Amino acid dipepetide frequency for Sulfurovum sp. (strain NBC37-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.644AlaAla: 5.644 ± 0.137	0.705AlaCys: 0.705 ± 0.035	3.556AlaAsp: 3.556 ± 0.07	4.18AlaGlu: 4.18 ± 0.084	3.565AlaPhe: 3.565 ± 0.075	4.795AlaGly: 4.795 ± 0.098	1.525AlaHis: 1.525 ± 0.045	5.716AlaIle: 5.716 ± 0.103	6.432AlaLys: 6.432 ± 0.11	8.338AlaLeu: 8.338 ± 0.117	2.428AlaMet: 2.428 ± 0.061	2.775AlaAsn: 2.775 ± 0.064	2.139AlaPro: 2.139 ± 0.051	2.488AlaGln: 2.488 ± 0.066	2.732AlaArg: 2.732 ± 0.066	4.173AlaSer: 4.173 ± 0.074	3.715AlaThr: 3.715 ± 0.073	5.045AlaVal: 5.045 ± 0.098	0.639AlaTrp: 0.639 ± 0.031	3.1AlaTyr: 3.1 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.568CysAla: 0.568 ± 0.03	0.107CysCys: 0.107 ± 0.013	0.636CysAsp: 0.636 ± 0.032	0.62CysGlu: 0.62 ± 0.026	0.342CysPhe: 0.342 ± 0.021	0.748CysGly: 0.748 ± 0.035	0.36CysHis: 0.36 ± 0.036	0.55CysIle: 0.55 ± 0.031	0.614CysLys: 0.614 ± 0.027	0.571CysLeu: 0.571 ± 0.029	0.221CysMet: 0.221 ± 0.016	0.428CysAsn: 0.428 ± 0.022	0.394CysPro: 0.394 ± 0.029	0.236CysGln: 0.236 ± 0.017	0.368CysArg: 0.368 ± 0.021	0.589CysSer: 0.589 ± 0.031	0.462CysThr: 0.462 ± 0.025	0.458CysVal: 0.458 ± 0.024	0.068CysTrp: 0.068 ± 0.01	0.332CysTyr: 0.332 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.37AspAla: 4.37 ± 0.088	0.418AspCys: 0.418 ± 0.024	3.146AspAsp: 3.146 ± 0.072	4.76AspGlu: 4.76 ± 0.071	2.88AspPhe: 2.88 ± 0.061	3.501AspGly: 3.501 ± 0.075	1.026AspHis: 1.026 ± 0.037	5.045AspIle: 5.045 ± 0.093	4.14AspLys: 4.14 ± 0.08	5.038AspLeu: 5.038 ± 0.077	1.674AspMet: 1.674 ± 0.051	2.322AspAsn: 2.322 ± 0.067	2.09AspPro: 2.09 ± 0.053	1.209AspGln: 1.209 ± 0.038	2.364AspArg: 2.364 ± 0.059	2.844AspSer: 2.844 ± 0.071	3.265AspThr: 3.265 ± 0.072	3.556AspVal: 3.556 ± 0.071	0.505AspTrp: 0.505 ± 0.027	2.13AspTyr: 2.13 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	5.827GluAla: 5.827 ± 0.108	0.599GluCys: 0.599 ± 0.031	3.697GluAsp: 3.697 ± 0.07	6.206GluGlu: 6.206 ± 0.116	2.551GluPhe: 2.551 ± 0.064	4.372GluGly: 4.372 ± 0.078	1.804GluHis: 1.804 ± 0.052	5.546GluIle: 5.546 ± 0.085	7.035GluLys: 7.035 ± 0.123	6.45GluLeu: 6.45 ± 0.093	2.157GluMet: 2.157 ± 0.052	3.601GluAsn: 3.601 ± 0.069	1.828GluPro: 1.828 ± 0.052	2.326GluGln: 2.326 ± 0.059	2.966GluArg: 2.966 ± 0.069	3.619GluSer: 3.619 ± 0.075	3.432GluThr: 3.432 ± 0.07	4.69GluVal: 4.69 ± 0.088	0.663GluTrp: 0.663 ± 0.032	2.524GluTyr: 2.524 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	3.414PheAla: 3.414 ± 0.073	0.388PheCys: 0.388 ± 0.021	3.2PheAsp: 3.2 ± 0.072	3.286PheGlu: 3.286 ± 0.069	2.579PhePhe: 2.579 ± 0.068	3.368PheGly: 3.368 ± 0.076	0.849PheHis: 0.849 ± 0.037	3.565PheIle: 3.565 ± 0.087	3.085PheLys: 3.085 ± 0.056	4.521PheLeu: 4.521 ± 0.091	1.333PheMet: 1.333 ± 0.043	2.04PheAsn: 2.04 ± 0.07	1.486PhePro: 1.486 ± 0.046	1.011PheGln: 1.011 ± 0.031	1.632PheArg: 1.632 ± 0.049	3.403PheSer: 3.403 ± 0.068	2.643PheThr: 2.643 ± 0.056	2.976PheVal: 2.976 ± 0.072	0.53PheTrp: 0.53 ± 0.026	1.819PheTyr: 1.819 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	4.546GlyAla: 4.546 ± 0.085	0.806GlyCys: 0.806 ± 0.04	3.439GlyAsp: 3.439 ± 0.071	4.217GlyGlu: 4.217 ± 0.074	3.286GlyPhe: 3.286 ± 0.071	4.397GlyGly: 4.397 ± 0.099	1.386GlyHis: 1.386 ± 0.044	5.307GlyIle: 5.307 ± 0.097	5.445GlyLys: 5.445 ± 0.101	5.8GlyLeu: 5.8 ± 0.09	2.112GlyMet: 2.112 ± 0.053	2.507GlyAsn: 2.507 ± 0.075	1.199GlyPro: 1.199 ± 0.038	1.6GlyGln: 1.6 ± 0.048	2.44GlyArg: 2.44 ± 0.059	3.752GlySer: 3.752 ± 0.07	3.52GlyThr: 3.52 ± 0.082	4.473GlyVal: 4.473 ± 0.078	0.798GlyTrp: 0.798 ± 0.033	3.1GlyTyr: 3.1 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.457HisAla: 1.457 ± 0.048	0.235HisCys: 0.235 ± 0.017	1.1HisAsp: 1.1 ± 0.042	1.265HisGlu: 1.265 ± 0.036	1.303HisPhe: 1.303 ± 0.045	1.39HisGly: 1.39 ± 0.047	0.606HisHis: 0.606 ± 0.031	1.788HisIle: 1.788 ± 0.047	1.456HisLys: 1.456 ± 0.045	2.142HisLeu: 2.142 ± 0.057	0.589HisMet: 0.589 ± 0.027	0.868HisAsn: 0.868 ± 0.034	1.156HisPro: 1.156 ± 0.047	0.687HisGln: 0.687 ± 0.028	0.973HisArg: 0.973 ± 0.04	1.242HisSer: 1.242 ± 0.043	1.32HisThr: 1.32 ± 0.048	1.062HisVal: 1.062 ± 0.036	0.232HisTrp: 0.232 ± 0.018	1.058HisTyr: 1.058 ± 0.043	0.0HisXaa: 0.0 ± 0.0
Ile	6.399IleAla: 6.399 ± 0.102	0.594IleCys: 0.594 ± 0.028	5.396IleAsp: 5.396 ± 0.086	5.977IleGlu: 5.977 ± 0.108	3.473IlePhe: 3.473 ± 0.083	5.081IleGly: 5.081 ± 0.082	1.495IleHis: 1.495 ± 0.049	5.459IleIle: 5.459 ± 0.103	5.397IleLys: 5.397 ± 0.078	7.046IleLeu: 7.046 ± 0.114	1.643IleMet: 1.643 ± 0.051	2.997IleAsn: 2.997 ± 0.073	2.946IlePro: 2.946 ± 0.058	2.002IleGln: 2.002 ± 0.052	2.941IleArg: 2.941 ± 0.068	4.846IleSer: 4.846 ± 0.081	4.173IleThr: 4.173 ± 0.078	5.397IleVal: 5.397 ± 0.08	0.569IleTrp: 0.569 ± 0.031	2.69IleTyr: 2.69 ± 0.075	0.0IleXaa: 0.0 ± 0.0
Lys	5.972LysAla: 5.972 ± 0.1	0.593LysCys: 0.593 ± 0.031	4.154LysAsp: 4.154 ± 0.084	7.941LysGlu: 7.941 ± 0.115	2.524LysPhe: 2.524 ± 0.058	4.529LysGly: 4.529 ± 0.084	1.73LysHis: 1.73 ± 0.047	6.161LysIle: 6.161 ± 0.102	7.972LysLys: 7.972 ± 0.132	6.752LysLeu: 6.752 ± 0.091	2.45LysMet: 2.45 ± 0.049	4.024LysAsn: 4.024 ± 0.09	2.722LysPro: 2.722 ± 0.078	2.554LysGln: 2.554 ± 0.059	3.589LysArg: 3.589 ± 0.076	4.274LysSer: 4.274 ± 0.086	4.152LysThr: 4.152 ± 0.076	5.104LysVal: 5.104 ± 0.082	0.68LysTrp: 0.68 ± 0.027	2.917LysTyr: 2.917 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	6.821LeuAla: 6.821 ± 0.125	0.798LeuCys: 0.798 ± 0.034	5.42LeuAsp: 5.42 ± 0.085	6.57LeuGlu: 6.57 ± 0.099	5.407LeuPhe: 5.407 ± 0.107	6.067LeuGly: 6.067 ± 0.095	2.195LeuHis: 2.195 ± 0.046	6.555LeuIle: 6.555 ± 0.116	7.978LeuLys: 7.978 ± 0.093	10.239LeuLeu: 10.239 ± 0.166	2.633LeuMet: 2.633 ± 0.066	3.953LeuAsn: 3.953 ± 0.081	3.842LeuPro: 3.842 ± 0.075	3.192LeuGln: 3.192 ± 0.074	3.523LeuArg: 3.523 ± 0.071	6.859LeuSer: 6.859 ± 0.102	4.752LeuThr: 4.752 ± 0.084	5.45LeuVal: 5.45 ± 0.091	0.915LeuTrp: 0.915 ± 0.042	3.693LeuTyr: 3.693 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	2.178MetAla: 2.178 ± 0.059	0.18MetCys: 0.18 ± 0.017	1.508MetAsp: 1.508 ± 0.056	1.82MetGlu: 1.82 ± 0.055	1.097MetPhe: 1.097 ± 0.048	1.946MetGly: 1.946 ± 0.05	0.684MetHis: 0.684 ± 0.031	2.218MetIle: 2.218 ± 0.056	2.584MetLys: 2.584 ± 0.063	2.927MetLeu: 2.927 ± 0.071	1.017MetMet: 1.017 ± 0.044	1.289MetAsn: 1.289 ± 0.04	1.245MetPro: 1.245 ± 0.043	1.177MetGln: 1.177 ± 0.039	1.123MetArg: 1.123 ± 0.039	1.652MetSer: 1.652 ± 0.047	1.489MetThr: 1.489 ± 0.044	1.823MetVal: 1.823 ± 0.052	0.213MetTrp: 0.213 ± 0.019	0.787MetTyr: 0.787 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.177AsnAla: 3.177 ± 0.062	0.337AsnCys: 0.337 ± 0.022	2.396AsnAsp: 2.396 ± 0.077	2.881AsnGlu: 2.881 ± 0.056	1.901AsnPhe: 1.901 ± 0.053	2.979AsnGly: 2.979 ± 0.062	0.836AsnHis: 0.836 ± 0.035	3.834AsnIle: 3.834 ± 0.069	2.987AsnLys: 2.987 ± 0.079	3.73AsnLeu: 3.73 ± 0.065	1.055AsnMet: 1.055 ± 0.038	1.93AsnAsn: 1.93 ± 0.063	2.003AsnPro: 2.003 ± 0.061	1.156AsnGln: 1.156 ± 0.044	2.005AsnArg: 2.005 ± 0.06	2.305AsnSer: 2.305 ± 0.067	2.25AsnThr: 2.25 ± 0.062	2.716AsnVal: 2.716 ± 0.067	0.358AsnTrp: 0.358 ± 0.023	1.755AsnTyr: 1.755 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.154ProAla: 2.154 ± 0.063	0.269ProCys: 0.269 ± 0.02	2.061ProAsp: 2.061 ± 0.059	2.665ProGlu: 2.665 ± 0.061	1.857ProPhe: 1.857 ± 0.047	1.831ProGly: 1.831 ± 0.048	0.831ProHis: 0.831 ± 0.034	2.353ProIle: 2.353 ± 0.053	2.97ProLys: 2.97 ± 0.071	3.496ProLeu: 3.496 ± 0.074	1.008ProMet: 1.008 ± 0.04	1.491ProAsn: 1.491 ± 0.05	0.979ProPro: 0.979 ± 0.044	1.075ProGln: 1.075 ± 0.039	1.124ProArg: 1.124 ± 0.033	2.022ProSer: 2.022 ± 0.056	1.834ProThr: 1.834 ± 0.054	2.631ProVal: 2.631 ± 0.064	0.321ProTrp: 0.321 ± 0.021	1.527ProTyr: 1.527 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.201GlnAla: 2.201 ± 0.058	0.287GlnCys: 0.287 ± 0.018	1.378GlnAsp: 1.378 ± 0.04	2.092GlnGlu: 2.092 ± 0.056	1.228GlnPhe: 1.228 ± 0.045	1.672GlnGly: 1.672 ± 0.043	0.679GlnHis: 0.679 ± 0.029	2.279GlnIle: 2.279 ± 0.055	3.217GlnLys: 3.217 ± 0.061	2.567GlnLeu: 2.567 ± 0.064	1.045GlnMet: 1.045 ± 0.039	1.63GlnAsn: 1.63 ± 0.05	0.932GlnPro: 0.932 ± 0.034	1.02GlnGln: 1.02 ± 0.042	1.37GlnArg: 1.37 ± 0.041	1.741GlnSer: 1.741 ± 0.045	1.605GlnThr: 1.605 ± 0.052	1.645GlnVal: 1.645 ± 0.047	0.308GlnTrp: 0.308 ± 0.026	1.169GlnTyr: 1.169 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.577ArgAla: 2.577 ± 0.059	0.329ArgCys: 0.329 ± 0.021	2.096ArgAsp: 2.096 ± 0.058	3.023ArgGlu: 3.023 ± 0.073	2.105ArgPhe: 2.105 ± 0.052	2.238ArgGly: 2.238 ± 0.056	0.846ArgHis: 0.846 ± 0.034	3.107ArgIle: 3.107 ± 0.068	3.091ArgLys: 3.091 ± 0.068	3.824ArgLeu: 3.824 ± 0.078	1.221ArgMet: 1.221 ± 0.045	1.773ArgAsn: 1.773 ± 0.052	1.177ArgPro: 1.177 ± 0.045	1.275ArgGln: 1.275 ± 0.043	1.702ArgArg: 1.702 ± 0.051	2.284ArgSer: 2.284 ± 0.059	1.935ArgThr: 1.935 ± 0.052	2.635ArgVal: 2.635 ± 0.061	0.421ArgTrp: 0.421 ± 0.025	2.167ArgTyr: 2.167 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	4.064SerAla: 4.064 ± 0.075	0.562SerCys: 0.562 ± 0.03	3.301SerAsp: 3.301 ± 0.069	3.538SerGlu: 3.538 ± 0.073	3.074SerPhe: 3.074 ± 0.064	4.216SerGly: 4.216 ± 0.077	1.343SerHis: 1.343 ± 0.045	4.627SerIle: 4.627 ± 0.08	4.506SerLys: 4.506 ± 0.091	5.915SerLeu: 5.915 ± 0.092	1.726SerMet: 1.726 ± 0.045	2.326SerAsn: 2.326 ± 0.065	1.819SerPro: 1.819 ± 0.055	1.899SerGln: 1.899 ± 0.048	2.395SerArg: 2.395 ± 0.053	3.744SerSer: 3.744 ± 0.089	3.109SerThr: 3.109 ± 0.063	3.978SerVal: 3.978 ± 0.085	0.649SerTrp: 0.649 ± 0.036	2.492SerTyr: 2.492 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.941ThrAla: 3.941 ± 0.077	0.398ThrCys: 0.398 ± 0.023	2.78ThrAsp: 2.78 ± 0.07	2.917ThrGlu: 2.917 ± 0.072	2.646ThrPhe: 2.646 ± 0.063	3.538ThrGly: 3.538 ± 0.075	1.196ThrHis: 1.196 ± 0.034	4.081ThrIle: 4.081 ± 0.075	3.624ThrLys: 3.624 ± 0.062	6.156ThrLeu: 6.156 ± 0.098	1.4ThrMet: 1.4 ± 0.046	1.827ThrAsn: 1.827 ± 0.051	2.445ThrPro: 2.445 ± 0.057	1.793ThrGln: 1.793 ± 0.054	1.736ThrArg: 1.736 ± 0.054	2.865ThrSer: 2.865 ± 0.062	2.753ThrThr: 2.753 ± 0.067	3.923ThrVal: 3.923 ± 0.081	0.452ThrTrp: 0.452 ± 0.024	2.105ThrTyr: 2.105 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.99ValAla: 4.99 ± 0.101	0.605ValCys: 0.605 ± 0.029	3.928ValAsp: 3.928 ± 0.078	4.592ValGlu: 4.592 ± 0.09	2.788ValPhe: 2.788 ± 0.063	4.144ValGly: 4.144 ± 0.088	1.26ValHis: 1.26 ± 0.04	4.772ValIle: 4.772 ± 0.083	4.88ValLys: 4.88 ± 0.088	6.488ValLeu: 6.488 ± 0.103	1.883ValMet: 1.883 ± 0.047	2.69ValAsn: 2.69 ± 0.062	2.369ValPro: 2.369 ± 0.055	1.767ValGln: 1.767 ± 0.045	2.423ValArg: 2.423 ± 0.064	4.25ValSer: 4.25 ± 0.088	3.593ValThr: 3.593 ± 0.081	4.618ValVal: 4.618 ± 0.097	0.65ValTrp: 0.65 ± 0.028	2.305ValTyr: 2.305 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.582TrpAla: 0.582 ± 0.029	0.116TrpCys: 0.116 ± 0.014	0.479TrpAsp: 0.479 ± 0.031	0.576TrpGlu: 0.576 ± 0.028	0.535TrpPhe: 0.535 ± 0.031	0.656TrpGly: 0.656 ± 0.032	0.266TrpHis: 0.266 ± 0.021	0.811TrpIle: 0.811 ± 0.033	0.624TrpLys: 0.624 ± 0.029	1.008TrpLeu: 1.008 ± 0.042	0.375TrpMet: 0.375 ± 0.025	0.413TrpAsn: 0.413 ± 0.026	0.229TrpPro: 0.229 ± 0.018	0.396TrpGln: 0.396 ± 0.025	0.38TrpArg: 0.38 ± 0.021	0.491TrpSer: 0.491 ± 0.03	0.394TrpThr: 0.394 ± 0.025	0.632TrpVal: 0.632 ± 0.03	0.136TrpTrp: 0.136 ± 0.014	0.401TrpTyr: 0.401 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.809TyrAla: 2.809 ± 0.06	0.347TyrCys: 0.347 ± 0.021	2.612TyrAsp: 2.612 ± 0.062	2.765TyrGlu: 2.765 ± 0.064	1.988TyrPhe: 1.988 ± 0.052	2.659TyrGly: 2.659 ± 0.061	1.011TyrHis: 1.011 ± 0.04	2.749TyrIle: 2.749 ± 0.063	2.759TyrLys: 2.759 ± 0.07	3.855TyrLeu: 3.855 ± 0.079	0.986TyrMet: 0.986 ± 0.036	1.707TyrAsn: 1.707 ± 0.05	1.499TyrPro: 1.499 ± 0.046	1.204TyrGln: 1.204 ± 0.038	2.041TyrArg: 2.041 ± 0.058	2.327TyrSer: 2.327 ± 0.06	2.181TyrThr: 2.181 ± 0.06	2.181TyrVal: 2.181 ± 0.057	0.392TyrTrp: 0.392 ± 0.024	1.721TyrTyr: 1.721 ± 0.066	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2433 proteins (765727 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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