Amino acid dipepetide frequency for Alloprevotella sp. OH1205_COT-284

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.0AlaAla: 8.0 ± 0.16	0.998AlaCys: 0.998 ± 0.039	5.125AlaAsp: 5.125 ± 0.113	5.868AlaGlu: 5.868 ± 0.12	3.726AlaPhe: 3.726 ± 0.088	5.163AlaGly: 5.163 ± 0.109	1.76AlaHis: 1.76 ± 0.059	4.412AlaIle: 4.412 ± 0.094	3.949AlaLys: 3.949 ± 0.084	8.041AlaLeu: 8.041 ± 0.128	1.973AlaMet: 1.973 ± 0.061	2.768AlaAsn: 2.768 ± 0.084	3.058AlaPro: 3.058 ± 0.08	3.255AlaGln: 3.255 ± 0.081	4.278AlaArg: 4.278 ± 0.1	4.312AlaSer: 4.312 ± 0.087	4.52AlaThr: 4.52 ± 0.089	5.844AlaVal: 5.844 ± 0.112	0.891AlaTrp: 0.891 ± 0.043	3.061AlaTyr: 3.061 ± 0.074	0.0AlaXaa: 0.0 ± 0.0
Cys	0.872CysAla: 0.872 ± 0.041	0.181CysCys: 0.181 ± 0.016	0.661CysAsp: 0.661 ± 0.036	0.73CysGlu: 0.73 ± 0.033	0.555CysPhe: 0.555 ± 0.033	1.082CysGly: 1.082 ± 0.045	0.311CysHis: 0.311 ± 0.025	0.689CysIle: 0.689 ± 0.034	0.503CysLys: 0.503 ± 0.034	1.14CysLeu: 1.14 ± 0.047	0.24CysMet: 0.24 ± 0.019	0.511CysAsn: 0.511 ± 0.027	0.58CysPro: 0.58 ± 0.035	0.32CysGln: 0.32 ± 0.022	0.806CysArg: 0.806 ± 0.036	0.681CysSer: 0.681 ± 0.031	0.642CysThr: 0.642 ± 0.034	0.814CysVal: 0.814 ± 0.037	0.136CysTrp: 0.136 ± 0.015	0.371CysTyr: 0.371 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.304AspAla: 4.304 ± 0.08	0.617AspCys: 0.617 ± 0.027	2.645AspAsp: 2.645 ± 0.076	3.797AspGlu: 3.797 ± 0.104	3.264AspPhe: 3.264 ± 0.077	4.02AspGly: 4.02 ± 0.089	1.069AspHis: 1.069 ± 0.044	3.801AspIle: 3.801 ± 0.088	2.807AspLys: 2.807 ± 0.074	4.983AspLeu: 4.983 ± 0.09	1.303AspMet: 1.303 ± 0.052	2.496AspAsn: 2.496 ± 0.071	1.984AspPro: 1.984 ± 0.06	1.208AspGln: 1.208 ± 0.043	3.324AspArg: 3.324 ± 0.075	2.735AspSer: 2.735 ± 0.075	2.88AspThr: 2.88 ± 0.072	3.572AspVal: 3.572 ± 0.081	0.733AspTrp: 0.733 ± 0.032	2.492AspTyr: 2.492 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	5.661GluAla: 5.661 ± 0.119	0.602GluCys: 0.602 ± 0.03	2.985GluAsp: 2.985 ± 0.082	5.251GluGlu: 5.251 ± 0.111	2.287GluPhe: 2.287 ± 0.066	4.373GluGly: 4.373 ± 0.081	1.509GluHis: 1.509 ± 0.05	4.271GluIle: 4.271 ± 0.083	4.567GluLys: 4.567 ± 0.113	5.827GluLeu: 5.827 ± 0.108	1.973GluMet: 1.973 ± 0.061	3.227GluAsn: 3.227 ± 0.069	1.676GluPro: 1.676 ± 0.055	2.905GluGln: 2.905 ± 0.082	4.54GluArg: 4.54 ± 0.101	3.031GluSer: 3.031 ± 0.065	3.73GluThr: 3.73 ± 0.087	4.356GluVal: 4.356 ± 0.091	0.789GluTrp: 0.789 ± 0.037	2.069GluTyr: 2.069 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.43PheAla: 3.43 ± 0.076	0.702PheCys: 0.702 ± 0.036	2.889PheAsp: 2.889 ± 0.079	2.815PheGlu: 2.815 ± 0.073	2.438PhePhe: 2.438 ± 0.071	3.32PheGly: 3.32 ± 0.079	1.008PheHis: 1.008 ± 0.042	2.506PheIle: 2.506 ± 0.062	2.104PheLys: 2.104 ± 0.047	4.442PheLeu: 4.442 ± 0.089	1.162PheMet: 1.162 ± 0.046	2.055PheAsn: 2.055 ± 0.063	1.717PhePro: 1.717 ± 0.051	1.271PheGln: 1.271 ± 0.047	2.81PheArg: 2.81 ± 0.068	3.739PheSer: 3.739 ± 0.08	2.471PheThr: 2.471 ± 0.067	3.283PheVal: 3.283 ± 0.083	0.533PheTrp: 0.533 ± 0.029	1.803PheTyr: 1.803 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.016GlyAla: 5.016 ± 0.11	0.896GlyCys: 0.896 ± 0.043	3.241GlyAsp: 3.241 ± 0.077	4.457GlyGlu: 4.457 ± 0.088	3.313GlyPhe: 3.313 ± 0.077	5.155GlyGly: 5.155 ± 0.131	1.495GlyHis: 1.495 ± 0.053	4.712GlyIle: 4.712 ± 0.096	4.777GlyLys: 4.777 ± 0.097	5.964GlyLeu: 5.964 ± 0.121	2.014GlyMet: 2.014 ± 0.069	3.143GlyAsn: 3.143 ± 0.084	0.978GlyPro: 0.978 ± 0.037	2.149GlyGln: 2.149 ± 0.059	4.37GlyArg: 4.37 ± 0.101	3.72GlySer: 3.72 ± 0.087	4.225GlyThr: 4.225 ± 0.096	5.157GlyVal: 5.157 ± 0.098	0.964GlyTrp: 0.964 ± 0.044	2.824GlyTyr: 2.824 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.818HisAla: 1.818 ± 0.06	0.366HisCys: 0.366 ± 0.025	1.131HisAsp: 1.131 ± 0.042	1.148HisGlu: 1.148 ± 0.04	1.292HisPhe: 1.292 ± 0.041	1.426HisGly: 1.426 ± 0.052	0.667HisHis: 0.667 ± 0.036	1.558HisIle: 1.558 ± 0.056	0.957HisLys: 0.957 ± 0.04	2.588HisLeu: 2.588 ± 0.064	0.339HisMet: 0.339 ± 0.021	1.016HisAsn: 1.016 ± 0.046	1.317HisPro: 1.317 ± 0.045	0.714HisGln: 0.714 ± 0.038	1.651HisArg: 1.651 ± 0.054	1.315HisSer: 1.315 ± 0.048	1.274HisThr: 1.274 ± 0.05	1.247HisVal: 1.247 ± 0.045	0.252HisTrp: 0.252 ± 0.018	0.987HisTyr: 0.987 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	5.288IleAla: 5.288 ± 0.101	0.806IleCys: 0.806 ± 0.034	4.302IleAsp: 4.302 ± 0.089	4.313IleGlu: 4.313 ± 0.09	2.444IlePhe: 2.444 ± 0.074	4.365IleGly: 4.365 ± 0.091	1.26IleHis: 1.26 ± 0.048	3.503IleIle: 3.503 ± 0.102	3.225IleLys: 3.225 ± 0.081	5.061IleLeu: 5.061 ± 0.093	1.222IleMet: 1.222 ± 0.05	2.64IleAsn: 2.64 ± 0.074	2.738IlePro: 2.738 ± 0.071	1.571IleGln: 1.571 ± 0.049	3.457IleArg: 3.457 ± 0.08	3.916IleSer: 3.916 ± 0.087	3.378IleThr: 3.378 ± 0.068	4.425IleVal: 4.425 ± 0.092	0.565IleTrp: 0.565 ± 0.032	2.115IleTyr: 2.115 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	4.684LysAla: 4.684 ± 0.101	0.416LysCys: 0.416 ± 0.029	2.881LysAsp: 2.881 ± 0.068	4.278LysGlu: 4.278 ± 0.103	1.957LysPhe: 1.957 ± 0.057	4.11LysGly: 4.11 ± 0.085	1.227LysHis: 1.227 ± 0.044	3.427LysIle: 3.427 ± 0.079	3.9LysLys: 3.9 ± 0.104	4.371LysLeu: 4.371 ± 0.092	1.713LysMet: 1.713 ± 0.054	2.899LysAsn: 2.899 ± 0.074	1.81LysPro: 1.81 ± 0.06	2.173LysGln: 2.173 ± 0.066	3.179LysArg: 3.179 ± 0.078	3.083LysSer: 3.083 ± 0.074	3.521LysThr: 3.521 ± 0.072	3.588LysVal: 3.588 ± 0.088	0.683LysTrp: 0.683 ± 0.034	2.015LysTyr: 2.015 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	7.085LeuAla: 7.085 ± 0.133	1.331LeuCys: 1.331 ± 0.055	4.947LeuAsp: 4.947 ± 0.095	5.018LeuGlu: 5.018 ± 0.086	4.698LeuPhe: 4.698 ± 0.096	5.848LeuGly: 5.848 ± 0.111	2.533LeuHis: 2.533 ± 0.078	5.204LeuIle: 5.204 ± 0.123	5.162LeuLys: 5.162 ± 0.098	10.225LeuLeu: 10.225 ± 0.188	2.321LeuMet: 2.321 ± 0.068	4.097LeuAsn: 4.097 ± 0.084	4.83LeuPro: 4.83 ± 0.095	3.644LeuGln: 3.644 ± 0.087	6.48LeuArg: 6.48 ± 0.12	7.656LeuSer: 7.656 ± 0.138	5.529LeuThr: 5.529 ± 0.099	5.327LeuVal: 5.327 ± 0.12	1.063LeuTrp: 1.063 ± 0.046	3.288LeuTyr: 3.288 ± 0.082	0.0LeuXaa: 0.0 ± 0.0
Met	2.208MetAla: 2.208 ± 0.073	0.221MetCys: 0.221 ± 0.019	1.011MetAsp: 1.011 ± 0.04	1.493MetGlu: 1.493 ± 0.055	0.91MetPhe: 0.91 ± 0.04	1.853MetGly: 1.853 ± 0.05	0.431MetHis: 0.431 ± 0.026	1.288MetIle: 1.288 ± 0.047	1.992MetLys: 1.992 ± 0.051	2.597MetLeu: 2.597 ± 0.082	0.752MetMet: 0.752 ± 0.038	1.296MetAsn: 1.296 ± 0.042	1.227MetPro: 1.227 ± 0.046	1.014MetGln: 1.014 ± 0.041	1.43MetArg: 1.43 ± 0.049	1.598MetSer: 1.598 ± 0.051	1.506MetThr: 1.506 ± 0.054	1.41MetVal: 1.41 ± 0.057	0.197MetTrp: 0.197 ± 0.02	0.602MetTyr: 0.602 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.599AsnAla: 3.599 ± 0.084	0.413AsnCys: 0.413 ± 0.03	2.307AsnAsp: 2.307 ± 0.065	2.507AsnGlu: 2.507 ± 0.072	2.023AsnPhe: 2.023 ± 0.055	3.458AsnGly: 3.458 ± 0.095	0.932AsnHis: 0.932 ± 0.047	3.028AsnIle: 3.028 ± 0.08	2.353AsnLys: 2.353 ± 0.071	3.939AsnLeu: 3.939 ± 0.089	0.913AsnMet: 0.913 ± 0.038	2.064AsnAsn: 2.064 ± 0.073	2.231AsnPro: 2.231 ± 0.062	1.165AsnGln: 1.165 ± 0.046	2.501AsnArg: 2.501 ± 0.071	2.372AsnSer: 2.372 ± 0.063	2.473AsnThr: 2.473 ± 0.066	2.917AsnVal: 2.917 ± 0.07	0.524AsnTrp: 0.524 ± 0.033	1.762AsnTyr: 1.762 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.99ProAla: 2.99 ± 0.068	0.401ProCys: 0.401 ± 0.03	2.793ProAsp: 2.793 ± 0.064	3.209ProGlu: 3.209 ± 0.068	1.96ProPhe: 1.96 ± 0.061	2.336ProGly: 2.336 ± 0.057	1.064ProHis: 1.064 ± 0.041	2.378ProIle: 2.378 ± 0.059	1.929ProLys: 1.929 ± 0.051	3.897ProLeu: 3.897 ± 0.08	1.028ProMet: 1.028 ± 0.036	1.568ProAsn: 1.568 ± 0.055	1.227ProPro: 1.227 ± 0.047	1.632ProGln: 1.632 ± 0.047	1.831ProArg: 1.831 ± 0.057	2.716ProSer: 2.716 ± 0.071	2.567ProThr: 2.567 ± 0.071	2.463ProVal: 2.463 ± 0.069	0.44ProTrp: 0.44 ± 0.026	1.569ProTyr: 1.569 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	2.574GlnAla: 2.574 ± 0.074	0.334GlnCys: 0.334 ± 0.021	1.424GlnAsp: 1.424 ± 0.045	2.252GlnGlu: 2.252 ± 0.071	1.211GlnPhe: 1.211 ± 0.043	2.033GlnGly: 2.033 ± 0.065	0.856GlnHis: 0.856 ± 0.042	2.295GlnIle: 2.295 ± 0.066	2.255GlnLys: 2.255 ± 0.073	3.474GlnLeu: 3.474 ± 0.084	1.066GlnMet: 1.066 ± 0.044	1.605GlnAsn: 1.605 ± 0.05	1.367GlnPro: 1.367 ± 0.042	1.657GlnGln: 1.657 ± 0.072	2.178GlnArg: 2.178 ± 0.065	1.97GlnSer: 1.97 ± 0.063	2.34GlnThr: 2.34 ± 0.06	1.944GlnVal: 1.944 ± 0.063	0.456GlnTrp: 0.456 ± 0.025	1.31GlnTyr: 1.31 ± 0.052	0.0GlnXaa: 0.0 ± 0.0
Arg	3.946ArgAla: 3.946 ± 0.086	0.642ArgCys: 0.642 ± 0.038	2.608ArgAsp: 2.608 ± 0.066	3.879ArgGlu: 3.879 ± 0.095	3.045ArgPhe: 3.045 ± 0.065	3.299ArgGly: 3.299 ± 0.074	1.815ArgHis: 1.815 ± 0.056	3.927ArgIle: 3.927 ± 0.083	3.607ArgLys: 3.607 ± 0.08	6.581ArgLeu: 6.581 ± 0.134	1.692ArgMet: 1.692 ± 0.052	2.719ArgAsn: 2.719 ± 0.076	2.507ArgPro: 2.507 ± 0.068	2.541ArgGln: 2.541 ± 0.074	4.504ArgArg: 4.504 ± 0.126	3.326ArgSer: 3.326 ± 0.075	3.189ArgThr: 3.189 ± 0.074	3.367ArgVal: 3.367 ± 0.068	0.836ArgTrp: 0.836 ± 0.037	2.392ArgTyr: 2.392 ± 0.068	0.0ArgXaa: 0.0 ± 0.0
Ser	4.947SerAla: 4.947 ± 0.106	0.76SerCys: 0.76 ± 0.038	3.138SerAsp: 3.138 ± 0.067	3.76SerGlu: 3.76 ± 0.086	3.249SerPhe: 3.249 ± 0.07	4.535SerGly: 4.535 ± 0.094	1.459SerHis: 1.459 ± 0.046	3.681SerIle: 3.681 ± 0.079	2.91SerLys: 2.91 ± 0.076	6.015SerLeu: 6.015 ± 0.12	1.426SerMet: 1.426 ± 0.045	2.271SerAsn: 2.271 ± 0.067	2.883SerPro: 2.883 ± 0.064	1.921SerGln: 1.921 ± 0.055	3.195SerArg: 3.195 ± 0.074	4.025SerSer: 4.025 ± 0.102	3.397SerThr: 3.397 ± 0.081	4.419SerVal: 4.419 ± 0.089	0.71SerTrp: 0.71 ± 0.04	2.148SerTyr: 2.148 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	5.163ThrAla: 5.163 ± 0.103	0.563ThrCys: 0.563 ± 0.033	3.517ThrAsp: 3.517 ± 0.074	3.43ThrGlu: 3.43 ± 0.083	2.793ThrPhe: 2.793 ± 0.064	3.861ThrGly: 3.861 ± 0.074	1.351ThrHis: 1.351 ± 0.054	3.624ThrIle: 3.624 ± 0.076	2.336ThrLys: 2.336 ± 0.055	6.453ThrLeu: 6.453 ± 0.117	1.213ThrMet: 1.213 ± 0.039	2.02ThrAsn: 2.02 ± 0.069	3.441ThrPro: 3.441 ± 0.078	1.848ThrGln: 1.848 ± 0.049	2.79ThrArg: 2.79 ± 0.073	3.266ThrSer: 3.266 ± 0.077	3.531ThrThr: 3.531 ± 0.094	3.493ThrVal: 3.493 ± 0.073	0.634ThrTrp: 0.634 ± 0.034	2.097ThrTyr: 2.097 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	5.614ValAla: 5.614 ± 0.102	1.022ValCys: 1.022 ± 0.046	3.406ValAsp: 3.406 ± 0.084	4.545ValGlu: 4.545 ± 0.087	3.011ValPhe: 3.011 ± 0.076	4.797ValGly: 4.797 ± 0.088	1.139ValHis: 1.139 ± 0.044	3.711ValIle: 3.711 ± 0.077	3.909ValLys: 3.909 ± 0.088	6.04ValLeu: 6.04 ± 0.115	1.542ValMet: 1.542 ± 0.052	2.69ValAsn: 2.69 ± 0.069	2.593ValPro: 2.593 ± 0.059	1.919ValGln: 1.919 ± 0.056	3.849ValArg: 3.849 ± 0.085	4.599ValSer: 4.599 ± 0.09	3.353ValThr: 3.353 ± 0.08	5.233ValVal: 5.233 ± 0.113	0.659ValTrp: 0.659 ± 0.028	2.285ValTyr: 2.285 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.762TrpAla: 0.762 ± 0.038	0.14TrpCys: 0.14 ± 0.015	0.596TrpAsp: 0.596 ± 0.033	0.705TrpGlu: 0.705 ± 0.031	0.479TrpPhe: 0.479 ± 0.03	0.882TrpGly: 0.882 ± 0.043	0.341TrpHis: 0.341 ± 0.023	0.632TrpIle: 0.632 ± 0.032	0.826TrpLys: 0.826 ± 0.037	1.156TrpLeu: 1.156 ± 0.05	0.361TrpMet: 0.361 ± 0.029	0.667TrpAsn: 0.667 ± 0.039	0.259TrpPro: 0.259 ± 0.021	0.598TrpGln: 0.598 ± 0.031	0.713TrpArg: 0.713 ± 0.035	0.677TrpSer: 0.677 ± 0.034	0.662TrpThr: 0.662 ± 0.037	0.718TrpVal: 0.718 ± 0.038	0.188TrpTrp: 0.188 ± 0.016	0.364TrpTyr: 0.364 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.042TyrAla: 3.042 ± 0.072	0.413TyrCys: 0.413 ± 0.023	2.425TyrAsp: 2.425 ± 0.065	2.172TyrGlu: 2.172 ± 0.062	1.842TyrPhe: 1.842 ± 0.072	2.656TyrGly: 2.656 ± 0.071	0.837TyrHis: 0.837 ± 0.036	1.946TyrIle: 1.946 ± 0.06	1.85TyrLys: 1.85 ± 0.056	3.491TyrLeu: 3.491 ± 0.075	0.782TyrMet: 0.782 ± 0.035	1.732TyrAsn: 1.732 ± 0.068	1.574TyrPro: 1.574 ± 0.059	1.096TyrGln: 1.096 ± 0.044	2.534TyrArg: 2.534 ± 0.065	2.112TyrSer: 2.112 ± 0.062	2.236TyrThr: 2.236 ± 0.071	2.339TyrVal: 2.339 ± 0.067	0.475TyrTrp: 0.475 ± 0.031	1.579TyrTyr: 1.579 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1708 proteins (634113 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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