Amino acid dipepetide frequency for Streptomyces bingchenggensis (strain BCW-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.818AlaAla: 21.818 ± 0.12	1.094AlaCys: 1.094 ± 0.017	8.74AlaAsp: 8.74 ± 0.051	9.081AlaGlu: 9.081 ± 0.078	3.44AlaPhe: 3.44 ± 0.033	12.792AlaGly: 12.792 ± 0.097	2.975AlaHis: 2.975 ± 0.031	3.689AlaIle: 3.689 ± 0.038	2.758AlaLys: 2.758 ± 0.039	14.717AlaLeu: 14.717 ± 0.112	2.521AlaMet: 2.521 ± 0.027	1.928AlaAsn: 1.928 ± 0.023	7.197AlaPro: 7.197 ± 0.049	3.834AlaGln: 3.834 ± 0.039	10.403AlaArg: 10.403 ± 0.069	5.82AlaSer: 5.82 ± 0.048	7.274AlaThr: 7.274 ± 0.054	12.142AlaVal: 12.142 ± 0.087	1.891AlaTrp: 1.891 ± 0.024	2.746AlaTyr: 2.746 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.098CysAla: 1.098 ± 0.018	0.093CysCys: 0.093 ± 0.006	0.5CysAsp: 0.5 ± 0.012	0.429CysGlu: 0.429 ± 0.012	0.227CysPhe: 0.227 ± 0.008	0.924CysGly: 0.924 ± 0.021	0.205CysHis: 0.205 ± 0.009	0.154CysIle: 0.154 ± 0.006	0.117CysLys: 0.117 ± 0.005	0.729CysLeu: 0.729 ± 0.017	0.117CysMet: 0.117 ± 0.006	0.134CysAsn: 0.134 ± 0.006	0.481CysPro: 0.481 ± 0.016	0.194CysGln: 0.194 ± 0.009	0.651CysArg: 0.651 ± 0.014	0.474CysSer: 0.474 ± 0.013	0.472CysThr: 0.472 ± 0.012	0.661CysVal: 0.661 ± 0.015	0.138CysTrp: 0.138 ± 0.006	0.15CysTyr: 0.15 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	7.658AspAla: 7.658 ± 0.061	0.423AspCys: 0.423 ± 0.012	3.532AspAsp: 3.532 ± 0.04	3.799AspGlu: 3.799 ± 0.039	1.703AspPhe: 1.703 ± 0.023	6.561AspGly: 6.561 ± 0.063	1.535AspHis: 1.535 ± 0.021	2.018AspIle: 2.018 ± 0.023	1.184AspLys: 1.184 ± 0.023	6.093AspLeu: 6.093 ± 0.046	0.808AspMet: 0.808 ± 0.015	0.998AspAsn: 0.998 ± 0.021	4.628AspPro: 4.628 ± 0.046	1.653AspGln: 1.653 ± 0.023	4.922AspArg: 4.922 ± 0.039	2.663AspSer: 2.663 ± 0.033	3.361AspThr: 3.361 ± 0.037	4.451AspVal: 4.451 ± 0.035	1.074AspTrp: 1.074 ± 0.019	1.222AspTyr: 1.222 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	7.458GluAla: 7.458 ± 0.061	0.391GluCys: 0.391 ± 0.013	2.8GluAsp: 2.8 ± 0.032	3.388GluGlu: 3.388 ± 0.036	1.471GluPhe: 1.471 ± 0.023	4.285GluGly: 4.285 ± 0.033	1.538GluHis: 1.538 ± 0.024	2.113GluIle: 2.113 ± 0.025	1.271GluLys: 1.271 ± 0.029	6.884GluLeu: 6.884 ± 0.063	0.852GluMet: 0.852 ± 0.016	0.931GluAsn: 0.931 ± 0.018	3.488GluPro: 3.488 ± 0.033	2.218GluGln: 2.218 ± 0.037	5.667GluArg: 5.667 ± 0.055	2.523GluSer: 2.523 ± 0.027	2.844GluThr: 2.844 ± 0.033	4.384GluVal: 4.384 ± 0.037	0.792GluTrp: 0.792 ± 0.016	1.081GluTyr: 1.081 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.64PheAla: 3.64 ± 0.031	0.249PheCys: 0.249 ± 0.008	1.99PheAsp: 1.99 ± 0.028	1.418PheGlu: 1.418 ± 0.021	0.856PhePhe: 0.856 ± 0.017	2.973PheGly: 2.973 ± 0.028	0.637PheHis: 0.637 ± 0.014	0.794PheIle: 0.794 ± 0.016	0.499PheLys: 0.499 ± 0.014	2.543PheLeu: 2.543 ± 0.034	0.394PheMet: 0.394 ± 0.014	0.579PheAsn: 0.579 ± 0.013	1.376PhePro: 1.376 ± 0.021	0.723PheGln: 0.723 ± 0.017	1.84PheArg: 1.84 ± 0.025	1.502PheSer: 1.502 ± 0.019	1.971PheThr: 1.971 ± 0.024	2.127PheVal: 2.127 ± 0.031	0.431PheTrp: 0.431 ± 0.012	0.574PheTyr: 0.574 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	11.369GlyAla: 11.369 ± 0.086	0.84GlyCys: 0.84 ± 0.015	5.128GlyAsp: 5.128 ± 0.049	5.157GlyGlu: 5.157 ± 0.042	2.762GlyPhe: 2.762 ± 0.033	9.143GlyGly: 9.143 ± 0.086	2.477GlyHis: 2.477 ± 0.03	3.355GlyIle: 3.355 ± 0.033	2.399GlyLys: 2.399 ± 0.04	9.373GlyLeu: 9.373 ± 0.064	2.014GlyMet: 2.014 ± 0.025	1.693GlyAsn: 1.693 ± 0.027	5.448GlyPro: 5.448 ± 0.053	2.791GlyGln: 2.791 ± 0.036	7.935GlyArg: 7.935 ± 0.065	5.403GlySer: 5.403 ± 0.044	6.044GlyThr: 6.044 ± 0.049	7.379GlyVal: 7.379 ± 0.059	1.725GlyTrp: 1.725 ± 0.022	2.33GlyTyr: 2.33 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.729HisAla: 2.729 ± 0.026	0.214HisCys: 0.214 ± 0.008	1.352HisAsp: 1.352 ± 0.024	1.217HisGlu: 1.217 ± 0.022	0.638HisPhe: 0.638 ± 0.016	2.458HisGly: 2.458 ± 0.032	0.755HisHis: 0.755 ± 0.017	0.804HisIle: 0.804 ± 0.017	0.353HisLys: 0.353 ± 0.009	2.538HisLeu: 2.538 ± 0.028	0.331HisMet: 0.331 ± 0.009	0.385HisAsn: 0.385 ± 0.012	1.974HisPro: 1.974 ± 0.027	0.724HisGln: 0.724 ± 0.015	2.165HisArg: 2.165 ± 0.034	1.09HisSer: 1.09 ± 0.017	1.497HisThr: 1.497 ± 0.024	1.581HisVal: 1.581 ± 0.021	0.404HisTrp: 0.404 ± 0.011	0.499HisTyr: 0.499 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.937IleAla: 4.937 ± 0.039	0.3IleCys: 0.3 ± 0.009	2.314IleAsp: 2.314 ± 0.023	2.0IleGlu: 2.0 ± 0.027	0.715IlePhe: 0.715 ± 0.017	3.487IleGly: 3.487 ± 0.04	0.674IleHis: 0.674 ± 0.012	0.842IleIle: 0.842 ± 0.02	0.761IleLys: 0.761 ± 0.018	2.376IleLeu: 2.376 ± 0.026	0.462IleMet: 0.462 ± 0.012	0.725IleAsn: 0.725 ± 0.014	1.846IlePro: 1.846 ± 0.028	0.719IleGln: 0.719 ± 0.015	2.376IleArg: 2.376 ± 0.028	1.823IleSer: 1.823 ± 0.023	2.285IleThr: 2.285 ± 0.03	2.604IleVal: 2.604 ± 0.031	0.399IleTrp: 0.399 ± 0.012	0.567IleTyr: 0.567 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	2.782LysAla: 2.782 ± 0.045	0.107LysCys: 0.107 ± 0.006	1.297LysAsp: 1.297 ± 0.023	1.133LysGlu: 1.133 ± 0.026	0.437LysPhe: 0.437 ± 0.015	1.738LysGly: 1.738 ± 0.03	0.426LysHis: 0.426 ± 0.011	0.834LysIle: 0.834 ± 0.018	0.819LysLys: 0.819 ± 0.027	1.955LysLeu: 1.955 ± 0.029	0.38LysMet: 0.38 ± 0.011	0.508LysAsn: 0.508 ± 0.014	1.3LysPro: 1.3 ± 0.028	0.67LysGln: 0.67 ± 0.022	1.413LysArg: 1.413 ± 0.024	1.163LysSer: 1.163 ± 0.025	1.289LysThr: 1.289 ± 0.026	1.805LysVal: 1.805 ± 0.028	0.283LysTrp: 0.283 ± 0.01	0.439LysTyr: 0.439 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	15.231LeuAla: 15.231 ± 0.101	0.849LeuCys: 0.849 ± 0.015	6.725LeuAsp: 6.725 ± 0.045	4.746LeuGlu: 4.746 ± 0.042	2.63LeuPhe: 2.63 ± 0.034	9.31LeuGly: 9.31 ± 0.057	2.352LeuHis: 2.352 ± 0.027	3.464LeuIle: 3.464 ± 0.039	1.861LeuLys: 1.861 ± 0.03	11.186LeuLeu: 11.186 ± 0.084	1.617LeuMet: 1.617 ± 0.021	1.682LeuAsn: 1.682 ± 0.02	6.539LeuPro: 6.539 ± 0.047	2.114LeuGln: 2.114 ± 0.024	9.105LeuArg: 9.105 ± 0.067	5.515LeuSer: 5.515 ± 0.04	6.937LeuThr: 6.937 ± 0.046	8.371LeuVal: 8.371 ± 0.058	1.31LeuTrp: 1.31 ± 0.022	1.854LeuTyr: 1.854 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.366MetAla: 2.366 ± 0.028	0.126MetCys: 0.126 ± 0.006	0.92MetAsp: 0.92 ± 0.018	0.742MetGlu: 0.742 ± 0.013	0.463MetPhe: 0.463 ± 0.01	1.337MetGly: 1.337 ± 0.02	0.337MetHis: 0.337 ± 0.01	0.627MetIle: 0.627 ± 0.018	0.394MetLys: 0.394 ± 0.011	1.703MetLeu: 1.703 ± 0.029	0.292MetMet: 0.292 ± 0.008	0.422MetAsn: 0.422 ± 0.012	1.086MetPro: 1.086 ± 0.017	0.403MetGln: 0.403 ± 0.01	1.429MetArg: 1.429 ± 0.021	1.285MetSer: 1.285 ± 0.02	1.429MetThr: 1.429 ± 0.024	1.382MetVal: 1.382 ± 0.023	0.229MetTrp: 0.229 ± 0.009	0.327MetTyr: 0.327 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.165AsnAla: 2.165 ± 0.027	0.165AsnCys: 0.165 ± 0.008	0.938AsnAsp: 0.938 ± 0.016	0.8AsnGlu: 0.8 ± 0.015	0.505AsnPhe: 0.505 ± 0.012	1.871AsnGly: 1.871 ± 0.032	0.421AsnHis: 0.421 ± 0.012	0.639AsnIle: 0.639 ± 0.015	0.421AsnLys: 0.421 ± 0.015	1.685AsnLeu: 1.685 ± 0.021	0.287AsnMet: 0.287 ± 0.01	0.438AsnAsn: 0.438 ± 0.013	1.352AsnPro: 1.352 ± 0.021	0.557AsnGln: 0.557 ± 0.016	1.26AsnArg: 1.26 ± 0.021	0.949AsnSer: 0.949 ± 0.02	1.171AsnThr: 1.171 ± 0.022	1.296AsnVal: 1.296 ± 0.018	0.281AsnTrp: 0.281 ± 0.01	0.438AsnTyr: 0.438 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.629ProAla: 8.629 ± 0.057	0.359ProCys: 0.359 ± 0.009	4.739ProAsp: 4.739 ± 0.045	4.266ProGlu: 4.266 ± 0.038	1.504ProPhe: 1.504 ± 0.026	6.802ProGly: 6.802 ± 0.063	1.439ProHis: 1.439 ± 0.03	1.375ProIle: 1.375 ± 0.02	1.249ProLys: 1.249 ± 0.026	5.52ProLeu: 5.52 ± 0.048	1.039ProMet: 1.039 ± 0.016	0.952ProAsn: 0.952 ± 0.019	3.686ProPro: 3.686 ± 0.035	1.767ProGln: 1.767 ± 0.03	4.12ProArg: 4.12 ± 0.043	3.24ProSer: 3.24 ± 0.035	3.428ProThr: 3.428 ± 0.038	5.16ProVal: 5.16 ± 0.04	0.951ProTrp: 0.951 ± 0.017	1.391ProTyr: 1.391 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.895GlnAla: 3.895 ± 0.046	0.172GlnCys: 0.172 ± 0.007	1.421GlnAsp: 1.421 ± 0.02	1.444GlnGlu: 1.444 ± 0.029	0.671GlnPhe: 0.671 ± 0.014	2.405GlnGly: 2.405 ± 0.029	0.684GlnHis: 0.684 ± 0.016	1.074GlnIle: 1.074 ± 0.017	0.572GlnLys: 0.572 ± 0.016	3.1GlnLeu: 3.1 ± 0.033	0.491GlnMet: 0.491 ± 0.012	0.516GlnAsn: 0.516 ± 0.014	1.777GlnPro: 1.777 ± 0.03	1.274GlnGln: 1.274 ± 0.032	2.447GlnArg: 2.447 ± 0.03	1.272GlnSer: 1.272 ± 0.021	1.397GlnThr: 1.397 ± 0.019	2.328GlnVal: 2.328 ± 0.028	0.501GlnTrp: 0.501 ± 0.01	0.565GlnTyr: 0.565 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	10.093ArgAla: 10.093 ± 0.065	0.659ArgCys: 0.659 ± 0.017	4.321ArgAsp: 4.321 ± 0.034	4.682ArgGlu: 4.682 ± 0.041	2.396ArgPhe: 2.396 ± 0.032	5.982ArgGly: 5.982 ± 0.058	2.286ArgHis: 2.286 ± 0.027	3.273ArgIle: 3.273 ± 0.031	1.581ArgLys: 1.581 ± 0.029	9.272ArgLeu: 9.272 ± 0.083	1.745ArgMet: 1.745 ± 0.023	1.333ArgAsn: 1.333 ± 0.017	5.197ArgPro: 5.197 ± 0.049	2.465ArgGln: 2.465 ± 0.026	8.024ArgArg: 8.024 ± 0.077	3.906ArgSer: 3.906 ± 0.04	5.344ArgThr: 5.344 ± 0.046	5.745ArgVal: 5.745 ± 0.05	1.431ArgTrp: 1.431 ± 0.019	1.863ArgTyr: 1.863 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.894SerAla: 6.894 ± 0.054	0.421SerCys: 0.421 ± 0.012	2.745SerAsp: 2.745 ± 0.035	2.397SerGlu: 2.397 ± 0.024	1.541SerPhe: 1.541 ± 0.02	6.256SerGly: 6.256 ± 0.051	1.027SerHis: 1.027 ± 0.014	1.442SerIle: 1.442 ± 0.022	1.023SerLys: 1.023 ± 0.02	4.92SerLeu: 4.92 ± 0.047	1.06SerMet: 1.06 ± 0.015	0.941SerAsn: 0.941 ± 0.018	3.277SerPro: 3.277 ± 0.04	1.312SerGln: 1.312 ± 0.023	3.673SerArg: 3.673 ± 0.033	3.029SerSer: 3.029 ± 0.046	2.905SerThr: 2.905 ± 0.033	4.182SerVal: 4.182 ± 0.043	0.953SerTrp: 0.953 ± 0.018	1.241SerTyr: 1.241 ± 0.015	0.0SerXaa: 0.0 ± 0.0
Thr	9.093ThrAla: 9.093 ± 0.048	0.408ThrCys: 0.408 ± 0.013	3.652ThrAsp: 3.652 ± 0.037	3.149ThrGlu: 3.149 ± 0.028	1.584ThrPhe: 1.584 ± 0.021	6.721ThrGly: 6.721 ± 0.054	1.23ThrHis: 1.23 ± 0.024	1.744ThrIle: 1.744 ± 0.024	1.158ThrLys: 1.158 ± 0.026	5.765ThrLeu: 5.765 ± 0.045	0.934ThrMet: 0.934 ± 0.013	1.024ThrAsn: 1.024 ± 0.021	4.135ThrPro: 4.135 ± 0.043	1.345ThrGln: 1.345 ± 0.025	3.874ThrArg: 3.874 ± 0.04	3.239ThrSer: 3.239 ± 0.036	3.873ThrThr: 3.873 ± 0.047	5.9ThrVal: 5.9 ± 0.05	0.913ThrTrp: 0.913 ± 0.018	1.314ThrTyr: 1.314 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.545ValAla: 10.545 ± 0.07	0.744ValCys: 0.744 ± 0.015	4.77ValAsp: 4.77 ± 0.038	4.514ValGlu: 4.514 ± 0.042	2.453ValPhe: 2.453 ± 0.032	6.348ValGly: 6.348 ± 0.055	1.902ValHis: 1.902 ± 0.026	2.908ValIle: 2.908 ± 0.031	1.606ValLys: 1.606 ± 0.028	9.128ValLeu: 9.128 ± 0.061	1.405ValMet: 1.405 ± 0.022	1.583ValAsn: 1.583 ± 0.022	4.897ValPro: 4.897 ± 0.039	1.951ValGln: 1.951 ± 0.02	7.016ValArg: 7.016 ± 0.05	4.363ValSer: 4.363 ± 0.036	5.265ValThr: 5.265 ± 0.048	7.494ValVal: 7.494 ± 0.049	1.15ValTrp: 1.15 ± 0.014	1.509ValTyr: 1.509 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.686TrpAla: 1.686 ± 0.021	0.159TrpCys: 0.159 ± 0.008	0.901TrpAsp: 0.901 ± 0.021	0.761TrpGlu: 0.761 ± 0.015	0.491TrpPhe: 0.491 ± 0.011	1.116TrpGly: 1.116 ± 0.02	0.401TrpHis: 0.401 ± 0.01	0.545TrpIle: 0.545 ± 0.012	0.368TrpLys: 0.368 ± 0.013	1.813TrpLeu: 1.813 ± 0.026	0.283TrpMet: 0.283 ± 0.008	0.422TrpAsn: 0.422 ± 0.012	0.821TrpPro: 0.821 ± 0.017	0.655TrpGln: 0.655 ± 0.018	1.43TrpArg: 1.43 ± 0.018	0.989TrpSer: 0.989 ± 0.015	1.057TrpThr: 1.057 ± 0.02	0.967TrpVal: 0.967 ± 0.018	0.335TrpTrp: 0.335 ± 0.011	0.383TrpTyr: 0.383 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.773TyrAla: 2.773 ± 0.027	0.173TyrCys: 0.173 ± 0.008	1.502TyrAsp: 1.502 ± 0.027	1.255TyrGlu: 1.255 ± 0.02	0.627TyrPhe: 0.627 ± 0.014	2.256TyrGly: 2.256 ± 0.027	0.405TyrHis: 0.405 ± 0.009	0.521TyrIle: 0.521 ± 0.015	0.387TyrLys: 0.387 ± 0.01	2.098TyrLeu: 2.098 ± 0.027	0.268TyrMet: 0.268 ± 0.009	0.446TyrAsn: 0.446 ± 0.012	1.11TyrPro: 1.11 ± 0.02	0.636TyrGln: 0.636 ± 0.014	1.848TyrArg: 1.848 ± 0.027	0.99TyrSer: 0.99 ± 0.019	1.211TyrThr: 1.211 ± 0.023	1.594TyrVal: 1.594 ± 0.022	0.391TyrTrp: 0.391 ± 0.012	0.475TyrTyr: 0.475 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10019 proteins (3433066 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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