Amino acid dipepetide frequency for Acidibacillus sulfuroxidans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.739AlaAla: 8.739 ± 0.144	0.696AlaCys: 0.696 ± 0.033	4.139AlaAsp: 4.139 ± 0.076	5.016AlaGlu: 5.016 ± 0.087	3.765AlaPhe: 3.765 ± 0.077	6.101AlaGly: 6.101 ± 0.096	2.327AlaHis: 2.327 ± 0.058	6.445AlaIle: 6.445 ± 0.094	4.781AlaLys: 4.781 ± 0.082	10.417AlaLeu: 10.417 ± 0.136	2.638AlaMet: 2.638 ± 0.058	3.027AlaAsn: 3.027 ± 0.063	3.027AlaPro: 3.027 ± 0.065	4.345AlaGln: 4.345 ± 0.085	5.169AlaArg: 5.169 ± 0.076	5.012AlaSer: 5.012 ± 0.09	4.929AlaThr: 4.929 ± 0.094	7.1AlaVal: 7.1 ± 0.109	0.975AlaTrp: 0.975 ± 0.031	2.739AlaTyr: 2.739 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.653CysAla: 0.653 ± 0.031	0.088CysCys: 0.088 ± 0.011	0.475CysAsp: 0.475 ± 0.025	0.509CysGlu: 0.509 ± 0.027	0.258CysPhe: 0.258 ± 0.017	0.801CysGly: 0.801 ± 0.033	0.191CysHis: 0.191 ± 0.016	0.45CysIle: 0.45 ± 0.023	0.328CysLys: 0.328 ± 0.022	0.632CysLeu: 0.632 ± 0.028	0.16CysMet: 0.16 ± 0.013	0.247CysAsn: 0.247 ± 0.015	0.403CysPro: 0.403 ± 0.022	0.253CysGln: 0.253 ± 0.02	0.367CysArg: 0.367 ± 0.02	0.459CysSer: 0.459 ± 0.026	0.49CysThr: 0.49 ± 0.026	0.523CysVal: 0.523 ± 0.026	0.063CysTrp: 0.063 ± 0.008	0.22CysTyr: 0.22 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.384AspAla: 4.384 ± 0.075	0.366AspCys: 0.366 ± 0.021	2.102AspAsp: 2.102 ± 0.054	3.667AspGlu: 3.667 ± 0.068	2.09AspPhe: 2.09 ± 0.052	3.201AspGly: 3.201 ± 0.079	1.39AspHis: 1.39 ± 0.045	2.693AspIle: 2.693 ± 0.059	1.625AspLys: 1.625 ± 0.051	5.443AspLeu: 5.443 ± 0.094	1.087AspMet: 1.087 ± 0.042	1.005AspAsn: 1.005 ± 0.036	2.469AspPro: 2.469 ± 0.054	2.101AspGln: 2.101 ± 0.049	3.044AspArg: 3.044 ± 0.065	2.081AspSer: 2.081 ± 0.052	2.136AspThr: 2.136 ± 0.053	4.342AspVal: 4.342 ± 0.083	0.593AspTrp: 0.593 ± 0.03	1.506AspTyr: 1.506 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.443GluAla: 5.443 ± 0.079	0.364GluCys: 0.364 ± 0.024	2.771GluAsp: 2.771 ± 0.059	4.673GluGlu: 4.673 ± 0.096	2.253GluPhe: 2.253 ± 0.047	3.581GluGly: 3.581 ± 0.066	1.676GluHis: 1.676 ± 0.043	4.328GluIle: 4.328 ± 0.076	3.194GluLys: 3.194 ± 0.069	6.784GluLeu: 6.784 ± 0.109	1.85GluMet: 1.85 ± 0.044	2.003GluAsn: 2.003 ± 0.051	2.01GluPro: 2.01 ± 0.05	3.856GluGln: 3.856 ± 0.078	4.853GluArg: 4.853 ± 0.089	3.212GluSer: 3.212 ± 0.065	3.251GluThr: 3.251 ± 0.062	4.876GluVal: 4.876 ± 0.074	0.906GluTrp: 0.906 ± 0.037	1.714GluTyr: 1.714 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	4.292PheAla: 4.292 ± 0.079	0.385PheCys: 0.385 ± 0.021	2.135PheAsp: 2.135 ± 0.053	2.242PheGlu: 2.242 ± 0.052	1.865PhePhe: 1.865 ± 0.058	3.43PheGly: 3.43 ± 0.071	1.016PheHis: 1.016 ± 0.031	2.63PheIle: 2.63 ± 0.069	1.172PheLys: 1.172 ± 0.04	4.296PheLeu: 4.296 ± 0.091	0.91PheMet: 0.91 ± 0.032	1.063PheAsn: 1.063 ± 0.034	1.775PhePro: 1.775 ± 0.052	1.298PheGln: 1.298 ± 0.041	1.909PheArg: 1.909 ± 0.047	2.946PheSer: 2.946 ± 0.069	2.538PheThr: 2.538 ± 0.057	3.487PheVal: 3.487 ± 0.067	0.547PheTrp: 0.547 ± 0.027	1.355PheTyr: 1.355 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	6.092GlyAla: 6.092 ± 0.114	0.661GlyCys: 0.661 ± 0.032	3.268GlyAsp: 3.268 ± 0.073	4.086GlyGlu: 4.086 ± 0.071	3.264GlyPhe: 3.264 ± 0.074	5.152GlyGly: 5.152 ± 0.112	1.739GlyHis: 1.739 ± 0.054	5.521GlyIle: 5.521 ± 0.1	3.63GlyLys: 3.63 ± 0.064	7.088GlyLeu: 7.088 ± 0.094	2.13GlyMet: 2.13 ± 0.058	2.25GlyAsn: 2.25 ± 0.056	2.183GlyPro: 2.183 ± 0.055	2.926GlyGln: 2.926 ± 0.066	3.765GlyArg: 3.765 ± 0.068	4.039GlySer: 4.039 ± 0.088	4.236GlyThr: 4.236 ± 0.086	6.091GlyVal: 6.091 ± 0.102	0.914GlyTrp: 0.914 ± 0.037	2.722GlyTyr: 2.722 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.282HisAla: 2.282 ± 0.048	0.218HisCys: 0.218 ± 0.016	1.09HisAsp: 1.09 ± 0.044	1.602HisGlu: 1.602 ± 0.046	1.165HisPhe: 1.165 ± 0.04	1.797HisGly: 1.797 ± 0.05	0.749HisHis: 0.749 ± 0.037	1.394HisIle: 1.394 ± 0.043	0.872HisLys: 0.872 ± 0.033	2.788HisLeu: 2.788 ± 0.054	0.615HisMet: 0.615 ± 0.027	0.633HisAsn: 0.633 ± 0.027	1.515HisPro: 1.515 ± 0.042	0.913HisGln: 0.913 ± 0.032	1.516HisArg: 1.516 ± 0.052	1.511HisSer: 1.511 ± 0.048	1.343HisThr: 1.343 ± 0.039	2.214HisVal: 2.214 ± 0.051	0.298HisTrp: 0.298 ± 0.02	0.846HisTyr: 0.846 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	7.205IleAla: 7.205 ± 0.104	0.553IleCys: 0.553 ± 0.028	3.569IleAsp: 3.569 ± 0.065	4.463IleGlu: 4.463 ± 0.079	2.389IlePhe: 2.389 ± 0.065	5.525IleGly: 5.525 ± 0.092	1.591IleHis: 1.591 ± 0.045	2.947IleIle: 2.947 ± 0.07	2.145IleLys: 2.145 ± 0.058	6.215IleLeu: 6.215 ± 0.091	1.201IleMet: 1.201 ± 0.04	1.654IleAsn: 1.654 ± 0.049	3.212IlePro: 3.212 ± 0.072	2.457IleGln: 2.457 ± 0.059	3.696IleArg: 3.696 ± 0.062	3.926IleSer: 3.926 ± 0.065	3.453IleThr: 3.453 ± 0.071	5.284IleVal: 5.284 ± 0.089	0.693IleTrp: 0.693 ± 0.025	1.819IleTyr: 1.819 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	3.47LysAla: 3.47 ± 0.07	0.209LysCys: 0.209 ± 0.014	1.907LysAsp: 1.907 ± 0.047	3.526LysGlu: 3.526 ± 0.058	1.242LysPhe: 1.242 ± 0.038	2.79LysGly: 2.79 ± 0.061	0.933LysHis: 0.933 ± 0.034	2.631LysIle: 2.631 ± 0.056	2.442LysLys: 2.442 ± 0.051	3.869LysLeu: 3.869 ± 0.069	1.311LysMet: 1.311 ± 0.042	1.541LysAsn: 1.541 ± 0.054	1.651LysPro: 1.651 ± 0.052	2.154LysGln: 2.154 ± 0.056	3.137LysArg: 3.137 ± 0.064	2.36LysSer: 2.36 ± 0.059	2.505LysThr: 2.505 ± 0.056	3.079LysVal: 3.079 ± 0.065	0.649LysTrp: 0.649 ± 0.029	1.219LysTyr: 1.219 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.38LeuAla: 10.38 ± 0.114	0.858LeuCys: 0.858 ± 0.029	4.775LeuAsp: 4.775 ± 0.085	5.963LeuGlu: 5.963 ± 0.095	4.648LeuPhe: 4.648 ± 0.092	7.578LeuGly: 7.578 ± 0.115	2.976LeuHis: 2.976 ± 0.063	6.204LeuIle: 6.204 ± 0.103	3.621LeuLys: 3.621 ± 0.067	11.744LeuLeu: 11.744 ± 0.175	2.377LeuMet: 2.377 ± 0.06	2.825LeuAsn: 2.825 ± 0.059	4.877LeuPro: 4.877 ± 0.068	5.437LeuGln: 5.437 ± 0.086	6.991LeuArg: 6.991 ± 0.093	6.893LeuSer: 6.893 ± 0.108	5.966LeuThr: 5.966 ± 0.078	7.258LeuVal: 7.258 ± 0.098	1.18LeuTrp: 1.18 ± 0.045	3.154LeuTyr: 3.154 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.333MetAla: 2.333 ± 0.052	0.176MetCys: 0.176 ± 0.016	1.195MetAsp: 1.195 ± 0.037	1.599MetGlu: 1.599 ± 0.044	0.815MetPhe: 0.815 ± 0.034	1.783MetGly: 1.783 ± 0.047	0.594MetHis: 0.594 ± 0.026	1.821MetIle: 1.821 ± 0.044	1.329MetLys: 1.329 ± 0.039	2.368MetLeu: 2.368 ± 0.058	0.749MetMet: 0.749 ± 0.031	1.098MetAsn: 1.098 ± 0.041	1.08MetPro: 1.08 ± 0.042	1.241MetGln: 1.241 ± 0.036	1.798MetArg: 1.798 ± 0.048	1.605MetSer: 1.605 ± 0.047	1.591MetThr: 1.591 ± 0.048	1.757MetVal: 1.757 ± 0.042	0.305MetTrp: 0.305 ± 0.019	0.67MetTyr: 0.67 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.741AsnAla: 2.741 ± 0.073	0.228AsnCys: 0.228 ± 0.019	1.386AsnAsp: 1.386 ± 0.043	1.914AsnGlu: 1.914 ± 0.047	1.147AsnPhe: 1.147 ± 0.043	2.441AsnGly: 2.441 ± 0.067	0.838AsnHis: 0.838 ± 0.032	1.74AsnIle: 1.74 ± 0.049	1.108AsnLys: 1.108 ± 0.043	3.078AsnLeu: 3.078 ± 0.069	0.735AsnMet: 0.735 ± 0.03	0.883AsnAsn: 0.883 ± 0.044	1.967AsnPro: 1.967 ± 0.059	1.488AsnGln: 1.488 ± 0.047	1.866AsnArg: 1.866 ± 0.049	1.718AsnSer: 1.718 ± 0.056	1.61AsnThr: 1.61 ± 0.049	2.3AsnVal: 2.3 ± 0.054	0.465AsnTrp: 0.465 ± 0.024	0.992AsnTyr: 0.992 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.072ProAla: 3.072 ± 0.061	0.255ProCys: 0.255 ± 0.022	2.227ProAsp: 2.227 ± 0.058	2.803ProGlu: 2.803 ± 0.065	2.087ProPhe: 2.087 ± 0.051	2.974ProGly: 2.974 ± 0.067	1.153ProHis: 1.153 ± 0.041	2.852ProIle: 2.852 ± 0.06	1.775ProLys: 1.775 ± 0.045	4.633ProLeu: 4.633 ± 0.077	1.053ProMet: 1.053 ± 0.035	1.515ProAsn: 1.515 ± 0.044	1.521ProPro: 1.521 ± 0.039	1.678ProGln: 1.678 ± 0.05	1.877ProArg: 1.877 ± 0.046	2.776ProSer: 2.776 ± 0.05	2.475ProThr: 2.475 ± 0.058	3.391ProVal: 3.391 ± 0.072	0.576ProTrp: 0.576 ± 0.029	1.529ProTyr: 1.529 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	4.215GlnAla: 4.215 ± 0.079	0.265GlnCys: 0.265 ± 0.017	1.703GlnAsp: 1.703 ± 0.048	2.836GlnGlu: 2.836 ± 0.066	1.762GlnPhe: 1.762 ± 0.046	2.949GlnGly: 2.949 ± 0.058	0.93GlnHis: 0.93 ± 0.034	3.089GlnIle: 3.089 ± 0.066	2.168GlnLys: 2.168 ± 0.054	4.649GlnLeu: 4.649 ± 0.088	1.425GlnMet: 1.425 ± 0.048	1.504GlnAsn: 1.504 ± 0.051	1.682GlnPro: 1.682 ± 0.049	2.331GlnGln: 2.331 ± 0.064	2.624GlnArg: 2.624 ± 0.058	2.673GlnSer: 2.673 ± 0.054	2.802GlnThr: 2.802 ± 0.059	3.491GlnVal: 3.491 ± 0.075	0.596GlnTrp: 0.596 ± 0.027	1.231GlnTyr: 1.231 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	4.917ArgAla: 4.917 ± 0.093	0.37ArgCys: 0.37 ± 0.021	2.988ArgAsp: 2.988 ± 0.062	4.63ArgGlu: 4.63 ± 0.082	2.506ArgPhe: 2.506 ± 0.053	3.667ArgGly: 3.667 ± 0.075	1.391ArgHis: 1.391 ± 0.037	4.185ArgIle: 4.185 ± 0.076	3.11ArgLys: 3.11 ± 0.067	6.131ArgLeu: 6.131 ± 0.092	1.786ArgMet: 1.786 ± 0.049	1.821ArgAsn: 1.821 ± 0.042	2.185ArgPro: 2.185 ± 0.058	2.601ArgGln: 2.601 ± 0.056	3.412ArgArg: 3.412 ± 0.068	3.252ArgSer: 3.252 ± 0.063	2.989ArgThr: 2.989 ± 0.06	4.624ArgVal: 4.624 ± 0.076	0.544ArgTrp: 0.544 ± 0.027	2.021ArgTyr: 2.021 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.196SerAla: 5.196 ± 0.092	0.424SerCys: 0.424 ± 0.023	2.802SerAsp: 2.802 ± 0.058	3.568SerGlu: 3.568 ± 0.071	2.677SerPhe: 2.677 ± 0.064	4.81SerGly: 4.81 ± 0.084	1.338SerHis: 1.338 ± 0.044	3.673SerIle: 3.673 ± 0.069	2.311SerLys: 2.311 ± 0.051	6.411SerLeu: 6.411 ± 0.098	1.61SerMet: 1.61 ± 0.043	1.747SerAsn: 1.747 ± 0.056	2.609SerPro: 2.609 ± 0.06	2.395SerGln: 2.395 ± 0.059	2.974SerArg: 2.974 ± 0.067	3.878SerSer: 3.878 ± 0.084	3.352SerThr: 3.352 ± 0.085	4.534SerVal: 4.534 ± 0.08	0.679SerTrp: 0.679 ± 0.029	1.854SerTyr: 1.854 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.163ThrAla: 5.163 ± 0.091	0.424ThrCys: 0.424 ± 0.023	2.57ThrAsp: 2.57 ± 0.057	3.144ThrGlu: 3.144 ± 0.064	2.293ThrPhe: 2.293 ± 0.054	4.428ThrGly: 4.428 ± 0.085	1.412ThrHis: 1.412 ± 0.038	3.438ThrIle: 3.438 ± 0.067	2.264ThrLys: 2.264 ± 0.058	6.297ThrLeu: 6.297 ± 0.094	1.302ThrMet: 1.302 ± 0.039	1.758ThrAsn: 1.758 ± 0.057	2.949ThrPro: 2.949 ± 0.056	2.096ThrGln: 2.096 ± 0.049	2.826ThrArg: 2.826 ± 0.066	3.417ThrSer: 3.417 ± 0.069	3.339ThrThr: 3.339 ± 0.073	4.627ThrVal: 4.627 ± 0.075	0.72ThrTrp: 0.72 ± 0.034	1.684ThrTyr: 1.684 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	7.275ValAla: 7.275 ± 0.104	0.673ValCys: 0.673 ± 0.026	3.998ValAsp: 3.998 ± 0.078	4.664ValGlu: 4.664 ± 0.083	3.167ValPhe: 3.167 ± 0.077	5.419ValGly: 5.419 ± 0.084	1.953ValHis: 1.953 ± 0.054	5.313ValIle: 5.313 ± 0.077	3.204ValLys: 3.204 ± 0.059	8.063ValLeu: 8.063 ± 0.108	1.901ValMet: 1.901 ± 0.053	2.642ValAsn: 2.642 ± 0.054	3.334ValPro: 3.334 ± 0.056	3.386ValGln: 3.386 ± 0.067	4.566ValArg: 4.566 ± 0.088	4.683ValSer: 4.683 ± 0.08	4.82ValThr: 4.82 ± 0.077	6.377ValVal: 6.377 ± 0.095	0.84ValTrp: 0.84 ± 0.03	2.308ValTyr: 2.308 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.728TrpAla: 0.728 ± 0.031	0.098TrpCys: 0.098 ± 0.01	0.568TrpAsp: 0.568 ± 0.025	0.654TrpGlu: 0.654 ± 0.026	0.518TrpPhe: 0.518 ± 0.024	0.701TrpGly: 0.701 ± 0.03	0.293TrpHis: 0.293 ± 0.018	0.992TrpIle: 0.992 ± 0.037	0.546TrpLys: 0.546 ± 0.025	1.533TrpLeu: 1.533 ± 0.05	0.432TrpMet: 0.432 ± 0.02	0.505TrpAsn: 0.505 ± 0.026	0.409TrpPro: 0.409 ± 0.02	0.624TrpGln: 0.624 ± 0.029	0.786TrpArg: 0.786 ± 0.031	0.699TrpSer: 0.699 ± 0.031	0.661TrpThr: 0.661 ± 0.03	0.805TrpVal: 0.805 ± 0.033	0.211TrpTrp: 0.211 ± 0.017	0.322TrpTyr: 0.322 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.808TyrAla: 2.808 ± 0.053	0.258TyrCys: 0.258 ± 0.017	1.656TyrAsp: 1.656 ± 0.046	2.04TyrGlu: 2.04 ± 0.053	1.379TyrPhe: 1.379 ± 0.04	2.628TyrGly: 2.628 ± 0.06	0.871TyrHis: 0.871 ± 0.036	1.65TyrIle: 1.65 ± 0.049	1.001TyrLys: 1.001 ± 0.037	3.265TyrLeu: 3.265 ± 0.066	0.634TyrMet: 0.634 ± 0.028	0.925TyrAsn: 0.925 ± 0.04	1.363TyrPro: 1.363 ± 0.04	1.344TyrGln: 1.344 ± 0.045	1.958TyrArg: 1.958 ± 0.051	1.702TyrSer: 1.702 ± 0.041	1.665TyrThr: 1.665 ± 0.044	2.426TyrVal: 2.426 ± 0.065	0.329TyrTrp: 0.329 ± 0.02	0.998TyrTyr: 0.998 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2818 proteins (825953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---