Amino acid dipepetide frequency for Streptococcus satellite phage Javan67

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.926AlaAla: 2.926 ± 0.872
0.732AlaCys: 0.732 ± 0.411
5.486AlaAsp: 5.486 ± 1.552
5.486AlaGlu: 5.486 ± 1.417
2.195AlaPhe: 2.195 ± 0.66
4.389AlaGly: 4.389 ± 1.299
0.366AlaHis: 0.366 ± 0.447
6.584AlaIle: 6.584 ± 1.391
6.95AlaLys: 6.95 ± 1.745
9.876AlaLeu: 9.876 ± 2.505
1.829AlaMet: 1.829 ± 0.736
2.195AlaAsn: 2.195 ± 1.079
1.829AlaPro: 1.829 ± 0.794
2.56AlaGln: 2.56 ± 0.737
3.292AlaArg: 3.292 ± 0.859
3.292AlaSer: 3.292 ± 1.192
3.292AlaThr: 3.292 ± 0.775
2.56AlaVal: 2.56 ± 0.977
0.366AlaTrp: 0.366 ± 0.411
2.926AlaTyr: 2.926 ± 1.2
0.0AlaXaa: 0.0 ± 0.0
Cys
1.097CysAla: 1.097 ± 0.523
0.0CysCys: 0.0 ± 0.0
0.366CysAsp: 0.366 ± 0.364
0.366CysGlu: 0.366 ± 0.368
0.0CysPhe: 0.0 ± 0.0
0.732CysGly: 0.732 ± 0.508
0.366CysHis: 0.366 ± 0.361
0.732CysIle: 0.732 ± 0.545
1.097CysLys: 1.097 ± 0.519
0.366CysLeu: 0.366 ± 0.361
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.366CysGln: 0.366 ± 0.402
0.366CysArg: 0.366 ± 0.368
0.366CysSer: 0.366 ± 0.368
0.366CysThr: 0.366 ± 0.411
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.366CysTyr: 0.366 ± 0.364
0.0CysXaa: 0.0 ± 0.0
Asp
2.195AspAla: 2.195 ± 0.687
0.732AspCys: 0.732 ± 0.516
2.195AspAsp: 2.195 ± 0.638
3.658AspGlu: 3.658 ± 0.764
2.195AspPhe: 2.195 ± 0.864
2.56AspGly: 2.56 ± 1.206
0.732AspHis: 0.732 ± 0.468
6.584AspIle: 6.584 ± 1.268
6.95AspLys: 6.95 ± 1.406
5.121AspLeu: 5.121 ± 1.119
2.56AspMet: 2.56 ± 0.979
4.389AspAsn: 4.389 ± 1.75
0.732AspPro: 0.732 ± 0.472
1.097AspGln: 1.097 ± 0.494
1.097AspArg: 1.097 ± 0.597
2.195AspSer: 2.195 ± 0.937
2.56AspThr: 2.56 ± 0.924
2.56AspVal: 2.56 ± 1.09
0.732AspTrp: 0.732 ± 0.525
2.56AspTyr: 2.56 ± 0.989
0.0AspXaa: 0.0 ± 0.0
Glu
6.218GluAla: 6.218 ± 1.508
0.366GluCys: 0.366 ± 0.325
2.926GluAsp: 2.926 ± 1.249
4.755GluGlu: 4.755 ± 1.495
2.56GluPhe: 2.56 ± 1.341
2.195GluGly: 2.195 ± 0.854
0.366GluHis: 0.366 ± 0.411
7.315GluIle: 7.315 ± 1.895
9.876GluLys: 9.876 ± 1.442
10.241GluLeu: 10.241 ± 1.868
3.658GluMet: 3.658 ± 1.163
2.56GluAsn: 2.56 ± 0.845
1.097GluPro: 1.097 ± 0.587
5.852GluGln: 5.852 ± 2.013
6.584GluArg: 6.584 ± 2.05
3.292GluSer: 3.292 ± 0.97
4.389GluThr: 4.389 ± 0.793
2.195GluVal: 2.195 ± 0.743
1.097GluTrp: 1.097 ± 0.533
2.926GluTyr: 2.926 ± 1.101
0.0GluXaa: 0.0 ± 0.0
Phe
2.56PheAla: 2.56 ± 0.756
0.732PheCys: 0.732 ± 0.504
2.926PheAsp: 2.926 ± 1.004
4.023PheGlu: 4.023 ± 1.191
1.829PhePhe: 1.829 ± 0.636
2.926PheGly: 2.926 ± 0.869
1.097PheHis: 1.097 ± 0.5
3.292PheIle: 3.292 ± 1.046
2.56PheLys: 2.56 ± 0.921
2.926PheLeu: 2.926 ± 1.136
0.366PheMet: 0.366 ± 0.368
1.097PheAsn: 1.097 ± 0.655
1.097PhePro: 1.097 ± 0.618
1.463PheGln: 1.463 ± 0.664
2.56PheArg: 2.56 ± 0.802
2.195PheSer: 2.195 ± 0.931
1.829PheThr: 1.829 ± 0.821
1.463PheVal: 1.463 ± 0.605
0.366PheTrp: 0.366 ± 0.379
1.463PheTyr: 1.463 ± 0.586
0.0PheXaa: 0.0 ± 0.0
Gly
2.56GlyAla: 2.56 ± 0.754
0.0GlyCys: 0.0 ± 0.0
0.732GlyAsp: 0.732 ± 0.592
2.56GlyGlu: 2.56 ± 1.099
1.829GlyPhe: 1.829 ± 0.876
2.926GlyGly: 2.926 ± 1.351
0.732GlyHis: 0.732 ± 0.422
4.389GlyIle: 4.389 ± 1.402
4.023GlyLys: 4.023 ± 0.942
8.778GlyLeu: 8.778 ± 1.482
1.829GlyMet: 1.829 ± 0.775
1.463GlyAsn: 1.463 ± 0.826
0.0GlyPro: 0.0 ± 0.0
1.829GlyGln: 1.829 ± 0.923
2.195GlyArg: 2.195 ± 0.698
2.926GlySer: 2.926 ± 0.948
1.463GlyThr: 1.463 ± 0.58
2.926GlyVal: 2.926 ± 0.997
1.097GlyTrp: 1.097 ± 0.665
3.292GlyTyr: 3.292 ± 0.979
0.0GlyXaa: 0.0 ± 0.0
His
1.097HisAla: 1.097 ± 0.925
0.0HisCys: 0.0 ± 0.0
0.366HisAsp: 0.366 ± 0.325
0.366HisGlu: 0.366 ± 0.375
0.366HisPhe: 0.366 ± 0.375
2.195HisGly: 2.195 ± 1.001
1.829HisHis: 1.829 ± 1.14
1.463HisIle: 1.463 ± 0.629
1.097HisLys: 1.097 ± 0.816
3.292HisLeu: 3.292 ± 0.986
0.0HisMet: 0.0 ± 0.0
0.732HisAsn: 0.732 ± 0.575
0.732HisPro: 0.732 ± 0.478
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
1.097HisThr: 1.097 ± 0.509
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.732HisTyr: 0.732 ± 0.457
0.0HisXaa: 0.0 ± 0.0
Ile
4.389IleAla: 4.389 ± 1.225
1.463IleCys: 1.463 ± 0.767
7.315IleAsp: 7.315 ± 1.479
5.486IleGlu: 5.486 ± 1.629
2.926IlePhe: 2.926 ± 0.982
1.829IleGly: 1.829 ± 0.9
1.097IleHis: 1.097 ± 0.631
4.389IleIle: 4.389 ± 1.25
4.389IleLys: 4.389 ± 1.06
8.778IleLeu: 8.778 ± 2.416
0.732IleMet: 0.732 ± 0.577
2.195IleAsn: 2.195 ± 0.834
2.56IlePro: 2.56 ± 1.027
3.292IleGln: 3.292 ± 1.339
5.852IleArg: 5.852 ± 1.16
4.389IleSer: 4.389 ± 1.641
5.852IleThr: 5.852 ± 1.688
1.829IleVal: 1.829 ± 0.792
1.829IleTrp: 1.829 ± 0.735
2.926IleTyr: 2.926 ± 0.846
0.0IleXaa: 0.0 ± 0.0
Lys
10.607LysAla: 10.607 ± 2.08
0.366LysCys: 0.366 ± 0.379
3.292LysAsp: 3.292 ± 1.496
11.339LysGlu: 11.339 ± 2.021
3.658LysPhe: 3.658 ± 0.929
3.292LysGly: 3.292 ± 0.977
1.097LysHis: 1.097 ± 0.752
4.389LysIle: 4.389 ± 1.146
9.51LysLys: 9.51 ± 2.084
6.95LysLeu: 6.95 ± 1.547
2.195LysMet: 2.195 ± 0.877
7.681LysAsn: 7.681 ± 1.452
3.658LysPro: 3.658 ± 1.05
5.486LysGln: 5.486 ± 1.192
3.658LysArg: 3.658 ± 1.122
3.658LysSer: 3.658 ± 1.358
8.047LysThr: 8.047 ± 1.446
5.852LysVal: 5.852 ± 1.452
0.366LysTrp: 0.366 ± 0.411
1.463LysTyr: 1.463 ± 1.087
0.0LysXaa: 0.0 ± 0.0
Leu
9.144LeuAla: 9.144 ± 1.974
0.732LeuCys: 0.732 ± 0.573
8.047LeuAsp: 8.047 ± 1.388
13.168LeuGlu: 13.168 ± 2.491
5.121LeuPhe: 5.121 ± 1.69
6.584LeuGly: 6.584 ± 1.625
0.732LeuHis: 0.732 ± 0.509
5.121LeuIle: 5.121 ± 1.259
13.533LeuLys: 13.533 ± 2.413
14.265LeuLeu: 14.265 ± 1.979
2.926LeuMet: 2.926 ± 0.773
4.023LeuAsn: 4.023 ± 1.073
2.56LeuPro: 2.56 ± 1.226
5.486LeuGln: 5.486 ± 1.116
3.292LeuArg: 3.292 ± 1.141
5.486LeuSer: 5.486 ± 1.247
8.778LeuThr: 8.778 ± 1.45
2.926LeuVal: 2.926 ± 0.946
0.732LeuTrp: 0.732 ± 0.723
3.658LeuTyr: 3.658 ± 1.359
0.0LeuXaa: 0.0 ± 0.0
Met
3.292MetAla: 3.292 ± 1.081
0.0MetCys: 0.0 ± 0.0
1.463MetAsp: 1.463 ± 0.716
2.195MetGlu: 2.195 ± 0.828
0.0MetPhe: 0.0 ± 0.0
0.366MetGly: 0.366 ± 0.332
0.0MetHis: 0.0 ± 0.0
1.829MetIle: 1.829 ± 0.766
1.463MetLys: 1.463 ± 0.768
2.56MetLeu: 2.56 ± 1.012
0.0MetMet: 0.0 ± 0.0
1.829MetAsn: 1.829 ± 0.908
0.732MetPro: 0.732 ± 0.599
0.366MetGln: 0.366 ± 0.332
1.463MetArg: 1.463 ± 0.536
0.732MetSer: 0.732 ± 0.576
2.56MetThr: 2.56 ± 0.806
1.097MetVal: 1.097 ± 0.771
0.366MetTrp: 0.366 ± 0.364
1.097MetTyr: 1.097 ± 0.632
0.0MetXaa: 0.0 ± 0.0
Asn
2.56AsnAla: 2.56 ± 0.99
0.0AsnCys: 0.0 ± 0.0
1.829AsnAsp: 1.829 ± 1.113
2.926AsnGlu: 2.926 ± 1.094
2.56AsnPhe: 2.56 ± 0.919
2.56AsnGly: 2.56 ± 0.918
0.732AsnHis: 0.732 ± 0.478
2.195AsnIle: 2.195 ± 0.855
5.486AsnLys: 5.486 ± 0.656
4.389AsnLeu: 4.389 ± 1.07
0.732AsnMet: 0.732 ± 0.422
3.292AsnAsn: 3.292 ± 0.933
0.732AsnPro: 0.732 ± 0.419
2.195AsnGln: 2.195 ± 0.861
2.195AsnArg: 2.195 ± 1.06
2.56AsnSer: 2.56 ± 1.074
2.195AsnThr: 2.195 ± 1.288
0.732AsnVal: 0.732 ± 0.848
0.366AsnTrp: 0.366 ± 0.402
1.829AsnTyr: 1.829 ± 0.731
0.0AsnXaa: 0.0 ± 0.0
Pro
2.195ProAla: 2.195 ± 0.946
0.0ProCys: 0.0 ± 0.0
1.829ProAsp: 1.829 ± 0.593
1.463ProGlu: 1.463 ± 1.018
0.732ProPhe: 0.732 ± 0.498
0.366ProGly: 0.366 ± 0.379
0.366ProHis: 0.366 ± 0.325
0.732ProIle: 0.732 ± 0.552
2.56ProLys: 2.56 ± 1.156
2.56ProLeu: 2.56 ± 0.972
0.0ProMet: 0.0 ± 0.0
0.0ProAsn: 0.0 ± 0.0
0.366ProPro: 0.366 ± 0.397
2.56ProGln: 2.56 ± 1.023
2.195ProArg: 2.195 ± 0.839
1.463ProSer: 1.463 ± 0.634
1.463ProThr: 1.463 ± 0.578
0.732ProVal: 0.732 ± 0.419
0.366ProTrp: 0.366 ± 0.39
1.463ProTyr: 1.463 ± 0.708
0.0ProXaa: 0.0 ± 0.0
Gln
3.658GlnAla: 3.658 ± 1.54
0.366GlnCys: 0.366 ± 0.368
2.195GlnAsp: 2.195 ± 0.934
3.292GlnGlu: 3.292 ± 0.965
0.732GlnPhe: 0.732 ± 0.664
2.926GlnGly: 2.926 ± 0.82
1.097GlnHis: 1.097 ± 0.733
3.658GlnIle: 3.658 ± 1.498
3.658GlnLys: 3.658 ± 1.213
7.681GlnLeu: 7.681 ± 1.771
0.366GlnMet: 0.366 ± 0.332
1.829GlnAsn: 1.829 ± 0.766
2.195GlnPro: 2.195 ± 1.211
3.658GlnGln: 3.658 ± 1.201
2.56GlnArg: 2.56 ± 0.744
2.56GlnSer: 2.56 ± 0.667
4.389GlnThr: 4.389 ± 1.41
3.658GlnVal: 3.658 ± 1.108
0.366GlnTrp: 0.366 ± 0.332
0.732GlnTyr: 0.732 ± 0.617
0.0GlnXaa: 0.0 ± 0.0
Arg
2.926ArgAla: 2.926 ± 1.094
0.366ArgCys: 0.366 ± 0.308
2.195ArgAsp: 2.195 ± 0.851
5.121ArgGlu: 5.121 ± 1.235
1.829ArgPhe: 1.829 ± 0.713
2.926ArgGly: 2.926 ± 1.034
0.366ArgHis: 0.366 ± 0.308
3.292ArgIle: 3.292 ± 1.161
2.926ArgLys: 2.926 ± 0.924
4.755ArgLeu: 4.755 ± 0.972
0.366ArgMet: 0.366 ± 0.402
1.829ArgAsn: 1.829 ± 0.794
1.097ArgPro: 1.097 ± 0.768
5.121ArgGln: 5.121 ± 1.583
3.658ArgArg: 3.658 ± 1.082
2.56ArgSer: 2.56 ± 1.148
2.195ArgThr: 2.195 ± 1.135
2.195ArgVal: 2.195 ± 0.833
0.732ArgTrp: 0.732 ± 0.504
2.56ArgTyr: 2.56 ± 0.812
0.0ArgXaa: 0.0 ± 0.0
Ser
2.926SerAla: 2.926 ± 0.997
0.0SerCys: 0.0 ± 0.0
4.755SerAsp: 4.755 ± 0.852
4.755SerGlu: 4.755 ± 1.43
0.732SerPhe: 0.732 ± 0.756
1.097SerGly: 1.097 ± 0.599
1.097SerHis: 1.097 ± 0.528
5.121SerIle: 5.121 ± 1.141
4.389SerLys: 4.389 ± 1.667
4.755SerLeu: 4.755 ± 0.912
0.732SerMet: 0.732 ± 0.563
1.829SerAsn: 1.829 ± 0.805
0.366SerPro: 0.366 ± 0.332
1.463SerGln: 1.463 ± 0.685
1.829SerArg: 1.829 ± 0.89
1.829SerSer: 1.829 ± 0.787
3.292SerThr: 3.292 ± 1.318
4.389SerVal: 4.389 ± 1.007
0.732SerTrp: 0.732 ± 0.49
4.023SerTyr: 4.023 ± 1.206
0.0SerXaa: 0.0 ± 0.0
Thr
2.926ThrAla: 2.926 ± 1.11
0.366ThrCys: 0.366 ± 0.379
2.926ThrAsp: 2.926 ± 0.813
3.658ThrGlu: 3.658 ± 1.141
2.195ThrPhe: 2.195 ± 0.676
4.755ThrGly: 4.755 ± 1.64
1.097ThrHis: 1.097 ± 0.633
5.852ThrIle: 5.852 ± 1.31
6.584ThrLys: 6.584 ± 1.314
7.681ThrLeu: 7.681 ± 1.098
2.56ThrMet: 2.56 ± 1.482
1.829ThrAsn: 1.829 ± 0.731
1.463ThrPro: 1.463 ± 0.733
4.755ThrGln: 4.755 ± 1.733
2.56ThrArg: 2.56 ± 0.931
2.56ThrSer: 2.56 ± 1.158
3.658ThrThr: 3.658 ± 1.067
5.486ThrVal: 5.486 ± 1.74
0.366ThrTrp: 0.366 ± 0.332
2.195ThrTyr: 2.195 ± 0.909
0.0ThrXaa: 0.0 ± 0.0
Val
2.195ValAla: 2.195 ± 0.672
0.0ValCys: 0.0 ± 0.0
1.463ValAsp: 1.463 ± 0.633
2.56ValGlu: 2.56 ± 1.162
2.926ValPhe: 2.926 ± 1.152
1.463ValGly: 1.463 ± 0.752
0.366ValHis: 0.366 ± 0.453
3.292ValIle: 3.292 ± 0.932
5.121ValLys: 5.121 ± 1.689
4.023ValLeu: 4.023 ± 1.11
0.366ValMet: 0.366 ± 0.411
1.829ValAsn: 1.829 ± 0.707
1.097ValPro: 1.097 ± 0.522
1.463ValGln: 1.463 ± 0.623
1.463ValArg: 1.463 ± 0.908
3.658ValSer: 3.658 ± 0.902
5.121ValThr: 5.121 ± 1.409
2.56ValVal: 2.56 ± 0.902
0.366ValTrp: 0.366 ± 0.377
3.292ValTyr: 3.292 ± 1.019
0.0ValXaa: 0.0 ± 0.0
Trp
1.463TrpAla: 1.463 ± 0.843
0.366TrpCys: 0.366 ± 0.361
0.0TrpAsp: 0.0 ± 0.0
1.463TrpGlu: 1.463 ± 0.73
0.366TrpPhe: 0.366 ± 0.361
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.366TrpIle: 0.366 ± 0.402
1.097TrpLys: 1.097 ± 0.507
2.195TrpLeu: 2.195 ± 0.605
0.366TrpMet: 0.366 ± 0.361
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.366TrpGln: 0.366 ± 0.379
0.0TrpArg: 0.0 ± 0.0
0.732TrpSer: 0.732 ± 0.525
0.732TrpThr: 0.732 ± 0.419
0.732TrpVal: 0.732 ± 0.599
0.0TrpTrp: 0.0 ± 0.0
0.366TrpTyr: 0.366 ± 0.368
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.195TyrAla: 2.195 ± 0.967
0.366TyrCys: 0.366 ± 0.361
1.097TyrAsp: 1.097 ± 0.675
1.829TyrGlu: 1.829 ± 0.907
4.023TyrPhe: 4.023 ± 1.275
1.463TyrGly: 1.463 ± 0.611
1.829TyrHis: 1.829 ± 0.708
2.926TyrIle: 2.926 ± 1.083
3.658TyrLys: 3.658 ± 1.258
5.121TyrLeu: 5.121 ± 1.099
1.463TyrMet: 1.463 ± 0.576
1.463TyrAsn: 1.463 ± 0.551
1.097TyrPro: 1.097 ± 0.648
2.195TyrGln: 2.195 ± 0.896
2.195TyrArg: 2.195 ± 0.868
3.658TyrSer: 3.658 ± 1.173
2.195TyrThr: 2.195 ± 0.858
0.732TyrVal: 0.732 ± 0.411
0.366TyrTrp: 0.366 ± 0.424
1.829TyrTyr: 1.829 ± 0.651
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18 proteins (2735 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski