Amino acid dipepetide frequency for Permianibacter aggregans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.488AlaAla: 10.488 ± 0.138	1.101AlaCys: 1.101 ± 0.037	5.542AlaAsp: 5.542 ± 0.07	7.309AlaGlu: 7.309 ± 0.097	3.755AlaPhe: 3.755 ± 0.06	7.339AlaGly: 7.339 ± 0.094	2.118AlaHis: 2.118 ± 0.038	5.764AlaIle: 5.764 ± 0.073	4.291AlaLys: 4.291 ± 0.068	12.41AlaLeu: 12.41 ± 0.147	3.028AlaMet: 3.028 ± 0.057	3.53AlaAsn: 3.53 ± 0.075	4.046AlaPro: 4.046 ± 0.067	4.39AlaGln: 4.39 ± 0.063	5.708AlaArg: 5.708 ± 0.081	5.85AlaSer: 5.85 ± 0.07	4.894AlaThr: 4.894 ± 0.074	7.184AlaVal: 7.184 ± 0.08	1.392AlaTrp: 1.392 ± 0.033	2.499AlaTyr: 2.499 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.96CysAla: 0.96 ± 0.029	0.144CysCys: 0.144 ± 0.011	0.518CysAsp: 0.518 ± 0.02	0.498CysGlu: 0.498 ± 0.019	0.343CysPhe: 0.343 ± 0.014	0.882CysGly: 0.882 ± 0.033	0.344CysHis: 0.344 ± 0.021	0.396CysIle: 0.396 ± 0.02	0.298CysLys: 0.298 ± 0.017	0.93CysLeu: 0.93 ± 0.03	0.161CysMet: 0.161 ± 0.011	0.299CysAsn: 0.299 ± 0.016	0.44CysPro: 0.44 ± 0.022	0.477CysGln: 0.477 ± 0.02	0.566CysArg: 0.566 ± 0.021	0.578CysSer: 0.578 ± 0.022	0.463CysThr: 0.463 ± 0.018	0.605CysVal: 0.605 ± 0.024	0.165CysTrp: 0.165 ± 0.013	0.256CysTyr: 0.256 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.508AspAla: 5.508 ± 0.071	0.513AspCys: 0.513 ± 0.02	3.058AspAsp: 3.058 ± 0.063	3.673AspGlu: 3.673 ± 0.074	2.065AspPhe: 2.065 ± 0.045	4.267AspGly: 4.267 ± 0.085	1.137AspHis: 1.137 ± 0.033	3.199AspIle: 3.199 ± 0.047	2.332AspLys: 2.332 ± 0.046	5.049AspLeu: 5.049 ± 0.067	1.223AspMet: 1.223 ± 0.034	1.991AspAsn: 1.991 ± 0.041	2.318AspPro: 2.318 ± 0.047	2.19AspGln: 2.19 ± 0.044	2.966AspArg: 2.966 ± 0.054	2.96AspSer: 2.96 ± 0.057	2.441AspThr: 2.441 ± 0.052	3.743AspVal: 3.743 ± 0.054	1.081AspTrp: 1.081 ± 0.035	1.762AspTyr: 1.762 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.989GluAla: 5.989 ± 0.082	0.433GluCys: 0.433 ± 0.021	2.3GluAsp: 2.3 ± 0.054	2.975GluGlu: 2.975 ± 0.065	2.316GluPhe: 2.316 ± 0.043	3.389GluGly: 3.389 ± 0.063	1.729GluHis: 1.729 ± 0.042	3.086GluIle: 3.086 ± 0.054	3.204GluLys: 3.204 ± 0.062	6.983GluLeu: 6.983 ± 0.075	1.492GluMet: 1.492 ± 0.041	2.112GluAsn: 2.112 ± 0.045	2.628GluPro: 2.628 ± 0.047	4.705GluGln: 4.705 ± 0.07	4.642GluArg: 4.642 ± 0.076	3.376GluSer: 3.376 ± 0.054	3.181GluThr: 3.181 ± 0.052	3.89GluVal: 3.89 ± 0.064	0.878GluTrp: 0.878 ± 0.026	1.471GluTyr: 1.471 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.213PheAla: 4.213 ± 0.063	0.45PheCys: 0.45 ± 0.021	2.651PheAsp: 2.651 ± 0.044	2.166PheGlu: 2.166 ± 0.046	1.674PhePhe: 1.674 ± 0.048	3.281PheGly: 3.281 ± 0.055	0.874PheHis: 0.874 ± 0.026	2.027PheIle: 2.027 ± 0.047	1.286PheLys: 1.286 ± 0.031	3.555PheLeu: 3.555 ± 0.071	0.826PheMet: 0.826 ± 0.027	1.55PheAsn: 1.55 ± 0.034	1.563PhePro: 1.563 ± 0.036	1.402PheGln: 1.402 ± 0.031	2.172PheArg: 2.172 ± 0.045	2.91PheSer: 2.91 ± 0.046	2.091PheThr: 2.091 ± 0.045	2.876PheVal: 2.876 ± 0.048	0.6PheTrp: 0.6 ± 0.027	1.2PheTyr: 1.2 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.264GlyAla: 6.264 ± 0.077	0.767GlyCys: 0.767 ± 0.027	3.847GlyAsp: 3.847 ± 0.069	4.703GlyGlu: 4.703 ± 0.079	3.305GlyPhe: 3.305 ± 0.05	5.239GlyGly: 5.239 ± 0.086	1.628GlyHis: 1.628 ± 0.04	4.088GlyIle: 4.088 ± 0.07	3.645GlyLys: 3.645 ± 0.067	7.016GlyLeu: 7.016 ± 0.093	1.89GlyMet: 1.89 ± 0.039	2.533GlyAsn: 2.533 ± 0.061	1.989GlyPro: 1.989 ± 0.041	3.053GlyGln: 3.053 ± 0.062	3.909GlyArg: 3.909 ± 0.063	4.029GlySer: 4.029 ± 0.076	3.376GlyThr: 3.376 ± 0.067	5.421GlyVal: 5.421 ± 0.067	1.166GlyTrp: 1.166 ± 0.032	2.271GlyTyr: 2.271 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.139HisAla: 2.139 ± 0.043	0.337HisCys: 0.337 ± 0.017	1.329HisAsp: 1.329 ± 0.034	1.336HisGlu: 1.336 ± 0.034	1.135HisPhe: 1.135 ± 0.032	1.922HisGly: 1.922 ± 0.04	0.755HisHis: 0.755 ± 0.026	1.193HisIle: 1.193 ± 0.033	0.774HisLys: 0.774 ± 0.026	2.422HisLeu: 2.422 ± 0.046	0.466HisMet: 0.466 ± 0.021	0.71HisAsn: 0.71 ± 0.024	1.331HisPro: 1.331 ± 0.037	1.263HisGln: 1.263 ± 0.035	1.602HisArg: 1.602 ± 0.039	1.355HisSer: 1.355 ± 0.034	0.99HisThr: 0.99 ± 0.024	1.521HisVal: 1.521 ± 0.035	0.542HisTrp: 0.542 ± 0.021	0.918HisTyr: 0.918 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.392IleAla: 6.392 ± 0.089	0.505IleCys: 0.505 ± 0.023	3.743IleAsp: 3.743 ± 0.062	3.925IleGlu: 3.925 ± 0.066	1.617IlePhe: 1.617 ± 0.04	4.457IleGly: 4.457 ± 0.066	1.095IleHis: 1.095 ± 0.028	2.554IleIle: 2.554 ± 0.042	2.095IleLys: 2.095 ± 0.045	3.881IleLeu: 3.881 ± 0.062	0.929IleMet: 0.929 ± 0.033	2.146IleAsn: 2.146 ± 0.048	2.284IlePro: 2.284 ± 0.039	1.776IleGln: 1.776 ± 0.038	3.058IleArg: 3.058 ± 0.049	3.529IleSer: 3.529 ± 0.061	2.844IleThr: 2.844 ± 0.053	3.827IleVal: 3.827 ± 0.056	0.652IleTrp: 0.652 ± 0.024	1.315IleTyr: 1.315 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.652LysAla: 4.652 ± 0.083	0.231LysCys: 0.231 ± 0.014	1.969LysAsp: 1.969 ± 0.045	2.297LysGlu: 2.297 ± 0.056	1.168LysPhe: 1.168 ± 0.031	2.442LysGly: 2.442 ± 0.044	1.022LysHis: 1.022 ± 0.024	1.89LysIle: 1.89 ± 0.044	2.078LysLys: 2.078 ± 0.055	4.365LysLeu: 4.365 ± 0.063	0.988LysMet: 0.988 ± 0.032	1.449LysAsn: 1.449 ± 0.035	2.508LysPro: 2.508 ± 0.045	2.095LysGln: 2.095 ± 0.033	2.73LysArg: 2.73 ± 0.051	2.252LysSer: 2.252 ± 0.05	2.349LysThr: 2.349 ± 0.044	2.783LysVal: 2.783 ± 0.052	0.447LysTrp: 0.447 ± 0.018	0.833LysTyr: 0.833 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.856LeuAla: 11.856 ± 0.141	0.964LeuCys: 0.964 ± 0.027	5.443LeuAsp: 5.443 ± 0.064	5.447LeuGlu: 5.447 ± 0.076	4.103LeuPhe: 4.103 ± 0.067	6.845LeuGly: 6.845 ± 0.085	2.667LeuHis: 2.667 ± 0.046	5.636LeuIle: 5.636 ± 0.086	4.464LeuLys: 4.464 ± 0.072	12.728LeuLeu: 12.728 ± 0.191	2.69LeuMet: 2.69 ± 0.044	3.957LeuAsn: 3.957 ± 0.058	6.113LeuPro: 6.113 ± 0.069	5.599LeuGln: 5.599 ± 0.089	6.983LeuArg: 6.983 ± 0.082	7.592LeuSer: 7.592 ± 0.096	5.623LeuThr: 5.623 ± 0.079	6.853LeuVal: 6.853 ± 0.075	1.461LeuTrp: 1.461 ± 0.041	2.402LeuTyr: 2.402 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.662MetAla: 2.662 ± 0.055	0.162MetCys: 0.162 ± 0.011	1.073MetAsp: 1.073 ± 0.03	1.141MetGlu: 1.141 ± 0.038	0.808MetPhe: 0.808 ± 0.025	1.341MetGly: 1.341 ± 0.039	0.559MetHis: 0.559 ± 0.021	1.153MetIle: 1.153 ± 0.031	1.178MetLys: 1.178 ± 0.035	2.858MetLeu: 2.858 ± 0.052	0.602MetMet: 0.602 ± 0.02	1.016MetAsn: 1.016 ± 0.028	1.437MetPro: 1.437 ± 0.036	1.315MetGln: 1.315 ± 0.037	1.636MetArg: 1.636 ± 0.039	1.732MetSer: 1.732 ± 0.036	1.367MetThr: 1.367 ± 0.03	1.558MetVal: 1.558 ± 0.038	0.223MetTrp: 0.223 ± 0.013	0.475MetTyr: 0.475 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.949AsnAla: 3.949 ± 0.065	0.305AsnCys: 0.305 ± 0.019	2.033AsnAsp: 2.033 ± 0.045	2.229AsnGlu: 2.229 ± 0.041	1.15AsnPhe: 1.15 ± 0.027	2.957AsnGly: 2.957 ± 0.079	0.731AsnHis: 0.731 ± 0.024	1.827AsnIle: 1.827 ± 0.042	1.267AsnLys: 1.267 ± 0.036	3.257AsnLeu: 3.257 ± 0.053	0.688AsnMet: 0.688 ± 0.025	1.318AsnAsn: 1.318 ± 0.042	1.962AsnPro: 1.962 ± 0.041	1.52AsnGln: 1.52 ± 0.037	2.166AsnArg: 2.166 ± 0.043	1.811AsnSer: 1.811 ± 0.048	1.815AsnThr: 1.815 ± 0.045	2.378AsnVal: 2.378 ± 0.05	0.561AsnTrp: 0.561 ± 0.024	0.96AsnTyr: 0.96 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.691ProAla: 4.691 ± 0.072	0.334ProCys: 0.334 ± 0.017	2.736ProAsp: 2.736 ± 0.043	3.713ProGlu: 3.713 ± 0.057	1.907ProPhe: 1.907 ± 0.038	3.138ProGly: 3.138 ± 0.053	0.953ProHis: 0.953 ± 0.028	2.335ProIle: 2.335 ± 0.046	1.767ProLys: 1.767 ± 0.038	4.839ProLeu: 4.839 ± 0.067	1.261ProMet: 1.261 ± 0.031	1.676ProAsn: 1.676 ± 0.039	1.843ProPro: 1.843 ± 0.053	1.646ProGln: 1.646 ± 0.036	2.097ProArg: 2.097 ± 0.049	2.611ProSer: 2.611 ± 0.048	2.348ProThr: 2.348 ± 0.079	3.862ProVal: 3.862 ± 0.067	0.629ProTrp: 0.629 ± 0.022	1.235ProTyr: 1.235 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.215GlnAla: 5.215 ± 0.085	0.405GlnCys: 0.405 ± 0.019	1.829GlnAsp: 1.829 ± 0.037	2.291GlnGlu: 2.291 ± 0.048	1.978GlnPhe: 1.978 ± 0.034	2.779GlnGly: 2.779 ± 0.054	1.524GlnHis: 1.524 ± 0.037	2.355GlnIle: 2.355 ± 0.044	1.849GlnLys: 1.849 ± 0.041	5.72GlnLeu: 5.72 ± 0.082	1.237GlnMet: 1.237 ± 0.032	1.418GlnAsn: 1.418 ± 0.038	2.249GlnPro: 2.249 ± 0.042	4.023GlnGln: 4.023 ± 0.088	3.93GlnArg: 3.93 ± 0.064	2.743GlnSer: 2.743 ± 0.047	2.411GlnThr: 2.411 ± 0.049	3.054GlnVal: 3.054 ± 0.055	0.979GlnTrp: 0.979 ± 0.028	1.21GlnTyr: 1.21 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.529ArgAla: 5.529 ± 0.079	0.628ArgCys: 0.628 ± 0.025	3.451ArgAsp: 3.451 ± 0.051	4.181ArgGlu: 4.181 ± 0.067	2.985ArgPhe: 2.985 ± 0.049	3.48ArgGly: 3.48 ± 0.056	1.754ArgHis: 1.754 ± 0.044	3.589ArgIle: 3.589 ± 0.055	2.366ArgLys: 2.366 ± 0.053	7.137ArgLeu: 7.137 ± 0.088	1.615ArgMet: 1.615 ± 0.033	1.949ArgAsn: 1.949 ± 0.042	2.151ArgPro: 2.151 ± 0.043	3.546ArgGln: 3.546 ± 0.063	3.916ArgArg: 3.916 ± 0.079	3.227ArgSer: 3.227 ± 0.047	2.544ArgThr: 2.544 ± 0.044	4.235ArgVal: 4.235 ± 0.063	1.209ArgTrp: 1.209 ± 0.036	2.274ArgTyr: 2.274 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.306SerAla: 6.306 ± 0.07	0.53SerCys: 0.53 ± 0.024	3.19SerAsp: 3.19 ± 0.058	3.889SerGlu: 3.889 ± 0.054	2.521SerPhe: 2.521 ± 0.049	4.863SerGly: 4.863 ± 0.095	1.354SerHis: 1.354 ± 0.036	3.044SerIle: 3.044 ± 0.059	2.274SerLys: 2.274 ± 0.043	6.618SerLeu: 6.618 ± 0.075	1.43SerMet: 1.43 ± 0.032	2.06SerAsn: 2.06 ± 0.061	2.6SerPro: 2.6 ± 0.051	2.308SerGln: 2.308 ± 0.037	3.329SerArg: 3.329 ± 0.054	3.679SerSer: 3.679 ± 0.078	3.001SerThr: 3.001 ± 0.048	4.362SerVal: 4.362 ± 0.071	0.936SerTrp: 0.936 ± 0.031	1.661SerTyr: 1.661 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.095ThrAla: 5.095 ± 0.065	0.395ThrCys: 0.395 ± 0.019	2.813ThrAsp: 2.813 ± 0.059	3.0ThrGlu: 3.0 ± 0.055	1.759ThrPhe: 1.759 ± 0.046	4.139ThrGly: 4.139 ± 0.066	1.09ThrHis: 1.09 ± 0.031	2.789ThrIle: 2.789 ± 0.056	1.421ThrLys: 1.421 ± 0.037	6.081ThrLeu: 6.081 ± 0.076	1.181ThrMet: 1.181 ± 0.031	1.393ThrAsn: 1.393 ± 0.037	3.133ThrPro: 3.133 ± 0.089	1.815ThrGln: 1.815 ± 0.038	2.813ThrArg: 2.813 ± 0.045	2.656ThrSer: 2.656 ± 0.057	2.726ThrThr: 2.726 ± 0.058	3.928ThrVal: 3.928 ± 0.072	0.579ThrTrp: 0.579 ± 0.022	1.139ThrTyr: 1.139 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.11ValAla: 7.11 ± 0.087	0.655ValCys: 0.655 ± 0.024	3.976ValAsp: 3.976 ± 0.056	4.211ValGlu: 4.211 ± 0.058	2.825ValPhe: 2.825 ± 0.053	4.536ValGly: 4.536 ± 0.07	1.566ValHis: 1.566 ± 0.035	3.979ValIle: 3.979 ± 0.053	2.733ValLys: 2.733 ± 0.058	7.976ValLeu: 7.976 ± 0.097	1.762ValMet: 1.762 ± 0.039	2.525ValAsn: 2.525 ± 0.055	3.038ValPro: 3.038 ± 0.05	2.818ValGln: 2.818 ± 0.054	4.125ValArg: 4.125 ± 0.057	4.537ValSer: 4.537 ± 0.064	3.544ValThr: 3.544 ± 0.066	5.23ValVal: 5.23 ± 0.078	0.935ValTrp: 0.935 ± 0.029	1.759ValTyr: 1.759 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.064TrpAla: 1.064 ± 0.029	0.158TrpCys: 0.158 ± 0.01	0.546TrpAsp: 0.546 ± 0.022	0.525TrpGlu: 0.525 ± 0.021	0.7TrpPhe: 0.7 ± 0.022	0.773TrpGly: 0.773 ± 0.027	0.491TrpHis: 0.491 ± 0.019	0.664TrpIle: 0.664 ± 0.026	0.432TrpLys: 0.432 ± 0.016	2.363TrpLeu: 2.363 ± 0.059	0.371TrpMet: 0.371 ± 0.017	0.47TrpAsn: 0.47 ± 0.019	0.713TrpPro: 0.713 ± 0.029	1.548TrpGln: 1.548 ± 0.044	1.331TrpArg: 1.331 ± 0.035	0.921TrpSer: 0.921 ± 0.03	0.657TrpThr: 0.657 ± 0.019	0.84TrpVal: 0.84 ± 0.024	0.332TrpTrp: 0.332 ± 0.019	0.384TrpTyr: 0.384 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.555TyrAla: 2.555 ± 0.045	0.308TyrCys: 0.308 ± 0.017	1.426TyrAsp: 1.426 ± 0.039	1.271TyrGlu: 1.271 ± 0.028	1.252TyrPhe: 1.252 ± 0.034	2.072TyrGly: 2.072 ± 0.045	0.651TyrHis: 0.651 ± 0.023	1.055TyrIle: 1.055 ± 0.029	0.791TyrLys: 0.791 ± 0.027	3.24TyrLeu: 3.24 ± 0.055	0.455TyrMet: 0.455 ± 0.02	0.785TyrAsn: 0.785 ± 0.026	1.275TyrPro: 1.275 ± 0.032	1.712TyrGln: 1.712 ± 0.038	2.083TyrArg: 2.083 ± 0.044	1.604TyrSer: 1.604 ± 0.041	1.28TyrThr: 1.28 ± 0.036	1.688TyrVal: 1.688 ± 0.04	0.518TyrTrp: 0.518 ± 0.021	0.821TyrTyr: 0.821 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3735 proteins (1253671 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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