Amino acid dipepetide frequency for Caldisalinibacter kiritimatiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.743AlaAla: 3.743 ± 0.092	0.531AlaCys: 0.531 ± 0.031	2.576AlaAsp: 2.576 ± 0.053	3.561AlaGlu: 3.561 ± 0.074	2.274AlaPhe: 2.274 ± 0.052	3.779AlaGly: 3.779 ± 0.095	0.839AlaHis: 0.839 ± 0.037	5.75AlaIle: 5.75 ± 0.103	4.772AlaLys: 4.772 ± 0.104	5.631AlaLeu: 5.631 ± 0.09	1.538AlaMet: 1.538 ± 0.046	2.617AlaAsn: 2.617 ± 0.059	1.505AlaPro: 1.505 ± 0.046	1.416AlaGln: 1.416 ± 0.044	2.002AlaArg: 2.002 ± 0.054	3.115AlaSer: 3.115 ± 0.073	2.807AlaThr: 2.807 ± 0.075	4.064AlaVal: 4.064 ± 0.073	0.363AlaTrp: 0.363 ± 0.025	1.998AlaTyr: 1.998 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.413CysAla: 0.413 ± 0.023	0.1CysCys: 0.1 ± 0.012	0.511CysAsp: 0.511 ± 0.029	0.598CysGlu: 0.598 ± 0.032	0.327CysPhe: 0.327 ± 0.016	0.831CysGly: 0.831 ± 0.039	0.165CysHis: 0.165 ± 0.015	0.853CysIle: 0.853 ± 0.037	0.721CysLys: 0.721 ± 0.036	0.652CysLeu: 0.652 ± 0.027	0.203CysMet: 0.203 ± 0.016	0.539CysAsn: 0.539 ± 0.03	0.447CysPro: 0.447 ± 0.028	0.211CysGln: 0.211 ± 0.016	0.309CysArg: 0.309 ± 0.02	0.518CysSer: 0.518 ± 0.027	0.426CysThr: 0.426 ± 0.024	0.497CysVal: 0.497 ± 0.025	0.06CysTrp: 0.06 ± 0.009	0.343CysTyr: 0.343 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	2.443AspAla: 2.443 ± 0.061	0.463AspCys: 0.463 ± 0.025	2.774AspAsp: 2.774 ± 0.072	4.53AspGlu: 4.53 ± 0.099	2.486AspPhe: 2.486 ± 0.066	3.294AspGly: 3.294 ± 0.076	0.588AspHis: 0.588 ± 0.025	7.105AspIle: 7.105 ± 0.095	5.758AspLys: 5.758 ± 0.1	4.683AspLeu: 4.683 ± 0.071	1.485AspMet: 1.485 ± 0.041	3.427AspAsn: 3.427 ± 0.085	1.418AspPro: 1.418 ± 0.048	0.782AspGln: 0.782 ± 0.034	1.981AspArg: 1.981 ± 0.05	2.92AspSer: 2.92 ± 0.07	2.557AspThr: 2.557 ± 0.066	3.757AspVal: 3.757 ± 0.065	0.426AspTrp: 0.426 ± 0.023	2.608AspTyr: 2.608 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	4.165GluAla: 4.165 ± 0.093	0.507GluCys: 0.507 ± 0.028	4.4GluAsp: 4.4 ± 0.095	7.739GluGlu: 7.739 ± 0.134	2.88GluPhe: 2.88 ± 0.066	4.414GluGly: 4.414 ± 0.087	1.117GluHis: 1.117 ± 0.039	7.889GluIle: 7.889 ± 0.095	8.229GluLys: 8.229 ± 0.118	7.494GluLeu: 7.494 ± 0.116	2.073GluMet: 2.073 ± 0.053	5.089GluAsn: 5.089 ± 0.088	1.663GluPro: 1.663 ± 0.05	2.056GluGln: 2.056 ± 0.055	2.959GluArg: 2.959 ± 0.067	3.229GluSer: 3.229 ± 0.061	3.085GluThr: 3.085 ± 0.066	5.561GluVal: 5.561 ± 0.11	0.497GluTrp: 0.497 ± 0.022	3.37GluTyr: 3.37 ± 0.072	0.0GluXaa: 0.0 ± 0.0
Phe	2.258PheAla: 2.258 ± 0.055	0.392PheCys: 0.392 ± 0.02	2.371PheAsp: 2.371 ± 0.064	2.676PheGlu: 2.676 ± 0.057	1.861PhePhe: 1.861 ± 0.061	2.741PheGly: 2.741 ± 0.059	0.566PheHis: 0.566 ± 0.025	4.464PheIle: 4.464 ± 0.096	3.547PheLys: 3.547 ± 0.062	3.494PheLeu: 3.494 ± 0.073	1.02PheMet: 1.02 ± 0.044	2.709PheAsn: 2.709 ± 0.061	1.185PhePro: 1.185 ± 0.042	0.859PheGln: 0.859 ± 0.035	1.345PheArg: 1.345 ± 0.048	2.668PheSer: 2.668 ± 0.075	2.356PheThr: 2.356 ± 0.061	2.601PheVal: 2.601 ± 0.058	0.307PheTrp: 0.307 ± 0.023	1.667PheTyr: 1.667 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	3.969GlyAla: 3.969 ± 0.109	0.75GlyCys: 0.75 ± 0.037	3.239GlyAsp: 3.239 ± 0.069	4.307GlyGlu: 4.307 ± 0.089	3.072GlyPhe: 3.072 ± 0.076	4.248GlyGly: 4.248 ± 0.104	1.032GlyHis: 1.032 ± 0.036	6.964GlyIle: 6.964 ± 0.106	5.577GlyLys: 5.577 ± 0.11	5.846GlyLeu: 5.846 ± 0.099	1.792GlyMet: 1.792 ± 0.059	3.163GlyAsn: 3.163 ± 0.065	1.452GlyPro: 1.452 ± 0.055	1.563GlyGln: 1.563 ± 0.046	2.429GlyArg: 2.429 ± 0.062	3.067GlySer: 3.067 ± 0.061	3.472GlyThr: 3.472 ± 0.08	4.798GlyVal: 4.798 ± 0.097	0.552GlyTrp: 0.552 ± 0.027	3.145GlyTyr: 3.145 ± 0.073	0.0GlyXaa: 0.0 ± 0.0
His	0.657HisAla: 0.657 ± 0.033	0.176HisCys: 0.176 ± 0.015	0.671HisAsp: 0.671 ± 0.028	0.894HisGlu: 0.894 ± 0.033	0.662HisPhe: 0.662 ± 0.03	1.009HisGly: 1.009 ± 0.04	0.298HisHis: 0.298 ± 0.024	1.554HisIle: 1.554 ± 0.047	1.092HisLys: 1.092 ± 0.035	1.257HisLeu: 1.257 ± 0.04	0.346HisMet: 0.346 ± 0.017	0.839HisAsn: 0.839 ± 0.037	0.762HisPro: 0.762 ± 0.032	0.371HisGln: 0.371 ± 0.024	0.6HisArg: 0.6 ± 0.027	0.846HisSer: 0.846 ± 0.035	0.727HisThr: 0.727 ± 0.03	0.819HisVal: 0.819 ± 0.028	0.124HisTrp: 0.124 ± 0.013	0.585HisTyr: 0.585 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.869IleAla: 5.869 ± 0.109	0.871IleCys: 0.871 ± 0.034	6.471IleAsp: 6.471 ± 0.101	8.142IleGlu: 8.142 ± 0.124	3.785IlePhe: 3.785 ± 0.085	6.6IleGly: 6.6 ± 0.118	1.387IleHis: 1.387 ± 0.048	9.722IleIle: 9.722 ± 0.148	9.414IleLys: 9.414 ± 0.123	9.183IleLeu: 9.183 ± 0.127	2.176IleMet: 2.176 ± 0.057	6.145IleAsn: 6.145 ± 0.109	3.494IlePro: 3.494 ± 0.066	2.445IleGln: 2.445 ± 0.053	3.403IleArg: 3.403 ± 0.066	6.457IleSer: 6.457 ± 0.095	5.12IleThr: 5.12 ± 0.09	6.888IleVal: 6.888 ± 0.097	0.597IleTrp: 0.597 ± 0.032	3.518IleTyr: 3.518 ± 0.076	0.0IleXaa: 0.0 ± 0.0
Lys	5.001LysAla: 5.001 ± 0.093	0.725LysCys: 0.725 ± 0.037	5.796LysAsp: 5.796 ± 0.093	9.711LysGlu: 9.711 ± 0.127	3.045LysPhe: 3.045 ± 0.076	5.616LysGly: 5.616 ± 0.079	1.29LysHis: 1.29 ± 0.041	8.607LysIle: 8.607 ± 0.12	8.984LysLys: 8.984 ± 0.142	8.059LysLeu: 8.059 ± 0.099	2.302LysMet: 2.302 ± 0.063	5.74LysAsn: 5.74 ± 0.103	2.319LysPro: 2.319 ± 0.057	2.502LysGln: 2.502 ± 0.061	3.636LysArg: 3.636 ± 0.078	4.447LysSer: 4.447 ± 0.083	4.111LysThr: 4.111 ± 0.069	6.583LysVal: 6.583 ± 0.102	0.616LysTrp: 0.616 ± 0.028	4.299LysTyr: 4.299 ± 0.08	0.0LysXaa: 0.0 ± 0.0
Leu	5.483LeuAla: 5.483 ± 0.096	0.69LeuCys: 0.69 ± 0.035	5.212LeuAsp: 5.212 ± 0.099	6.591LeuGlu: 6.591 ± 0.097	3.575LeuPhe: 3.575 ± 0.078	6.271LeuGly: 6.271 ± 0.108	1.171LeuHis: 1.171 ± 0.039	8.223LeuIle: 8.223 ± 0.124	8.737LeuLys: 8.737 ± 0.114	8.11LeuLeu: 8.11 ± 0.125	2.205LeuMet: 2.205 ± 0.061	5.738LeuAsn: 5.738 ± 0.099	2.982LeuPro: 2.982 ± 0.066	2.214LeuGln: 2.214 ± 0.052	3.136LeuArg: 3.136 ± 0.065	5.925LeuSer: 5.925 ± 0.098	4.569LeuThr: 4.569 ± 0.088	5.915LeuVal: 5.915 ± 0.092	0.545LeuTrp: 0.545 ± 0.026	3.145LeuTyr: 3.145 ± 0.076	0.0LeuXaa: 0.0 ± 0.0
Met	1.726MetAla: 1.726 ± 0.052	0.167MetCys: 0.167 ± 0.016	1.368MetAsp: 1.368 ± 0.043	1.865MetGlu: 1.865 ± 0.045	0.952MetPhe: 0.952 ± 0.036	1.701MetGly: 1.701 ± 0.053	0.316MetHis: 0.316 ± 0.021	2.219MetIle: 2.219 ± 0.058	2.436MetLys: 2.436 ± 0.057	2.182MetLeu: 2.182 ± 0.058	0.63MetMet: 0.63 ± 0.033	1.567MetAsn: 1.567 ± 0.041	0.846MetPro: 0.846 ± 0.039	0.587MetGln: 0.587 ± 0.025	0.989MetArg: 0.989 ± 0.032	1.42MetSer: 1.42 ± 0.043	1.318MetThr: 1.318 ± 0.039	1.537MetVal: 1.537 ± 0.043	0.148MetTrp: 0.148 ± 0.014	0.854MetTyr: 0.854 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	2.523AsnAla: 2.523 ± 0.059	0.524AsnCys: 0.524 ± 0.027	2.938AsnAsp: 2.938 ± 0.064	4.822AsnGlu: 4.822 ± 0.082	2.173AsnPhe: 2.173 ± 0.051	3.315AsnGly: 3.315 ± 0.074	0.823AsnHis: 0.823 ± 0.03	7.013AsnIle: 7.013 ± 0.113	6.337AsnLys: 6.337 ± 0.103	4.975AsnLeu: 4.975 ± 0.08	1.491AsnMet: 1.491 ± 0.043	4.194AsnAsn: 4.194 ± 0.106	2.14AsnPro: 2.14 ± 0.057	1.553AsnGln: 1.553 ± 0.044	2.241AsnArg: 2.241 ± 0.055	3.359AsnSer: 3.359 ± 0.074	3.007AsnThr: 3.007 ± 0.07	3.66AsnVal: 3.66 ± 0.074	0.459AsnTrp: 0.459 ± 0.026	2.497AsnTyr: 2.497 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.46ProAla: 1.46 ± 0.05	0.29ProCys: 0.29 ± 0.021	1.735ProAsp: 1.735 ± 0.057	2.364ProGlu: 2.364 ± 0.065	1.475ProPhe: 1.475 ± 0.042	1.889ProGly: 1.889 ± 0.061	0.529ProHis: 0.529 ± 0.032	2.924ProIle: 2.924 ± 0.059	2.499ProLys: 2.499 ± 0.058	2.573ProLeu: 2.573 ± 0.065	0.716ProMet: 0.716 ± 0.033	1.745ProAsn: 1.745 ± 0.042	0.8ProPro: 0.8 ± 0.033	0.772ProGln: 0.772 ± 0.038	1.034ProArg: 1.034 ± 0.036	1.678ProSer: 1.678 ± 0.047	1.611ProThr: 1.611 ± 0.055	2.334ProVal: 2.334 ± 0.057	0.242ProTrp: 0.242 ± 0.017	1.393ProTyr: 1.393 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	1.433GlnAla: 1.433 ± 0.044	0.188GlnCys: 0.188 ± 0.017	1.168GlnAsp: 1.168 ± 0.037	1.87GlnGlu: 1.87 ± 0.05	0.96GlnPhe: 0.96 ± 0.04	1.515GlnGly: 1.515 ± 0.047	0.364GlnHis: 0.364 ± 0.022	2.429GlnIle: 2.429 ± 0.059	2.218GlnLys: 2.218 ± 0.052	2.384GlnLeu: 2.384 ± 0.053	0.676GlnMet: 0.676 ± 0.024	1.433GlnAsn: 1.433 ± 0.04	0.712GlnPro: 0.712 ± 0.031	0.892GlnGln: 0.892 ± 0.041	1.065GlnArg: 1.065 ± 0.035	1.193GlnSer: 1.193 ± 0.037	1.104GlnThr: 1.104 ± 0.043	1.635GlnVal: 1.635 ± 0.05	0.194GlnTrp: 0.194 ± 0.016	1.056GlnTyr: 1.056 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	1.921ArgAla: 1.921 ± 0.055	0.327ArgCys: 0.327 ± 0.02	1.882ArgAsp: 1.882 ± 0.044	2.993ArgGlu: 2.993 ± 0.071	1.611ArgPhe: 1.611 ± 0.04	2.215ArgGly: 2.215 ± 0.062	0.536ArgHis: 0.536 ± 0.026	3.614ArgIle: 3.614 ± 0.075	3.583ArgLys: 3.583 ± 0.069	3.423ArgLeu: 3.423 ± 0.074	0.978ArgMet: 0.978 ± 0.042	2.148ArgAsn: 2.148 ± 0.052	1.167ArgPro: 1.167 ± 0.043	1.061ArgGln: 1.061 ± 0.033	1.804ArgArg: 1.804 ± 0.063	1.438ArgSer: 1.438 ± 0.049	1.636ArgThr: 1.636 ± 0.045	2.497ArgVal: 2.497 ± 0.063	0.236ArgTrp: 0.236 ± 0.017	1.562ArgTyr: 1.562 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	2.647SerAla: 2.647 ± 0.075	0.469SerCys: 0.469 ± 0.027	2.764SerAsp: 2.764 ± 0.056	3.73SerGlu: 3.73 ± 0.074	2.628SerPhe: 2.628 ± 0.061	3.624SerGly: 3.624 ± 0.06	0.823SerHis: 0.823 ± 0.034	5.988SerIle: 5.988 ± 0.099	5.147SerLys: 5.147 ± 0.09	5.352SerLeu: 5.352 ± 0.09	1.401SerMet: 1.401 ± 0.046	3.262SerAsn: 3.262 ± 0.074	1.608SerPro: 1.608 ± 0.043	1.498SerGln: 1.498 ± 0.045	1.997SerArg: 1.997 ± 0.053	3.386SerSer: 3.386 ± 0.086	2.918SerThr: 2.918 ± 0.064	3.55SerVal: 3.55 ± 0.072	0.39SerTrp: 0.39 ± 0.024	2.302SerTyr: 2.302 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	2.872ThrAla: 2.872 ± 0.066	0.414ThrCys: 0.414 ± 0.021	2.619ThrAsp: 2.619 ± 0.07	3.481ThrGlu: 3.481 ± 0.071	2.081ThrPhe: 2.081 ± 0.058	3.754ThrGly: 3.754 ± 0.082	0.764ThrHis: 0.764 ± 0.027	4.883ThrIle: 4.883 ± 0.081	3.896ThrLys: 3.896 ± 0.067	4.647ThrLeu: 4.647 ± 0.068	1.102ThrMet: 1.102 ± 0.034	2.709ThrAsn: 2.709 ± 0.061	1.832ThrPro: 1.832 ± 0.049	1.122ThrGln: 1.122 ± 0.04	1.644ThrArg: 1.644 ± 0.044	2.929ThrSer: 2.929 ± 0.059	2.707ThrThr: 2.707 ± 0.07	3.616ThrVal: 3.616 ± 0.075	0.358ThrTrp: 0.358 ± 0.023	1.94ThrTyr: 1.94 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.005ValAla: 4.005 ± 0.078	0.635ValCys: 0.635 ± 0.028	4.087ValAsp: 4.087 ± 0.082	5.198ValGlu: 5.198 ± 0.104	3.046ValPhe: 3.046 ± 0.074	4.458ValGly: 4.458 ± 0.103	0.923ValHis: 0.923 ± 0.041	6.642ValIle: 6.642 ± 0.09	6.007ValLys: 6.007 ± 0.109	6.154ValLeu: 6.154 ± 0.1	1.574ValMet: 1.574 ± 0.046	3.857ValAsn: 3.857 ± 0.082	2.167ValPro: 2.167 ± 0.06	1.45ValGln: 1.45 ± 0.043	2.226ValArg: 2.226 ± 0.057	4.048ValSer: 4.048 ± 0.078	3.487ValThr: 3.487 ± 0.084	5.094ValVal: 5.094 ± 0.109	0.431ValTrp: 0.431 ± 0.027	2.704ValTyr: 2.704 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.415TrpAla: 0.415 ± 0.023	0.051TrpCys: 0.051 ± 0.008	0.413TrpAsp: 0.413 ± 0.023	0.469TrpGlu: 0.469 ± 0.024	0.311TrpPhe: 0.311 ± 0.02	0.532TrpGly: 0.532 ± 0.029	0.115TrpHis: 0.115 ± 0.013	0.644TrpIle: 0.644 ± 0.029	0.534TrpLys: 0.534 ± 0.027	0.619TrpLeu: 0.619 ± 0.03	0.185TrpMet: 0.185 ± 0.016	0.418TrpAsn: 0.418 ± 0.026	0.193TrpPro: 0.193 ± 0.017	0.187TrpGln: 0.187 ± 0.017	0.238TrpArg: 0.238 ± 0.019	0.398TrpSer: 0.398 ± 0.024	0.331TrpThr: 0.331 ± 0.018	0.441TrpVal: 0.441 ± 0.027	0.081TrpTrp: 0.081 ± 0.009	0.32TrpTyr: 0.32 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.877TyrAla: 1.877 ± 0.052	0.453TyrCys: 0.453 ± 0.028	2.49TyrAsp: 2.49 ± 0.067	2.875TyrGlu: 2.875 ± 0.066	1.88TyrPhe: 1.88 ± 0.056	2.631TyrGly: 2.631 ± 0.067	0.643TyrHis: 0.643 ± 0.029	4.198TyrIle: 4.198 ± 0.088	3.901TyrLys: 3.901 ± 0.081	3.721TyrLeu: 3.721 ± 0.077	0.934TyrMet: 0.934 ± 0.032	2.705TyrAsn: 2.705 ± 0.069	1.372TyrPro: 1.372 ± 0.045	0.949TyrGln: 0.949 ± 0.033	1.595TyrArg: 1.595 ± 0.051	2.444TyrSer: 2.444 ± 0.051	2.024TyrThr: 2.024 ± 0.049	2.344TyrVal: 2.344 ± 0.057	0.268TyrTrp: 0.268 ± 0.019	1.868TyrTyr: 1.868 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2681 proteins (782275 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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