Amino acid dipepetide frequency for Holzapfelia floricola DSM 23037 = JCM 16512

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.48AlaAla: 4.48 ± 0.124
0.323AlaCys: 0.323 ± 0.03
3.795AlaAsp: 3.795 ± 0.111
3.612AlaGlu: 3.612 ± 0.102
2.948AlaPhe: 2.948 ± 0.094
4.319AlaGly: 4.319 ± 0.142
1.254AlaHis: 1.254 ± 0.062
5.885AlaIle: 5.885 ± 0.146
5.416AlaLys: 5.416 ± 0.136
6.531AlaLeu: 6.531 ± 0.14
1.702AlaMet: 1.702 ± 0.075
3.44AlaAsn: 3.44 ± 0.112
1.754AlaPro: 1.754 ± 0.072
3.302AlaGln: 3.302 ± 0.109
2.314AlaArg: 2.314 ± 0.094
4.063AlaSer: 4.063 ± 0.123
4.167AlaThr: 4.167 ± 0.126
4.725AlaVal: 4.725 ± 0.131
0.401AlaTrp: 0.401 ± 0.037
2.359AlaTyr: 2.359 ± 0.092
0.0AlaXaa: 0.0 ± 0.0
Cys
0.229CysAla: 0.229 ± 0.024
0.052CysCys: 0.052 ± 0.012
0.214CysAsp: 0.214 ± 0.025
0.253CysGlu: 0.253 ± 0.029
0.151CysPhe: 0.151 ± 0.019
0.323CysGly: 0.323 ± 0.033
0.096CysHis: 0.096 ± 0.016
0.172CysIle: 0.172 ± 0.02
0.102CysLys: 0.102 ± 0.016
0.48CysLeu: 0.48 ± 0.037
0.06CysMet: 0.06 ± 0.013
0.154CysAsn: 0.154 ± 0.02
0.162CysPro: 0.162 ± 0.024
0.235CysGln: 0.235 ± 0.026
0.143CysArg: 0.143 ± 0.021
0.276CysSer: 0.276 ± 0.025
0.164CysThr: 0.164 ± 0.02
0.245CysVal: 0.245 ± 0.026
0.036CysTrp: 0.036 ± 0.01
0.193CysTyr: 0.193 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.607AspAla: 3.607 ± 0.107
0.227AspCys: 0.227 ± 0.025
3.203AspAsp: 3.203 ± 0.093
4.17AspGlu: 4.17 ± 0.136
3.135AspPhe: 3.135 ± 0.087
3.148AspGly: 3.148 ± 0.102
1.043AspHis: 1.043 ± 0.056
4.436AspIle: 4.436 ± 0.113
4.183AspLys: 4.183 ± 0.106
5.914AspLeu: 5.914 ± 0.124
1.379AspMet: 1.379 ± 0.06
3.482AspAsn: 3.482 ± 0.13
1.632AspPro: 1.632 ± 0.067
2.578AspGln: 2.578 ± 0.093
1.936AspArg: 1.936 ± 0.077
3.516AspSer: 3.516 ± 0.115
2.752AspThr: 2.752 ± 0.085
3.709AspVal: 3.709 ± 0.107
0.573AspTrp: 0.573 ± 0.043
3.195AspTyr: 3.195 ± 0.121
0.0AspXaa: 0.0 ± 0.0
Glu
4.366GluAla: 4.366 ± 0.109
0.188GluCys: 0.188 ± 0.021
3.375GluAsp: 3.375 ± 0.112
4.055GluGlu: 4.055 ± 0.122
2.546GluPhe: 2.546 ± 0.083
3.01GluGly: 3.01 ± 0.097
0.959GluHis: 0.959 ± 0.061
4.78GluIle: 4.78 ± 0.102
5.103GluLys: 5.103 ± 0.13
6.662GluLeu: 6.662 ± 0.148
1.658GluMet: 1.658 ± 0.067
3.829GluAsn: 3.829 ± 0.097
1.598GluPro: 1.598 ± 0.07
3.135GluGln: 3.135 ± 0.102
2.223GluArg: 2.223 ± 0.091
3.578GluSer: 3.578 ± 0.112
3.435GluThr: 3.435 ± 0.1
4.574GluVal: 4.574 ± 0.132
0.404GluTrp: 0.404 ± 0.031
1.658GluTyr: 1.658 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
2.893PheAla: 2.893 ± 0.085
0.222PheCys: 0.222 ± 0.025
3.198PheAsp: 3.198 ± 0.095
3.081PheGlu: 3.081 ± 0.091
1.994PhePhe: 1.994 ± 0.088
3.055PheGly: 3.055 ± 0.085
0.659PheHis: 0.659 ± 0.046
3.495PheIle: 3.495 ± 0.127
3.088PheLys: 3.088 ± 0.09
4.128PheLeu: 4.128 ± 0.127
1.069PheMet: 1.069 ± 0.054
2.7PheAsn: 2.7 ± 0.092
1.235PhePro: 1.235 ± 0.054
1.347PheGln: 1.347 ± 0.055
1.298PheArg: 1.298 ± 0.065
3.456PheSer: 3.456 ± 0.085
2.367PheThr: 2.367 ± 0.075
3.065PheVal: 3.065 ± 0.098
0.383PheTrp: 0.383 ± 0.031
1.754PheTyr: 1.754 ± 0.069
0.0PheXaa: 0.0 ± 0.0
Gly
4.074GlyAla: 4.074 ± 0.132
0.268GlyCys: 0.268 ± 0.024
3.187GlyAsp: 3.187 ± 0.1
3.383GlyGlu: 3.383 ± 0.105
3.208GlyPhe: 3.208 ± 0.093
3.766GlyGly: 3.766 ± 0.13
1.316GlyHis: 1.316 ± 0.058
5.14GlyIle: 5.14 ± 0.144
3.881GlyLys: 3.881 ± 0.097
6.203GlyLeu: 6.203 ± 0.145
1.684GlyMet: 1.684 ± 0.071
2.854GlyAsn: 2.854 ± 0.112
1.444GlyPro: 1.444 ± 0.068
3.143GlyGln: 3.143 ± 0.095
2.184GlyArg: 2.184 ± 0.089
3.74GlySer: 3.74 ± 0.12
3.49GlyThr: 3.49 ± 0.098
4.402GlyVal: 4.402 ± 0.128
0.453GlyTrp: 0.453 ± 0.038
2.666GlyTyr: 2.666 ± 0.078
0.005GlyXaa: 0.005 ± 0.004
His
1.089HisAla: 1.089 ± 0.049
0.07HisCys: 0.07 ± 0.012
1.058HisAsp: 1.058 ± 0.057
1.147HisGlu: 1.147 ± 0.05
0.954HisPhe: 0.954 ± 0.058
1.181HisGly: 1.181 ± 0.067
0.678HisHis: 0.678 ± 0.047
1.233HisIle: 1.233 ± 0.067
0.983HisLys: 0.983 ± 0.052
1.965HisLeu: 1.965 ± 0.073
0.394HisMet: 0.394 ± 0.029
1.029HisAsn: 1.029 ± 0.066
0.842HisPro: 0.842 ± 0.048
1.152HisGln: 1.152 ± 0.062
0.782HisArg: 0.782 ± 0.042
1.108HisSer: 1.108 ± 0.051
0.912HisThr: 0.912 ± 0.048
1.175HisVal: 1.175 ± 0.065
0.146HisTrp: 0.146 ± 0.018
0.93HisTyr: 0.93 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
5.614IleAla: 5.614 ± 0.138
0.388IleCys: 0.388 ± 0.034
4.77IleAsp: 4.77 ± 0.109
5.158IleGlu: 5.158 ± 0.116
3.237IlePhe: 3.237 ± 0.117
5.061IleGly: 5.061 ± 0.126
1.248IleHis: 1.248 ± 0.058
6.073IleIle: 6.073 ± 0.186
5.635IleLys: 5.635 ± 0.14
7.339IleLeu: 7.339 ± 0.199
1.877IleMet: 1.877 ± 0.078
4.274IleAsn: 4.274 ± 0.149
2.666IlePro: 2.666 ± 0.073
2.987IleGln: 2.987 ± 0.098
2.4IleArg: 2.4 ± 0.078
5.695IleSer: 5.695 ± 0.132
4.603IleThr: 4.603 ± 0.095
5.51IleVal: 5.51 ± 0.164
0.5IleTrp: 0.5 ± 0.038
2.614IleTyr: 2.614 ± 0.083
0.0IleXaa: 0.0 ± 0.0
Lys
4.741LysAla: 4.741 ± 0.126
0.172LysCys: 0.172 ± 0.025
4.074LysAsp: 4.074 ± 0.099
5.14LysGlu: 5.14 ± 0.128
2.142LysPhe: 2.142 ± 0.073
3.485LysGly: 3.485 ± 0.106
1.136LysHis: 1.136 ± 0.056
5.327LysIle: 5.327 ± 0.115
5.979LysLys: 5.979 ± 0.145
6.529LysLeu: 6.529 ± 0.136
2.161LysMet: 2.161 ± 0.076
4.587LysAsn: 4.587 ± 0.131
2.307LysPro: 2.307 ± 0.079
4.222LysGln: 4.222 ± 0.13
3.208LysArg: 3.208 ± 0.1
4.704LysSer: 4.704 ± 0.117
4.611LysThr: 4.611 ± 0.112
4.762LysVal: 4.762 ± 0.114
0.573LysTrp: 0.573 ± 0.039
2.38LysTyr: 2.38 ± 0.079
0.003LysXaa: 0.003 ± 0.002
Leu
7.167LeuAla: 7.167 ± 0.137
0.321LeuCys: 0.321 ± 0.031
5.749LeuAsp: 5.749 ± 0.133
5.312LeuGlu: 5.312 ± 0.127
4.415LeuPhe: 4.415 ± 0.134
6.015LeuGly: 6.015 ± 0.173
1.381LeuHis: 1.381 ± 0.064
8.022LeuIle: 8.022 ± 0.19
7.358LeuLys: 7.358 ± 0.132
9.169LeuLeu: 9.169 ± 0.219
2.554LeuMet: 2.554 ± 0.091
5.877LeuAsn: 5.877 ± 0.142
3.737LeuPro: 3.737 ± 0.101
3.612LeuGln: 3.612 ± 0.107
3.101LeuArg: 3.101 ± 0.09
7.874LeuSer: 7.874 ± 0.143
6.964LeuThr: 6.964 ± 0.15
6.792LeuVal: 6.792 ± 0.126
0.581LeuTrp: 0.581 ± 0.035
2.856LeuTyr: 2.856 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
1.968MetAla: 1.968 ± 0.075
0.089MetCys: 0.089 ± 0.014
1.194MetAsp: 1.194 ± 0.056
1.087MetGlu: 1.087 ± 0.054
0.774MetPhe: 0.774 ± 0.045
1.665MetGly: 1.665 ± 0.07
0.42MetHis: 0.42 ± 0.033
2.062MetIle: 2.062 ± 0.077
2.176MetLys: 2.176 ± 0.068
2.041MetLeu: 2.041 ± 0.072
0.897MetMet: 0.897 ± 0.049
1.439MetAsn: 1.439 ± 0.069
1.027MetPro: 1.027 ± 0.046
1.095MetGln: 1.095 ± 0.052
0.92MetArg: 0.92 ± 0.05
1.89MetSer: 1.89 ± 0.067
2.009MetThr: 2.009 ± 0.075
1.611MetVal: 1.611 ± 0.068
0.128MetTrp: 0.128 ± 0.018
0.599MetTyr: 0.599 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.31AsnAla: 3.31 ± 0.118
0.198AsnCys: 0.198 ± 0.023
2.995AsnAsp: 2.995 ± 0.093
3.237AsnGlu: 3.237 ± 0.104
2.453AsnPhe: 2.453 ± 0.088
3.399AsnGly: 3.399 ± 0.115
1.426AsnHis: 1.426 ± 0.068
4.019AsnIle: 4.019 ± 0.122
3.69AsnLys: 3.69 ± 0.114
5.176AsnLeu: 5.176 ± 0.135
1.454AsnMet: 1.454 ± 0.059
3.432AsnAsn: 3.432 ± 0.15
2.622AsnPro: 2.622 ± 0.087
4.251AsnGln: 4.251 ± 0.138
2.228AsnArg: 2.228 ± 0.078
3.339AsnSer: 3.339 ± 0.125
2.75AsnThr: 2.75 ± 0.103
3.229AsnVal: 3.229 ± 0.108
0.524AsnTrp: 0.524 ± 0.036
2.57AsnTyr: 2.57 ± 0.096
0.0AsnXaa: 0.0 ± 0.0
Pro
1.929ProAla: 1.929 ± 0.068
0.102ProCys: 0.102 ± 0.017
2.041ProAsp: 2.041 ± 0.073
2.726ProGlu: 2.726 ± 0.096
1.538ProPhe: 1.538 ± 0.068
2.028ProGly: 2.028 ± 0.078
0.639ProHis: 0.639 ± 0.044
2.565ProIle: 2.565 ± 0.09
2.492ProLys: 2.492 ± 0.076
3.036ProLeu: 3.036 ± 0.1
0.675ProMet: 0.675 ± 0.041
1.837ProAsn: 1.837 ± 0.074
0.508ProPro: 0.508 ± 0.036
1.514ProGln: 1.514 ± 0.062
0.915ProArg: 0.915 ± 0.055
2.085ProSer: 2.085 ± 0.077
2.085ProThr: 2.085 ± 0.082
2.406ProVal: 2.406 ± 0.076
0.211ProTrp: 0.211 ± 0.02
1.261ProTyr: 1.261 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
3.563GlnAla: 3.563 ± 0.128
0.089GlnCys: 0.089 ± 0.014
2.669GlnAsp: 2.669 ± 0.088
2.956GlnGlu: 2.956 ± 0.094
2.09GlnPhe: 2.09 ± 0.079
2.299GlnGly: 2.299 ± 0.077
0.826GlnHis: 0.826 ± 0.048
3.505GlnIle: 3.505 ± 0.111
4.212GlnLys: 4.212 ± 0.099
5.716GlnLeu: 5.716 ± 0.151
1.282GlnMet: 1.282 ± 0.061
3.365GlnAsn: 3.365 ± 0.099
1.449GlnPro: 1.449 ± 0.061
2.737GlnGln: 2.737 ± 0.107
1.738GlnArg: 1.738 ± 0.089
3.276GlnSer: 3.276 ± 0.116
3.367GlnThr: 3.367 ± 0.095
3.214GlnVal: 3.214 ± 0.093
0.438GlnTrp: 0.438 ± 0.033
1.655GlnTyr: 1.655 ± 0.063
0.0GlnXaa: 0.0 ± 0.0
Arg
2.03ArgAla: 2.03 ± 0.071
0.12ArgCys: 0.12 ± 0.018
1.942ArgAsp: 1.942 ± 0.076
2.155ArgGlu: 2.155 ± 0.084
1.785ArgPhe: 1.785 ± 0.074
2.028ArgGly: 2.028 ± 0.087
0.855ArgHis: 0.855 ± 0.046
2.58ArgIle: 2.58 ± 0.088
2.411ArgLys: 2.411 ± 0.078
3.826ArgLeu: 3.826 ± 0.1
0.928ArgMet: 0.928 ± 0.047
1.689ArgAsn: 1.689 ± 0.075
1.28ArgPro: 1.28 ± 0.056
2.348ArgGln: 2.348 ± 0.091
1.866ArgArg: 1.866 ± 0.088
1.895ArgSer: 1.895 ± 0.069
1.629ArgThr: 1.629 ± 0.06
2.455ArgVal: 2.455 ± 0.073
0.268ArgTrp: 0.268 ± 0.03
1.473ArgTyr: 1.473 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
4.238SerAla: 4.238 ± 0.1
0.232SerCys: 0.232 ± 0.022
4.16SerAsp: 4.16 ± 0.133
3.954SerGlu: 3.954 ± 0.104
3.19SerPhe: 3.19 ± 0.098
4.644SerGly: 4.644 ± 0.123
1.42SerHis: 1.42 ± 0.064
4.775SerIle: 4.775 ± 0.117
4.501SerLys: 4.501 ± 0.12
6.643SerLeu: 6.643 ± 0.14
1.488SerMet: 1.488 ± 0.054
3.482SerAsn: 3.482 ± 0.132
1.9SerPro: 1.9 ± 0.071
3.878SerGln: 3.878 ± 0.134
2.4SerArg: 2.4 ± 0.085
4.59SerSer: 4.59 ± 0.175
3.469SerThr: 3.469 ± 0.095
4.311SerVal: 4.311 ± 0.107
0.526SerTrp: 0.526 ± 0.043
2.82SerTyr: 2.82 ± 0.092
0.0SerXaa: 0.0 ± 0.0
Thr
3.938ThrAla: 3.938 ± 0.112
0.177ThrCys: 0.177 ± 0.023
3.336ThrAsp: 3.336 ± 0.099
3.081ThrGlu: 3.081 ± 0.099
2.578ThrPhe: 2.578 ± 0.076
3.899ThrGly: 3.899 ± 0.116
1.251ThrHis: 1.251 ± 0.059
4.988ThrIle: 4.988 ± 0.12
4.097ThrLys: 4.097 ± 0.101
5.575ThrLeu: 5.575 ± 0.127
1.149ThrMet: 1.149 ± 0.052
3.005ThrAsn: 3.005 ± 0.109
2.565ThrPro: 2.565 ± 0.089
2.963ThrGln: 2.963 ± 0.103
1.936ThrArg: 1.936 ± 0.07
3.849ThrSer: 3.849 ± 0.101
3.636ThrThr: 3.636 ± 0.113
4.032ThrVal: 4.032 ± 0.106
0.394ThrTrp: 0.394 ± 0.031
2.192ThrTyr: 2.192 ± 0.092
0.0ThrXaa: 0.0 ± 0.0
Val
4.949ValAla: 4.949 ± 0.125
0.3ValCys: 0.3 ± 0.026
4.048ValAsp: 4.048 ± 0.106
4.233ValGlu: 4.233 ± 0.127
2.948ValPhe: 2.948 ± 0.092
4.454ValGly: 4.454 ± 0.145
1.04ValHis: 1.04 ± 0.052
5.637ValIle: 5.637 ± 0.135
4.77ValLys: 4.77 ± 0.135
6.69ValLeu: 6.69 ± 0.153
1.783ValMet: 1.783 ± 0.07
3.469ValAsn: 3.469 ± 0.111
2.273ValPro: 2.273 ± 0.074
2.593ValGln: 2.593 ± 0.091
2.093ValArg: 2.093 ± 0.096
4.902ValSer: 4.902 ± 0.111
4.079ValThr: 4.079 ± 0.108
4.91ValVal: 4.91 ± 0.113
0.448ValTrp: 0.448 ± 0.037
2.194ValTyr: 2.194 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.401TrpAla: 0.401 ± 0.033
0.029TrpCys: 0.029 ± 0.008
0.375TrpAsp: 0.375 ± 0.031
0.31TrpGlu: 0.31 ± 0.028
0.425TrpPhe: 0.425 ± 0.041
0.417TrpGly: 0.417 ± 0.034
0.182TrpHis: 0.182 ± 0.021
0.607TrpIle: 0.607 ± 0.042
0.336TrpLys: 0.336 ± 0.027
0.933TrpLeu: 0.933 ± 0.054
0.206TrpMet: 0.206 ± 0.019
0.331TrpAsn: 0.331 ± 0.032
0.198TrpPro: 0.198 ± 0.023
0.526TrpGln: 0.526 ± 0.041
0.295TrpArg: 0.295 ± 0.03
0.487TrpSer: 0.487 ± 0.039
0.331TrpThr: 0.331 ± 0.029
0.506TrpVal: 0.506 ± 0.036
0.068TrpTrp: 0.068 ± 0.012
0.352TrpTyr: 0.352 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.205TyrAla: 2.205 ± 0.078
0.175TyrCys: 0.175 ± 0.019
2.434TyrAsp: 2.434 ± 0.085
2.088TyrGlu: 2.088 ± 0.083
1.976TyrPhe: 1.976 ± 0.084
2.296TyrGly: 2.296 ± 0.082
0.998TyrHis: 0.998 ± 0.055
2.348TyrIle: 2.348 ± 0.089
1.83TyrLys: 1.83 ± 0.085
4.303TyrLeu: 4.303 ± 0.126
0.688TyrMet: 0.688 ± 0.042
2.025TyrAsn: 2.025 ± 0.074
1.394TyrPro: 1.394 ± 0.06
2.825TyrGln: 2.825 ± 0.114
1.579TyrArg: 1.579 ± 0.067
2.299TyrSer: 2.299 ± 0.077
1.822TyrThr: 1.822 ± 0.076
2.181TyrVal: 2.181 ± 0.075
0.258TyrTrp: 0.258 ± 0.031
1.71TyrTyr: 1.71 ± 0.086
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.003XaaAsp: 0.003 ± 0.003
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.003XaaLys: 0.003 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.003XaaTyr: 0.003 ± 0.002
0.138XaaXaa: 0.138 ± 0.095
Statistics based on 1222 proteins (383689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski