Amino acid dipepetide frequency for Streptococcus satellite phage Javan594

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.428AlaCys: 0.428 ± 0.427
2.566AlaAsp: 2.566 ± 0.802
5.56AlaGlu: 5.56 ± 1.684
1.283AlaPhe: 1.283 ± 0.628
2.566AlaGly: 2.566 ± 1.078
1.283AlaHis: 1.283 ± 0.747
6.843AlaIle: 6.843 ± 1.32
2.566AlaLys: 2.566 ± 0.783
4.277AlaLeu: 4.277 ± 1.197
2.566AlaMet: 2.566 ± 1.182
2.139AlaAsn: 2.139 ± 0.714
2.994AlaPro: 2.994 ± 0.919
1.283AlaGln: 1.283 ± 0.657
2.566AlaArg: 2.566 ± 0.677
2.566AlaSer: 2.566 ± 1.104
5.988AlaThr: 5.988 ± 2.223
2.566AlaVal: 2.566 ± 1.18
0.428AlaTrp: 0.428 ± 0.432
3.422AlaTyr: 3.422 ± 1.184
0.0AlaXaa: 0.0 ± 0.0
Cys
0.428CysAla: 0.428 ± 0.359
0.0CysCys: 0.0 ± 0.0
0.855CysAsp: 0.855 ± 0.463
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.428CysGly: 0.428 ± 0.493
0.0CysHis: 0.0 ± 0.0
0.855CysIle: 0.855 ± 0.45
1.283CysLys: 1.283 ± 0.675
0.428CysLeu: 0.428 ± 0.427
0.0CysMet: 0.0 ± 0.0
0.428CysAsn: 0.428 ± 0.35
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.283CysArg: 1.283 ± 0.578
0.0CysSer: 0.0 ± 0.0
0.855CysThr: 0.855 ± 0.751
0.428CysVal: 0.428 ± 0.35
0.0CysTrp: 0.0 ± 0.0
0.855CysTyr: 0.855 ± 0.587
0.0CysXaa: 0.0 ± 0.0
Asp
1.283AspAla: 1.283 ± 0.861
0.0AspCys: 0.0 ± 0.0
1.711AspAsp: 1.711 ± 0.919
5.133AspGlu: 5.133 ± 0.908
1.283AspPhe: 1.283 ± 0.649
4.705AspGly: 4.705 ± 0.971
0.428AspHis: 0.428 ± 0.421
6.416AspIle: 6.416 ± 1.594
5.988AspLys: 5.988 ± 1.546
5.133AspLeu: 5.133 ± 1.321
2.139AspMet: 2.139 ± 1.073
2.994AspAsn: 2.994 ± 1.22
0.428AspPro: 0.428 ± 0.35
0.428AspGln: 0.428 ± 0.493
2.139AspArg: 2.139 ± 0.505
2.994AspSer: 2.994 ± 1.077
2.566AspThr: 2.566 ± 0.824
0.855AspVal: 0.855 ± 0.751
0.428AspTrp: 0.428 ± 0.493
3.849AspTyr: 3.849 ± 1.408
0.0AspXaa: 0.0 ± 0.0
Glu
6.416GluAla: 6.416 ± 0.971
1.711GluCys: 1.711 ± 0.567
3.849GluAsp: 3.849 ± 1.568
9.41GluGlu: 9.41 ± 3.22
2.994GluPhe: 2.994 ± 1.204
0.428GluGly: 0.428 ± 0.397
2.994GluHis: 2.994 ± 1.38
2.994GluIle: 2.994 ± 1.356
5.133GluLys: 5.133 ± 2.268
11.548GluLeu: 11.548 ± 1.852
2.139GluMet: 2.139 ± 0.963
5.133GluAsn: 5.133 ± 1.548
1.711GluPro: 1.711 ± 0.722
3.849GluGln: 3.849 ± 1.074
6.416GluArg: 6.416 ± 1.467
2.566GluSer: 2.566 ± 1.245
5.133GluThr: 5.133 ± 1.471
5.133GluVal: 5.133 ± 1.735
1.283GluTrp: 1.283 ± 0.9
2.566GluTyr: 2.566 ± 0.798
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.0PheCys: 0.0 ± 0.0
1.283PheAsp: 1.283 ± 0.719
3.422PheGlu: 3.422 ± 0.838
0.855PhePhe: 0.855 ± 0.443
1.283PheGly: 1.283 ± 0.551
1.283PheHis: 1.283 ± 0.781
0.855PheIle: 0.855 ± 0.565
2.994PheLys: 2.994 ± 0.979
3.422PheLeu: 3.422 ± 1.081
0.855PheMet: 0.855 ± 0.626
2.566PheAsn: 2.566 ± 0.654
0.855PhePro: 0.855 ± 0.483
1.711PheGln: 1.711 ± 1.042
1.711PheArg: 1.711 ± 0.989
0.855PheSer: 0.855 ± 0.525
2.139PheThr: 2.139 ± 0.723
1.283PheVal: 1.283 ± 0.821
0.0PheTrp: 0.0 ± 0.0
2.994PheTyr: 2.994 ± 1.111
0.0PheXaa: 0.0 ± 0.0
Gly
2.139GlyAla: 2.139 ± 0.914
0.855GlyCys: 0.855 ± 0.515
0.428GlyAsp: 0.428 ± 0.427
0.855GlyGlu: 0.855 ± 0.543
1.283GlyPhe: 1.283 ± 0.896
1.711GlyGly: 1.711 ± 1.187
1.711GlyHis: 1.711 ± 0.702
6.416GlyIle: 6.416 ± 1.363
3.422GlyLys: 3.422 ± 1.403
8.127GlyLeu: 8.127 ± 1.864
1.711GlyMet: 1.711 ± 0.827
1.711GlyAsn: 1.711 ± 0.918
0.0GlyPro: 0.0 ± 0.0
1.283GlyGln: 1.283 ± 0.624
4.277GlyArg: 4.277 ± 0.712
1.711GlySer: 1.711 ± 0.831
1.711GlyThr: 1.711 ± 0.814
3.422GlyVal: 3.422 ± 1.248
0.855GlyTrp: 0.855 ± 0.441
3.422GlyTyr: 3.422 ± 1.373
0.0GlyXaa: 0.0 ± 0.0
His
1.711HisAla: 1.711 ± 0.729
0.0HisCys: 0.0 ± 0.0
2.139HisAsp: 2.139 ± 0.858
2.139HisGlu: 2.139 ± 0.771
1.283HisPhe: 1.283 ± 0.551
0.855HisGly: 0.855 ± 0.525
0.0HisHis: 0.0 ± 0.0
1.711HisIle: 1.711 ± 0.781
2.566HisLys: 2.566 ± 0.92
3.849HisLeu: 3.849 ± 0.968
0.0HisMet: 0.0 ± 0.0
1.711HisAsn: 1.711 ± 0.545
0.0HisPro: 0.0 ± 0.0
0.855HisGln: 0.855 ± 0.751
1.711HisArg: 1.711 ± 0.825
2.139HisSer: 2.139 ± 0.811
2.139HisThr: 2.139 ± 1.05
0.428HisVal: 0.428 ± 0.423
0.855HisTrp: 0.855 ± 0.562
1.283HisTyr: 1.283 ± 0.576
0.0HisXaa: 0.0 ± 0.0
Ile
4.705IleAla: 4.705 ± 1.984
0.0IleCys: 0.0 ± 0.0
4.705IleAsp: 4.705 ± 1.181
4.277IleGlu: 4.277 ± 1.51
1.283IlePhe: 1.283 ± 0.834
1.711IleGly: 1.711 ± 0.921
2.994IleHis: 2.994 ± 0.669
2.994IleIle: 2.994 ± 1.211
7.271IleLys: 7.271 ± 1.398
8.554IleLeu: 8.554 ± 2.274
0.855IleMet: 0.855 ± 0.477
2.139IleAsn: 2.139 ± 0.962
2.994IlePro: 2.994 ± 1.165
0.855IleGln: 0.855 ± 0.525
5.133IleArg: 5.133 ± 1.47
5.988IleSer: 5.988 ± 1.45
3.422IleThr: 3.422 ± 1.223
4.705IleVal: 4.705 ± 0.906
0.0IleTrp: 0.0 ± 0.0
1.711IleTyr: 1.711 ± 0.732
0.0IleXaa: 0.0 ± 0.0
Lys
6.416LysAla: 6.416 ± 1.144
0.855LysCys: 0.855 ± 0.521
6.843LysAsp: 6.843 ± 1.713
9.41LysGlu: 9.41 ± 1.575
2.566LysPhe: 2.566 ± 0.854
3.422LysGly: 3.422 ± 1.014
3.849LysHis: 3.849 ± 1.316
3.849LysIle: 3.849 ± 1.295
9.837LysLys: 9.837 ± 2.602
7.699LysLeu: 7.699 ± 1.726
1.711LysMet: 1.711 ± 0.799
5.56LysAsn: 5.56 ± 1.686
2.994LysPro: 2.994 ± 1.073
3.422LysGln: 3.422 ± 1.505
5.133LysArg: 5.133 ± 1.328
1.711LysSer: 1.711 ± 0.875
8.127LysThr: 8.127 ± 1.74
2.994LysVal: 2.994 ± 0.716
1.283LysTrp: 1.283 ± 0.861
4.277LysTyr: 4.277 ± 1.972
0.0LysXaa: 0.0 ± 0.0
Leu
5.133LeuAla: 5.133 ± 1.603
0.428LeuCys: 0.428 ± 0.376
6.843LeuAsp: 6.843 ± 1.47
13.259LeuGlu: 13.259 ± 2.733
2.994LeuPhe: 2.994 ± 0.762
6.416LeuGly: 6.416 ± 2.094
2.139LeuHis: 2.139 ± 0.873
5.56LeuIle: 5.56 ± 1.734
11.121LeuLys: 11.121 ± 1.812
10.693LeuLeu: 10.693 ± 1.464
2.566LeuMet: 2.566 ± 0.796
5.988LeuAsn: 5.988 ± 1.716
4.277LeuPro: 4.277 ± 1.887
3.849LeuGln: 3.849 ± 1.148
4.705LeuArg: 4.705 ± 1.117
6.416LeuSer: 6.416 ± 1.598
6.416LeuThr: 6.416 ± 1.1
3.849LeuVal: 3.849 ± 1.18
2.139LeuTrp: 2.139 ± 1.081
2.994LeuTyr: 2.994 ± 1.095
0.0LeuXaa: 0.0 ± 0.0
Met
2.139MetAla: 2.139 ± 0.832
0.0MetCys: 0.0 ± 0.0
0.855MetAsp: 0.855 ± 0.561
2.566MetGlu: 2.566 ± 1.154
0.0MetPhe: 0.0 ± 0.0
0.855MetGly: 0.855 ± 0.557
0.428MetHis: 0.428 ± 0.376
1.711MetIle: 1.711 ± 0.848
1.283MetLys: 1.283 ± 0.65
2.139MetLeu: 2.139 ± 0.949
0.855MetMet: 0.855 ± 0.564
1.283MetAsn: 1.283 ± 0.713
1.711MetPro: 1.711 ± 0.966
0.855MetGln: 0.855 ± 0.63
1.283MetArg: 1.283 ± 0.753
1.711MetSer: 1.711 ± 0.964
3.422MetThr: 3.422 ± 0.773
0.855MetVal: 0.855 ± 0.51
0.0MetTrp: 0.0 ± 0.0
0.428MetTyr: 0.428 ± 0.39
0.0MetXaa: 0.0 ± 0.0
Asn
2.994AsnAla: 2.994 ± 1.468
0.0AsnCys: 0.0 ± 0.0
1.711AsnAsp: 1.711 ± 0.629
2.566AsnGlu: 2.566 ± 0.689
2.139AsnPhe: 2.139 ± 0.945
3.422AsnGly: 3.422 ± 1.422
1.283AsnHis: 1.283 ± 0.65
5.988AsnIle: 5.988 ± 1.995
5.133AsnLys: 5.133 ± 0.972
5.133AsnLeu: 5.133 ± 1.432
0.428AsnMet: 0.428 ± 0.359
2.994AsnAsn: 2.994 ± 1.029
2.139AsnPro: 2.139 ± 0.932
1.711AsnGln: 1.711 ± 0.692
3.422AsnArg: 3.422 ± 1.025
2.566AsnSer: 2.566 ± 1.373
2.994AsnThr: 2.994 ± 1.045
2.139AsnVal: 2.139 ± 0.525
1.283AsnTrp: 1.283 ± 0.512
2.566AsnTyr: 2.566 ± 0.84
0.0AsnXaa: 0.0 ± 0.0
Pro
1.283ProAla: 1.283 ± 0.959
0.0ProCys: 0.0 ± 0.0
0.855ProAsp: 0.855 ± 0.604
2.994ProGlu: 2.994 ± 1.313
1.283ProPhe: 1.283 ± 0.691
0.428ProGly: 0.428 ± 0.35
0.855ProHis: 0.855 ± 0.66
2.139ProIle: 2.139 ± 0.989
2.139ProLys: 2.139 ± 0.836
3.849ProLeu: 3.849 ± 1.39
0.428ProMet: 0.428 ± 0.39
2.566ProAsn: 2.566 ± 0.911
2.994ProPro: 2.994 ± 1.336
1.711ProGln: 1.711 ± 0.814
0.855ProArg: 0.855 ± 0.62
2.139ProSer: 2.139 ± 0.762
1.711ProThr: 1.711 ± 0.993
0.428ProVal: 0.428 ± 0.493
0.428ProTrp: 0.428 ± 0.561
1.711ProTyr: 1.711 ± 0.806
0.0ProXaa: 0.0 ± 0.0
Gln
3.422GlnAla: 3.422 ± 0.781
0.855GlnCys: 0.855 ± 0.536
1.283GlnAsp: 1.283 ± 0.72
4.277GlnGlu: 4.277 ± 1.35
2.139GlnPhe: 2.139 ± 0.935
2.994GlnGly: 2.994 ± 0.98
1.711GlnHis: 1.711 ± 0.782
1.283GlnIle: 1.283 ± 0.664
3.422GlnLys: 3.422 ± 1.098
2.566GlnLeu: 2.566 ± 0.813
0.855GlnMet: 0.855 ± 0.515
1.283GlnAsn: 1.283 ± 0.722
0.0GlnPro: 0.0 ± 0.0
2.566GlnGln: 2.566 ± 0.985
1.283GlnArg: 1.283 ± 0.59
2.139GlnSer: 2.139 ± 0.907
1.711GlnThr: 1.711 ± 0.771
2.566GlnVal: 2.566 ± 1.081
0.0GlnTrp: 0.0 ± 0.0
1.711GlnTyr: 1.711 ± 0.827
0.0GlnXaa: 0.0 ± 0.0
Arg
3.422ArgAla: 3.422 ± 1.338
0.0ArgCys: 0.0 ± 0.0
3.422ArgAsp: 3.422 ± 1.585
2.566ArgGlu: 2.566 ± 0.933
1.711ArgPhe: 1.711 ± 0.735
3.422ArgGly: 3.422 ± 1.068
2.566ArgHis: 2.566 ± 0.912
3.849ArgIle: 3.849 ± 0.827
5.133ArgLys: 5.133 ± 1.447
7.699ArgLeu: 7.699 ± 2.102
2.139ArgMet: 2.139 ± 0.908
2.566ArgAsn: 2.566 ± 1.021
1.711ArgPro: 1.711 ± 0.668
2.139ArgGln: 2.139 ± 0.851
6.416ArgArg: 6.416 ± 1.708
4.277ArgSer: 4.277 ± 1.483
2.139ArgThr: 2.139 ± 0.661
3.422ArgVal: 3.422 ± 1.123
0.428ArgTrp: 0.428 ± 0.485
4.277ArgTyr: 4.277 ± 0.908
0.0ArgXaa: 0.0 ± 0.0
Ser
2.139SerAla: 2.139 ± 0.738
0.855SerCys: 0.855 ± 0.463
4.277SerAsp: 4.277 ± 0.808
5.56SerGlu: 5.56 ± 1.639
1.283SerPhe: 1.283 ± 0.751
2.139SerGly: 2.139 ± 0.733
1.711SerHis: 1.711 ± 0.782
3.422SerIle: 3.422 ± 1.243
7.271SerLys: 7.271 ± 1.71
6.416SerLeu: 6.416 ± 1.891
1.711SerMet: 1.711 ± 0.756
3.849SerAsn: 3.849 ± 1.361
1.283SerPro: 1.283 ± 0.63
2.566SerGln: 2.566 ± 1.077
3.422SerArg: 3.422 ± 1.246
2.994SerSer: 2.994 ± 1.076
0.855SerThr: 0.855 ± 0.531
1.711SerVal: 1.711 ± 0.739
1.283SerTrp: 1.283 ± 1.191
2.566SerTyr: 2.566 ± 1.201
0.0SerXaa: 0.0 ± 0.0
Thr
3.422ThrAla: 3.422 ± 1.211
0.0ThrCys: 0.0 ± 0.0
2.994ThrAsp: 2.994 ± 0.921
3.849ThrGlu: 3.849 ± 1.378
2.566ThrPhe: 2.566 ± 0.904
4.705ThrGly: 4.705 ± 1.843
0.855ThrHis: 0.855 ± 0.525
3.422ThrIle: 3.422 ± 1.204
4.705ThrLys: 4.705 ± 1.641
5.56ThrLeu: 5.56 ± 0.996
0.428ThrMet: 0.428 ± 0.432
2.139ThrAsn: 2.139 ± 0.653
2.994ThrPro: 2.994 ± 0.994
2.139ThrGln: 2.139 ± 0.684
3.849ThrArg: 3.849 ± 1.613
5.133ThrSer: 5.133 ± 1.204
4.705ThrThr: 4.705 ± 0.922
3.422ThrVal: 3.422 ± 1.103
2.139ThrTrp: 2.139 ± 0.785
1.711ThrTyr: 1.711 ± 0.589
0.0ThrXaa: 0.0 ± 0.0
Val
5.56ValAla: 5.56 ± 1.632
0.428ValCys: 0.428 ± 0.493
0.855ValAsp: 0.855 ± 0.528
3.422ValGlu: 3.422 ± 1.182
2.139ValPhe: 2.139 ± 0.797
1.283ValGly: 1.283 ± 0.821
0.428ValHis: 0.428 ± 0.359
2.994ValIle: 2.994 ± 1.264
4.277ValLys: 4.277 ± 1.492
3.422ValLeu: 3.422 ± 1.396
1.283ValMet: 1.283 ± 0.683
2.994ValAsn: 2.994 ± 0.742
0.0ValPro: 0.0 ± 0.0
1.283ValGln: 1.283 ± 0.797
2.566ValArg: 2.566 ± 0.926
6.416ValSer: 6.416 ± 1.762
2.139ValThr: 2.139 ± 0.785
1.283ValVal: 1.283 ± 0.509
0.855ValTrp: 0.855 ± 0.441
0.855ValTyr: 0.855 ± 0.479
0.0ValXaa: 0.0 ± 0.0
Trp
0.428TrpAla: 0.428 ± 0.39
0.428TrpCys: 0.428 ± 0.376
0.855TrpAsp: 0.855 ± 0.78
1.283TrpGlu: 1.283 ± 0.803
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.428TrpHis: 0.428 ± 0.421
0.855TrpIle: 0.855 ± 0.572
0.428TrpLys: 0.428 ± 0.35
2.139TrpLeu: 2.139 ± 0.592
0.428TrpMet: 0.428 ± 0.421
0.428TrpAsn: 0.428 ± 0.423
0.0TrpPro: 0.0 ± 0.0
1.711TrpGln: 1.711 ± 0.722
0.855TrpArg: 0.855 ± 0.528
0.855TrpSer: 0.855 ± 0.483
1.283TrpThr: 1.283 ± 0.699
1.283TrpVal: 1.283 ± 0.876
0.428TrpTrp: 0.428 ± 0.423
0.428TrpTyr: 0.428 ± 0.427
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.283TyrAla: 1.283 ± 0.668
1.283TyrCys: 1.283 ± 0.569
2.566TyrAsp: 2.566 ± 1.041
0.855TyrGlu: 0.855 ± 0.574
1.283TyrPhe: 1.283 ± 0.605
4.277TyrGly: 4.277 ± 1.289
0.428TyrHis: 0.428 ± 0.489
2.139TyrIle: 2.139 ± 1.071
5.988TyrLys: 5.988 ± 1.852
5.133TyrLeu: 5.133 ± 0.976
0.855TyrMet: 0.855 ± 0.548
2.139TyrAsn: 2.139 ± 0.825
1.711TyrPro: 1.711 ± 1.09
3.849TyrGln: 3.849 ± 0.985
4.277TyrArg: 4.277 ± 1.246
2.139TyrSer: 2.139 ± 1.099
1.283TyrThr: 1.283 ± 0.53
1.711TyrVal: 1.711 ± 0.53
0.428TyrTrp: 0.428 ± 0.35
2.994TyrTyr: 2.994 ± 1.079
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2339 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski