Amino acid dipepetide frequency for Syntrophothermus lipocalidus (strain DSM 12680 / TGB-C1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.46AlaAla: 8.46 ± 0.129	1.248AlaCys: 1.248 ± 0.042	3.94AlaAsp: 3.94 ± 0.072	6.083AlaGlu: 6.083 ± 0.13	3.083AlaPhe: 3.083 ± 0.074	7.522AlaGly: 7.522 ± 0.125	1.273AlaHis: 1.273 ± 0.041	4.732AlaIle: 4.732 ± 0.095	4.175AlaLys: 4.175 ± 0.092	8.962AlaLeu: 8.962 ± 0.128	2.197AlaMet: 2.197 ± 0.066	2.353AlaAsn: 2.353 ± 0.069	2.414AlaPro: 2.414 ± 0.071	2.935AlaGln: 2.935 ± 0.074	6.312AlaArg: 6.312 ± 0.114	4.469AlaSer: 4.469 ± 0.083	3.655AlaThr: 3.655 ± 0.086	8.195AlaVal: 8.195 ± 0.109	0.872AlaTrp: 0.872 ± 0.037	2.579AlaTyr: 2.579 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.871CysAla: 0.871 ± 0.034	0.223CysCys: 0.223 ± 0.017	0.601CysAsp: 0.601 ± 0.032	0.779CysGlu: 0.779 ± 0.04	0.523CysPhe: 0.523 ± 0.03	1.35CysGly: 1.35 ± 0.047	0.312CysHis: 0.312 ± 0.022	0.652CysIle: 0.652 ± 0.032	0.425CysLys: 0.425 ± 0.023	1.409CysLeu: 1.409 ± 0.058	0.259CysMet: 0.259 ± 0.02	0.421CysAsn: 0.421 ± 0.026	0.868CysPro: 0.868 ± 0.036	0.507CysGln: 0.507 ± 0.03	0.928CysArg: 0.928 ± 0.04	0.716CysSer: 0.716 ± 0.035	0.591CysThr: 0.591 ± 0.029	0.751CysVal: 0.751 ± 0.029	0.153CysTrp: 0.153 ± 0.015	0.418CysTyr: 0.418 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	3.465AspAla: 3.465 ± 0.072	0.581AspCys: 0.581 ± 0.033	2.075AspAsp: 2.075 ± 0.059	4.051AspGlu: 4.051 ± 0.084	2.158AspPhe: 2.158 ± 0.051	3.608AspGly: 3.608 ± 0.08	0.783AspHis: 0.783 ± 0.035	3.974AspIle: 3.974 ± 0.094	2.529AspLys: 2.529 ± 0.047	5.271AspLeu: 5.271 ± 0.11	1.38AspMet: 1.38 ± 0.035	1.517AspAsn: 1.517 ± 0.048	2.308AspPro: 2.308 ± 0.048	1.428AspGln: 1.428 ± 0.041	3.218AspArg: 3.218 ± 0.066	2.267AspSer: 2.267 ± 0.057	2.282AspThr: 2.282 ± 0.058	4.029AspVal: 4.029 ± 0.069	0.626AspTrp: 0.626 ± 0.025	1.944AspTyr: 1.944 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	6.763GluAla: 6.763 ± 0.116	0.625GluCys: 0.625 ± 0.035	3.368GluAsp: 3.368 ± 0.081	6.699GluGlu: 6.699 ± 0.14	2.493GluPhe: 2.493 ± 0.063	5.232GluGly: 5.232 ± 0.091	1.249GluHis: 1.249 ± 0.041	5.447GluIle: 5.447 ± 0.095	4.975GluLys: 4.975 ± 0.122	7.582GluLeu: 7.582 ± 0.132	2.238GluMet: 2.238 ± 0.056	2.64GluAsn: 2.64 ± 0.067	2.49GluPro: 2.49 ± 0.064	2.569GluGln: 2.569 ± 0.059	4.783GluArg: 4.783 ± 0.097	3.067GluSer: 3.067 ± 0.065	3.597GluThr: 3.597 ± 0.074	6.609GluVal: 6.609 ± 0.085	0.722GluTrp: 0.722 ± 0.033	2.113GluTyr: 2.113 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.058PheAla: 3.058 ± 0.08	0.62PheCys: 0.62 ± 0.029	1.995PheAsp: 1.995 ± 0.056	2.365PheGlu: 2.365 ± 0.052	1.618PhePhe: 1.618 ± 0.061	3.008PheGly: 3.008 ± 0.065	0.641PheHis: 0.641 ± 0.035	2.19PheIle: 2.19 ± 0.058	1.634PheLys: 1.634 ± 0.05	3.834PheLeu: 3.834 ± 0.08	0.894PheMet: 0.894 ± 0.044	1.144PheAsn: 1.144 ± 0.043	1.609PhePro: 1.609 ± 0.042	1.069PheGln: 1.069 ± 0.041	2.146PheArg: 2.146 ± 0.061	2.261PheSer: 2.261 ± 0.062	1.964PheThr: 1.964 ± 0.057	2.732PheVal: 2.732 ± 0.077	0.491PheTrp: 0.491 ± 0.023	1.324PheTyr: 1.324 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.968GlyAla: 5.968 ± 0.116	1.324GlyCys: 1.324 ± 0.054	3.726GlyAsp: 3.726 ± 0.076	5.338GlyGlu: 5.338 ± 0.097	3.317GlyPhe: 3.317 ± 0.072	5.786GlyGly: 5.786 ± 0.123	1.375GlyHis: 1.375 ± 0.045	5.968GlyIle: 5.968 ± 0.11	5.009GlyLys: 5.009 ± 0.093	8.39GlyLeu: 8.39 ± 0.128	2.267GlyMet: 2.267 ± 0.067	2.421GlyAsn: 2.421 ± 0.06	2.56GlyPro: 2.56 ± 0.064	2.834GlyGln: 2.834 ± 0.075	4.9GlyArg: 4.9 ± 0.101	4.045GlySer: 4.045 ± 0.071	4.208GlyThr: 4.208 ± 0.083	6.33GlyVal: 6.33 ± 0.104	0.938GlyTrp: 0.938 ± 0.042	3.0GlyTyr: 3.0 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	1.105HisAla: 1.105 ± 0.032	0.275HisCys: 0.275 ± 0.017	0.764HisAsp: 0.764 ± 0.03	1.013HisGlu: 1.013 ± 0.038	0.713HisPhe: 0.713 ± 0.029	1.402HisGly: 1.402 ± 0.04	0.475HisHis: 0.475 ± 0.027	0.981HisIle: 0.981 ± 0.034	0.607HisLys: 0.607 ± 0.033	1.905HisLeu: 1.905 ± 0.058	0.386HisMet: 0.386 ± 0.021	0.581HisAsn: 0.581 ± 0.028	1.16HisPro: 1.16 ± 0.046	0.638HisGln: 0.638 ± 0.03	1.319HisArg: 1.319 ± 0.043	0.913HisSer: 0.913 ± 0.033	0.763HisThr: 0.763 ± 0.039	1.134HisVal: 1.134 ± 0.04	0.176HisTrp: 0.176 ± 0.014	0.625HisTyr: 0.625 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.5IleAla: 5.5 ± 0.102	0.767IleCys: 0.767 ± 0.034	3.502IleAsp: 3.502 ± 0.072	4.645IleGlu: 4.645 ± 0.088	1.88IlePhe: 1.88 ± 0.048	4.815IleGly: 4.815 ± 0.086	1.021IleHis: 1.021 ± 0.039	3.905IleIle: 3.905 ± 0.082	3.463IleLys: 3.463 ± 0.075	5.948IleLeu: 5.948 ± 0.094	1.459IleMet: 1.459 ± 0.046	2.197IleAsn: 2.197 ± 0.057	3.157IlePro: 3.157 ± 0.065	1.832IleGln: 1.832 ± 0.055	3.846IleArg: 3.846 ± 0.073	3.439IleSer: 3.439 ± 0.061	3.458IleThr: 3.458 ± 0.076	4.673IleVal: 4.673 ± 0.083	0.494IleTrp: 0.494 ± 0.028	1.685IleTyr: 1.685 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.853LysAla: 4.853 ± 0.09	0.479LysCys: 0.479 ± 0.03	2.733LysAsp: 2.733 ± 0.071	4.662LysGlu: 4.662 ± 0.09	1.242LysPhe: 1.242 ± 0.05	4.106LysGly: 4.106 ± 0.093	0.799LysHis: 0.799 ± 0.041	3.002LysIle: 3.002 ± 0.069	3.406LysLys: 3.406 ± 0.091	4.687LysLeu: 4.687 ± 0.084	1.399LysMet: 1.399 ± 0.041	1.925LysAsn: 1.925 ± 0.051	2.306LysPro: 2.306 ± 0.052	1.765LysGln: 1.765 ± 0.059	3.368LysArg: 3.368 ± 0.087	2.587LysSer: 2.587 ± 0.068	2.967LysThr: 2.967 ± 0.066	4.706LysVal: 4.706 ± 0.082	0.51LysTrp: 0.51 ± 0.029	1.516LysTyr: 1.516 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	10.559LeuAla: 10.559 ± 0.139	1.13LeuCys: 1.13 ± 0.041	5.351LeuAsp: 5.351 ± 0.091	7.768LeuGlu: 7.768 ± 0.127	3.541LeuPhe: 3.541 ± 0.08	8.231LeuGly: 8.231 ± 0.128	1.613LeuHis: 1.613 ± 0.053	5.345LeuIle: 5.345 ± 0.098	5.929LeuLys: 5.929 ± 0.097	9.482LeuLeu: 9.482 ± 0.129	2.4LeuMet: 2.4 ± 0.072	3.323LeuAsn: 3.323 ± 0.067	4.533LeuPro: 4.533 ± 0.074	3.1LeuGln: 3.1 ± 0.073	6.15LeuArg: 6.15 ± 0.11	5.747LeuSer: 5.747 ± 0.116	4.99LeuThr: 4.99 ± 0.11	9.154LeuVal: 9.154 ± 0.131	0.96LeuTrp: 0.96 ± 0.04	2.705LeuTyr: 2.705 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.605MetAla: 2.605 ± 0.077	0.269MetCys: 0.269 ± 0.02	1.204MetAsp: 1.204 ± 0.04	1.797MetGlu: 1.797 ± 0.059	0.858MetPhe: 0.858 ± 0.032	2.014MetGly: 2.014 ± 0.062	0.361MetHis: 0.361 ± 0.022	1.364MetIle: 1.364 ± 0.042	1.533MetLys: 1.533 ± 0.051	2.467MetLeu: 2.467 ± 0.055	0.646MetMet: 0.646 ± 0.032	0.901MetAsn: 0.901 ± 0.039	1.072MetPro: 1.072 ± 0.047	0.775MetGln: 0.775 ± 0.031	1.471MetArg: 1.471 ± 0.046	1.411MetSer: 1.411 ± 0.039	1.343MetThr: 1.343 ± 0.051	2.322MetVal: 2.322 ± 0.047	0.181MetTrp: 0.181 ± 0.018	0.609MetTyr: 0.609 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.187AsnAla: 2.187 ± 0.06	0.491AsnCys: 0.491 ± 0.022	1.277AsnAsp: 1.277 ± 0.046	1.896AsnGlu: 1.896 ± 0.056	1.089AsnPhe: 1.089 ± 0.046	2.41AsnGly: 2.41 ± 0.065	0.628AsnHis: 0.628 ± 0.034	2.2AsnIle: 2.2 ± 0.064	1.42AsnLys: 1.42 ± 0.044	3.827AsnLeu: 3.827 ± 0.075	0.811AsnMet: 0.811 ± 0.041	1.006AsnAsn: 1.006 ± 0.04	2.078AsnPro: 2.078 ± 0.06	1.278AsnGln: 1.278 ± 0.044	2.47AsnArg: 2.47 ± 0.058	1.606AsnSer: 1.606 ± 0.041	1.516AsnThr: 1.516 ± 0.056	2.443AsnVal: 2.443 ± 0.058	0.406AsnTrp: 0.406 ± 0.028	1.019AsnTyr: 1.019 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.285ProAla: 3.285 ± 0.078	0.502ProCys: 0.502 ± 0.026	2.665ProAsp: 2.665 ± 0.058	4.032ProGlu: 4.032 ± 0.081	1.666ProPhe: 1.666 ± 0.059	4.214ProGly: 4.214 ± 0.078	0.786ProHis: 0.786 ± 0.029	2.027ProIle: 2.027 ± 0.051	1.676ProLys: 1.676 ± 0.046	3.78ProLeu: 3.78 ± 0.08	0.804ProMet: 0.804 ± 0.04	1.264ProAsn: 1.264 ± 0.034	1.785ProPro: 1.785 ± 0.068	1.452ProGln: 1.452 ± 0.055	2.435ProArg: 2.435 ± 0.062	2.369ProSer: 2.369 ± 0.068	1.836ProThr: 1.836 ± 0.055	4.341ProVal: 4.341 ± 0.078	0.494ProTrp: 0.494 ± 0.025	1.343ProTyr: 1.343 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.541GlnAla: 3.541 ± 0.083	0.332GlnCys: 0.332 ± 0.023	1.656GlnAsp: 1.656 ± 0.05	2.906GlnGlu: 2.906 ± 0.066	0.992GlnPhe: 0.992 ± 0.033	2.603GlnGly: 2.603 ± 0.066	0.542GlnHis: 0.542 ± 0.029	1.651GlnIle: 1.651 ± 0.05	1.97GlnLys: 1.97 ± 0.063	3.0GlnLeu: 3.0 ± 0.061	0.878GlnMet: 0.878 ± 0.038	1.088GlnAsn: 1.088 ± 0.039	1.31GlnPro: 1.31 ± 0.045	1.19GlnGln: 1.19 ± 0.049	1.953GlnArg: 1.953 ± 0.052	1.506GlnSer: 1.506 ± 0.055	1.479GlnThr: 1.479 ± 0.053	3.326GlnVal: 3.326 ± 0.068	0.317GlnTrp: 0.317 ± 0.021	0.978GlnTyr: 0.978 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	4.783ArgAla: 4.783 ± 0.1	0.796ArgCys: 0.796 ± 0.033	3.163ArgAsp: 3.163 ± 0.061	5.638ArgGlu: 5.638 ± 0.12	2.574ArgPhe: 2.574 ± 0.074	4.361ArgGly: 4.361 ± 0.074	1.108ArgHis: 1.108 ± 0.049	4.262ArgIle: 4.262 ± 0.081	3.407ArgLys: 3.407 ± 0.073	7.021ArgLeu: 7.021 ± 0.103	1.84ArgMet: 1.84 ± 0.051	2.108ArgAsn: 2.108 ± 0.056	2.478ArgPro: 2.478 ± 0.06	2.468ArgGln: 2.468 ± 0.058	4.199ArgArg: 4.199 ± 0.093	2.917ArgSer: 2.917 ± 0.066	2.732ArgThr: 2.732 ± 0.067	5.558ArgVal: 5.558 ± 0.114	0.772ArgTrp: 0.772 ± 0.038	2.229ArgTyr: 2.229 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	3.725SerAla: 3.725 ± 0.084	0.716SerCys: 0.716 ± 0.031	2.471SerAsp: 2.471 ± 0.071	3.311SerGlu: 3.311 ± 0.078	2.094SerPhe: 2.094 ± 0.055	4.751SerGly: 4.751 ± 0.101	0.958SerHis: 0.958 ± 0.038	3.117SerIle: 3.117 ± 0.059	2.295SerLys: 2.295 ± 0.061	5.832SerLeu: 5.832 ± 0.091	1.305SerMet: 1.305 ± 0.047	1.456SerAsn: 1.456 ± 0.051	2.602SerPro: 2.602 ± 0.073	1.84SerGln: 1.84 ± 0.055	3.627SerArg: 3.627 ± 0.068	3.093SerSer: 3.093 ± 0.087	2.547SerThr: 2.547 ± 0.085	4.004SerVal: 4.004 ± 0.078	0.665SerTrp: 0.665 ± 0.036	1.689SerTyr: 1.689 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.304ThrAla: 4.304 ± 0.082	0.639ThrCys: 0.639 ± 0.031	2.411ThrAsp: 2.411 ± 0.064	3.071ThrGlu: 3.071 ± 0.068	1.631ThrPhe: 1.631 ± 0.053	5.026ThrGly: 5.026 ± 0.078	0.805ThrHis: 0.805 ± 0.035	2.78ThrIle: 2.78 ± 0.067	2.082ThrLys: 2.082 ± 0.052	4.654ThrLeu: 4.654 ± 0.102	0.995ThrMet: 0.995 ± 0.041	1.439ThrAsn: 1.439 ± 0.046	2.424ThrPro: 2.424 ± 0.055	1.276ThrGln: 1.276 ± 0.04	3.099ThrArg: 3.099 ± 0.069	2.702ThrSer: 2.702 ± 0.064	2.502ThrThr: 2.502 ± 0.059	5.044ThrVal: 5.044 ± 0.105	0.476ThrTrp: 0.476 ± 0.03	1.485ThrTyr: 1.485 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	7.327ValAla: 7.327 ± 0.124	1.12ValCys: 1.12 ± 0.038	4.396ValAsp: 4.396 ± 0.086	6.226ValGlu: 6.226 ± 0.109	3.458ValPhe: 3.458 ± 0.075	5.967ValGly: 5.967 ± 0.092	1.303ValHis: 1.303 ± 0.038	5.845ValIle: 5.845 ± 0.092	4.792ValLys: 4.792 ± 0.087	9.035ValLeu: 9.035 ± 0.143	2.17ValMet: 2.17 ± 0.061	2.938ValAsn: 2.938 ± 0.06	3.607ValPro: 3.607 ± 0.072	2.455ValGln: 2.455 ± 0.061	5.039ValArg: 5.039 ± 0.1	4.696ValSer: 4.696 ± 0.097	4.489ValThr: 4.489 ± 0.101	7.968ValVal: 7.968 ± 0.116	0.818ValTrp: 0.818 ± 0.034	2.678ValTyr: 2.678 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.913TrpAla: 0.913 ± 0.043	0.134TrpCys: 0.134 ± 0.014	0.619TrpAsp: 0.619 ± 0.031	0.898TrpGlu: 0.898 ± 0.039	0.396TrpPhe: 0.396 ± 0.023	0.789TrpGly: 0.789 ± 0.034	0.202TrpHis: 0.202 ± 0.018	0.501TrpIle: 0.501 ± 0.032	0.498TrpLys: 0.498 ± 0.024	1.273TrpLeu: 1.273 ± 0.048	0.268TrpMet: 0.268 ± 0.019	0.352TrpAsn: 0.352 ± 0.025	0.422TrpPro: 0.422 ± 0.028	0.505TrpGln: 0.505 ± 0.023	0.628TrpArg: 0.628 ± 0.026	0.552TrpSer: 0.552 ± 0.033	0.405TrpThr: 0.405 ± 0.023	0.802TrpVal: 0.802 ± 0.03	0.192TrpTrp: 0.192 ± 0.017	0.29TrpTyr: 0.29 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.186TyrAla: 2.186 ± 0.061	0.485TyrCys: 0.485 ± 0.025	1.578TyrAsp: 1.578 ± 0.045	2.081TyrGlu: 2.081 ± 0.05	1.271TyrPhe: 1.271 ± 0.048	2.506TyrGly: 2.506 ± 0.059	0.703TyrHis: 0.703 ± 0.034	1.739TyrIle: 1.739 ± 0.045	1.195TyrLys: 1.195 ± 0.046	3.656TyrLeu: 3.656 ± 0.067	0.604TyrMet: 0.604 ± 0.025	0.981TyrAsn: 0.981 ± 0.036	1.57TyrPro: 1.57 ± 0.048	1.303TyrGln: 1.303 ± 0.042	2.526TyrArg: 2.526 ± 0.067	1.736TyrSer: 1.736 ± 0.047	1.522TyrThr: 1.522 ± 0.053	2.207TyrVal: 2.207 ± 0.06	0.377TyrTrp: 0.377 ± 0.024	1.296TyrTyr: 1.296 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2311 proteins (686777 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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