Amino acid dipepetide frequency for Thermincola potens (strain JR)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.261AlaAla: 8.261 ± 0.132	0.93AlaCys: 0.93 ± 0.039	4.245AlaAsp: 4.245 ± 0.068	5.965AlaGlu: 5.965 ± 0.102	2.982AlaPhe: 2.982 ± 0.062	7.715AlaGly: 7.715 ± 0.108	1.296AlaHis: 1.296 ± 0.041	5.352AlaIle: 5.352 ± 0.088	5.152AlaLys: 5.152 ± 0.081	8.612AlaLeu: 8.612 ± 0.124	2.192AlaMet: 2.192 ± 0.052	2.888AlaAsn: 2.888 ± 0.061	2.554AlaPro: 2.554 ± 0.057	2.698AlaGln: 2.698 ± 0.059	4.735AlaArg: 4.735 ± 0.088	3.516AlaSer: 3.516 ± 0.065	3.55AlaThr: 3.55 ± 0.084	7.346AlaVal: 7.346 ± 0.106	0.733AlaTrp: 0.733 ± 0.033	2.372AlaTyr: 2.372 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.833CysAla: 0.833 ± 0.036	0.189CysCys: 0.189 ± 0.019	0.5CysAsp: 0.5 ± 0.027	0.543CysGlu: 0.543 ± 0.022	0.48CysPhe: 0.48 ± 0.024	1.208CysGly: 1.208 ± 0.038	0.733CysHis: 0.733 ± 0.116	0.67CysIle: 0.67 ± 0.028	0.532CysLys: 0.532 ± 0.027	1.081CysLeu: 1.081 ± 0.038	0.269CysMet: 0.269 ± 0.015	0.413CysAsn: 0.413 ± 0.023	0.72CysPro: 0.72 ± 0.034	0.378CysGln: 0.378 ± 0.022	0.717CysArg: 0.717 ± 0.034	0.744CysSer: 0.744 ± 0.035	0.609CysThr: 0.609 ± 0.032	0.645CysVal: 0.645 ± 0.029	0.115CysTrp: 0.115 ± 0.013	0.395CysTyr: 0.395 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.48AspAla: 3.48 ± 0.072	0.597AspCys: 0.597 ± 0.031	2.16AspAsp: 2.16 ± 0.06	3.442AspGlu: 3.442 ± 0.06	2.213AspPhe: 2.213 ± 0.052	3.305AspGly: 3.305 ± 0.071	0.75AspHis: 0.75 ± 0.029	4.379AspIle: 4.379 ± 0.074	3.526AspLys: 3.526 ± 0.061	5.096AspLeu: 5.096 ± 0.086	1.329AspMet: 1.329 ± 0.035	1.95AspAsn: 1.95 ± 0.054	2.331AspPro: 2.331 ± 0.053	1.25AspGln: 1.25 ± 0.036	2.825AspArg: 2.825 ± 0.062	2.274AspSer: 2.274 ± 0.055	2.46AspThr: 2.46 ± 0.066	3.574AspVal: 3.574 ± 0.061	0.593AspTrp: 0.593 ± 0.029	1.949AspTyr: 1.949 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.598GluAla: 5.598 ± 0.091	0.637GluCys: 0.637 ± 0.03	3.042GluAsp: 3.042 ± 0.066	5.856GluGlu: 5.856 ± 0.102	2.415GluPhe: 2.415 ± 0.05	4.309GluGly: 4.309 ± 0.072	1.102GluHis: 1.102 ± 0.035	5.91GluIle: 5.91 ± 0.107	6.262GluLys: 6.262 ± 0.095	6.757GluLeu: 6.757 ± 0.117	2.047GluMet: 2.047 ± 0.05	3.062GluAsn: 3.062 ± 0.061	2.221GluPro: 2.221 ± 0.056	2.677GluGln: 2.677 ± 0.06	3.358GluArg: 3.358 ± 0.071	2.403GluSer: 2.403 ± 0.052	3.371GluThr: 3.371 ± 0.06	5.125GluVal: 5.125 ± 0.077	0.526GluTrp: 0.526 ± 0.027	2.149GluTyr: 2.149 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.15PheAla: 3.15 ± 0.066	0.57PheCys: 0.57 ± 0.027	2.097PheAsp: 2.097 ± 0.053	2.133PheGlu: 2.133 ± 0.05	1.911PhePhe: 1.911 ± 0.056	3.286PheGly: 3.286 ± 0.064	0.673PheHis: 0.673 ± 0.028	2.894PheIle: 2.894 ± 0.054	2.287PheLys: 2.287 ± 0.053	4.137PheLeu: 4.137 ± 0.085	0.987PheMet: 0.987 ± 0.032	1.73PheAsn: 1.73 ± 0.045	1.682PhePro: 1.682 ± 0.046	1.056PheGln: 1.056 ± 0.032	1.897PheArg: 1.897 ± 0.046	2.477PheSer: 2.477 ± 0.054	2.339PheThr: 2.339 ± 0.053	2.896PheVal: 2.896 ± 0.058	0.452PheTrp: 0.452 ± 0.024	1.449PheTyr: 1.449 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.776GlyAla: 5.776 ± 0.082	1.162GlyCys: 1.162 ± 0.039	3.515GlyAsp: 3.515 ± 0.064	4.782GlyGlu: 4.782 ± 0.083	3.323GlyPhe: 3.323 ± 0.058	5.269GlyGly: 5.269 ± 0.087	1.408GlyHis: 1.408 ± 0.04	6.407GlyIle: 6.407 ± 0.108	5.44GlyLys: 5.44 ± 0.083	7.913GlyLeu: 7.913 ± 0.104	2.147GlyMet: 2.147 ± 0.057	2.905GlyAsn: 2.905 ± 0.071	2.48GlyPro: 2.48 ± 0.052	2.773GlyGln: 2.773 ± 0.062	3.904GlyArg: 3.904 ± 0.066	4.02GlySer: 4.02 ± 0.081	4.359GlyThr: 4.359 ± 0.104	5.565GlyVal: 5.565 ± 0.089	0.796GlyTrp: 0.796 ± 0.036	2.93GlyTyr: 2.93 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.229HisAla: 1.229 ± 0.043	0.241HisCys: 0.241 ± 0.019	0.91HisAsp: 0.91 ± 0.043	1.013HisGlu: 1.013 ± 0.032	0.748HisPhe: 0.748 ± 0.03	1.515HisGly: 1.515 ± 0.061	0.43HisHis: 0.43 ± 0.024	1.261HisIle: 1.261 ± 0.04	1.013HisLys: 1.013 ± 0.033	1.732HisLeu: 1.732 ± 0.049	0.423HisMet: 0.423 ± 0.022	0.807HisAsn: 0.807 ± 0.039	1.085HisPro: 1.085 ± 0.033	0.531HisGln: 0.531 ± 0.027	0.891HisArg: 0.891 ± 0.031	0.953HisSer: 0.953 ± 0.046	0.949HisThr: 0.949 ± 0.032	1.122HisVal: 1.122 ± 0.039	0.19HisTrp: 0.19 ± 0.016	0.701HisTyr: 0.701 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.049IleAla: 6.049 ± 0.091	0.863IleCys: 0.863 ± 0.036	3.897IleAsp: 3.897 ± 0.062	4.521IleGlu: 4.521 ± 0.081	2.877IlePhe: 2.877 ± 0.064	5.466IleGly: 5.466 ± 0.086	1.191IleHis: 1.191 ± 0.036	5.777IleIle: 5.777 ± 0.093	4.888IleLys: 4.888 ± 0.073	6.858IleLeu: 6.858 ± 0.106	1.8IleMet: 1.8 ± 0.052	3.309IleAsn: 3.309 ± 0.064	3.504IlePro: 3.504 ± 0.066	1.869IleGln: 1.869 ± 0.05	3.647IleArg: 3.647 ± 0.069	4.371IleSer: 4.371 ± 0.078	4.295IleThr: 4.295 ± 0.089	5.07IleVal: 5.07 ± 0.079	0.544IleTrp: 0.544 ± 0.025	2.245IleTyr: 2.245 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	5.443LysAla: 5.443 ± 0.083	0.657LysCys: 0.657 ± 0.037	3.34LysAsp: 3.34 ± 0.059	5.521LysGlu: 5.521 ± 0.102	2.209LysPhe: 2.209 ± 0.055	4.599LysGly: 4.599 ± 0.071	1.056LysHis: 1.056 ± 0.036	5.225LysIle: 5.225 ± 0.085	5.194LysLys: 5.194 ± 0.085	5.873LysLeu: 5.873 ± 0.083	1.876LysMet: 1.876 ± 0.044	3.147LysAsn: 3.147 ± 0.064	2.647LysPro: 2.647 ± 0.056	2.199LysGln: 2.199 ± 0.049	2.94LysArg: 2.94 ± 0.064	2.862LysSer: 2.862 ± 0.054	3.484LysThr: 3.484 ± 0.073	5.268LysVal: 5.268 ± 0.091	0.605LysTrp: 0.605 ± 0.028	2.318LysTyr: 2.318 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	9.615LeuAla: 9.615 ± 0.131	1.069LeuCys: 1.069 ± 0.045	4.849LeuAsp: 4.849 ± 0.077	6.622LeuGlu: 6.622 ± 0.111	3.935LeuPhe: 3.935 ± 0.077	7.503LeuGly: 7.503 ± 0.122	1.667LeuHis: 1.667 ± 0.053	6.576LeuIle: 6.576 ± 0.12	6.758LeuLys: 6.758 ± 0.089	9.671LeuLeu: 9.671 ± 0.136	2.387LeuMet: 2.387 ± 0.061	4.019LeuAsn: 4.019 ± 0.072	4.417LeuPro: 4.417 ± 0.073	3.419LeuGln: 3.419 ± 0.079	4.661LeuArg: 4.661 ± 0.072	5.277LeuSer: 5.277 ± 0.1	5.451LeuThr: 5.451 ± 0.088	7.435LeuVal: 7.435 ± 0.101	0.822LeuTrp: 0.822 ± 0.031	2.832LeuTyr: 2.832 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.645MetAla: 2.645 ± 0.061	0.21MetCys: 0.21 ± 0.016	1.413MetAsp: 1.413 ± 0.041	1.864MetGlu: 1.864 ± 0.049	0.898MetPhe: 0.898 ± 0.035	2.011MetGly: 2.011 ± 0.051	0.434MetHis: 0.434 ± 0.023	1.462MetIle: 1.462 ± 0.041	1.693MetLys: 1.693 ± 0.045	2.476MetLeu: 2.476 ± 0.052	0.623MetMet: 0.623 ± 0.03	1.069MetAsn: 1.069 ± 0.035	1.147MetPro: 1.147 ± 0.04	0.9MetGln: 0.9 ± 0.031	1.225MetArg: 1.225 ± 0.036	1.323MetSer: 1.323 ± 0.039	1.242MetThr: 1.242 ± 0.039	2.1MetVal: 2.1 ± 0.045	0.167MetTrp: 0.167 ± 0.015	0.638MetTyr: 0.638 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.689AsnAla: 2.689 ± 0.058	0.605AsnCys: 0.605 ± 0.042	1.663AsnAsp: 1.663 ± 0.047	2.304AsnGlu: 2.304 ± 0.05	1.692AsnPhe: 1.692 ± 0.046	2.928AsnGly: 2.928 ± 0.077	0.74AsnHis: 0.74 ± 0.03	3.374AsnIle: 3.374 ± 0.068	2.738AsnLys: 2.738 ± 0.051	4.434AsnLeu: 4.434 ± 0.073	1.067AsnMet: 1.067 ± 0.032	1.921AsnAsn: 1.921 ± 0.061	2.428AsnPro: 2.428 ± 0.066	1.239AsnGln: 1.239 ± 0.039	2.305AsnArg: 2.305 ± 0.051	2.245AsnSer: 2.245 ± 0.063	2.105AsnThr: 2.105 ± 0.061	2.706AsnVal: 2.706 ± 0.057	0.438AsnTrp: 0.438 ± 0.026	1.611AsnTyr: 1.611 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	3.659ProAla: 3.659 ± 0.073	0.42ProCys: 0.42 ± 0.02	2.628ProAsp: 2.628 ± 0.055	3.63ProGlu: 3.63 ± 0.067	1.705ProPhe: 1.705 ± 0.051	3.836ProGly: 3.836 ± 0.073	0.866ProHis: 0.866 ± 0.043	2.185ProIle: 2.185 ± 0.055	2.144ProLys: 2.144 ± 0.049	3.767ProLeu: 3.767 ± 0.067	0.86ProMet: 0.86 ± 0.03	1.536ProAsn: 1.536 ± 0.044	1.556ProPro: 1.556 ± 0.04	1.345ProGln: 1.345 ± 0.036	1.787ProArg: 1.787 ± 0.044	1.839ProSer: 1.839 ± 0.053	1.894ProThr: 1.894 ± 0.053	4.264ProVal: 4.264 ± 0.073	0.501ProTrp: 0.501 ± 0.026	1.415ProTyr: 1.415 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.911GlnAla: 2.911 ± 0.066	0.303GlnCys: 0.303 ± 0.02	1.434GlnAsp: 1.434 ± 0.038	2.454GlnGlu: 2.454 ± 0.067	1.073GlnPhe: 1.073 ± 0.033	2.259GlnGly: 2.259 ± 0.047	0.533GlnHis: 0.533 ± 0.022	2.314GlnIle: 2.314 ± 0.051	2.475GlnLys: 2.475 ± 0.054	3.006GlnLeu: 3.006 ± 0.06	0.939GlnMet: 0.939 ± 0.039	1.395GlnAsn: 1.395 ± 0.044	1.292GlnPro: 1.292 ± 0.038	1.322GlnGln: 1.322 ± 0.049	1.666GlnArg: 1.666 ± 0.044	1.408GlnSer: 1.408 ± 0.038	1.493GlnThr: 1.493 ± 0.049	2.82GlnVal: 2.82 ± 0.056	0.323GlnTrp: 0.323 ± 0.018	0.961GlnTyr: 0.961 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.52ArgAla: 3.52 ± 0.07	0.565ArgCys: 0.565 ± 0.028	2.56ArgAsp: 2.56 ± 0.057	4.39ArgGlu: 4.39 ± 0.07	2.074ArgPhe: 2.074 ± 0.051	3.22ArgGly: 3.22 ± 0.074	0.988ArgHis: 0.988 ± 0.033	3.724ArgIle: 3.724 ± 0.073	3.508ArgLys: 3.508 ± 0.062	5.278ArgLeu: 5.278 ± 0.091	1.335ArgMet: 1.335 ± 0.038	2.074ArgAsn: 2.074 ± 0.044	1.961ArgPro: 1.961 ± 0.058	2.099ArgGln: 2.099 ± 0.054	2.721ArgArg: 2.721 ± 0.067	2.165ArgSer: 2.165 ± 0.051	2.22ArgThr: 2.22 ± 0.054	3.933ArgVal: 3.933 ± 0.07	0.507ArgTrp: 0.507 ± 0.024	1.78ArgTyr: 1.78 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.965SerAla: 3.965 ± 0.082	0.636SerCys: 0.636 ± 0.034	2.298SerAsp: 2.298 ± 0.055	2.851SerGlu: 2.851 ± 0.063	2.284SerPhe: 2.284 ± 0.052	4.481SerGly: 4.481 ± 0.086	0.917SerHis: 0.917 ± 0.035	3.429SerIle: 3.429 ± 0.065	2.606SerLys: 2.606 ± 0.061	5.351SerLeu: 5.351 ± 0.088	1.268SerMet: 1.268 ± 0.04	1.774SerAsn: 1.774 ± 0.053	2.209SerPro: 2.209 ± 0.057	1.483SerGln: 1.483 ± 0.046	2.646SerArg: 2.646 ± 0.042	2.767SerSer: 2.767 ± 0.077	2.54SerThr: 2.54 ± 0.081	3.945SerVal: 3.945 ± 0.08	0.569SerTrp: 0.569 ± 0.027	1.676SerTyr: 1.676 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.612ThrAla: 4.612 ± 0.084	0.663ThrCys: 0.663 ± 0.044	2.632ThrAsp: 2.632 ± 0.067	3.168ThrGlu: 3.168 ± 0.058	1.994ThrPhe: 1.994 ± 0.05	5.49ThrGly: 5.49 ± 0.084	0.853ThrHis: 0.853 ± 0.033	3.295ThrIle: 3.295 ± 0.064	2.698ThrLys: 2.698 ± 0.061	4.743ThrLeu: 4.743 ± 0.073	1.096ThrMet: 1.096 ± 0.033	1.855ThrAsn: 1.855 ± 0.057	2.411ThrPro: 2.411 ± 0.051	1.258ThrGln: 1.258 ± 0.043	2.526ThrArg: 2.526 ± 0.055	2.471ThrSer: 2.471 ± 0.072	2.765ThrThr: 2.765 ± 0.082	5.058ThrVal: 5.058 ± 0.117	0.479ThrTrp: 0.479 ± 0.032	1.601ThrTyr: 1.601 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	6.716ValAla: 6.716 ± 0.087	0.892ValCys: 0.892 ± 0.034	4.047ValAsp: 4.047 ± 0.074	5.222ValGlu: 5.222 ± 0.084	3.324ValPhe: 3.324 ± 0.068	5.184ValGly: 5.184 ± 0.088	1.222ValHis: 1.222 ± 0.037	6.056ValIle: 6.056 ± 0.093	5.061ValLys: 5.061 ± 0.072	7.601ValLeu: 7.601 ± 0.116	1.925ValMet: 1.925 ± 0.055	3.427ValAsn: 3.427 ± 0.067	3.226ValPro: 3.226 ± 0.068	2.339ValGln: 2.339 ± 0.051	3.631ValArg: 3.631 ± 0.074	4.368ValSer: 4.368 ± 0.07	4.39ValThr: 4.39 ± 0.099	6.161ValVal: 6.161 ± 0.103	0.608ValTrp: 0.608 ± 0.028	2.488ValTyr: 2.488 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.717TrpAla: 0.717 ± 0.03	0.098TrpCys: 0.098 ± 0.011	0.567TrpAsp: 0.567 ± 0.026	0.644TrpGlu: 0.644 ± 0.026	0.421TrpPhe: 0.421 ± 0.022	0.694TrpGly: 0.694 ± 0.031	0.208TrpHis: 0.208 ± 0.016	0.486TrpIle: 0.486 ± 0.022	0.536TrpLys: 0.536 ± 0.025	1.032TrpLeu: 1.032 ± 0.035	0.25TrpMet: 0.25 ± 0.018	0.396TrpAsn: 0.396 ± 0.024	0.384TrpPro: 0.384 ± 0.027	0.488TrpGln: 0.488 ± 0.026	0.48TrpArg: 0.48 ± 0.025	0.489TrpSer: 0.489 ± 0.032	0.447TrpThr: 0.447 ± 0.023	0.706TrpVal: 0.706 ± 0.03	0.128TrpTrp: 0.128 ± 0.012	0.32TrpTyr: 0.32 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.23TyrAla: 2.23 ± 0.044	0.467TyrCys: 0.467 ± 0.024	1.688TyrAsp: 1.688 ± 0.049	1.904TyrGlu: 1.904 ± 0.048	1.545TyrPhe: 1.545 ± 0.048	2.595TyrGly: 2.595 ± 0.063	0.679TyrHis: 0.679 ± 0.033	2.265TyrIle: 2.265 ± 0.047	1.948TyrLys: 1.948 ± 0.055	3.567TyrLeu: 3.567 ± 0.071	0.719TyrMet: 0.719 ± 0.028	1.551TyrAsn: 1.551 ± 0.05	1.583TyrPro: 1.583 ± 0.049	1.058TyrGln: 1.058 ± 0.034	2.06TyrArg: 2.06 ± 0.055	1.721TyrSer: 1.721 ± 0.045	1.705TyrThr: 1.705 ± 0.061	2.15TyrVal: 2.15 ± 0.048	0.394TyrTrp: 0.394 ± 0.023	1.427TyrTyr: 1.427 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2908 proteins (885596 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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