Amino acid dipepetide frequency for Stenotrophomonas phage vB_SmaS-AXL_3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.82AlaAla: 11.82 ± 1.497
1.081AlaCys: 1.081 ± 0.233
5.876AlaAsp: 5.876 ± 0.594
5.606AlaGlu: 5.606 ± 0.626
2.702AlaPhe: 2.702 ± 0.41
6.754AlaGly: 6.754 ± 0.809
1.418AlaHis: 1.418 ± 0.344
3.58AlaIle: 3.58 ± 0.614
6.754AlaLys: 6.754 ± 0.955
7.7AlaLeu: 7.7 ± 0.756
2.161AlaMet: 2.161 ± 0.475
4.525AlaAsn: 4.525 ± 0.635
3.85AlaPro: 3.85 ± 0.553
3.985AlaGln: 3.985 ± 0.769
5.944AlaArg: 5.944 ± 0.753
4.863AlaSer: 4.863 ± 0.62
6.349AlaThr: 6.349 ± 0.774
7.362AlaVal: 7.362 ± 0.698
1.081AlaTrp: 1.081 ± 0.308
2.364AlaTyr: 2.364 ± 0.326
0.0AlaXaa: 0.0 ± 0.0
Cys
0.946CysAla: 0.946 ± 0.307
0.068CysCys: 0.068 ± 0.067
0.338CysAsp: 0.338 ± 0.138
0.405CysGlu: 0.405 ± 0.152
0.54CysPhe: 0.54 ± 0.195
0.743CysGly: 0.743 ± 0.193
0.27CysHis: 0.27 ± 0.132
0.54CysIle: 0.54 ± 0.176
0.608CysLys: 0.608 ± 0.237
0.878CysLeu: 0.878 ± 0.251
0.27CysMet: 0.27 ± 0.128
0.338CysAsn: 0.338 ± 0.139
0.473CysPro: 0.473 ± 0.164
0.068CysGln: 0.068 ± 0.072
1.081CysArg: 1.081 ± 0.259
0.54CysSer: 0.54 ± 0.197
0.54CysThr: 0.54 ± 0.194
0.405CysVal: 0.405 ± 0.204
0.338CysTrp: 0.338 ± 0.151
0.135CysTyr: 0.135 ± 0.095
0.0CysXaa: 0.0 ± 0.0
Asp
6.417AspAla: 6.417 ± 0.576
0.54AspCys: 0.54 ± 0.206
3.985AspAsp: 3.985 ± 0.564
5.133AspGlu: 5.133 ± 0.5
2.364AspPhe: 2.364 ± 0.403
5.336AspGly: 5.336 ± 0.555
1.148AspHis: 1.148 ± 0.268
2.499AspIle: 2.499 ± 0.352
2.769AspLys: 2.769 ± 0.443
6.417AspLeu: 6.417 ± 0.67
1.554AspMet: 1.554 ± 0.334
2.026AspAsn: 2.026 ± 0.342
3.783AspPro: 3.783 ± 0.532
2.769AspGln: 2.769 ± 0.407
3.242AspArg: 3.242 ± 0.493
2.904AspSer: 2.904 ± 0.464
2.769AspThr: 2.769 ± 0.421
5.201AspVal: 5.201 ± 0.603
1.418AspTrp: 1.418 ± 0.379
2.364AspTyr: 2.364 ± 0.505
0.0AspXaa: 0.0 ± 0.0
Glu
5.539GluAla: 5.539 ± 0.574
0.27GluCys: 0.27 ± 0.13
4.323GluAsp: 4.323 ± 0.496
6.282GluGlu: 6.282 ± 1.884
2.904GluPhe: 2.904 ± 0.382
3.647GluGly: 3.647 ± 0.448
1.081GluHis: 1.081 ± 0.31
1.891GluIle: 1.891 ± 0.363
2.972GluLys: 2.972 ± 0.467
7.903GluLeu: 7.903 ± 0.906
1.554GluMet: 1.554 ± 0.336
1.824GluAsn: 1.824 ± 0.311
2.634GluPro: 2.634 ± 0.476
4.053GluGln: 4.053 ± 0.618
4.593GluArg: 4.593 ± 0.617
2.432GluSer: 2.432 ± 0.462
2.567GluThr: 2.567 ± 0.381
4.39GluVal: 4.39 ± 0.57
1.554GluTrp: 1.554 ± 0.348
2.229GluTyr: 2.229 ± 0.309
0.0GluXaa: 0.0 ± 0.0
Phe
3.242PheAla: 3.242 ± 0.553
0.068PheCys: 0.068 ± 0.062
3.512PheAsp: 3.512 ± 0.683
2.161PheGlu: 2.161 ± 0.389
1.351PhePhe: 1.351 ± 0.304
3.175PheGly: 3.175 ± 0.47
0.608PheHis: 0.608 ± 0.178
1.891PheIle: 1.891 ± 0.289
1.959PheLys: 1.959 ± 0.36
2.364PheLeu: 2.364 ± 0.38
1.148PheMet: 1.148 ± 0.295
1.824PheAsn: 1.824 ± 0.333
1.283PhePro: 1.283 ± 0.342
1.756PheGln: 1.756 ± 0.366
1.824PheArg: 1.824 ± 0.301
1.621PheSer: 1.621 ± 0.348
2.229PheThr: 2.229 ± 0.4
2.364PheVal: 2.364 ± 0.432
0.405PheTrp: 0.405 ± 0.168
1.554PheTyr: 1.554 ± 0.336
0.0PheXaa: 0.0 ± 0.0
Gly
6.282GlyAla: 6.282 ± 0.686
0.743GlyCys: 0.743 ± 0.199
4.323GlyAsp: 4.323 ± 0.553
4.39GlyGlu: 4.39 ± 0.461
3.242GlyPhe: 3.242 ± 0.637
6.957GlyGly: 6.957 ± 0.929
1.486GlyHis: 1.486 ± 0.324
2.026GlyIle: 2.026 ± 0.345
4.593GlyLys: 4.593 ± 0.651
7.497GlyLeu: 7.497 ± 0.704
1.959GlyMet: 1.959 ± 0.406
2.364GlyAsn: 2.364 ± 0.461
2.634GlyPro: 2.634 ± 0.473
1.891GlyGln: 1.891 ± 0.401
3.783GlyArg: 3.783 ± 0.475
5.201GlySer: 5.201 ± 0.647
4.796GlyThr: 4.796 ± 0.664
6.147GlyVal: 6.147 ± 0.593
1.418GlyTrp: 1.418 ± 0.288
2.161GlyTyr: 2.161 ± 0.322
0.0GlyXaa: 0.0 ± 0.0
His
1.418HisAla: 1.418 ± 0.323
0.338HisCys: 0.338 ± 0.127
1.148HisAsp: 1.148 ± 0.317
1.756HisGlu: 1.756 ± 0.382
0.878HisPhe: 0.878 ± 0.225
1.418HisGly: 1.418 ± 0.334
0.473HisHis: 0.473 ± 0.242
0.743HisIle: 0.743 ± 0.232
1.081HisLys: 1.081 ± 0.297
1.013HisLeu: 1.013 ± 0.248
0.54HisMet: 0.54 ± 0.155
0.675HisAsn: 0.675 ± 0.195
1.081HisPro: 1.081 ± 0.231
0.54HisGln: 0.54 ± 0.162
0.54HisArg: 0.54 ± 0.184
1.013HisSer: 1.013 ± 0.231
0.743HisThr: 0.743 ± 0.27
1.418HisVal: 1.418 ± 0.358
0.135HisTrp: 0.135 ± 0.104
0.675HisTyr: 0.675 ± 0.188
0.0HisXaa: 0.0 ± 0.0
Ile
4.458IleAla: 4.458 ± 0.659
0.135IleCys: 0.135 ± 0.081
3.04IleAsp: 3.04 ± 0.385
2.837IleGlu: 2.837 ± 0.524
1.824IlePhe: 1.824 ± 0.247
2.769IleGly: 2.769 ± 0.489
1.486IleHis: 1.486 ± 0.375
2.094IleIle: 2.094 ± 0.276
2.904IleLys: 2.904 ± 0.527
3.31IleLeu: 3.31 ± 0.431
0.946IleMet: 0.946 ± 0.254
2.026IleAsn: 2.026 ± 0.352
2.229IlePro: 2.229 ± 0.414
1.689IleGln: 1.689 ± 0.479
2.769IleArg: 2.769 ± 0.41
2.229IleSer: 2.229 ± 0.392
2.297IleThr: 2.297 ± 0.394
3.107IleVal: 3.107 ± 0.416
0.338IleTrp: 0.338 ± 0.141
1.081IleTyr: 1.081 ± 0.264
0.0IleXaa: 0.0 ± 0.0
Lys
5.471LysAla: 5.471 ± 0.787
0.338LysCys: 0.338 ± 0.149
3.31LysAsp: 3.31 ± 0.586
3.985LysGlu: 3.985 ± 0.593
1.486LysPhe: 1.486 ± 0.303
2.499LysGly: 2.499 ± 0.372
1.081LysHis: 1.081 ± 0.304
2.229LysIle: 2.229 ± 0.411
5.809LysLys: 5.809 ± 0.955
6.147LysLeu: 6.147 ± 0.863
1.418LysMet: 1.418 ± 0.301
2.094LysAsn: 2.094 ± 0.319
4.188LysPro: 4.188 ± 0.656
2.229LysGln: 2.229 ± 0.308
4.525LysArg: 4.525 ± 0.77
3.04LysSer: 3.04 ± 0.509
4.458LysThr: 4.458 ± 0.548
3.985LysVal: 3.985 ± 0.577
0.946LysTrp: 0.946 ± 0.213
1.756LysTyr: 1.756 ± 0.319
0.0LysXaa: 0.0 ± 0.0
Leu
8.646LeuAla: 8.646 ± 0.903
0.743LeuCys: 0.743 ± 0.193
6.282LeuAsp: 6.282 ± 0.693
6.484LeuGlu: 6.484 ± 0.857
3.31LeuPhe: 3.31 ± 0.509
6.079LeuGly: 6.079 ± 0.618
1.216LeuHis: 1.216 ± 0.31
4.525LeuIle: 4.525 ± 0.563
4.593LeuLys: 4.593 ± 0.658
7.295LeuLeu: 7.295 ± 0.727
2.161LeuMet: 2.161 ± 0.295
4.12LeuAsn: 4.12 ± 0.536
4.458LeuPro: 4.458 ± 0.651
3.377LeuGln: 3.377 ± 0.499
6.822LeuArg: 6.822 ± 0.607
5.539LeuSer: 5.539 ± 0.502
4.39LeuThr: 4.39 ± 0.676
5.471LeuVal: 5.471 ± 0.724
1.283LeuTrp: 1.283 ± 0.252
2.229LeuTyr: 2.229 ± 0.32
0.0LeuXaa: 0.0 ± 0.0
Met
2.229MetAla: 2.229 ± 0.406
0.068MetCys: 0.068 ± 0.064
1.418MetAsp: 1.418 ± 0.26
1.554MetGlu: 1.554 ± 0.399
0.878MetPhe: 0.878 ± 0.248
0.946MetGly: 0.946 ± 0.231
0.203MetHis: 0.203 ± 0.128
1.013MetIle: 1.013 ± 0.273
1.756MetLys: 1.756 ± 0.349
2.499MetLeu: 2.499 ± 0.395
0.27MetMet: 0.27 ± 0.125
1.283MetAsn: 1.283 ± 0.241
1.486MetPro: 1.486 ± 0.35
1.148MetGln: 1.148 ± 0.255
1.689MetArg: 1.689 ± 0.288
1.756MetSer: 1.756 ± 0.328
1.486MetThr: 1.486 ± 0.336
1.351MetVal: 1.351 ± 0.277
0.203MetTrp: 0.203 ± 0.093
0.338MetTyr: 0.338 ± 0.12
0.0MetXaa: 0.0 ± 0.0
Asn
3.377AsnAla: 3.377 ± 0.473
0.27AsnCys: 0.27 ± 0.131
3.242AsnAsp: 3.242 ± 0.579
2.634AsnGlu: 2.634 ± 0.453
1.756AsnPhe: 1.756 ± 0.405
4.39AsnGly: 4.39 ± 0.607
0.811AsnHis: 0.811 ± 0.202
1.418AsnIle: 1.418 ± 0.3
2.297AsnLys: 2.297 ± 0.292
2.904AsnLeu: 2.904 ± 0.349
0.608AsnMet: 0.608 ± 0.184
2.094AsnAsn: 2.094 ± 0.507
2.364AsnPro: 2.364 ± 0.344
1.621AsnGln: 1.621 ± 0.299
1.824AsnArg: 1.824 ± 0.358
1.824AsnSer: 1.824 ± 0.333
3.175AsnThr: 3.175 ± 0.443
2.094AsnVal: 2.094 ± 0.328
0.878AsnTrp: 0.878 ± 0.234
1.689AsnTyr: 1.689 ± 0.362
0.0AsnXaa: 0.0 ± 0.0
Pro
4.796ProAla: 4.796 ± 0.45
0.675ProCys: 0.675 ± 0.203
2.567ProAsp: 2.567 ± 0.495
2.094ProGlu: 2.094 ± 0.459
1.351ProPhe: 1.351 ± 0.33
4.593ProGly: 4.593 ± 0.633
0.946ProHis: 0.946 ± 0.284
2.499ProIle: 2.499 ± 0.388
3.107ProLys: 3.107 ± 0.542
3.783ProLeu: 3.783 ± 0.667
1.554ProMet: 1.554 ± 0.309
2.567ProAsn: 2.567 ± 0.414
2.769ProPro: 2.769 ± 0.413
1.216ProGln: 1.216 ± 0.251
2.297ProArg: 2.297 ± 0.48
2.837ProSer: 2.837 ± 0.415
3.58ProThr: 3.58 ± 0.6
3.715ProVal: 3.715 ± 0.579
0.878ProTrp: 0.878 ± 0.236
2.297ProTyr: 2.297 ± 0.326
0.0ProXaa: 0.0 ± 0.0
Gln
4.728GlnAla: 4.728 ± 0.803
0.675GlnCys: 0.675 ± 0.222
1.418GlnAsp: 1.418 ± 0.309
2.364GlnGlu: 2.364 ± 0.434
1.418GlnPhe: 1.418 ± 0.236
2.972GlnGly: 2.972 ± 0.469
1.013GlnHis: 1.013 ± 0.257
1.891GlnIle: 1.891 ± 0.345
1.621GlnLys: 1.621 ± 0.321
4.39GlnLeu: 4.39 ± 0.787
0.675GlnMet: 0.675 ± 0.232
1.351GlnAsn: 1.351 ± 0.316
1.824GlnPro: 1.824 ± 0.352
1.689GlnGln: 1.689 ± 0.448
2.634GlnArg: 2.634 ± 0.422
2.297GlnSer: 2.297 ± 0.351
2.229GlnThr: 2.229 ± 0.37
2.297GlnVal: 2.297 ± 0.34
0.743GlnTrp: 0.743 ± 0.177
1.081GlnTyr: 1.081 ± 0.399
0.0GlnXaa: 0.0 ± 0.0
Arg
5.606ArgAla: 5.606 ± 0.732
0.743ArgCys: 0.743 ± 0.259
3.85ArgAsp: 3.85 ± 0.443
4.661ArgGlu: 4.661 ± 0.713
1.959ArgPhe: 1.959 ± 0.443
3.985ArgGly: 3.985 ± 0.519
1.081ArgHis: 1.081 ± 0.284
3.377ArgIle: 3.377 ± 0.455
4.053ArgLys: 4.053 ± 0.477
4.931ArgLeu: 4.931 ± 0.489
1.824ArgMet: 1.824 ± 0.341
2.567ArgAsn: 2.567 ± 0.414
2.364ArgPro: 2.364 ± 0.53
2.297ArgGln: 2.297 ± 0.386
4.728ArgArg: 4.728 ± 0.531
2.634ArgSer: 2.634 ± 0.376
3.445ArgThr: 3.445 ± 0.506
3.85ArgVal: 3.85 ± 0.553
1.081ArgTrp: 1.081 ± 0.273
2.229ArgTyr: 2.229 ± 0.467
0.0ArgXaa: 0.0 ± 0.0
Ser
5.066SerAla: 5.066 ± 0.55
0.608SerCys: 0.608 ± 0.181
3.445SerAsp: 3.445 ± 0.48
3.107SerGlu: 3.107 ± 0.481
1.554SerPhe: 1.554 ± 0.393
3.985SerGly: 3.985 ± 0.543
0.675SerHis: 0.675 ± 0.231
2.297SerIle: 2.297 ± 0.367
3.175SerLys: 3.175 ± 0.548
4.661SerLeu: 4.661 ± 0.663
1.216SerMet: 1.216 ± 0.291
2.026SerAsn: 2.026 ± 0.324
2.567SerPro: 2.567 ± 0.446
1.824SerGln: 1.824 ± 0.379
3.58SerArg: 3.58 ± 0.388
2.432SerSer: 2.432 ± 0.462
3.04SerThr: 3.04 ± 0.38
3.107SerVal: 3.107 ± 0.686
1.013SerTrp: 1.013 ± 0.324
1.689SerTyr: 1.689 ± 0.307
0.0SerXaa: 0.0 ± 0.0
Thr
5.268ThrAla: 5.268 ± 0.847
0.608ThrCys: 0.608 ± 0.233
3.715ThrAsp: 3.715 ± 0.504
2.567ThrGlu: 2.567 ± 0.412
2.567ThrPhe: 2.567 ± 0.418
5.674ThrGly: 5.674 ± 0.618
0.811ThrHis: 0.811 ± 0.246
3.107ThrIle: 3.107 ± 0.506
4.12ThrLys: 4.12 ± 0.579
4.796ThrLeu: 4.796 ± 0.744
0.946ThrMet: 0.946 ± 0.286
2.499ThrAsn: 2.499 ± 0.389
3.242ThrPro: 3.242 ± 0.442
2.364ThrGln: 2.364 ± 0.384
2.567ThrArg: 2.567 ± 0.543
2.364ThrSer: 2.364 ± 0.542
4.39ThrThr: 4.39 ± 0.525
4.255ThrVal: 4.255 ± 0.555
1.554ThrTrp: 1.554 ± 0.332
2.026ThrTyr: 2.026 ± 0.415
0.0ThrXaa: 0.0 ± 0.0
Val
6.214ValAla: 6.214 ± 0.77
0.675ValCys: 0.675 ± 0.2
5.336ValAsp: 5.336 ± 0.653
4.053ValGlu: 4.053 ± 0.575
2.364ValPhe: 2.364 ± 0.535
4.593ValGly: 4.593 ± 0.585
0.946ValHis: 0.946 ± 0.281
3.985ValIle: 3.985 ± 0.555
4.255ValLys: 4.255 ± 0.494
6.349ValLeu: 6.349 ± 0.598
1.689ValMet: 1.689 ± 0.351
2.634ValAsn: 2.634 ± 0.591
4.255ValPro: 4.255 ± 0.7
2.837ValGln: 2.837 ± 0.555
3.85ValArg: 3.85 ± 0.608
3.377ValSer: 3.377 ± 0.55
4.728ValThr: 4.728 ± 0.726
5.404ValVal: 5.404 ± 0.63
0.878ValTrp: 0.878 ± 0.272
1.554ValTyr: 1.554 ± 0.353
0.0ValXaa: 0.0 ± 0.0
Trp
1.351TrpAla: 1.351 ± 0.274
0.338TrpCys: 0.338 ± 0.134
1.081TrpAsp: 1.081 ± 0.254
0.946TrpGlu: 0.946 ± 0.213
0.675TrpPhe: 0.675 ± 0.254
1.148TrpGly: 1.148 ± 0.268
0.473TrpHis: 0.473 ± 0.153
0.675TrpIle: 0.675 ± 0.233
0.675TrpLys: 0.675 ± 0.215
1.554TrpLeu: 1.554 ± 0.291
0.27TrpMet: 0.27 ± 0.131
1.148TrpAsn: 1.148 ± 0.296
0.743TrpPro: 0.743 ± 0.266
0.675TrpGln: 0.675 ± 0.174
1.486TrpArg: 1.486 ± 0.375
0.946TrpSer: 0.946 ± 0.277
0.743TrpThr: 0.743 ± 0.224
1.216TrpVal: 1.216 ± 0.314
0.338TrpTrp: 0.338 ± 0.175
0.608TrpTyr: 0.608 ± 0.185
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.904TyrAla: 2.904 ± 0.379
0.54TyrCys: 0.54 ± 0.184
2.432TyrAsp: 2.432 ± 0.468
1.621TyrGlu: 1.621 ± 0.29
1.216TyrPhe: 1.216 ± 0.277
2.229TyrGly: 2.229 ± 0.497
0.405TyrHis: 0.405 ± 0.133
1.283TyrIle: 1.283 ± 0.3
1.891TyrLys: 1.891 ± 0.351
2.634TyrLeu: 2.634 ± 0.41
0.743TyrMet: 0.743 ± 0.241
1.283TyrAsn: 1.283 ± 0.206
1.891TyrPro: 1.891 ± 0.292
1.283TyrGln: 1.283 ± 0.344
1.486TyrArg: 1.486 ± 0.3
1.216TyrSer: 1.216 ± 0.365
1.486TyrThr: 1.486 ± 0.304
2.837TyrVal: 2.837 ± 0.46
0.608TyrTrp: 0.608 ± 0.215
0.878TyrTyr: 0.878 ± 0.271
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (14806 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski