Amino acid dipepetide frequency for Brenneria goodwinii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.818AlaAla: 10.818 ± 0.135
1.084AlaCys: 1.084 ± 0.034
5.44AlaAsp: 5.44 ± 0.131
5.863AlaGlu: 5.863 ± 0.079
3.507AlaPhe: 3.507 ± 0.053
7.883AlaGly: 7.883 ± 0.14
1.754AlaHis: 1.754 ± 0.041
6.195AlaIle: 6.195 ± 0.073
3.569AlaLys: 3.569 ± 0.064
11.906AlaLeu: 11.906 ± 0.124
2.784AlaMet: 2.784 ± 0.051
3.1AlaAsn: 3.1 ± 0.059
3.806AlaPro: 3.806 ± 0.103
4.493AlaGln: 4.493 ± 0.061
5.553AlaArg: 5.553 ± 0.083
5.658AlaSer: 5.658 ± 0.069
4.729AlaThr: 4.729 ± 0.095
6.688AlaVal: 6.688 ± 0.077
1.273AlaTrp: 1.273 ± 0.034
2.374AlaTyr: 2.374 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.993CysAla: 0.993 ± 0.029
0.179CysCys: 0.179 ± 0.011
0.576CysAsp: 0.576 ± 0.022
0.529CysGlu: 0.529 ± 0.022
0.43CysPhe: 0.43 ± 0.018
1.04CysGly: 1.04 ± 0.027
0.311CysHis: 0.311 ± 0.015
0.581CysIle: 0.581 ± 0.021
0.288CysLys: 0.288 ± 0.015
1.068CysLeu: 1.068 ± 0.026
0.25CysMet: 0.25 ± 0.016
0.319CysAsn: 0.319 ± 0.016
0.474CysPro: 0.474 ± 0.019
0.428CysGln: 0.428 ± 0.019
0.69CysArg: 0.69 ± 0.024
0.639CysSer: 0.639 ± 0.021
0.443CysThr: 0.443 ± 0.016
0.762CysVal: 0.762 ± 0.026
0.175CysTrp: 0.175 ± 0.011
0.33CysTyr: 0.33 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
5.168AspAla: 5.168 ± 0.075
0.478AspCys: 0.478 ± 0.017
3.035AspAsp: 3.035 ± 0.055
3.468AspGlu: 3.468 ± 0.045
2.157AspPhe: 2.157 ± 0.045
4.086AspGly: 4.086 ± 0.091
0.933AspHis: 0.933 ± 0.028
3.832AspIle: 3.832 ± 0.058
2.302AspLys: 2.302 ± 0.039
4.833AspLeu: 4.833 ± 0.064
1.35AspMet: 1.35 ± 0.028
2.316AspAsn: 2.316 ± 0.057
2.243AspPro: 2.243 ± 0.046
1.536AspGln: 1.536 ± 0.034
2.971AspArg: 2.971 ± 0.049
2.941AspSer: 2.941 ± 0.049
2.575AspThr: 2.575 ± 0.107
3.678AspVal: 3.678 ± 0.072
0.822AspTrp: 0.822 ± 0.027
1.902AspTyr: 1.902 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
4.86GluAla: 4.86 ± 0.069
0.451GluCys: 0.451 ± 0.018
2.277GluAsp: 2.277 ± 0.051
3.024GluGlu: 3.024 ± 0.061
1.81GluPhe: 1.81 ± 0.039
3.215GluGly: 3.215 ± 0.057
1.301GluHis: 1.301 ± 0.03
3.337GluIle: 3.337 ± 0.057
2.98GluLys: 2.98 ± 0.054
5.798GluLeu: 5.798 ± 0.071
1.657GluMet: 1.657 ± 0.039
2.409GluAsn: 2.409 ± 0.04
2.074GluPro: 2.074 ± 0.043
3.485GluGln: 3.485 ± 0.061
3.875GluArg: 3.875 ± 0.065
3.092GluSer: 3.092 ± 0.059
2.793GluThr: 2.793 ± 0.049
3.409GluVal: 3.409 ± 0.055
0.676GluTrp: 0.676 ± 0.02
1.441GluTyr: 1.441 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.523PheAla: 3.523 ± 0.059
0.52PheCys: 0.52 ± 0.021
2.273PheAsp: 2.273 ± 0.04
1.642PheGlu: 1.642 ± 0.037
1.687PhePhe: 1.687 ± 0.043
3.09PheGly: 3.09 ± 0.055
0.843PheHis: 0.843 ± 0.023
2.662PheIle: 2.662 ± 0.048
1.245PheLys: 1.245 ± 0.032
3.465PheLeu: 3.465 ± 0.057
0.96PheMet: 0.96 ± 0.025
1.736PheAsn: 1.736 ± 0.037
1.625PhePro: 1.625 ± 0.037
1.205PheGln: 1.205 ± 0.026
1.842PheArg: 1.842 ± 0.041
3.305PheSer: 3.305 ± 0.052
2.192PheThr: 2.192 ± 0.038
2.368PheVal: 2.368 ± 0.051
0.565PheTrp: 0.565 ± 0.021
1.255PheTyr: 1.255 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
6.285GlyAla: 6.285 ± 0.071
1.035GlyCys: 1.035 ± 0.03
3.747GlyAsp: 3.747 ± 0.077
4.448GlyGlu: 4.448 ± 0.062
3.19GlyPhe: 3.19 ± 0.054
5.533GlyGly: 5.533 ± 0.089
1.538GlyHis: 1.538 ± 0.032
5.124GlyIle: 5.124 ± 0.076
3.838GlyLys: 3.838 ± 0.056
7.472GlyLeu: 7.472 ± 0.09
2.337GlyMet: 2.337 ± 0.045
2.895GlyAsn: 2.895 ± 0.15
2.006GlyPro: 2.006 ± 0.043
2.972GlyGln: 2.972 ± 0.063
3.973GlyArg: 3.973 ± 0.053
4.402GlySer: 4.402 ± 0.083
3.499GlyThr: 3.499 ± 0.074
5.715GlyVal: 5.715 ± 0.065
1.241GlyTrp: 1.241 ± 0.032
2.673GlyTyr: 2.673 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.914HisAla: 1.914 ± 0.035
0.311HisCys: 0.311 ± 0.014
1.208HisAsp: 1.208 ± 0.03
1.068HisGlu: 1.068 ± 0.03
1.0HisPhe: 1.0 ± 0.027
1.648HisGly: 1.648 ± 0.033
0.777HisHis: 0.777 ± 0.027
1.369HisIle: 1.369 ± 0.033
0.708HisLys: 0.708 ± 0.023
2.184HisLeu: 2.184 ± 0.041
0.484HisMet: 0.484 ± 0.018
0.803HisAsn: 0.803 ± 0.026
1.342HisPro: 1.342 ± 0.031
1.241HisGln: 1.241 ± 0.029
1.306HisArg: 1.306 ± 0.028
1.246HisSer: 1.246 ± 0.028
0.989HisThr: 0.989 ± 0.023
1.216HisVal: 1.216 ± 0.03
0.391HisTrp: 0.391 ± 0.016
0.818HisTyr: 0.818 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.835IleAla: 6.835 ± 0.081
0.709IleCys: 0.709 ± 0.026
3.711IleAsp: 3.711 ± 0.058
3.472IleGlu: 3.472 ± 0.05
2.215IlePhe: 2.215 ± 0.047
5.005IleGly: 5.005 ± 0.067
1.234IleHis: 1.234 ± 0.032
3.635IleIle: 3.635 ± 0.07
2.428IleLys: 2.428 ± 0.052
5.378IleLeu: 5.378 ± 0.082
1.397IleMet: 1.397 ± 0.033
2.783IleAsn: 2.783 ± 0.065
2.869IlePro: 2.869 ± 0.056
2.048IleGln: 2.048 ± 0.039
3.328IleArg: 3.328 ± 0.046
4.219IleSer: 4.219 ± 0.07
3.663IleThr: 3.663 ± 0.077
4.08IleVal: 4.08 ± 0.064
0.704IleTrp: 0.704 ± 0.024
1.675IleTyr: 1.675 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
3.7LysAla: 3.7 ± 0.061
0.24LysCys: 0.24 ± 0.011
1.907LysAsp: 1.907 ± 0.048
2.147LysGlu: 2.147 ± 0.047
1.098LysPhe: 1.098 ± 0.027
2.587LysGly: 2.587 ± 0.047
0.826LysHis: 0.826 ± 0.023
2.484LysIle: 2.484 ± 0.051
2.165LysLys: 2.165 ± 0.044
4.021LysLeu: 4.021 ± 0.062
1.14LysMet: 1.14 ± 0.03
1.768LysAsn: 1.768 ± 0.042
1.993LysPro: 1.993 ± 0.034
2.011LysGln: 2.011 ± 0.039
2.469LysArg: 2.469 ± 0.05
2.342LysSer: 2.342 ± 0.045
2.465LysThr: 2.465 ± 0.044
2.635LysVal: 2.635 ± 0.043
0.399LysTrp: 0.399 ± 0.015
1.025LysTyr: 1.025 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
11.79LeuAla: 11.79 ± 0.092
1.248LeuCys: 1.248 ± 0.034
5.611LeuAsp: 5.611 ± 0.069
5.204LeuGlu: 5.204 ± 0.075
4.318LeuPhe: 4.318 ± 0.071
7.497LeuGly: 7.497 ± 0.085
2.254LeuHis: 2.254 ± 0.043
6.37LeuIle: 6.37 ± 0.087
4.237LeuLys: 4.237 ± 0.061
12.525LeuLeu: 12.525 ± 0.156
2.842LeuMet: 2.842 ± 0.048
4.229LeuAsn: 4.229 ± 0.067
5.84LeuPro: 5.84 ± 0.086
4.347LeuGln: 4.347 ± 0.065
6.249LeuArg: 6.249 ± 0.084
8.003LeuSer: 8.003 ± 0.091
6.456LeuThr: 6.456 ± 0.098
6.807LeuVal: 6.807 ± 0.088
1.303LeuTrp: 1.303 ± 0.034
2.718LeuTyr: 2.718 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.758MetAla: 2.758 ± 0.053
0.197MetCys: 0.197 ± 0.012
1.215MetAsp: 1.215 ± 0.029
1.18MetGlu: 1.18 ± 0.032
0.861MetPhe: 0.861 ± 0.028
1.768MetGly: 1.768 ± 0.036
0.484MetHis: 0.484 ± 0.017
1.503MetIle: 1.503 ± 0.031
1.257MetLys: 1.257 ± 0.031
3.146MetLeu: 3.146 ± 0.051
0.85MetMet: 0.85 ± 0.028
1.074MetAsn: 1.074 ± 0.024
1.328MetPro: 1.328 ± 0.031
1.141MetGln: 1.141 ± 0.025
1.471MetArg: 1.471 ± 0.036
1.835MetSer: 1.835 ± 0.035
1.706MetThr: 1.706 ± 0.038
1.898MetVal: 1.898 ± 0.038
0.221MetTrp: 0.221 ± 0.014
0.513MetTyr: 0.513 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.678AsnAla: 3.678 ± 0.11
0.327AsnCys: 0.327 ± 0.016
2.049AsnAsp: 2.049 ± 0.044
1.892AsnGlu: 1.892 ± 0.033
1.304AsnPhe: 1.304 ± 0.032
2.918AsnGly: 2.918 ± 0.062
0.818AsnHis: 0.818 ± 0.026
2.523AsnIle: 2.523 ± 0.046
1.57AsnLys: 1.57 ± 0.041
3.613AsnLeu: 3.613 ± 0.06
0.949AsnMet: 0.949 ± 0.023
1.645AsnAsn: 1.645 ± 0.037
2.09AsnPro: 2.09 ± 0.038
1.699AsnGln: 1.699 ± 0.053
2.108AsnArg: 2.108 ± 0.036
2.12AsnSer: 2.12 ± 0.047
2.093AsnThr: 2.093 ± 0.091
2.619AsnVal: 2.619 ± 0.1
0.538AsnTrp: 0.538 ± 0.026
1.157AsnTyr: 1.157 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
4.762ProAla: 4.762 ± 0.067
0.393ProCys: 0.393 ± 0.018
2.878ProAsp: 2.878 ± 0.067
3.19ProGlu: 3.19 ± 0.059
1.777ProPhe: 1.777 ± 0.038
3.357ProGly: 3.357 ± 0.056
1.06ProHis: 1.06 ± 0.027
2.156ProIle: 2.156 ± 0.039
1.451ProLys: 1.451 ± 0.032
5.292ProLeu: 5.292 ± 0.081
1.052ProMet: 1.052 ± 0.028
1.343ProAsn: 1.343 ± 0.034
1.76ProPro: 1.76 ± 0.041
2.253ProGln: 2.253 ± 0.042
2.059ProArg: 2.059 ± 0.041
2.439ProSer: 2.439 ± 0.047
2.149ProThr: 2.149 ± 0.039
3.55ProVal: 3.55 ± 0.054
0.659ProTrp: 0.659 ± 0.022
1.422ProTyr: 1.422 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
4.937GlnAla: 4.937 ± 0.078
0.369GlnCys: 0.369 ± 0.017
2.018GlnAsp: 2.018 ± 0.039
2.174GlnGlu: 2.174 ± 0.043
1.379GlnPhe: 1.379 ± 0.032
3.204GlnGly: 3.204 ± 0.062
1.223GlnHis: 1.223 ± 0.033
2.522GlnIle: 2.522 ± 0.043
1.729GlnLys: 1.729 ± 0.038
5.105GlnLeu: 5.105 ± 0.074
1.132GlnMet: 1.132 ± 0.029
1.448GlnAsn: 1.448 ± 0.036
2.229GlnPro: 2.229 ± 0.047
3.535GlnGln: 3.535 ± 0.079
3.433GlnArg: 3.433 ± 0.062
2.585GlnSer: 2.585 ± 0.049
2.35GlnThr: 2.35 ± 0.082
2.97GlnVal: 2.97 ± 0.049
0.673GlnTrp: 0.673 ± 0.023
1.154GlnTyr: 1.154 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
4.742ArgAla: 4.742 ± 0.07
0.609ArgCys: 0.609 ± 0.02
3.031ArgAsp: 3.031 ± 0.051
3.476ArgGlu: 3.476 ± 0.06
2.547ArgPhe: 2.547 ± 0.045
3.316ArgGly: 3.316 ± 0.053
1.718ArgHis: 1.718 ± 0.035
3.717ArgIle: 3.717 ± 0.06
2.224ArgLys: 2.224 ± 0.042
6.942ArgLeu: 6.942 ± 0.092
1.601ArgMet: 1.601 ± 0.035
2.11ArgAsn: 2.11 ± 0.036
2.327ArgPro: 2.327 ± 0.039
3.747ArgGln: 3.747 ± 0.061
3.934ArgArg: 3.934 ± 0.062
2.919ArgSer: 2.919 ± 0.049
2.526ArgThr: 2.526 ± 0.043
3.797ArgVal: 3.797 ± 0.057
1.008ArgTrp: 1.008 ± 0.028
2.288ArgTyr: 2.288 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
6.27SerAla: 6.27 ± 0.083
0.615SerCys: 0.615 ± 0.022
3.19SerAsp: 3.19 ± 0.054
3.155SerGlu: 3.155 ± 0.041
2.331SerPhe: 2.331 ± 0.037
5.618SerGly: 5.618 ± 0.084
1.449SerHis: 1.449 ± 0.03
3.435SerIle: 3.435 ± 0.06
1.963SerLys: 1.963 ± 0.04
7.24SerLeu: 7.24 ± 0.091
1.561SerMet: 1.561 ± 0.036
1.931SerAsn: 1.931 ± 0.052
2.79SerPro: 2.79 ± 0.046
2.729SerGln: 2.729 ± 0.043
3.603SerArg: 3.603 ± 0.052
3.934SerSer: 3.934 ± 0.073
2.973SerThr: 2.973 ± 0.057
4.528SerVal: 4.528 ± 0.115
0.952SerTrp: 0.952 ± 0.028
1.764SerTyr: 1.764 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.276ThrAla: 5.276 ± 0.199
0.425ThrCys: 0.425 ± 0.017
2.662ThrAsp: 2.662 ± 0.052
2.615ThrGlu: 2.615 ± 0.046
1.932ThrPhe: 1.932 ± 0.037
4.17ThrGly: 4.17 ± 0.066
1.174ThrHis: 1.174 ± 0.028
3.049ThrIle: 3.049 ± 0.112
1.385ThrLys: 1.385 ± 0.031
7.269ThrLeu: 7.269 ± 0.08
1.065ThrMet: 1.065 ± 0.026
1.584ThrAsn: 1.584 ± 0.036
3.119ThrPro: 3.119 ± 0.043
2.155ThrGln: 2.155 ± 0.042
2.859ThrArg: 2.859 ± 0.048
2.93ThrSer: 2.93 ± 0.058
2.936ThrThr: 2.936 ± 0.164
4.103ThrVal: 4.103 ± 0.242
0.68ThrTrp: 0.68 ± 0.038
1.339ThrTyr: 1.339 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
6.728ValAla: 6.728 ± 0.07
0.768ValCys: 0.768 ± 0.027
3.673ValAsp: 3.673 ± 0.068
3.7ValGlu: 3.7 ± 0.057
2.609ValPhe: 2.609 ± 0.045
4.831ValGly: 4.831 ± 0.102
1.163ValHis: 1.163 ± 0.031
4.649ValIle: 4.649 ± 0.063
2.786ValLys: 2.786 ± 0.049
7.114ValLeu: 7.114 ± 0.076
2.055ValMet: 2.055 ± 0.04
2.778ValAsn: 2.778 ± 0.094
2.914ValPro: 2.914 ± 0.047
2.294ValGln: 2.294 ± 0.053
3.639ValArg: 3.639 ± 0.055
4.757ValSer: 4.757 ± 0.076
4.301ValThr: 4.301 ± 0.212
5.162ValVal: 5.162 ± 0.079
0.813ValTrp: 0.813 ± 0.028
1.747ValTyr: 1.747 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.936TrpAla: 0.936 ± 0.032
0.151TrpCys: 0.151 ± 0.009
0.575TrpAsp: 0.575 ± 0.022
0.531TrpGlu: 0.531 ± 0.02
0.609TrpPhe: 0.609 ± 0.021
0.912TrpGly: 0.912 ± 0.029
0.396TrpHis: 0.396 ± 0.015
0.718TrpIle: 0.718 ± 0.025
0.426TrpLys: 0.426 ± 0.018
2.176TrpLeu: 2.176 ± 0.053
0.369TrpMet: 0.369 ± 0.014
0.474TrpAsn: 0.474 ± 0.021
0.629TrpPro: 0.629 ± 0.023
1.023TrpGln: 1.023 ± 0.027
1.14TrpArg: 1.14 ± 0.032
0.831TrpSer: 0.831 ± 0.046
0.481TrpThr: 0.481 ± 0.02
0.828TrpVal: 0.828 ± 0.025
0.222TrpTrp: 0.222 ± 0.012
0.359TrpTyr: 0.359 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.505TyrAla: 2.505 ± 0.044
0.397TyrCys: 0.397 ± 0.016
1.546TyrAsp: 1.546 ± 0.031
1.184TyrGlu: 1.184 ± 0.032
1.245TyrPhe: 1.245 ± 0.031
2.243TyrGly: 2.243 ± 0.044
0.768TyrHis: 0.768 ± 0.024
1.53TyrIle: 1.53 ± 0.034
0.867TyrLys: 0.867 ± 0.023
3.299TyrLeu: 3.299 ± 0.057
0.571TyrMet: 0.571 ± 0.018
0.966TyrAsn: 0.966 ± 0.026
1.545TyrPro: 1.545 ± 0.033
1.83TyrGln: 1.83 ± 0.053
2.077TyrArg: 2.077 ± 0.037
1.834TyrSer: 1.834 ± 0.036
1.409TyrThr: 1.409 ± 0.027
1.668TyrVal: 1.668 ± 0.035
0.47TyrTrp: 0.47 ± 0.021
0.966TyrTyr: 0.966 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4958 proteins (1522365 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski