Amino acid dipepetide frequency for Haliaeetus albicilla (White-tailed sea-eagle) (Falco albicilla)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.34AlaAla: 5.34 ± 0.063	1.288AlaCys: 1.288 ± 0.022	2.998AlaAsp: 2.998 ± 0.03	4.477AlaGlu: 4.477 ± 0.042	2.62AlaPhe: 2.62 ± 0.03	3.666AlaGly: 3.666 ± 0.035	1.318AlaHis: 1.318 ± 0.018	3.178AlaIle: 3.178 ± 0.033	3.795AlaLys: 3.795 ± 0.04	6.317AlaLeu: 6.317 ± 0.062	1.522AlaMet: 1.522 ± 0.023	2.279AlaAsn: 2.279 ± 0.031	2.729AlaPro: 2.729 ± 0.039	2.674AlaGln: 2.674 ± 0.031	2.826AlaArg: 2.826 ± 0.034	5.027AlaSer: 5.027 ± 0.047	3.271AlaThr: 3.271 ± 0.036	4.841AlaVal: 4.841 ± 0.04	0.665AlaTrp: 0.665 ± 0.017	1.659AlaTyr: 1.659 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.147CysAla: 1.147 ± 0.021	0.656CysCys: 0.656 ± 0.018	1.071CysAsp: 1.071 ± 0.026	1.321CysGlu: 1.321 ± 0.03	0.94CysPhe: 0.94 ± 0.019	1.422CysGly: 1.422 ± 0.028	0.639CysHis: 0.639 ± 0.016	1.226CysIle: 1.226 ± 0.027	1.375CysLys: 1.375 ± 0.022	2.16CysLeu: 2.16 ± 0.031	0.472CysMet: 0.472 ± 0.011	0.971CysAsn: 0.971 ± 0.02	1.215CysPro: 1.215 ± 0.028	1.064CysGln: 1.064 ± 0.023	1.206CysArg: 1.206 ± 0.021	1.999CysSer: 1.999 ± 0.03	1.192CysThr: 1.192 ± 0.022	1.329CysVal: 1.329 ± 0.023	0.293CysTrp: 0.293 ± 0.01	0.721CysTyr: 0.721 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	2.921AspAla: 2.921 ± 0.029	1.127AspCys: 1.127 ± 0.021	2.887AspAsp: 2.887 ± 0.042	3.747AspGlu: 3.747 ± 0.04	2.283AspPhe: 2.283 ± 0.029	3.278AspGly: 3.278 ± 0.043	1.208AspHis: 1.208 ± 0.021	3.09AspIle: 3.09 ± 0.034	2.869AspLys: 2.869 ± 0.033	5.077AspLeu: 5.077 ± 0.044	1.189AspMet: 1.189 ± 0.019	2.049AspAsn: 2.049 ± 0.029	2.603AspPro: 2.603 ± 0.035	1.9AspGln: 1.9 ± 0.024	2.381AspArg: 2.381 ± 0.029	4.164AspSer: 4.164 ± 0.038	2.534AspThr: 2.534 ± 0.028	3.259AspVal: 3.259 ± 0.031	0.669AspTrp: 0.669 ± 0.017	1.719AspTyr: 1.719 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	4.605GluAla: 4.605 ± 0.041	1.326GluCys: 1.326 ± 0.033	4.579GluAsp: 4.579 ± 0.04	7.837GluGlu: 7.837 ± 0.087	2.289GluPhe: 2.289 ± 0.025	3.849GluGly: 3.849 ± 0.036	1.572GluHis: 1.572 ± 0.021	3.658GluIle: 3.658 ± 0.038	5.875GluLys: 5.875 ± 0.065	6.385GluLeu: 6.385 ± 0.06	1.859GluMet: 1.859 ± 0.025	3.638GluAsn: 3.638 ± 0.039	2.423GluPro: 2.423 ± 0.03	3.233GluGln: 3.233 ± 0.038	3.771GluArg: 3.771 ± 0.045	4.556GluSer: 4.556 ± 0.041	3.622GluThr: 3.622 ± 0.043	4.411GluVal: 4.411 ± 0.043	0.737GluTrp: 0.737 ± 0.015	1.854GluTyr: 1.854 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	2.18PheAla: 2.18 ± 0.028	1.036PheCys: 1.036 ± 0.02	1.9PheAsp: 1.9 ± 0.024	2.191PheGlu: 2.191 ± 0.027	1.932PhePhe: 1.932 ± 0.029	2.351PheGly: 2.351 ± 0.034	1.099PheHis: 1.099 ± 0.02	2.228PheIle: 2.228 ± 0.033	2.219PheLys: 2.219 ± 0.028	4.302PheLeu: 4.302 ± 0.047	0.835PheMet: 0.835 ± 0.018	1.591PheAsn: 1.591 ± 0.02	1.955PhePro: 1.955 ± 0.031	1.858PheGln: 1.858 ± 0.024	1.954PheArg: 1.954 ± 0.025	3.493PheSer: 3.493 ± 0.034	2.349PheThr: 2.349 ± 0.025	2.408PheVal: 2.408 ± 0.027	0.534PheTrp: 0.534 ± 0.014	1.381PheTyr: 1.381 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	3.291GlyAla: 3.291 ± 0.036	1.185GlyCys: 1.185 ± 0.024	2.899GlyAsp: 2.899 ± 0.038	3.64GlyGlu: 3.64 ± 0.04	2.531GlyPhe: 2.531 ± 0.032	3.64GlyGly: 3.64 ± 0.053	1.49GlyHis: 1.49 ± 0.023	3.163GlyIle: 3.163 ± 0.034	3.979GlyLys: 3.979 ± 0.044	4.98GlyLeu: 4.98 ± 0.05	1.353GlyMet: 1.353 ± 0.019	2.683GlyAsn: 2.683 ± 0.031	2.491GlyPro: 2.491 ± 0.055	2.429GlyGln: 2.429 ± 0.029	2.993GlyArg: 2.993 ± 0.038	4.847GlySer: 4.847 ± 0.05	3.358GlyThr: 3.358 ± 0.036	3.419GlyVal: 3.419 ± 0.034	0.747GlyTrp: 0.747 ± 0.02	1.879GlyTyr: 1.879 ± 0.03	0.001GlyXaa: 0.001 ± 0.001
His	1.309HisAla: 1.309 ± 0.022	0.735HisCys: 0.735 ± 0.016	0.942HisAsp: 0.942 ± 0.019	1.383HisGlu: 1.383 ± 0.02	1.122HisPhe: 1.122 ± 0.018	1.431HisGly: 1.431 ± 0.023	0.874HisHis: 0.874 ± 0.021	1.377HisIle: 1.377 ± 0.023	1.394HisLys: 1.394 ± 0.024	2.835HisLeu: 2.835 ± 0.034	0.591HisMet: 0.591 ± 0.015	1.011HisAsn: 1.011 ± 0.02	1.439HisPro: 1.439 ± 0.025	1.19HisGln: 1.19 ± 0.02	1.397HisArg: 1.397 ± 0.024	2.194HisSer: 2.194 ± 0.03	1.286HisThr: 1.286 ± 0.021	1.542HisVal: 1.542 ± 0.023	0.411HisTrp: 0.411 ± 0.011	0.88HisTyr: 0.88 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.156IleAla: 3.156 ± 0.033	1.282IleCys: 1.282 ± 0.02	2.436IleAsp: 2.436 ± 0.035	3.022IleGlu: 3.022 ± 0.027	2.273IlePhe: 2.273 ± 0.031	2.534IleGly: 2.534 ± 0.031	1.433IleHis: 1.433 ± 0.022	2.907IleIle: 2.907 ± 0.033	3.216IleLys: 3.216 ± 0.035	5.155IleLeu: 5.155 ± 0.043	1.13IleMet: 1.13 ± 0.022	2.301IleAsn: 2.301 ± 0.029	2.927IlePro: 2.927 ± 0.032	2.563IleGln: 2.563 ± 0.034	2.614IleArg: 2.614 ± 0.029	4.265IleSer: 4.265 ± 0.038	2.98IleThr: 2.98 ± 0.032	3.016IleVal: 3.016 ± 0.037	0.612IleTrp: 0.612 ± 0.014	1.715IleTyr: 1.715 ± 0.025	0.001IleXaa: 0.001 ± 0.001
Lys	4.183LysAla: 4.183 ± 0.04	1.283LysCys: 1.283 ± 0.025	3.532LysAsp: 3.532 ± 0.036	5.881LysGlu: 5.881 ± 0.057	2.046LysPhe: 2.046 ± 0.023	3.422LysGly: 3.422 ± 0.049	1.625LysHis: 1.625 ± 0.021	3.384LysIle: 3.384 ± 0.037	5.656LysLys: 5.656 ± 0.073	5.903LysLeu: 5.903 ± 0.059	1.619LysMet: 1.619 ± 0.022	2.962LysAsn: 2.962 ± 0.033	3.097LysPro: 3.097 ± 0.036	3.086LysGln: 3.086 ± 0.04	3.574LysArg: 3.574 ± 0.039	4.401LysSer: 4.401 ± 0.049	3.531LysThr: 3.531 ± 0.036	3.864LysVal: 3.864 ± 0.039	0.696LysTrp: 0.696 ± 0.015	1.946LysTyr: 1.946 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	6.105LeuAla: 6.105 ± 0.051	2.204LeuCys: 2.204 ± 0.027	4.948LeuAsp: 4.948 ± 0.042	7.065LeuGlu: 7.065 ± 0.076	3.683LeuPhe: 3.683 ± 0.044	5.036LeuGly: 5.036 ± 0.049	2.703LeuHis: 2.703 ± 0.035	4.439LeuIle: 4.439 ± 0.043	6.645LeuLys: 6.645 ± 0.066	9.902LeuLeu: 9.902 ± 0.099	2.099LeuMet: 2.099 ± 0.027	4.021LeuAsn: 4.021 ± 0.039	5.228LeuPro: 5.228 ± 0.05	5.67LeuGln: 5.67 ± 0.06	5.032LeuArg: 5.032 ± 0.049	7.819LeuSer: 7.819 ± 0.055	5.019LeuThr: 5.019 ± 0.044	5.427LeuVal: 5.427 ± 0.045	1.078LeuTrp: 1.078 ± 0.022	2.87LeuTyr: 2.87 ± 0.032	0.002LeuXaa: 0.002 ± 0.001
Met	1.607MetAla: 1.607 ± 0.025	0.444MetCys: 0.444 ± 0.012	1.343MetAsp: 1.343 ± 0.02	1.939MetGlu: 1.939 ± 0.027	0.873MetPhe: 0.873 ± 0.018	1.258MetGly: 1.258 ± 0.021	0.53MetHis: 0.53 ± 0.014	1.035MetIle: 1.035 ± 0.019	1.651MetLys: 1.651 ± 0.023	2.127MetLeu: 2.127 ± 0.027	0.637MetMet: 0.637 ± 0.017	1.031MetAsn: 1.031 ± 0.02	1.041MetPro: 1.041 ± 0.019	1.072MetGln: 1.072 ± 0.018	1.054MetArg: 1.054 ± 0.02	1.56MetSer: 1.56 ± 0.022	1.208MetThr: 1.208 ± 0.022	1.454MetVal: 1.454 ± 0.023	0.267MetTrp: 0.267 ± 0.007	0.691MetTyr: 0.691 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.446AsnAla: 2.446 ± 0.029	1.009AsnCys: 1.009 ± 0.021	1.833AsnAsp: 1.833 ± 0.024	2.745AsnGlu: 2.745 ± 0.03	1.717AsnPhe: 1.717 ± 0.022	2.853AsnGly: 2.853 ± 0.04	1.031AsnHis: 1.031 ± 0.021	2.659AsnIle: 2.659 ± 0.029	2.753AsnLys: 2.753 ± 0.028	4.233AsnLeu: 4.233 ± 0.04	1.047AsnMet: 1.047 ± 0.018	1.964AsnAsn: 1.964 ± 0.029	2.335AsnPro: 2.335 ± 0.028	1.797AsnGln: 1.797 ± 0.026	2.136AsnArg: 2.136 ± 0.024	3.522AsnSer: 3.522 ± 0.04	2.332AsnThr: 2.332 ± 0.03	2.563AsnVal: 2.563 ± 0.027	0.533AsnTrp: 0.533 ± 0.012	1.357AsnTyr: 1.357 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	3.425ProAla: 3.425 ± 0.044	1.001ProCys: 1.001 ± 0.024	2.588ProAsp: 2.588 ± 0.03	3.786ProGlu: 3.786 ± 0.039	1.943ProPhe: 1.943 ± 0.029	3.337ProGly: 3.337 ± 0.083	1.182ProHis: 1.182 ± 0.024	2.007ProIle: 2.007 ± 0.025	2.728ProLys: 2.728 ± 0.031	4.543ProLeu: 4.543 ± 0.047	0.928ProMet: 0.928 ± 0.019	1.922ProAsn: 1.922 ± 0.026	3.963ProPro: 3.963 ± 0.077	2.244ProGln: 2.244 ± 0.036	2.39ProArg: 2.39 ± 0.031	4.752ProSer: 4.752 ± 0.053	2.607ProThr: 2.607 ± 0.034	3.68ProVal: 3.68 ± 0.036	0.549ProTrp: 0.549 ± 0.014	1.459ProTyr: 1.459 ± 0.025	0.001ProXaa: 0.001 ± 0.001
Gln	2.945GlnAla: 2.945 ± 0.033	0.968GlnCys: 0.968 ± 0.023	2.238GlnAsp: 2.238 ± 0.028	3.723GlnGlu: 3.723 ± 0.039	1.502GlnPhe: 1.502 ± 0.023	2.396GlnGly: 2.396 ± 0.03	1.265GlnHis: 1.265 ± 0.018	2.308GlnIle: 2.308 ± 0.027	3.308GlnLys: 3.308 ± 0.037	4.624GlnLeu: 4.624 ± 0.051	1.148GlnMet: 1.148 ± 0.018	2.119GlnAsn: 2.119 ± 0.031	2.285GlnPro: 2.285 ± 0.037	3.07GlnGln: 3.07 ± 0.068	2.592GlnArg: 2.592 ± 0.034	3.238GlnSer: 3.238 ± 0.035	2.432GlnThr: 2.432 ± 0.03	2.767GlnVal: 2.767 ± 0.033	0.527GlnTrp: 0.527 ± 0.013	1.357GlnTyr: 1.357 ± 0.021	0.001GlnXaa: 0.001 ± 0.0
Arg	2.854ArgAla: 2.854 ± 0.029	1.102ArgCys: 1.102 ± 0.023	2.533ArgAsp: 2.533 ± 0.032	3.702ArgGlu: 3.702 ± 0.038	1.936ArgPhe: 1.936 ± 0.026	2.647ArgGly: 2.647 ± 0.041	1.427ArgHis: 1.427 ± 0.023	2.659ArgIle: 2.659 ± 0.031	3.937ArgLys: 3.937 ± 0.043	4.892ArgLeu: 4.892 ± 0.05	1.158ArgMet: 1.158 ± 0.021	2.315ArgAsn: 2.315 ± 0.024	2.293ArgPro: 2.293 ± 0.032	2.453ArgGln: 2.453 ± 0.03	3.527ArgArg: 3.527 ± 0.047	3.792ArgSer: 3.792 ± 0.052	2.669ArgThr: 2.669 ± 0.031	2.864ArgVal: 2.864 ± 0.029	0.614ArgTrp: 0.614 ± 0.014	1.579ArgTyr: 1.579 ± 0.024	0.001ArgXaa: 0.001 ± 0.0
Ser	4.939SerAla: 4.939 ± 0.042	1.854SerCys: 1.854 ± 0.032	4.086SerAsp: 4.086 ± 0.038	5.156SerGlu: 5.156 ± 0.053	3.183SerPhe: 3.183 ± 0.032	4.792SerGly: 4.792 ± 0.046	2.013SerHis: 2.013 ± 0.03	3.705SerIle: 3.705 ± 0.04	4.612SerLys: 4.612 ± 0.051	7.979SerLeu: 7.979 ± 0.065	1.64SerMet: 1.64 ± 0.021	3.243SerAsn: 3.243 ± 0.033	4.908SerPro: 4.908 ± 0.063	3.622SerGln: 3.622 ± 0.043	3.894SerArg: 3.894 ± 0.043	8.981SerSer: 8.981 ± 0.107	4.601SerThr: 4.601 ± 0.041	5.141SerVal: 5.141 ± 0.044	0.955SerTrp: 0.955 ± 0.019	2.317SerTyr: 2.317 ± 0.03	0.001SerXaa: 0.001 ± 0.001
Thr	3.771ThrAla: 3.771 ± 0.036	1.333ThrCys: 1.333 ± 0.03	2.798ThrAsp: 2.798 ± 0.029	3.822ThrGlu: 3.822 ± 0.035	2.237ThrPhe: 2.237 ± 0.026	3.39ThrGly: 3.39 ± 0.042	1.176ThrHis: 1.176 ± 0.021	2.708ThrIle: 2.708 ± 0.031	3.006ThrLys: 3.006 ± 0.033	5.179ThrLeu: 5.179 ± 0.044	1.176ThrMet: 1.176 ± 0.019	2.043ThrAsn: 2.043 ± 0.027	3.025ThrPro: 3.025 ± 0.044	2.146ThrGln: 2.146 ± 0.028	2.303ThrArg: 2.303 ± 0.03	4.688ThrSer: 4.688 ± 0.048	3.06ThrThr: 3.06 ± 0.038	4.191ThrVal: 4.191 ± 0.039	0.659ThrTrp: 0.659 ± 0.014	1.587ThrTyr: 1.587 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	3.995ValAla: 3.995 ± 0.034	1.524ValCys: 1.524 ± 0.023	3.149ValAsp: 3.149 ± 0.035	3.962ValGlu: 3.962 ± 0.04	2.756ValPhe: 2.756 ± 0.036	3.25ValGly: 3.25 ± 0.032	1.606ValHis: 1.606 ± 0.026	3.423ValIle: 3.423 ± 0.036	3.971ValLys: 3.971 ± 0.038	6.228ValLeu: 6.228 ± 0.055	1.412ValMet: 1.412 ± 0.022	2.67ValAsn: 2.67 ± 0.031	3.301ValPro: 3.301 ± 0.036	2.856ValGln: 2.856 ± 0.034	2.979ValArg: 2.979 ± 0.032	4.988ValSer: 4.988 ± 0.038	3.872ValThr: 3.872 ± 0.042	4.299ValVal: 4.299 ± 0.044	0.73ValTrp: 0.73 ± 0.017	1.937ValTyr: 1.937 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	0.667TrpAla: 0.667 ± 0.015	0.266TrpCys: 0.266 ± 0.01	0.665TrpAsp: 0.665 ± 0.017	0.789TrpGlu: 0.789 ± 0.017	0.478TrpPhe: 0.478 ± 0.011	0.619TrpGly: 0.619 ± 0.018	0.312TrpHis: 0.312 ± 0.01	0.659TrpIle: 0.659 ± 0.014	0.929TrpLys: 0.929 ± 0.018	1.174TrpLeu: 1.174 ± 0.022	0.303TrpMet: 0.303 ± 0.01	0.669TrpAsn: 0.669 ± 0.015	0.421TrpPro: 0.421 ± 0.012	0.554TrpGln: 0.554 ± 0.012	0.629TrpArg: 0.629 ± 0.016	0.865TrpSer: 0.865 ± 0.019	0.665TrpThr: 0.665 ± 0.016	0.652TrpVal: 0.652 ± 0.014	0.197TrpTrp: 0.197 ± 0.007	0.37TrpTyr: 0.37 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.601TyrAla: 1.601 ± 0.023	0.795TyrCys: 0.795 ± 0.017	1.526TyrAsp: 1.526 ± 0.023	1.89TyrGlu: 1.89 ± 0.024	1.452TyrPhe: 1.452 ± 0.023	1.827TyrGly: 1.827 ± 0.025	0.842TyrHis: 0.842 ± 0.018	1.725TyrIle: 1.725 ± 0.025	1.772TyrLys: 1.772 ± 0.024	2.998TyrLeu: 2.998 ± 0.034	0.703TyrMet: 0.703 ± 0.014	1.386TyrAsn: 1.386 ± 0.022	1.354TyrPro: 1.354 ± 0.021	1.332TyrGln: 1.332 ± 0.022	1.7TyrArg: 1.7 ± 0.025	2.473TyrSer: 2.473 ± 0.033	1.707TyrThr: 1.707 ± 0.027	1.778TyrVal: 1.778 ± 0.025	0.415TyrTrp: 0.415 ± 0.014	1.143TyrTyr: 1.143 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.053XaaXaa: 0.053 ± 0.011

Statistics based on 8357 proteins (3523919 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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