Amino acid dipepetide frequency for Alloprevotella sp. E39

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.538AlaAla: 6.538 ± 0.119
0.927AlaCys: 0.927 ± 0.036
4.578AlaAsp: 4.578 ± 0.08
5.148AlaGlu: 5.148 ± 0.102
3.324AlaPhe: 3.324 ± 0.083
5.104AlaGly: 5.104 ± 0.093
1.35AlaHis: 1.35 ± 0.045
4.771AlaIle: 4.771 ± 0.08
4.362AlaLys: 4.362 ± 0.091
6.911AlaLeu: 6.911 ± 0.102
1.987AlaMet: 1.987 ± 0.059
3.565AlaAsn: 3.565 ± 0.084
2.443AlaPro: 2.443 ± 0.058
3.005AlaGln: 3.005 ± 0.08
3.305AlaArg: 3.305 ± 0.073
4.251AlaSer: 4.251 ± 0.082
4.491AlaThr: 4.491 ± 0.093
4.974AlaVal: 4.974 ± 0.083
0.81AlaTrp: 0.81 ± 0.033
3.066AlaTyr: 3.066 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.858CysAla: 0.858 ± 0.033
0.237CysCys: 0.237 ± 0.016
0.778CysAsp: 0.778 ± 0.032
0.778CysGlu: 0.778 ± 0.032
0.563CysPhe: 0.563 ± 0.024
1.107CysGly: 1.107 ± 0.04
0.325CysHis: 0.325 ± 0.021
0.867CysIle: 0.867 ± 0.033
0.751CysLys: 0.751 ± 0.033
1.08CysLeu: 1.08 ± 0.036
0.279CysMet: 0.279 ± 0.019
0.719CysAsn: 0.719 ± 0.034
0.585CysPro: 0.585 ± 0.029
0.364CysGln: 0.364 ± 0.019
0.659CysArg: 0.659 ± 0.025
0.866CysSer: 0.866 ± 0.044
0.817CysThr: 0.817 ± 0.032
0.813CysVal: 0.813 ± 0.034
0.138CysTrp: 0.138 ± 0.012
0.654CysTyr: 0.654 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
4.684AspAla: 4.684 ± 0.083
0.814AspCys: 0.814 ± 0.033
3.352AspAsp: 3.352 ± 0.077
4.185AspGlu: 4.185 ± 0.076
3.029AspPhe: 3.029 ± 0.07
4.651AspGly: 4.651 ± 0.101
0.963AspHis: 0.963 ± 0.034
4.339AspIle: 4.339 ± 0.078
3.436AspLys: 3.436 ± 0.066
4.476AspLeu: 4.476 ± 0.078
1.514AspMet: 1.514 ± 0.039
3.178AspAsn: 3.178 ± 0.065
1.777AspPro: 1.777 ± 0.051
1.221AspGln: 1.221 ± 0.039
2.462AspArg: 2.462 ± 0.053
3.188AspSer: 3.188 ± 0.074
3.066AspThr: 3.066 ± 0.07
3.993AspVal: 3.993 ± 0.071
0.787AspTrp: 0.787 ± 0.035
3.02AspTyr: 3.02 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
4.77GluAla: 4.77 ± 0.101
0.647GluCys: 0.647 ± 0.031
3.485GluAsp: 3.485 ± 0.068
5.075GluGlu: 5.075 ± 0.103
2.286GluPhe: 2.286 ± 0.059
4.465GluGly: 4.465 ± 0.07
1.271GluHis: 1.271 ± 0.041
4.25GluIle: 4.25 ± 0.088
4.948GluLys: 4.948 ± 0.092
5.495GluLeu: 5.495 ± 0.09
1.986GluMet: 1.986 ± 0.045
3.538GluAsn: 3.538 ± 0.06
1.808GluPro: 1.808 ± 0.057
2.677GluGln: 2.677 ± 0.066
3.509GluArg: 3.509 ± 0.087
3.088GluSer: 3.088 ± 0.056
3.561GluThr: 3.561 ± 0.066
4.097GluVal: 4.097 ± 0.085
0.868GluTrp: 0.868 ± 0.034
2.456GluTyr: 2.456 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.013PheAla: 3.013 ± 0.075
0.748PheCys: 0.748 ± 0.03
2.795PheAsp: 2.795 ± 0.061
2.536PheGlu: 2.536 ± 0.064
2.166PhePhe: 2.166 ± 0.054
3.109PheGly: 3.109 ± 0.06
0.822PheHis: 0.822 ± 0.035
2.927PheIle: 2.927 ± 0.071
2.305PheLys: 2.305 ± 0.05
3.637PheLeu: 3.637 ± 0.076
1.147PheMet: 1.147 ± 0.039
2.289PheAsn: 2.289 ± 0.059
1.532PhePro: 1.532 ± 0.049
1.234PheGln: 1.234 ± 0.038
2.143PheArg: 2.143 ± 0.054
3.305PheSer: 3.305 ± 0.079
2.579PheThr: 2.579 ± 0.069
2.862PheVal: 2.862 ± 0.068
0.543PheTrp: 0.543 ± 0.026
1.826PheTyr: 1.826 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.754GlyAla: 4.754 ± 0.095
1.05GlyCys: 1.05 ± 0.049
3.857GlyAsp: 3.857 ± 0.071
4.296GlyGlu: 4.296 ± 0.069
3.013GlyPhe: 3.013 ± 0.068
5.031GlyGly: 5.031 ± 0.114
1.348GlyHis: 1.348 ± 0.039
5.007GlyIle: 5.007 ± 0.089
5.04GlyLys: 5.04 ± 0.07
5.507GlyLeu: 5.507 ± 0.104
1.963GlyMet: 1.963 ± 0.054
3.893GlyAsn: 3.893 ± 0.089
1.341GlyPro: 1.341 ± 0.041
2.181GlyGln: 2.181 ± 0.054
3.168GlyArg: 3.168 ± 0.06
4.291GlySer: 4.291 ± 0.095
4.86GlyThr: 4.86 ± 0.093
4.659GlyVal: 4.659 ± 0.097
1.003GlyTrp: 1.003 ± 0.039
3.271GlyTyr: 3.271 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.319HisAla: 1.319 ± 0.035
0.322HisCys: 0.322 ± 0.018
1.087HisAsp: 1.087 ± 0.04
1.086HisGlu: 1.086 ± 0.039
1.106HisPhe: 1.106 ± 0.036
1.336HisGly: 1.336 ± 0.046
0.514HisHis: 0.514 ± 0.026
1.442HisIle: 1.442 ± 0.041
1.023HisLys: 1.023 ± 0.034
1.863HisLeu: 1.863 ± 0.055
0.309HisMet: 0.309 ± 0.018
0.947HisAsn: 0.947 ± 0.027
0.967HisPro: 0.967 ± 0.037
0.618HisGln: 0.618 ± 0.028
1.002HisArg: 1.002 ± 0.037
1.136HisSer: 1.136 ± 0.037
1.047HisThr: 1.047 ± 0.039
1.12HisVal: 1.12 ± 0.045
0.282HisTrp: 0.282 ± 0.02
0.956HisTyr: 0.956 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.052IleAla: 5.052 ± 0.09
0.99IleCys: 0.99 ± 0.036
4.469IleAsp: 4.469 ± 0.068
4.323IleGlu: 4.323 ± 0.077
2.718IlePhe: 2.718 ± 0.065
4.524IleGly: 4.524 ± 0.1
1.22IleHis: 1.22 ± 0.038
4.493IleIle: 4.493 ± 0.092
3.794IleLys: 3.794 ± 0.077
5.18IleLeu: 5.18 ± 0.097
1.448IleMet: 1.448 ± 0.051
3.447IleAsn: 3.447 ± 0.08
2.932IlePro: 2.932 ± 0.075
1.899IleGln: 1.899 ± 0.05
3.141IleArg: 3.141 ± 0.068
4.535IleSer: 4.535 ± 0.084
3.934IleThr: 3.934 ± 0.069
4.703IleVal: 4.703 ± 0.086
0.664IleTrp: 0.664 ± 0.029
2.678IleTyr: 2.678 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.831LysAla: 4.831 ± 0.103
0.562LysCys: 0.562 ± 0.026
3.671LysAsp: 3.671 ± 0.082
4.695LysGlu: 4.695 ± 0.097
2.15LysPhe: 2.15 ± 0.05
4.275LysGly: 4.275 ± 0.079
1.182LysHis: 1.182 ± 0.033
3.866LysIle: 3.866 ± 0.083
4.92LysLys: 4.92 ± 0.091
4.672LysLeu: 4.672 ± 0.09
2.062LysMet: 2.062 ± 0.052
3.422LysAsn: 3.422 ± 0.065
2.335LysPro: 2.335 ± 0.064
2.349LysGln: 2.349 ± 0.063
3.194LysArg: 3.194 ± 0.068
3.519LysSer: 3.519 ± 0.062
3.768LysThr: 3.768 ± 0.058
4.05LysVal: 4.05 ± 0.075
0.8LysTrp: 0.8 ± 0.036
2.821LysTyr: 2.821 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
6.139LeuAla: 6.139 ± 0.097
1.35LeuCys: 1.35 ± 0.04
4.578LeuAsp: 4.578 ± 0.079
4.666LeuGlu: 4.666 ± 0.1
3.83LeuPhe: 3.83 ± 0.076
5.343LeuGly: 5.343 ± 0.091
1.905LeuHis: 1.905 ± 0.054
4.984LeuIle: 4.984 ± 0.105
5.545LeuLys: 5.545 ± 0.082
8.037LeuLeu: 8.037 ± 0.136
2.354LeuMet: 2.354 ± 0.056
4.379LeuAsn: 4.379 ± 0.077
4.055LeuPro: 4.055 ± 0.079
3.27LeuGln: 3.27 ± 0.063
4.627LeuArg: 4.627 ± 0.093
6.204LeuSer: 6.204 ± 0.084
5.451LeuThr: 5.451 ± 0.103
4.913LeuVal: 4.913 ± 0.085
0.982LeuTrp: 0.982 ± 0.045
3.28LeuTyr: 3.28 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.254MetAla: 2.254 ± 0.056
0.261MetCys: 0.261 ± 0.018
1.276MetAsp: 1.276 ± 0.041
1.531MetGlu: 1.531 ± 0.047
0.899MetPhe: 0.899 ± 0.031
1.623MetGly: 1.623 ± 0.047
0.524MetHis: 0.524 ± 0.026
1.348MetIle: 1.348 ± 0.048
2.332MetLys: 2.332 ± 0.051
2.443MetLeu: 2.443 ± 0.055
0.833MetMet: 0.833 ± 0.039
1.417MetAsn: 1.417 ± 0.042
1.258MetPro: 1.258 ± 0.044
1.12MetGln: 1.12 ± 0.036
1.388MetArg: 1.388 ± 0.04
1.651MetSer: 1.651 ± 0.049
1.677MetThr: 1.677 ± 0.045
1.508MetVal: 1.508 ± 0.041
0.243MetTrp: 0.243 ± 0.016
0.781MetTyr: 0.781 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
4.105AsnAla: 4.105 ± 0.076
0.652AsnCys: 0.652 ± 0.03
3.055AsnAsp: 3.055 ± 0.071
2.96AsnGlu: 2.96 ± 0.062
2.294AsnPhe: 2.294 ± 0.05
4.369AsnGly: 4.369 ± 0.113
0.993AsnHis: 0.993 ± 0.041
3.746AsnIle: 3.746 ± 0.07
3.052AsnLys: 3.052 ± 0.072
4.267AsnLeu: 4.267 ± 0.078
1.203AsnMet: 1.203 ± 0.04
3.061AsnAsn: 3.061 ± 0.084
2.326AsnPro: 2.326 ± 0.053
1.46AsnGln: 1.46 ± 0.047
2.375AsnArg: 2.375 ± 0.058
3.219AsnSer: 3.219 ± 0.077
3.055AsnThr: 3.055 ± 0.08
3.649AsnVal: 3.649 ± 0.071
0.666AsnTrp: 0.666 ± 0.031
2.631AsnTyr: 2.631 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
2.966ProAla: 2.966 ± 0.066
0.415ProCys: 0.415 ± 0.026
2.464ProAsp: 2.464 ± 0.049
3.247ProGlu: 3.247 ± 0.077
1.716ProPhe: 1.716 ± 0.046
2.093ProGly: 2.093 ± 0.054
0.652ProHis: 0.652 ± 0.028
2.283ProIle: 2.283 ± 0.05
2.133ProLys: 2.133 ± 0.05
3.083ProLeu: 3.083 ± 0.056
0.908ProMet: 0.908 ± 0.037
2.007ProAsn: 2.007 ± 0.073
0.947ProPro: 0.947 ± 0.04
1.503ProGln: 1.503 ± 0.047
1.325ProArg: 1.325 ± 0.048
2.319ProSer: 2.319 ± 0.067
2.217ProThr: 2.217 ± 0.061
2.632ProVal: 2.632 ± 0.062
0.424ProTrp: 0.424 ± 0.024
1.627ProTyr: 1.627 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.364GlnAla: 2.364 ± 0.052
0.34GlnCys: 0.34 ± 0.02
1.602GlnAsp: 1.602 ± 0.043
2.126GlnGlu: 2.126 ± 0.061
1.26GlnPhe: 1.26 ± 0.037
2.163GlnGly: 2.163 ± 0.069
0.739GlnHis: 0.739 ± 0.031
2.227GlnIle: 2.227 ± 0.054
2.333GlnLys: 2.333 ± 0.056
3.135GlnLeu: 3.135 ± 0.073
1.099GlnMet: 1.099 ± 0.036
1.843GlnAsn: 1.843 ± 0.046
1.354GlnPro: 1.354 ± 0.05
1.681GlnGln: 1.681 ± 0.06
1.996GlnArg: 1.996 ± 0.046
1.969GlnSer: 1.969 ± 0.048
2.173GlnThr: 2.173 ± 0.048
1.948GlnVal: 1.948 ± 0.045
0.463GlnTrp: 0.463 ± 0.023
1.412GlnTyr: 1.412 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.916ArgAla: 2.916 ± 0.067
0.572ArgCys: 0.572 ± 0.025
2.358ArgAsp: 2.358 ± 0.058
3.123ArgGlu: 3.123 ± 0.073
2.179ArgPhe: 2.179 ± 0.055
2.789ArgGly: 2.789 ± 0.057
1.139ArgHis: 1.139 ± 0.038
3.509ArgIle: 3.509 ± 0.069
3.374ArgLys: 3.374 ± 0.08
4.766ArgLeu: 4.766 ± 0.083
1.4ArgMet: 1.4 ± 0.038
2.665ArgAsn: 2.665 ± 0.066
1.703ArgPro: 1.703 ± 0.055
2.12ArgGln: 2.12 ± 0.058
2.639ArgArg: 2.639 ± 0.062
2.551ArgSer: 2.551 ± 0.058
2.706ArgThr: 2.706 ± 0.064
2.803ArgVal: 2.803 ± 0.057
0.623ArgTrp: 0.623 ± 0.027
2.158ArgTyr: 2.158 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.77SerAla: 4.77 ± 0.092
0.84SerCys: 0.84 ± 0.031
3.618SerAsp: 3.618 ± 0.071
3.677SerGlu: 3.677 ± 0.064
2.797SerPhe: 2.797 ± 0.063
5.029SerGly: 5.029 ± 0.096
1.156SerHis: 1.156 ± 0.036
4.121SerIle: 4.121 ± 0.11
3.482SerLys: 3.482 ± 0.068
5.564SerLeu: 5.564 ± 0.088
1.442SerMet: 1.442 ± 0.049
3.134SerAsn: 3.134 ± 0.072
2.199SerPro: 2.199 ± 0.053
2.026SerGln: 2.026 ± 0.055
2.753SerArg: 2.753 ± 0.067
4.134SerSer: 4.134 ± 0.099
3.762SerThr: 3.762 ± 0.09
4.38SerVal: 4.38 ± 0.104
0.745SerTrp: 0.745 ± 0.034
2.525SerTyr: 2.525 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
4.731ThrAla: 4.731 ± 0.092
0.621ThrCys: 0.621 ± 0.026
3.774ThrAsp: 3.774 ± 0.081
3.533ThrGlu: 3.533 ± 0.073
2.86ThrPhe: 2.86 ± 0.062
4.456ThrGly: 4.456 ± 0.083
1.083ThrHis: 1.083 ± 0.038
4.379ThrIle: 4.379 ± 0.086
3.087ThrLys: 3.087 ± 0.061
5.591ThrLeu: 5.591 ± 0.086
1.363ThrMet: 1.363 ± 0.041
2.805ThrAsn: 2.805 ± 0.073
2.888ThrPro: 2.888 ± 0.067
1.748ThrGln: 1.748 ± 0.046
2.384ThrArg: 2.384 ± 0.049
3.937ThrSer: 3.937 ± 0.121
4.102ThrThr: 4.102 ± 0.098
3.867ThrVal: 3.867 ± 0.084
0.683ThrTrp: 0.683 ± 0.035
2.696ThrTyr: 2.696 ± 0.066
0.0ThrXaa: 0.0 ± 0.0
Val
4.985ValAla: 4.985 ± 0.087
1.041ValCys: 1.041 ± 0.035
3.721ValAsp: 3.721 ± 0.072
4.108ValGlu: 4.108 ± 0.067
2.857ValPhe: 2.857 ± 0.058
4.282ValGly: 4.282 ± 0.086
1.112ValHis: 1.112 ± 0.04
4.087ValIle: 4.087 ± 0.081
4.059ValLys: 4.059 ± 0.068
5.449ValLeu: 5.449 ± 0.092
1.699ValMet: 1.699 ± 0.047
3.428ValAsn: 3.428 ± 0.066
2.629ValPro: 2.629 ± 0.058
1.852ValGln: 1.852 ± 0.052
3.237ValArg: 3.237 ± 0.063
4.583ValSer: 4.583 ± 0.073
3.95ValThr: 3.95 ± 0.113
4.612ValVal: 4.612 ± 0.092
0.709ValTrp: 0.709 ± 0.035
2.53ValTyr: 2.53 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.755TrpAla: 0.755 ± 0.031
0.21TrpCys: 0.21 ± 0.014
0.665TrpAsp: 0.665 ± 0.031
0.673TrpGlu: 0.673 ± 0.026
0.49TrpPhe: 0.49 ± 0.025
0.817TrpGly: 0.817 ± 0.04
0.344TrpHis: 0.344 ± 0.021
0.686TrpIle: 0.686 ± 0.029
0.822TrpLys: 0.822 ± 0.033
1.146TrpLeu: 1.146 ± 0.04
0.403TrpMet: 0.403 ± 0.023
0.775TrpAsn: 0.775 ± 0.034
0.285TrpPro: 0.285 ± 0.018
0.597TrpGln: 0.597 ± 0.026
0.607TrpArg: 0.607 ± 0.03
0.665TrpSer: 0.665 ± 0.027
0.773TrpThr: 0.773 ± 0.033
0.667TrpVal: 0.667 ± 0.032
0.178TrpTrp: 0.178 ± 0.016
0.561TrpTyr: 0.561 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.109TyrAla: 3.109 ± 0.073
0.639TyrCys: 0.639 ± 0.027
2.951TyrAsp: 2.951 ± 0.067
2.511TyrGlu: 2.511 ± 0.058
1.981TyrPhe: 1.981 ± 0.056
2.968TyrGly: 2.968 ± 0.064
0.839TyrHis: 0.839 ± 0.035
2.81TyrIle: 2.81 ± 0.056
2.348TyrLys: 2.348 ± 0.055
3.591TyrLeu: 3.591 ± 0.063
0.969TyrMet: 0.969 ± 0.037
2.625TyrAsn: 2.625 ± 0.074
1.597TyrPro: 1.597 ± 0.046
1.302TyrGln: 1.302 ± 0.037
2.179TyrArg: 2.179 ± 0.058
2.744TyrSer: 2.744 ± 0.065
2.598TyrThr: 2.598 ± 0.07
2.68TyrVal: 2.68 ± 0.06
0.508TyrTrp: 0.508 ± 0.024
2.188TyrTyr: 2.188 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2261 proteins (846569 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski