaa: 0.0 ± 0.0
Asn
3.948AsnAla: 3.948 ± 0.678
0.967AsnCys: 0.967 ± 0.257
2.095AsnAsp: 2.095 ± 0.385
2.417AsnGlu: 2.417 ± 0.439
1.289AsnPhe: 1.289 ± 0.331
4.673AsnGly: 4.673 ± 0.758
0.564AsnHis: 0.564 ± 0.181
2.9AsnIle: 2.9 ± 0.545
2.014AsnLys: 2.014 ± 0.378
3.223AsnLeu: 3.223 ± 0.453
0.886AsnMet: 0.886 ± 0.309
1.45AsnAsn: 1.45 ± 0.261
1.934AsnPro: 1.934 ± 0.366
1.37AsnGln: 1.37 ± 0.231
1.934AsnArg: 1.934 ± 0.512
2.578AsnSer: 2.578 ± 0.436
2.417AsnThr: 2.417 ± 0.432
2.659AsnVal: 2.659 ± 0.469
0.645AsnTrp: 0.645 ± 0.2
2.175AsnTyr: 2.175 ± 0.359
0.0AsnXaa: 0.0 ± 0.0
Pro
3.464ProAla: 3.464 ± 0.576
0.564ProCys: 0.564 ± 0.214
2.014ProAsp: 2.014 ± 0.393
3.867ProGlu: 3.867 ± 0.641
1.531ProPhe: 1.531 ± 0.274
2.336ProGly: 2.336 ± 0.382
0.564ProHis: 0.564 ± 0.198
0.967ProIle: 0.967 ± 0.304
2.498ProLys: 2.498 ± 0.399
2.9ProLeu: 2.9 ± 0.386
0.645ProMet: 0.645 ± 0.268
2.014ProAsn: 2.014 ± 0.383
0.967ProPro: 0.967 ± 0.305
1.209ProGln: 1.209 ± 0.282
1.853ProArg: 1.853 ± 0.373
2.336ProSer: 2.336 ± 0.427
1.934ProThr: 1.934 ± 0.38
2.82ProVal: 2.82 ± 0.322
0.725ProTrp: 0.725 ± 0.208
1.692ProTyr: 1.692 ± 0.37
0.0ProXaa: 0.0 ± 0.0
Gln
3.545GlnAla: 3.545 ± 0.679
0.242GlnCys: 0.242 ± 0.129
2.578GlnAsp: 2.578 ± 0.307
3.142GlnGlu: 3.142 ± 0.422
1.692GlnPhe: 1.692 ± 0.284
2.578GlnGly: 2.578 ± 0.414
0.403GlnHis: 0.403 ± 0.209
1.692GlnIle: 1.692 ± 0.321
2.739GlnLys: 2.739 ± 0.515
3.948GlnLeu: 3.948 ± 0.465
1.531GlnMet: 1.531 ± 0.506
1.289GlnAsn: 1.289 ± 0.305
1.853GlnPro: 1.853 ± 0.216
3.142GlnGln: 3.142 ± 0.598
2.175GlnArg: 2.175 ± 0.632
2.336GlnSer: 2.336 ± 0.354
1.772GlnThr: 1.772 ± 0.408
2.739GlnVal: 2.739 ± 0.418
0.806GlnTrp: 0.806 ± 0.216
2.095GlnTyr: 2.095 ± 0.498
0.0GlnXaa: 0.0 ± 0.0
Arg
5.156ArgAla: 5.156 ± 0.709
0.564ArgCys: 0.564 ± 0.205
3.142ArgAsp: 3.142 ± 0.461
4.028ArgGlu: 4.028 ± 0.573
1.611ArgPhe: 1.611 ± 0.338
4.189ArgGly: 4.189 ± 0.58
0.886ArgHis: 0.886 ± 0.253
3.384ArgIle: 3.384 ± 0.555
3.384ArgLys: 3.384 ± 0.552
4.351ArgLeu: 4.351 ± 0.675
1.289ArgMet: 1.289 ± 0.307
2.417ArgAsn: 2.417 ± 0.386
2.014ArgPro: 2.014 ± 0.266
2.82ArgGln: 2.82 ± 0.447
3.062ArgArg: 3.062 ± 0.372
3.867ArgSer: 3.867 ± 0.423
2.9ArgThr: 2.9 ± 0.407
3.303ArgVal: 3.303 ± 0.451
1.128ArgTrp: 1.128 ± 0.315
0.967ArgTyr: 0.967 ± 0.185
0.0ArgXaa: 0.0 ± 0.0
Ser
4.834SerAla: 4.834 ± 0.644
0.564SerCys: 0.564 ± 0.202
4.431SerAsp: 4.431 ± 0.589
4.109SerGlu: 4.109 ± 0.569
3.142SerPhe: 3.142 ± 0.504
5.962SerGly: 5.962 ± 0.854
1.531SerHis: 1.531 ± 0.35
2.336SerIle: 2.336 ± 0.439
4.189SerLys: 4.189 ± 0.484
4.673SerLeu: 4.673 ± 0.689
1.289SerMet: 1.289 ± 0.358
2.175SerAsn: 2.175 ± 0.479
2.175SerPro: 2.175 ± 0.473
2.9SerGln: 2.9 ± 0.404
3.062SerArg: 3.062 ± 0.5
3.867SerSer: 3.867 ± 0.824
4.028SerThr: 4.028 ± 0.651
4.431SerVal: 4.431 ± 0.577
0.725SerTrp: 0.725 ± 0.229
2.417SerTyr: 2.417 ± 0.457
0.0SerXaa: 0.0 ± 0.0
Thr
4.431ThrAla: 4.431 ± 0.703
0.886ThrCys: 0.886 ± 0.301
2.981ThrAsp: 2.981 ± 0.413
3.062ThrGlu: 3.062 ± 0.478
1.853ThrPhe: 1.853 ± 0.523
4.995ThrGly: 4.995 ± 0.534
1.128ThrHis: 1.128 ± 0.19
4.351ThrIle: 4.351 ± 0.779
4.27ThrLys: 4.27 ± 0.609
5.72ThrLeu: 5.72 ± 0.73
1.37ThrMet: 1.37 ± 0.255
1.934ThrAsn: 1.934 ± 0.509
2.659ThrPro: 2.659 ± 0.422
2.256ThrGln: 2.256 ± 0.436
2.336ThrArg: 2.336 ± 0.347
3.626ThrSer: 3.626 ± 0.668
3.142ThrThr: 3.142 ± 0.772
3.706ThrVal: 3.706 ± 0.612
0.886ThrTrp: 0.886 ± 0.248
1.128ThrTyr: 1.128 ± 0.209
0.0ThrXaa: 0.0 ± 0.0
Val
5.156ValAla: 5.156 ± 0.562
0.564ValCys: 0.564 ± 0.194
3.867ValAsp: 3.867 ± 0.648
4.351ValGlu: 4.351 ± 0.621
2.095ValPhe: 2.095 ± 0.472
5.881ValGly: 5.881 ± 0.819
1.128ValHis: 1.128 ± 0.298
3.545ValIle: 3.545 ± 0.542
3.787ValLys: 3.787 ± 0.598
5.156ValLeu: 5.156 ± 0.776
1.37ValMet: 1.37 ± 0.328
3.464ValAsn: 3.464 ± 0.621
2.498ValPro: 2.498 ± 0.454
2.175ValGln: 2.175 ± 0.324
3.787ValArg: 3.787 ± 0.592
4.673ValSer: 4.673 ± 0.834
5.559ValThr: 5.559 ± 0.689
4.915ValVal: 4.915 ± 0.697
0.725ValTrp: 0.725 ± 0.308
2.9ValTyr: 2.9 ± 0.598
0.0ValXaa: 0.0 ± 0.0
Trp
0.403TrpAla: 0.403 ± 0.185
0.483TrpCys: 0.483 ± 0.197
0.645TrpAsp: 0.645 ± 0.201
1.209TrpGlu: 1.209 ± 0.281
0.322TrpPhe: 0.322 ± 0.186
0.564TrpGly: 0.564 ± 0.229
0.322TrpHis: 0.322 ± 0.24
0.564TrpIle: 0.564 ± 0.234
1.45TrpLys: 1.45 ± 0.286
1.531TrpLeu: 1.531 ± 0.315
0.403TrpMet: 0.403 ± 0.17
0.725TrpAsn: 0.725 ± 0.213
0.242TrpPro: 0.242 ± 0.137
0.645TrpGln: 0.645 ± 0.21
1.128TrpArg: 1.128 ± 0.204
1.128TrpSer: 1.128 ± 0.38
0.645TrpThr: 0.645 ± 0.247
1.289TrpVal: 1.289 ± 0.358
0.483TrpTrp: 0.483 ± 0.175
0.081TrpTyr: 0.081 ± 0.074
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.498TyrAla: 2.498 ± 0.446
0.322TyrCys: 0.322 ± 0.158
2.578TyrAsp: 2.578 ± 0.5
2.498TyrGlu: 2.498 ± 0.474
1.128TyrPhe: 1.128 ± 0.242
3.303TyrGly: 3.303 ± 0.387
0.806TyrHis: 0.806 ± 0.382
1.611TyrIle: 1.611 ± 0.389
1.853TyrLys: 1.853 ± 0.299
2.256TyrLeu: 2.256 ± 0.342
1.209TyrMet: 1.209 ± 0.251
1.853TyrAsn: 1.853 ± 0.428
0.967TyrPro: 0.967 ± 0.284
1.37TyrGln: 1.37 ± 0.362
2.82TyrArg: 2.82 ± 0.451
1.692TyrSer: 1.692 ± 0.337
2.175TyrThr: 2.175 ± 0.494
2.578TyrVal: 2.578 ± 0.482
0.483TyrTrp: 0.483 ± 0.199
1.047TyrTyr: 1.047 ± 0.34
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 42 proteins (12413 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski