Amino acid dipepetide frequency for Hubei sobemo-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.124AlaAla: 8.124 ± 3.269
0.0AlaCys: 0.0 ± 0.0
4.431AlaAsp: 4.431 ± 2.473
4.431AlaGlu: 4.431 ± 1.778
2.216AlaPhe: 2.216 ± 0.847
5.17AlaGly: 5.17 ± 2.245
0.739AlaHis: 0.739 ± 0.492
5.17AlaIle: 5.17 ± 1.237
6.647AlaLys: 6.647 ± 1.733
8.863AlaLeu: 8.863 ± 1.573
2.216AlaMet: 2.216 ± 2.146
4.431AlaAsn: 4.431 ± 1.778
4.431AlaPro: 4.431 ± 2.567
3.693AlaGln: 3.693 ± 1.814
2.216AlaArg: 2.216 ± 0.393
12.555AlaSer: 12.555 ± 3.756
6.647AlaThr: 6.647 ± 1.807
8.863AlaVal: 8.863 ± 0.888
0.739AlaTrp: 0.739 ± 0.492
3.693AlaTyr: 3.693 ± 1.278
0.0AlaXaa: 0.0 ± 0.0
Cys
2.216CysAla: 2.216 ± 1.412
0.0CysCys: 0.0 ± 0.0
1.477CysAsp: 1.477 ± 0.611
1.477CysGlu: 1.477 ± 0.885
0.0CysPhe: 0.0 ± 0.0
0.739CysGly: 0.739 ± 0.492
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.477CysLys: 1.477 ± 0.885
1.477CysLeu: 1.477 ± 0.59
0.0CysMet: 0.0 ± 0.0
0.739CysAsn: 0.739 ± 0.715
2.216CysPro: 2.216 ± 0.393
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.739CysSer: 0.739 ± 0.715
0.0CysThr: 0.0 ± 0.0
0.739CysVal: 0.739 ± 0.772
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.693AspAla: 3.693 ± 0.678
1.477AspCys: 1.477 ± 0.885
2.216AspAsp: 2.216 ± 0.847
3.693AspGlu: 3.693 ± 1.393
5.17AspPhe: 5.17 ± 1.574
3.693AspGly: 3.693 ± 0.703
1.477AspHis: 1.477 ± 0.611
2.216AspIle: 2.216 ± 1.499
2.216AspLys: 2.216 ± 1.236
3.693AspLeu: 3.693 ± 1.691
2.954AspMet: 2.954 ± 1.032
0.739AspAsn: 0.739 ± 0.715
4.431AspPro: 4.431 ± 0.786
1.477AspGln: 1.477 ± 0.611
0.739AspArg: 0.739 ± 0.492
3.693AspSer: 3.693 ± 1.393
0.739AspThr: 0.739 ± 0.772
2.954AspVal: 2.954 ± 2.035
0.739AspTrp: 0.739 ± 0.715
2.954AspTyr: 2.954 ± 1.244
0.0AspXaa: 0.0 ± 0.0
Glu
4.431GluAla: 4.431 ± 1.833
0.739GluCys: 0.739 ± 0.492
3.693GluAsp: 3.693 ± 1.583
5.17GluGlu: 5.17 ± 3.441
1.477GluPhe: 1.477 ± 0.611
3.693GluGly: 3.693 ± 0.678
2.216GluHis: 2.216 ± 0.847
2.216GluIle: 2.216 ± 0.393
2.216GluLys: 2.216 ± 0.847
5.908GluLeu: 5.908 ± 1.172
2.954GluMet: 2.954 ± 1.966
2.216GluAsn: 2.216 ± 1.475
0.0GluPro: 0.0 ± 0.0
2.216GluGln: 2.216 ± 1.236
3.693GluArg: 3.693 ± 1.393
2.954GluSer: 2.954 ± 1.244
5.17GluThr: 5.17 ± 0.927
2.954GluVal: 2.954 ± 0.099
0.739GluTrp: 0.739 ± 0.492
1.477GluTyr: 1.477 ± 0.611
0.0GluXaa: 0.0 ± 0.0
Phe
2.216PheAla: 2.216 ± 1.499
2.216PheCys: 2.216 ± 0.393
1.477PheAsp: 1.477 ± 0.611
0.739PheGlu: 0.739 ± 0.715
2.216PhePhe: 2.216 ± 0.847
0.739PheGly: 0.739 ± 0.492
0.739PheHis: 0.739 ± 0.772
3.693PheIle: 3.693 ± 0.678
2.954PheLys: 2.954 ± 1.141
2.954PheLeu: 2.954 ± 1.966
0.0PheMet: 0.0 ± 0.0
1.477PheAsn: 1.477 ± 0.59
1.477PhePro: 1.477 ± 0.983
0.739PheGln: 0.739 ± 0.492
2.954PheArg: 2.954 ± 0.992
3.693PheSer: 3.693 ± 0.678
2.216PheThr: 2.216 ± 1.284
2.954PheVal: 2.954 ± 0.099
0.0PheTrp: 0.0 ± 0.0
0.739PheTyr: 0.739 ± 0.715
0.0PheXaa: 0.0 ± 0.0
Gly
10.34GlyAla: 10.34 ± 8.744
0.739GlyCys: 0.739 ± 0.715
2.216GlyAsp: 2.216 ± 0.847
0.739GlyGlu: 0.739 ± 0.772
2.954GlyPhe: 2.954 ± 1.141
4.431GlyGly: 4.431 ± 3.714
2.216GlyHis: 2.216 ± 0.393
1.477GlyIle: 1.477 ± 0.611
2.954GlyLys: 2.954 ± 0.099
5.908GlyLeu: 5.908 ± 0.925
2.216GlyMet: 2.216 ± 1.217
2.954GlyAsn: 2.954 ± 1.181
3.693GlyPro: 3.693 ± 0.678
1.477GlyGln: 1.477 ± 0.611
2.954GlyArg: 2.954 ± 1.926
2.954GlySer: 2.954 ± 1.141
0.739GlyThr: 0.739 ± 0.492
4.431GlyVal: 4.431 ± 2.95
2.954GlyTrp: 2.954 ± 0.992
2.954GlyTyr: 2.954 ± 0.099
0.0GlyXaa: 0.0 ± 0.0
His
2.216HisAla: 2.216 ± 0.764
0.739HisCys: 0.739 ± 0.715
1.477HisAsp: 1.477 ± 0.611
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
1.477HisGly: 1.477 ± 0.611
0.0HisHis: 0.0 ± 0.0
0.739HisIle: 0.739 ± 0.772
2.216HisLys: 2.216 ± 0.393
2.954HisLeu: 2.954 ± 1.244
0.0HisMet: 0.0 ± 0.0
1.477HisAsn: 1.477 ± 0.983
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
2.954HisSer: 2.954 ± 0.099
0.0HisThr: 0.0 ± 0.0
1.477HisVal: 1.477 ± 0.611
0.0HisTrp: 0.0 ± 0.0
0.739HisTyr: 0.739 ± 0.715
0.0HisXaa: 0.0 ± 0.0
Ile
3.693IleAla: 3.693 ± 2.629
0.0IleCys: 0.0 ± 0.0
3.693IleAsp: 3.693 ± 1.815
1.477IleGlu: 1.477 ± 0.59
2.216IlePhe: 2.216 ± 2.317
4.431IleGly: 4.431 ± 0.586
0.0IleHis: 0.0 ± 0.0
0.739IleIle: 0.739 ± 0.492
2.216IleLys: 2.216 ± 1.236
1.477IleLeu: 1.477 ± 0.983
0.739IleMet: 0.739 ± 0.715
0.0IleAsn: 0.0 ± 0.0
2.216IlePro: 2.216 ± 0.393
3.693IleGln: 3.693 ± 0.678
2.954IleArg: 2.954 ± 1.062
0.739IleSer: 0.739 ± 0.772
2.954IleThr: 2.954 ± 0.099
5.17IleVal: 5.17 ± 1.329
0.0IleTrp: 0.0 ± 0.0
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
2.954LysAla: 2.954 ± 0.099
0.739LysCys: 0.739 ± 0.715
2.216LysAsp: 2.216 ± 1.412
7.386LysGlu: 7.386 ± 2.464
0.739LysPhe: 0.739 ± 0.492
1.477LysGly: 1.477 ± 0.611
0.739LysHis: 0.739 ± 0.492
4.431LysIle: 4.431 ± 1.082
4.431LysLys: 4.431 ± 1.528
2.954LysLeu: 2.954 ± 1.222
1.477LysMet: 1.477 ± 0.611
2.954LysAsn: 2.954 ± 1.222
7.386LysPro: 7.386 ± 2.255
3.693LysGln: 3.693 ± 1.843
3.693LysArg: 3.693 ± 1.815
6.647LysSer: 6.647 ± 1.671
2.216LysThr: 2.216 ± 0.393
5.17LysVal: 5.17 ± 1.574
0.739LysTrp: 0.739 ± 0.772
0.739LysTyr: 0.739 ± 0.715
0.0LysXaa: 0.0 ± 0.0
Leu
8.124LeuAla: 8.124 ± 3.932
1.477LeuCys: 1.477 ± 1.544
5.17LeuAsp: 5.17 ± 0.927
2.954LeuGlu: 2.954 ± 1.966
4.431LeuPhe: 4.431 ± 1.778
5.908LeuGly: 5.908 ± 1.172
0.739LeuHis: 0.739 ± 0.492
0.739LeuIle: 0.739 ± 0.715
6.647LeuLys: 6.647 ± 2.542
8.124LeuLeu: 8.124 ± 2.42
2.954LeuMet: 2.954 ± 2.214
2.954LeuAsn: 2.954 ± 0.099
3.693LeuPro: 3.693 ± 1.393
2.216LeuGln: 2.216 ± 0.764
5.17LeuArg: 5.17 ± 0.927
5.908LeuSer: 5.908 ± 3.002
2.954LeuThr: 2.954 ± 0.992
7.386LeuVal: 7.386 ± 1.774
2.954LeuTrp: 2.954 ± 0.992
0.739LeuTyr: 0.739 ± 0.715
0.0LeuXaa: 0.0 ± 0.0
Met
1.477MetAla: 1.477 ± 0.611
0.0MetCys: 0.0 ± 0.0
0.739MetAsp: 0.739 ± 0.715
0.0MetGlu: 0.0 ± 0.0
1.477MetPhe: 1.477 ± 0.885
2.216MetGly: 2.216 ± 0.393
0.0MetHis: 0.0 ± 0.0
0.739MetIle: 0.739 ± 0.715
1.477MetLys: 1.477 ± 1.431
3.693MetLeu: 3.693 ± 2.797
0.739MetMet: 0.739 ± 0.492
0.0MetAsn: 0.0 ± 0.0
1.477MetPro: 1.477 ± 0.59
0.739MetGln: 0.739 ± 0.492
2.216MetArg: 2.216 ± 0.847
2.216MetSer: 2.216 ± 0.393
2.216MetThr: 2.216 ± 1.284
2.954MetVal: 2.954 ± 0.992
0.739MetTrp: 0.739 ± 0.492
0.739MetTyr: 0.739 ± 0.715
0.0MetXaa: 0.0 ± 0.0
Asn
4.431AsnAla: 4.431 ± 1.473
0.0AsnCys: 0.0 ± 0.0
0.739AsnAsp: 0.739 ± 0.492
1.477AsnGlu: 1.477 ± 0.611
0.739AsnPhe: 0.739 ± 0.492
2.216AsnGly: 2.216 ± 0.847
0.739AsnHis: 0.739 ± 0.772
1.477AsnIle: 1.477 ± 0.59
2.216AsnLys: 2.216 ± 0.847
1.477AsnLeu: 1.477 ± 0.59
1.477AsnMet: 1.477 ± 1.276
5.17AsnAsn: 5.17 ± 0.295
1.477AsnPro: 1.477 ± 0.611
0.739AsnGln: 0.739 ± 0.715
0.0AsnArg: 0.0 ± 0.0
9.601AsnSer: 9.601 ± 2.578
0.739AsnThr: 0.739 ± 0.492
1.477AsnVal: 1.477 ± 0.59
1.477AsnTrp: 1.477 ± 0.885
4.431AsnTyr: 4.431 ± 1.528
0.0AsnXaa: 0.0 ± 0.0
Pro
6.647ProAla: 6.647 ± 2.292
1.477ProCys: 1.477 ± 0.885
2.216ProAsp: 2.216 ± 0.393
2.216ProGlu: 2.216 ± 1.475
2.216ProPhe: 2.216 ± 1.284
4.431ProGly: 4.431 ± 2.391
0.0ProHis: 0.0 ± 0.0
0.0ProIle: 0.0 ± 0.0
3.693ProLys: 3.693 ± 0.59
6.647ProLeu: 6.647 ± 0.642
2.216ProMet: 2.216 ± 2.317
5.17ProAsn: 5.17 ± 2.105
4.431ProPro: 4.431 ± 2.95
2.216ProGln: 2.216 ± 0.764
1.477ProArg: 1.477 ± 0.59
8.124ProSer: 8.124 ± 2.615
5.17ProThr: 5.17 ± 1.879
1.477ProVal: 1.477 ± 0.983
0.0ProTrp: 0.0 ± 0.0
1.477ProTyr: 1.477 ± 0.885
0.0ProXaa: 0.0 ± 0.0
Gln
2.954GlnAla: 2.954 ± 0.099
0.739GlnCys: 0.739 ± 0.715
2.216GlnAsp: 2.216 ± 0.393
2.216GlnGlu: 2.216 ± 1.475
1.477GlnPhe: 1.477 ± 0.611
2.954GlnGly: 2.954 ± 1.141
0.739GlnHis: 0.739 ± 0.492
0.739GlnIle: 0.739 ± 0.715
2.216GlnLys: 2.216 ± 0.847
5.17GlnLeu: 5.17 ± 1.229
0.0GlnMet: 0.0 ± 0.0
2.216GlnAsn: 2.216 ± 0.847
1.477GlnPro: 1.477 ± 0.983
1.477GlnGln: 1.477 ± 0.885
2.216GlnArg: 2.216 ± 2.317
1.477GlnSer: 1.477 ± 0.59
2.954GlnThr: 2.954 ± 0.992
1.477GlnVal: 1.477 ± 0.59
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
5.17ArgAla: 5.17 ± 0.927
0.0ArgCys: 0.0 ± 0.0
2.216ArgAsp: 2.216 ± 0.847
3.693ArgGlu: 3.693 ± 1.691
1.477ArgPhe: 1.477 ± 0.611
2.216ArgGly: 2.216 ± 1.475
0.739ArgHis: 0.739 ± 0.715
2.954ArgIle: 2.954 ± 1.062
3.693ArgLys: 3.693 ± 0.59
5.908ArgLeu: 5.908 ± 3.851
1.477ArgMet: 1.477 ± 0.59
2.954ArgAsn: 2.954 ± 1.062
0.739ArgPro: 0.739 ± 0.772
1.477ArgGln: 1.477 ± 0.59
2.954ArgArg: 2.954 ± 1.062
2.216ArgSer: 2.216 ± 1.499
2.216ArgThr: 2.216 ± 2.317
3.693ArgVal: 3.693 ± 1.274
2.216ArgTrp: 2.216 ± 0.764
2.216ArgTyr: 2.216 ± 0.764
0.0ArgXaa: 0.0 ± 0.0
Ser
8.863SerAla: 8.863 ± 2.292
0.0SerCys: 0.0 ± 0.0
6.647SerAsp: 6.647 ± 1.627
4.431SerGlu: 4.431 ± 2.157
3.693SerPhe: 3.693 ± 0.59
7.386SerGly: 7.386 ± 1.406
1.477SerHis: 1.477 ± 1.431
0.739SerIle: 0.739 ± 0.492
6.647SerLys: 6.647 ± 1.671
3.693SerLeu: 3.693 ± 0.59
0.739SerMet: 0.739 ± 0.772
1.477SerAsn: 1.477 ± 0.611
7.386SerPro: 7.386 ± 1.584
3.693SerGln: 3.693 ± 1.583
5.17SerArg: 5.17 ± 1.833
10.34SerSer: 10.34 ± 4.616
7.386SerThr: 7.386 ± 2.951
8.124SerVal: 8.124 ± 1.23
2.216SerTrp: 2.216 ± 0.393
2.954SerTyr: 2.954 ± 1.062
0.0SerXaa: 0.0 ± 0.0
Thr
9.601ThrAla: 9.601 ± 3.718
1.477ThrCys: 1.477 ± 0.611
2.954ThrAsp: 2.954 ± 1.181
2.216ThrGlu: 2.216 ± 0.847
0.739ThrPhe: 0.739 ± 0.772
2.216ThrGly: 2.216 ± 1.284
0.0ThrHis: 0.0 ± 0.0
2.954ThrIle: 2.954 ± 1.062
2.954ThrLys: 2.954 ± 1.181
2.954ThrLeu: 2.954 ± 0.992
0.0ThrMet: 0.0 ± 0.0
1.477ThrAsn: 1.477 ± 0.59
5.17ThrPro: 5.17 ± 1.879
2.216ThrGln: 2.216 ± 0.764
2.216ThrArg: 2.216 ± 1.475
8.863ThrSer: 8.863 ± 0.863
5.17ThrThr: 5.17 ± 2.633
3.693ThrVal: 3.693 ± 1.843
0.0ThrTrp: 0.0 ± 0.0
1.477ThrTyr: 1.477 ± 0.983
0.0ThrXaa: 0.0 ± 0.0
Val
2.954ValAla: 2.954 ± 1.181
0.739ValCys: 0.739 ± 0.772
2.954ValAsp: 2.954 ± 1.181
5.908ValGlu: 5.908 ± 1.336
2.216ValPhe: 2.216 ± 1.236
4.431ValGly: 4.431 ± 2.579
3.693ValHis: 3.693 ± 0.59
5.17ValIle: 5.17 ± 1.329
5.908ValLys: 5.908 ± 0.925
4.431ValLeu: 4.431 ± 0.647
1.477ValMet: 1.477 ± 0.983
1.477ValAsn: 1.477 ± 0.983
5.908ValPro: 5.908 ± 0.199
1.477ValGln: 1.477 ± 0.885
7.386ValArg: 7.386 ± 1.181
3.693ValSer: 3.693 ± 1.274
5.908ValThr: 5.908 ± 1.221
5.17ValVal: 5.17 ± 3.441
0.739ValTrp: 0.739 ± 0.492
1.477ValTyr: 1.477 ± 0.59
0.0ValXaa: 0.0 ± 0.0
Trp
1.477TrpAla: 1.477 ± 0.983
0.0TrpCys: 0.0 ± 0.0
2.216TrpAsp: 2.216 ± 0.847
2.954TrpGlu: 2.954 ± 1.244
0.0TrpPhe: 0.0 ± 0.0
1.477TrpGly: 1.477 ± 0.885
0.739TrpHis: 0.739 ± 0.715
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.739TrpLeu: 0.739 ± 0.715
1.477TrpMet: 1.477 ± 1.431
0.739TrpAsn: 0.739 ± 0.492
2.216TrpPro: 2.216 ± 2.317
0.0TrpGln: 0.0 ± 0.0
0.739TrpArg: 0.739 ± 0.772
0.0TrpSer: 0.0 ± 0.0
1.477TrpThr: 1.477 ± 0.59
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.693TyrAla: 3.693 ± 2.736
0.739TyrCys: 0.739 ± 0.492
0.0TyrAsp: 0.0 ± 0.0
2.954TyrGlu: 2.954 ± 1.141
0.739TyrPhe: 0.739 ± 0.492
0.739TyrGly: 0.739 ± 0.492
1.477TyrHis: 1.477 ± 0.983
2.216TyrIle: 2.216 ± 1.412
0.0TyrLys: 0.0 ± 0.0
2.216TyrLeu: 2.216 ± 0.764
0.0TyrMet: 0.0 ± 0.0
1.477TyrAsn: 1.477 ± 1.544
1.477TyrPro: 1.477 ± 0.885
1.477TyrGln: 1.477 ± 0.611
1.477TyrArg: 1.477 ± 0.611
3.693TyrSer: 3.693 ± 0.59
1.477TyrThr: 1.477 ± 0.611
2.954TyrVal: 2.954 ± 1.062
0.0TyrTrp: 0.0 ± 0.0
2.216TyrTyr: 2.216 ± 0.393
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1355 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski