Amino acid dipepetide frequency for Dishui Lake phycodnavirus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.678AlaAla: 4.678 ± 0.761
1.123AlaCys: 1.123 ± 0.403
1.75AlaAsp: 1.75 ± 0.255
1.971AlaGlu: 1.971 ± 0.279
2.67AlaPhe: 2.67 ± 0.416
9.503AlaGly: 9.503 ± 3.651
1.179AlaHis: 1.179 ± 0.19
7.938AlaIle: 7.938 ± 3.007
3.02AlaLys: 3.02 ± 0.633
5.249AlaLeu: 5.249 ± 0.634
1.768AlaMet: 1.768 ± 0.252
3.683AlaAsn: 3.683 ± 0.708
2.413AlaPro: 2.413 ± 0.398
2.947AlaGln: 2.947 ± 0.643
1.805AlaArg: 1.805 ± 0.243
3.518AlaSer: 3.518 ± 0.328
3.978AlaThr: 3.978 ± 0.734
6.28AlaVal: 6.28 ± 1.74
0.424AlaTrp: 0.424 ± 0.126
2.302AlaTyr: 2.302 ± 0.337
0.0AlaXaa: 0.0 ± 0.0
Cys
0.792CysAla: 0.792 ± 0.193
0.239CysCys: 0.239 ± 0.074
0.792CysAsp: 0.792 ± 0.201
0.958CysGlu: 0.958 ± 0.224
0.479CysPhe: 0.479 ± 0.14
1.031CysGly: 1.031 ± 0.258
0.442CysHis: 0.442 ± 0.118
0.958CysIle: 0.958 ± 0.215
0.902CysLys: 0.902 ± 0.198
0.829CysLeu: 0.829 ± 0.18
0.516CysMet: 0.516 ± 0.117
0.755CysAsn: 0.755 ± 0.186
0.976CysPro: 0.976 ± 0.284
0.497CysGln: 0.497 ± 0.128
0.902CysArg: 0.902 ± 0.216
1.105CysSer: 1.105 ± 0.29
0.774CysThr: 0.774 ± 0.169
0.866CysVal: 0.866 ± 0.231
0.111CysTrp: 0.111 ± 0.043
0.479CysTyr: 0.479 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
3.131AspAla: 3.131 ± 0.229
0.774AspCys: 0.774 ± 0.197
3.831AspAsp: 3.831 ± 0.693
4.144AspGlu: 4.144 ± 0.676
1.897AspPhe: 1.897 ± 0.221
3.812AspGly: 3.812 ± 0.333
0.847AspHis: 0.847 ± 0.138
4.659AspIle: 4.659 ± 0.597
2.799AspLys: 2.799 ± 0.443
3.112AspLeu: 3.112 ± 0.498
1.363AspMet: 1.363 ± 0.266
2.173AspAsn: 2.173 ± 0.208
1.934AspPro: 1.934 ± 0.332
1.179AspGln: 1.179 ± 0.187
1.768AspArg: 1.768 ± 0.287
2.339AspSer: 2.339 ± 0.287
3.591AspThr: 3.591 ± 0.457
4.125AspVal: 4.125 ± 0.405
0.46AspTrp: 0.46 ± 0.122
2.634AspTyr: 2.634 ± 0.247
0.0AspXaa: 0.0 ± 0.0
Glu
2.928GluAla: 2.928 ± 0.298
0.921GluCys: 0.921 ± 0.213
3.481GluAsp: 3.481 ± 0.609
4.383GluGlu: 4.383 ± 0.761
2.634GluPhe: 2.634 ± 0.436
2.357GluGly: 2.357 ± 0.269
1.381GluHis: 1.381 ± 0.253
3.96GluIle: 3.96 ± 0.574
3.904GluLys: 3.904 ± 0.674
4.144GluLeu: 4.144 ± 0.621
1.823GluMet: 1.823 ± 0.311
3.647GluAsn: 3.647 ± 0.408
2.284GluPro: 2.284 ± 0.407
2.173GluGln: 2.173 ± 0.269
3.094GluArg: 3.094 ± 0.541
3.02GluSer: 3.02 ± 0.32
3.849GluThr: 3.849 ± 0.423
3.462GluVal: 3.462 ± 0.25
0.755GluTrp: 0.755 ± 0.181
2.56GluTyr: 2.56 ± 0.28
0.0GluXaa: 0.0 ± 0.0
Phe
2.928PheAla: 2.928 ± 0.415
0.737PheCys: 0.737 ± 0.189
2.357PheAsp: 2.357 ± 0.335
2.136PheGlu: 2.136 ± 0.381
1.952PhePhe: 1.952 ± 0.308
2.394PheGly: 2.394 ± 0.226
0.976PheHis: 0.976 ± 0.205
3.094PheIle: 3.094 ± 0.313
2.744PheLys: 2.744 ± 0.476
3.333PheLeu: 3.333 ± 0.436
1.326PheMet: 1.326 ± 0.234
2.615PheAsn: 2.615 ± 0.235
1.363PhePro: 1.363 ± 0.2
1.823PheGln: 1.823 ± 0.279
1.565PheArg: 1.565 ± 0.225
3.702PheSer: 3.702 ± 0.409
2.376PheThr: 2.376 ± 0.276
2.763PheVal: 2.763 ± 0.42
0.35PheTrp: 0.35 ± 0.11
1.989PheTyr: 1.989 ± 0.203
0.0PheXaa: 0.0 ± 0.0
Gly
4.089GlyAla: 4.089 ± 0.985
0.995GlyCys: 0.995 ± 0.161
4.365GlyAsp: 4.365 ± 0.479
3.665GlyGlu: 3.665 ± 0.34
3.554GlyPhe: 3.554 ± 0.636
3.72GlyGly: 3.72 ± 0.494
1.031GlyHis: 1.031 ± 0.167
4.383GlyIle: 4.383 ± 0.474
3.941GlyLys: 3.941 ± 0.352
4.917GlyLeu: 4.917 ± 0.289
2.744GlyMet: 2.744 ± 0.864
5.028GlyAsn: 5.028 ± 1.02
1.842GlyPro: 1.842 ± 0.193
4.844GlyGln: 4.844 ± 1.391
3.923GlyArg: 3.923 ± 0.962
7.79GlySer: 7.79 ± 2.613
4.42GlyThr: 4.42 ± 0.794
3.868GlyVal: 3.868 ± 0.521
0.497GlyTrp: 0.497 ± 0.098
4.567GlyTyr: 4.567 ± 1.473
0.0GlyXaa: 0.0 ± 0.0
His
1.16HisAla: 1.16 ± 0.166
0.368HisCys: 0.368 ± 0.095
0.884HisAsp: 0.884 ± 0.149
1.068HisGlu: 1.068 ± 0.237
0.939HisPhe: 0.939 ± 0.197
1.252HisGly: 1.252 ± 0.231
0.35HisHis: 0.35 ± 0.09
1.344HisIle: 1.344 ± 0.3
1.308HisLys: 1.308 ± 0.233
1.547HisLeu: 1.547 ± 0.165
0.442HisMet: 0.442 ± 0.128
0.995HisAsn: 0.995 ± 0.207
0.755HisPro: 0.755 ± 0.174
0.46HisGln: 0.46 ± 0.109
0.866HisArg: 0.866 ± 0.171
1.234HisSer: 1.234 ± 0.138
1.547HisThr: 1.547 ± 0.178
0.958HisVal: 0.958 ± 0.208
0.258HisTrp: 0.258 ± 0.078
0.737HisTyr: 0.737 ± 0.158
0.0HisXaa: 0.0 ± 0.0
Ile
5.507IleAla: 5.507 ± 1.421
0.921IleCys: 0.921 ± 0.184
4.052IleAsp: 4.052 ± 0.488
4.217IleGlu: 4.217 ± 0.529
2.67IlePhe: 2.67 ± 0.268
8.748IleGly: 8.748 ± 2.967
1.75IleHis: 1.75 ± 0.173
4.715IleIle: 4.715 ± 0.461
4.549IleLys: 4.549 ± 0.793
5.009IleLeu: 5.009 ± 0.577
1.51IleMet: 1.51 ± 0.265
3.61IleAsn: 3.61 ± 0.37
3.168IlePro: 3.168 ± 0.523
3.186IleGln: 3.186 ± 0.245
2.689IleArg: 2.689 ± 0.299
5.322IleSer: 5.322 ± 0.515
3.849IleThr: 3.849 ± 0.284
4.125IleVal: 4.125 ± 0.403
0.442IleTrp: 0.442 ± 0.112
2.615IleTyr: 2.615 ± 0.307
0.0IleXaa: 0.0 ± 0.0
Lys
3.02LysAla: 3.02 ± 0.554
0.921LysCys: 0.921 ± 0.221
3.149LysAsp: 3.149 ± 0.555
4.254LysGlu: 4.254 ± 0.723
2.91LysPhe: 2.91 ± 0.494
2.505LysGly: 2.505 ± 0.352
1.4LysHis: 1.4 ± 0.301
4.623LysIle: 4.623 ± 0.78
6.133LysLys: 6.133 ± 1.118
5.267LysLeu: 5.267 ± 0.822
1.971LysMet: 1.971 ± 0.378
4.788LysAsn: 4.788 ± 0.665
2.799LysPro: 2.799 ± 0.326
2.302LysGln: 2.302 ± 0.317
2.799LysArg: 2.799 ± 0.51
4.346LysSer: 4.346 ± 0.554
3.831LysThr: 3.831 ± 0.568
3.812LysVal: 3.812 ± 0.556
0.571LysTrp: 0.571 ± 0.144
3.149LysTyr: 3.149 ± 0.425
0.0LysXaa: 0.0 ± 0.0
Leu
3.904LeuAla: 3.904 ± 0.34
1.216LeuCys: 1.216 ± 0.29
4.236LeuAsp: 4.236 ± 0.529
4.31LeuGlu: 4.31 ± 0.5
3.775LeuPhe: 3.775 ± 0.53
4.604LeuGly: 4.604 ± 0.685
1.326LeuHis: 1.326 ± 0.184
4.254LeuIle: 4.254 ± 0.61
5.304LeuLys: 5.304 ± 0.904
5.341LeuLeu: 5.341 ± 0.817
1.823LeuMet: 1.823 ± 0.213
5.083LeuAsn: 5.083 ± 0.346
2.542LeuPro: 2.542 ± 0.497
3.37LeuGln: 3.37 ± 0.279
3.831LeuArg: 3.831 ± 0.555
5.507LeuSer: 5.507 ± 0.286
3.812LeuThr: 3.812 ± 0.342
4.494LeuVal: 4.494 ± 0.588
0.626LeuTrp: 0.626 ± 0.139
3.205LeuTyr: 3.205 ± 0.261
0.0LeuXaa: 0.0 ± 0.0
Met
1.492MetAla: 1.492 ± 0.154
0.516MetCys: 0.516 ± 0.111
1.289MetAsp: 1.289 ± 0.136
1.381MetGlu: 1.381 ± 0.198
1.068MetPhe: 1.068 ± 0.202
2.007MetGly: 2.007 ± 0.284
0.479MetHis: 0.479 ± 0.139
1.639MetIle: 1.639 ± 0.209
2.173MetLys: 2.173 ± 0.393
1.492MetLeu: 1.492 ± 0.162
0.829MetMet: 0.829 ± 0.196
1.952MetAsn: 1.952 ± 0.196
0.774MetPro: 0.774 ± 0.19
0.81MetGln: 0.81 ± 0.232
1.05MetArg: 1.05 ± 0.167
2.376MetSer: 2.376 ± 0.269
2.063MetThr: 2.063 ± 0.628
1.087MetVal: 1.087 ± 0.199
0.258MetTrp: 0.258 ± 0.083
1.602MetTyr: 1.602 ± 0.234
0.0MetXaa: 0.0 ± 0.0
Asn
6.851AsnAla: 6.851 ± 2.385
0.589AsnCys: 0.589 ± 0.158
2.707AsnAsp: 2.707 ± 0.345
3.112AsnGlu: 3.112 ± 0.392
2.376AsnPhe: 2.376 ± 0.408
3.407AsnGly: 3.407 ± 0.246
0.645AsnHis: 0.645 ± 0.151
5.562AsnIle: 5.562 ± 0.534
4.475AsnLys: 4.475 ± 0.698
5.23AsnLeu: 5.23 ± 0.605
1.179AsnMet: 1.179 ± 0.213
4.089AsnAsn: 4.089 ± 0.422
1.934AsnPro: 1.934 ± 0.305
3.112AsnGln: 3.112 ± 0.72
2.284AsnArg: 2.284 ± 0.354
5.009AsnSer: 5.009 ± 1.0
5.488AsnThr: 5.488 ± 0.81
5.654AsnVal: 5.654 ± 0.945
0.571AsnTrp: 0.571 ± 0.146
2.118AsnTyr: 2.118 ± 0.252
0.0AsnXaa: 0.0 ± 0.0
Pro
2.339ProAla: 2.339 ± 0.464
0.663ProCys: 0.663 ± 0.178
2.155ProAsp: 2.155 ± 0.319
2.652ProGlu: 2.652 ± 0.466
1.565ProPhe: 1.565 ± 0.27
1.952ProGly: 1.952 ± 0.353
0.718ProHis: 0.718 ± 0.147
2.413ProIle: 2.413 ± 0.246
2.081ProLys: 2.081 ± 0.351
2.652ProLeu: 2.652 ± 0.48
0.792ProMet: 0.792 ± 0.164
2.1ProAsn: 2.1 ± 0.285
1.786ProPro: 1.786 ± 0.372
1.437ProGln: 1.437 ± 0.241
1.381ProArg: 1.381 ± 0.242
2.468ProSer: 2.468 ± 0.396
2.431ProThr: 2.431 ± 0.404
2.634ProVal: 2.634 ± 0.283
0.276ProTrp: 0.276 ± 0.084
1.547ProTyr: 1.547 ± 0.247
0.0ProXaa: 0.0 ± 0.0
Gln
3.462GlnAla: 3.462 ± 0.89
0.313GlnCys: 0.313 ± 0.082
1.621GlnAsp: 1.621 ± 0.177
2.652GlnGlu: 2.652 ± 0.237
1.75GlnPhe: 1.75 ± 0.14
6.096GlnGly: 6.096 ± 2.708
0.626GlnHis: 0.626 ± 0.108
1.952GlnIle: 1.952 ± 0.269
2.321GlnLys: 2.321 ± 0.333
3.168GlnLeu: 3.168 ± 0.377
0.939GlnMet: 0.939 ± 0.135
3.739GlnAsn: 3.739 ± 0.862
1.326GlnPro: 1.326 ± 0.223
2.063GlnGln: 2.063 ± 0.318
1.621GlnArg: 1.621 ± 0.221
4.567GlnSer: 4.567 ± 1.023
1.989GlnThr: 1.989 ± 0.249
1.842GlnVal: 1.842 ± 0.259
0.239GlnTrp: 0.239 ± 0.088
1.713GlnTyr: 1.713 ± 0.163
0.0GlnXaa: 0.0 ± 0.0
Arg
2.523ArgAla: 2.523 ± 0.436
0.645ArgCys: 0.645 ± 0.156
2.173ArgAsp: 2.173 ± 0.242
2.357ArgGlu: 2.357 ± 0.378
1.86ArgPhe: 1.86 ± 0.23
1.805ArgGly: 1.805 ± 0.199
0.902ArgHis: 0.902 ± 0.176
2.965ArgIle: 2.965 ± 0.375
2.891ArgLys: 2.891 ± 0.525
3.904ArgLeu: 3.904 ± 0.349
1.197ArgMet: 1.197 ± 0.173
2.744ArgAsn: 2.744 ± 0.309
1.639ArgPro: 1.639 ± 0.276
1.639ArgGln: 1.639 ± 0.197
2.081ArgArg: 2.081 ± 0.328
2.891ArgSer: 2.891 ± 0.257
2.136ArgThr: 2.136 ± 0.229
2.505ArgVal: 2.505 ± 0.376
0.387ArgTrp: 0.387 ± 0.111
1.731ArgTyr: 1.731 ± 0.239
0.0ArgXaa: 0.0 ± 0.0
Ser
4.807SerAla: 4.807 ± 0.965
0.884SerCys: 0.884 ± 0.229
3.168SerAsp: 3.168 ± 0.453
3.444SerGlu: 3.444 ± 0.314
3.112SerPhe: 3.112 ± 0.267
5.801SerGly: 5.801 ± 0.61
1.271SerHis: 1.271 ± 0.174
7.054SerIle: 7.054 ± 1.414
4.567SerLys: 4.567 ± 0.459
4.715SerLeu: 4.715 ± 0.451
1.768SerMet: 1.768 ± 0.211
8.859SerAsn: 8.859 ± 3.355
2.1SerPro: 2.1 ± 0.402
3.72SerGln: 3.72 ± 0.775
2.67SerArg: 2.67 ± 0.266
5.212SerSer: 5.212 ± 0.641
4.512SerThr: 4.512 ± 0.546
4.438SerVal: 4.438 ± 0.728
0.442SerTrp: 0.442 ± 0.104
3.168SerTyr: 3.168 ± 0.453
0.0SerXaa: 0.0 ± 0.0
Thr
4.217ThrAla: 4.217 ± 0.935
0.774ThrCys: 0.774 ± 0.177
2.652ThrAsp: 2.652 ± 0.269
3.499ThrGlu: 3.499 ± 0.266
2.357ThrPhe: 2.357 ± 0.284
4.549ThrGly: 4.549 ± 0.542
1.087ThrHis: 1.087 ± 0.233
4.162ThrIle: 4.162 ± 0.283
3.554ThrLys: 3.554 ± 0.639
4.844ThrLeu: 4.844 ± 0.422
1.639ThrMet: 1.639 ± 0.174
3.978ThrAsn: 3.978 ± 0.396
2.339ThrPro: 2.339 ± 0.405
3.812ThrGln: 3.812 ± 0.842
1.934ThrArg: 1.934 ± 0.282
5.101ThrSer: 5.101 ± 0.764
4.494ThrThr: 4.494 ± 0.497
3.554ThrVal: 3.554 ± 0.255
0.295ThrTrp: 0.295 ± 0.077
2.523ThrTyr: 2.523 ± 0.257
0.0ThrXaa: 0.0 ± 0.0
Val
6.538ValAla: 6.538 ± 1.906
1.05ValCys: 1.05 ± 0.256
3.297ValAsp: 3.297 ± 0.419
3.628ValGlu: 3.628 ± 0.484
2.542ValPhe: 2.542 ± 0.362
5.801ValGly: 5.801 ± 1.264
1.271ValHis: 1.271 ± 0.151
3.426ValIle: 3.426 ± 0.317
4.236ValLys: 4.236 ± 0.47
4.328ValLeu: 4.328 ± 0.425
1.326ValMet: 1.326 ± 0.252
3.462ValAsn: 3.462 ± 0.423
2.615ValPro: 2.615 ± 0.358
2.615ValGln: 2.615 ± 0.324
2.726ValArg: 2.726 ± 0.221
4.752ValSer: 4.752 ± 0.58
2.781ValThr: 2.781 ± 0.302
3.573ValVal: 3.573 ± 0.296
0.442ValTrp: 0.442 ± 0.112
2.744ValTyr: 2.744 ± 0.393
0.0ValXaa: 0.0 ± 0.0
Trp
0.332TrpAla: 0.332 ± 0.087
0.239TrpCys: 0.239 ± 0.073
0.424TrpAsp: 0.424 ± 0.125
0.553TrpGlu: 0.553 ± 0.132
0.368TrpPhe: 0.368 ± 0.113
0.589TrpGly: 0.589 ± 0.23
0.166TrpHis: 0.166 ± 0.073
0.46TrpIle: 0.46 ± 0.127
0.608TrpLys: 0.608 ± 0.148
0.626TrpLeu: 0.626 ± 0.178
0.258TrpMet: 0.258 ± 0.082
0.626TrpAsn: 0.626 ± 0.126
0.184TrpPro: 0.184 ± 0.07
0.258TrpGln: 0.258 ± 0.067
0.276TrpArg: 0.276 ± 0.09
0.645TrpSer: 0.645 ± 0.137
0.424TrpThr: 0.424 ± 0.12
0.479TrpVal: 0.479 ± 0.115
0.074TrpTrp: 0.074 ± 0.037
0.184TrpTyr: 0.184 ± 0.079
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.499TyrAla: 3.499 ± 0.859
0.516TyrCys: 0.516 ± 0.128
2.192TyrAsp: 2.192 ± 0.274
2.376TyrGlu: 2.376 ± 0.371
2.044TyrPhe: 2.044 ± 0.201
2.247TyrGly: 2.247 ± 0.256
0.626TyrHis: 0.626 ± 0.143
3.094TyrIle: 3.094 ± 0.378
3.039TyrLys: 3.039 ± 0.527
2.855TyrLeu: 2.855 ± 0.398
1.105TyrMet: 1.105 ± 0.22
2.468TyrAsn: 2.468 ± 0.258
1.271TyrPro: 1.271 ± 0.234
1.75TyrGln: 1.75 ± 0.394
1.713TyrArg: 1.713 ± 0.207
4.807TyrSer: 4.807 ± 1.028
3.039TyrThr: 3.039 ± 0.237
2.634TyrVal: 2.634 ± 0.216
0.295TyrTrp: 0.295 ± 0.076
1.805TyrTyr: 1.805 ± 0.196
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 172 proteins (54299 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski