Amino acid dipepetide frequency for TM7 phylum sp. oral taxon 356

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.893AlaAla: 6.893 ± 0.314
0.562AlaCys: 0.562 ± 0.055
5.263AlaAsp: 5.263 ± 0.173
5.285AlaGlu: 5.285 ± 0.204
2.406AlaPhe: 2.406 ± 0.115
6.601AlaGly: 6.601 ± 0.209
1.453AlaHis: 1.453 ± 0.087
6.155AlaIle: 6.155 ± 0.197
5.957AlaLys: 5.957 ± 0.196
7.663AlaLeu: 7.663 ± 0.206
2.114AlaMet: 2.114 ± 0.115
3.617AlaAsn: 3.617 ± 0.148
2.758AlaPro: 2.758 ± 0.138
3.325AlaGln: 3.325 ± 0.132
4.955AlaArg: 4.955 ± 0.193
4.982AlaSer: 4.982 ± 0.173
5.026AlaThr: 5.026 ± 0.189
6.067AlaVal: 6.067 ± 0.223
0.908AlaTrp: 0.908 ± 0.077
2.428AlaTyr: 2.428 ± 0.115
0.0AlaXaa: 0.0 ± 0.0
Cys
0.529CysAla: 0.529 ± 0.06
0.121CysCys: 0.121 ± 0.032
0.578CysAsp: 0.578 ± 0.066
0.259CysGlu: 0.259 ± 0.039
0.275CysPhe: 0.275 ± 0.039
0.562CysGly: 0.562 ± 0.065
0.198CysHis: 0.198 ± 0.036
0.44CysIle: 0.44 ± 0.058
0.336CysLys: 0.336 ± 0.044
0.782CysLeu: 0.782 ± 0.069
0.11CysMet: 0.11 ± 0.024
0.303CysAsn: 0.303 ± 0.044
0.385CysPro: 0.385 ± 0.037
0.33CysGln: 0.33 ± 0.046
0.501CysArg: 0.501 ± 0.052
0.529CysSer: 0.529 ± 0.052
0.33CysThr: 0.33 ± 0.041
0.446CysVal: 0.446 ± 0.051
0.099CysTrp: 0.099 ± 0.024
0.352CysTyr: 0.352 ± 0.044
0.0CysXaa: 0.0 ± 0.0
Asp
3.936AspAla: 3.936 ± 0.159
0.44AspCys: 0.44 ± 0.047
4.514AspAsp: 4.514 ± 0.193
4.256AspGlu: 4.256 ± 0.159
2.45AspPhe: 2.45 ± 0.125
4.702AspGly: 4.702 ± 0.146
1.041AspHis: 1.041 ± 0.077
4.437AspIle: 4.437 ± 0.178
4.327AspLys: 4.327 ± 0.168
4.795AspLeu: 4.795 ± 0.176
1.409AspMet: 1.409 ± 0.086
2.945AspAsn: 2.945 ± 0.129
2.373AspPro: 2.373 ± 0.101
2.621AspGln: 2.621 ± 0.113
3.413AspArg: 3.413 ± 0.162
4.096AspSer: 4.096 ± 0.164
3.055AspThr: 3.055 ± 0.153
3.298AspVal: 3.298 ± 0.14
0.82AspTrp: 0.82 ± 0.075
2.824AspTyr: 2.824 ± 0.136
0.0AspXaa: 0.0 ± 0.0
Glu
4.503GluAla: 4.503 ± 0.158
0.369GluCys: 0.369 ± 0.046
2.565GluAsp: 2.565 ± 0.133
3.144GluGlu: 3.144 ± 0.154
1.883GluPhe: 1.883 ± 0.095
2.67GluGly: 2.67 ± 0.107
1.294GluHis: 1.294 ± 0.077
4.201GluIle: 4.201 ± 0.172
3.755GluLys: 3.755 ± 0.187
6.238GluLeu: 6.238 ± 0.216
1.299GluMet: 1.299 ± 0.093
2.142GluAsn: 2.142 ± 0.124
1.888GluPro: 1.888 ± 0.096
2.929GluGln: 2.929 ± 0.142
3.749GluArg: 3.749 ± 0.177
3.391GluSer: 3.391 ± 0.14
2.94GluThr: 2.94 ± 0.123
3.738GluVal: 3.738 ± 0.151
0.54GluTrp: 0.54 ± 0.061
1.949GluTyr: 1.949 ± 0.116
0.0GluXaa: 0.0 ± 0.0
Phe
2.978PheAla: 2.978 ± 0.136
0.363PheCys: 0.363 ± 0.052
2.362PheAsp: 2.362 ± 0.124
1.635PheGlu: 1.635 ± 0.094
1.409PhePhe: 1.409 ± 0.108
2.576PheGly: 2.576 ± 0.188
0.655PheHis: 0.655 ± 0.047
2.483PheIle: 2.483 ± 0.125
1.497PheLys: 1.497 ± 0.093
2.72PheLeu: 2.72 ± 0.116
0.859PheMet: 0.859 ± 0.061
1.927PheAsn: 1.927 ± 0.1
1.085PhePro: 1.085 ± 0.082
0.914PheGln: 0.914 ± 0.066
1.883PheArg: 1.883 ± 0.09
2.692PheSer: 2.692 ± 0.13
2.356PheThr: 2.356 ± 0.111
2.477PheVal: 2.477 ± 0.139
0.424PheTrp: 0.424 ± 0.049
1.404PheTyr: 1.404 ± 0.089
0.0PheXaa: 0.0 ± 0.0
Gly
4.933GlyAla: 4.933 ± 0.148
0.462GlyCys: 0.462 ± 0.058
4.58GlyAsp: 4.58 ± 0.173
3.925GlyGlu: 3.925 ± 0.162
2.488GlyPhe: 2.488 ± 0.147
4.916GlyGly: 4.916 ± 0.215
1.211GlyHis: 1.211 ± 0.089
4.349GlyIle: 4.349 ± 0.148
4.646GlyLys: 4.646 ± 0.161
6.755GlyLeu: 6.755 ± 0.223
1.53GlyMet: 1.53 ± 0.093
2.753GlyAsn: 2.753 ± 0.141
1.332GlyPro: 1.332 ± 0.088
2.819GlyGln: 2.819 ± 0.151
3.799GlyArg: 3.799 ± 0.15
4.624GlySer: 4.624 ± 0.186
3.303GlyThr: 3.303 ± 0.158
5.285GlyVal: 5.285 ± 0.186
0.974GlyTrp: 0.974 ± 0.092
2.632GlyTyr: 2.632 ± 0.138
0.0GlyXaa: 0.0 ± 0.0
His
1.195HisAla: 1.195 ± 0.093
0.176HisCys: 0.176 ± 0.033
1.228HisAsp: 1.228 ± 0.098
0.958HisGlu: 0.958 ± 0.082
0.666HisPhe: 0.666 ± 0.057
1.305HisGly: 1.305 ± 0.085
0.573HisHis: 0.573 ± 0.072
1.481HisIle: 1.481 ± 0.097
0.831HisLys: 0.831 ± 0.072
1.795HisLeu: 1.795 ± 0.098
0.446HisMet: 0.446 ± 0.051
0.875HisAsn: 0.875 ± 0.066
0.848HisPro: 0.848 ± 0.064
1.134HisGln: 1.134 ± 0.09
1.184HisArg: 1.184 ± 0.09
1.288HisSer: 1.288 ± 0.075
1.018HisThr: 1.018 ± 0.077
1.024HisVal: 1.024 ± 0.087
0.237HisTrp: 0.237 ± 0.037
0.892HisTyr: 0.892 ± 0.07
0.0HisXaa: 0.0 ± 0.0
Ile
6.672IleAla: 6.672 ± 0.216
0.595IleCys: 0.595 ± 0.056
4.861IleAsp: 4.861 ± 0.166
3.942IleGlu: 3.942 ± 0.153
2.268IlePhe: 2.268 ± 0.137
4.762IleGly: 4.762 ± 0.165
1.101IleHis: 1.101 ± 0.078
6.193IleIle: 6.193 ± 0.25
4.525IleLys: 4.525 ± 0.174
5.797IleLeu: 5.797 ± 0.187
1.536IleMet: 1.536 ± 0.09
3.369IleAsn: 3.369 ± 0.157
2.395IlePro: 2.395 ± 0.098
1.949IleGln: 1.949 ± 0.108
3.534IleArg: 3.534 ± 0.157
5.186IleSer: 5.186 ± 0.181
3.92IleThr: 3.92 ± 0.149
5.489IleVal: 5.489 ± 0.202
0.6IleTrp: 0.6 ± 0.058
2.455IleTyr: 2.455 ± 0.147
0.0IleXaa: 0.0 ± 0.0
Lys
4.536LysAla: 4.536 ± 0.177
0.38LysCys: 0.38 ± 0.051
3.204LysAsp: 3.204 ± 0.174
3.177LysGlu: 3.177 ± 0.154
1.888LysPhe: 1.888 ± 0.1
3.011LysGly: 3.011 ± 0.13
1.261LysHis: 1.261 ± 0.065
4.239LysIle: 4.239 ± 0.164
4.228LysLys: 4.228 ± 0.197
6.243LysLeu: 6.243 ± 0.203
1.481LysMet: 1.481 ± 0.104
2.764LysAsn: 2.764 ± 0.149
2.769LysPro: 2.769 ± 0.141
3.061LysGln: 3.061 ± 0.124
3.782LysArg: 3.782 ± 0.159
4.19LysSer: 4.19 ± 0.18
3.391LysThr: 3.391 ± 0.142
3.645LysVal: 3.645 ± 0.144
0.6LysTrp: 0.6 ± 0.06
2.466LysTyr: 2.466 ± 0.132
0.0LysXaa: 0.0 ± 0.0
Leu
9.843LeuAla: 9.843 ± 0.287
0.65LeuCys: 0.65 ± 0.063
5.648LeuAsp: 5.648 ± 0.203
4.795LeuGlu: 4.795 ± 0.184
3.303LeuPhe: 3.303 ± 0.173
5.759LeuGly: 5.759 ± 0.23
1.652LeuHis: 1.652 ± 0.103
6.221LeuIle: 6.221 ± 0.215
4.905LeuLys: 4.905 ± 0.166
8.643LeuLeu: 8.643 ± 0.312
2.439LeuMet: 2.439 ± 0.124
3.551LeuAsn: 3.551 ± 0.136
4.729LeuPro: 4.729 ± 0.151
2.907LeuGln: 2.907 ± 0.121
5.461LeuArg: 5.461 ± 0.181
6.992LeuSer: 6.992 ± 0.181
5.654LeuThr: 5.654 ± 0.178
6.65LeuVal: 6.65 ± 0.178
0.804LeuTrp: 0.804 ± 0.074
2.67LeuTyr: 2.67 ± 0.136
0.0LeuXaa: 0.0 ± 0.0
Met
2.075MetAla: 2.075 ± 0.1
0.154MetCys: 0.154 ± 0.03
0.969MetAsp: 0.969 ± 0.071
1.018MetGlu: 1.018 ± 0.077
0.765MetPhe: 0.765 ± 0.055
1.321MetGly: 1.321 ± 0.095
0.396MetHis: 0.396 ± 0.045
1.74MetIle: 1.74 ± 0.092
1.63MetLys: 1.63 ± 0.094
2.169MetLeu: 2.169 ± 0.097
0.639MetMet: 0.639 ± 0.058
1.14MetAsn: 1.14 ± 0.085
1.068MetPro: 1.068 ± 0.071
0.859MetGln: 0.859 ± 0.066
1.426MetArg: 1.426 ± 0.073
1.877MetSer: 1.877 ± 0.095
1.409MetThr: 1.409 ± 0.077
1.657MetVal: 1.657 ± 0.11
0.193MetTrp: 0.193 ± 0.031
0.6MetTyr: 0.6 ± 0.065
0.0MetXaa: 0.0 ± 0.0
Asn
3.199AsnAla: 3.199 ± 0.13
0.347AsnCys: 0.347 ± 0.042
2.72AsnAsp: 2.72 ± 0.125
2.351AsnGlu: 2.351 ± 0.122
1.641AsnPhe: 1.641 ± 0.104
2.962AsnGly: 2.962 ± 0.122
0.798AsnHis: 0.798 ± 0.069
3.391AsnIle: 3.391 ± 0.13
2.786AsnLys: 2.786 ± 0.134
3.837AsnLeu: 3.837 ± 0.147
0.798AsnMet: 0.798 ± 0.066
2.428AsnAsn: 2.428 ± 0.143
2.18AsnPro: 2.18 ± 0.142
2.378AsnGln: 2.378 ± 0.165
2.373AsnArg: 2.373 ± 0.122
2.835AsnSer: 2.835 ± 0.128
2.087AsnThr: 2.087 ± 0.099
2.769AsnVal: 2.769 ± 0.123
0.529AsnTrp: 0.529 ± 0.053
1.8AsnTyr: 1.8 ± 0.103
0.0AsnXaa: 0.0 ± 0.0
Pro
3.804ProAla: 3.804 ± 0.184
0.209ProCys: 0.209 ± 0.039
2.995ProAsp: 2.995 ± 0.142
2.857ProGlu: 2.857 ± 0.124
1.321ProPhe: 1.321 ± 0.092
2.698ProGly: 2.698 ± 0.122
0.815ProHis: 0.815 ± 0.06
2.395ProIle: 2.395 ± 0.113
2.279ProLys: 2.279 ± 0.12
3.182ProLeu: 3.182 ± 0.135
0.831ProMet: 0.831 ± 0.073
1.833ProAsn: 1.833 ± 0.115
1.63ProPro: 1.63 ± 0.128
1.712ProGln: 1.712 ± 0.114
1.569ProArg: 1.569 ± 0.097
2.648ProSer: 2.648 ± 0.121
2.637ProThr: 2.637 ± 0.158
2.901ProVal: 2.901 ± 0.118
0.396ProTrp: 0.396 ± 0.049
1.217ProTyr: 1.217 ± 0.081
0.0ProXaa: 0.0 ± 0.0
Gln
4.327GlnAla: 4.327 ± 0.186
0.242GlnCys: 0.242 ± 0.04
1.74GlnAsp: 1.74 ± 0.111
1.773GlnGlu: 1.773 ± 0.103
1.349GlnPhe: 1.349 ± 0.102
2.053GlnGly: 2.053 ± 0.123
0.776GlnHis: 0.776 ± 0.066
2.885GlnIle: 2.885 ± 0.114
2.323GlnLys: 2.323 ± 0.112
4.657GlnLeu: 4.657 ± 0.182
0.991GlnMet: 0.991 ± 0.075
1.635GlnAsn: 1.635 ± 0.103
2.521GlnPro: 2.521 ± 0.192
2.158GlnGln: 2.158 ± 0.134
2.411GlnArg: 2.411 ± 0.119
2.72GlnSer: 2.72 ± 0.139
2.576GlnThr: 2.576 ± 0.107
2.615GlnVal: 2.615 ± 0.131
0.495GlnTrp: 0.495 ± 0.059
1.426GlnTyr: 1.426 ± 0.112
0.0GlnXaa: 0.0 ± 0.0
Arg
4.641ArgAla: 4.641 ± 0.179
0.407ArgCys: 0.407 ± 0.065
3.364ArgAsp: 3.364 ± 0.138
3.144ArgGlu: 3.144 ± 0.127
1.943ArgPhe: 1.943 ± 0.107
3.358ArgGly: 3.358 ± 0.128
1.299ArgHis: 1.299 ± 0.09
3.386ArgIle: 3.386 ± 0.152
3.039ArgLys: 3.039 ± 0.149
6.304ArgLeu: 6.304 ± 0.244
1.288ArgMet: 1.288 ± 0.081
2.455ArgAsn: 2.455 ± 0.12
2.158ArgPro: 2.158 ± 0.135
3.446ArgGln: 3.446 ± 0.148
4.613ArgArg: 4.613 ± 0.199
3.485ArgSer: 3.485 ± 0.137
2.83ArgThr: 2.83 ± 0.125
3.562ArgVal: 3.562 ± 0.141
0.54ArgTrp: 0.54 ± 0.061
2.312ArgTyr: 2.312 ± 0.12
0.0ArgXaa: 0.0 ± 0.0
Ser
5.511SerAla: 5.511 ± 0.195
0.435SerCys: 0.435 ± 0.044
4.278SerAsp: 4.278 ± 0.148
4.002SerGlu: 4.002 ± 0.154
2.587SerPhe: 2.587 ± 0.134
5.676SerGly: 5.676 ± 0.214
1.365SerHis: 1.365 ± 0.094
4.404SerIle: 4.404 ± 0.154
3.622SerLys: 3.622 ± 0.145
6.315SerLeu: 6.315 ± 0.2
1.464SerMet: 1.464 ± 0.089
2.753SerAsn: 2.753 ± 0.118
2.758SerPro: 2.758 ± 0.126
2.956SerGln: 2.956 ± 0.127
3.793SerArg: 3.793 ± 0.162
5.136SerSer: 5.136 ± 0.221
3.694SerThr: 3.694 ± 0.171
4.338SerVal: 4.338 ± 0.15
0.743SerTrp: 0.743 ± 0.068
2.455SerTyr: 2.455 ± 0.129
0.0SerXaa: 0.0 ± 0.0
Thr
4.652ThrAla: 4.652 ± 0.191
0.369ThrCys: 0.369 ± 0.054
3.573ThrAsp: 3.573 ± 0.141
2.742ThrGlu: 2.742 ± 0.13
1.679ThrPhe: 1.679 ± 0.101
4.465ThrGly: 4.465 ± 0.155
1.074ThrHis: 1.074 ± 0.078
4.746ThrIle: 4.746 ± 0.168
3.463ThrLys: 3.463 ± 0.131
4.531ThrLeu: 4.531 ± 0.15
1.332ThrMet: 1.332 ± 0.085
2.549ThrAsn: 2.549 ± 0.111
3.028ThrPro: 3.028 ± 0.146
1.558ThrGln: 1.558 ± 0.1
2.34ThrArg: 2.34 ± 0.122
3.65ThrSer: 3.65 ± 0.158
3.711ThrThr: 3.711 ± 0.165
3.947ThrVal: 3.947 ± 0.127
0.495ThrTrp: 0.495 ± 0.049
1.855ThrTyr: 1.855 ± 0.092
0.0ThrXaa: 0.0 ± 0.0
Val
6.546ValAla: 6.546 ± 0.218
0.644ValCys: 0.644 ± 0.061
4.311ValAsp: 4.311 ± 0.167
3.821ValGlu: 3.821 ± 0.149
2.45ValPhe: 2.45 ± 0.14
4.657ValGly: 4.657 ± 0.168
1.09ValHis: 1.09 ± 0.082
5.214ValIle: 5.214 ± 0.161
3.925ValLys: 3.925 ± 0.135
5.786ValLeu: 5.786 ± 0.188
1.63ValMet: 1.63 ± 0.089
3.099ValAsn: 3.099 ± 0.13
2.422ValPro: 2.422 ± 0.132
2.131ValGln: 2.131 ± 0.114
3.391ValArg: 3.391 ± 0.165
4.9ValSer: 4.9 ± 0.2
3.694ValThr: 3.694 ± 0.159
5.825ValVal: 5.825 ± 0.238
0.589ValTrp: 0.589 ± 0.055
2.274ValTyr: 2.274 ± 0.116
0.0ValXaa: 0.0 ± 0.0
Trp
0.787TrpAla: 0.787 ± 0.069
0.138TrpCys: 0.138 ± 0.026
0.462TrpAsp: 0.462 ± 0.048
0.424TrpGlu: 0.424 ± 0.056
0.358TrpPhe: 0.358 ± 0.043
0.699TrpGly: 0.699 ± 0.079
0.275TrpHis: 0.275 ± 0.041
0.556TrpIle: 0.556 ± 0.062
0.435TrpLys: 0.435 ± 0.046
1.448TrpLeu: 1.448 ± 0.093
0.308TrpMet: 0.308 ± 0.049
0.396TrpAsn: 0.396 ± 0.054
0.281TrpPro: 0.281 ± 0.043
0.881TrpGln: 0.881 ± 0.069
0.941TrpArg: 0.941 ± 0.077
0.655TrpSer: 0.655 ± 0.067
0.44TrpThr: 0.44 ± 0.049
0.573TrpVal: 0.573 ± 0.055
0.171TrpTrp: 0.171 ± 0.028
0.33TrpTyr: 0.33 ± 0.049
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.857TyrAla: 2.857 ± 0.109
0.402TyrCys: 0.402 ± 0.051
2.538TyrAsp: 2.538 ± 0.13
1.679TyrGlu: 1.679 ± 0.092
1.569TyrPhe: 1.569 ± 0.096
2.565TyrGly: 2.565 ± 0.127
0.826TyrHis: 0.826 ± 0.074
2.235TyrIle: 2.235 ± 0.123
1.806TyrLys: 1.806 ± 0.12
3.617TyrLeu: 3.617 ± 0.147
0.595TyrMet: 0.595 ± 0.056
1.674TyrAsn: 1.674 ± 0.109
1.327TyrPro: 1.327 ± 0.091
1.608TyrGln: 1.608 ± 0.091
2.455TyrArg: 2.455 ± 0.145
2.411TyrSer: 2.411 ± 0.121
1.685TyrThr: 1.685 ± 0.104
2.092TyrVal: 2.092 ± 0.1
0.402TyrTrp: 0.402 ± 0.051
1.426TyrTyr: 1.426 ± 0.098
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 611 proteins (181644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski