Amino acid dipepetide frequency for Kribbella amoyensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.251AlaAla: 19.251 ± 0.119	0.875AlaCys: 0.875 ± 0.022	8.349AlaAsp: 8.349 ± 0.071	8.464AlaGlu: 8.464 ± 0.081	3.498AlaPhe: 3.498 ± 0.039	12.777AlaGly: 12.777 ± 0.082	2.126AlaHis: 2.126 ± 0.032	4.88AlaIle: 4.88 ± 0.05	3.264AlaLys: 3.264 ± 0.044	12.909AlaLeu: 12.909 ± 0.09	2.351AlaMet: 2.351 ± 0.031	2.376AlaAsn: 2.376 ± 0.035	5.753AlaPro: 5.753 ± 0.061	3.626AlaGln: 3.626 ± 0.046	8.458AlaArg: 8.458 ± 0.066	5.783AlaSer: 5.783 ± 0.055	7.629AlaThr: 7.629 ± 0.057	11.588AlaVal: 11.588 ± 0.081	1.847AlaTrp: 1.847 ± 0.032	2.691AlaTyr: 2.691 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.794CysAla: 0.794 ± 0.018	0.091CysCys: 0.091 ± 0.006	0.417CysAsp: 0.417 ± 0.013	0.353CysGlu: 0.353 ± 0.012	0.213CysPhe: 0.213 ± 0.009	0.799CysGly: 0.799 ± 0.02	0.165CysHis: 0.165 ± 0.009	0.164CysIle: 0.164 ± 0.007	0.116CysLys: 0.116 ± 0.007	0.646CysLeu: 0.646 ± 0.018	0.099CysMet: 0.099 ± 0.007	0.143CysAsn: 0.143 ± 0.008	0.411CysPro: 0.411 ± 0.015	0.166CysGln: 0.166 ± 0.008	0.498CysArg: 0.498 ± 0.016	0.43CysSer: 0.43 ± 0.014	0.447CysThr: 0.447 ± 0.014	0.564CysVal: 0.564 ± 0.016	0.115CysTrp: 0.115 ± 0.007	0.154CysTyr: 0.154 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.216AspAla: 7.216 ± 0.066	0.373AspCys: 0.373 ± 0.013	3.865AspAsp: 3.865 ± 0.051	4.15AspGlu: 4.15 ± 0.048	1.64AspPhe: 1.64 ± 0.023	6.263AspGly: 6.263 ± 0.062	1.49AspHis: 1.49 ± 0.027	1.638AspIle: 1.638 ± 0.026	1.321AspLys: 1.321 ± 0.028	7.11AspLeu: 7.11 ± 0.066	0.649AspMet: 0.649 ± 0.015	1.121AspAsn: 1.121 ± 0.022	4.578AspPro: 4.578 ± 0.046	2.243AspGln: 2.243 ± 0.033	4.945AspArg: 4.945 ± 0.05	2.532AspSer: 2.532 ± 0.031	2.823AspThr: 2.823 ± 0.037	5.102AspVal: 5.102 ± 0.047	1.087AspTrp: 1.087 ± 0.024	1.176AspTyr: 1.176 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.592GluAla: 6.592 ± 0.067	0.284GluCys: 0.284 ± 0.011	2.68GluAsp: 2.68 ± 0.037	2.753GluGlu: 2.753 ± 0.041	1.606GluPhe: 1.606 ± 0.031	3.503GluGly: 3.503 ± 0.037	1.423GluHis: 1.423 ± 0.025	2.318GluIle: 2.318 ± 0.032	1.313GluLys: 1.313 ± 0.023	7.317GluLeu: 7.317 ± 0.07	0.784GluMet: 0.784 ± 0.021	1.06GluAsn: 1.06 ± 0.02	3.279GluPro: 3.279 ± 0.04	2.446GluGln: 2.446 ± 0.034	4.708GluArg: 4.708 ± 0.054	2.704GluSer: 2.704 ± 0.035	2.884GluThr: 2.884 ± 0.034	4.818GluVal: 4.818 ± 0.043	0.819GluTrp: 0.819 ± 0.018	1.344GluTyr: 1.344 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.864PheAla: 3.864 ± 0.041	0.257PheCys: 0.257 ± 0.01	2.145PheAsp: 2.145 ± 0.031	1.524PheGlu: 1.524 ± 0.026	0.943PhePhe: 0.943 ± 0.021	3.227PheGly: 3.227 ± 0.039	0.629PheHis: 0.629 ± 0.017	0.732PheIle: 0.732 ± 0.021	0.543PheLys: 0.543 ± 0.018	2.705PheLeu: 2.705 ± 0.035	0.348PheMet: 0.348 ± 0.011	0.608PheAsn: 0.608 ± 0.014	1.308PhePro: 1.308 ± 0.027	0.767PheGln: 0.767 ± 0.019	1.912PheArg: 1.912 ± 0.024	1.486PheSer: 1.486 ± 0.025	2.015PheThr: 2.015 ± 0.03	2.785PheVal: 2.785 ± 0.034	0.501PheTrp: 0.501 ± 0.013	0.648PheTyr: 0.648 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	9.627GlyAla: 9.627 ± 0.064	0.787GlyCys: 0.787 ± 0.019	5.071GlyAsp: 5.071 ± 0.048	4.714GlyGlu: 4.714 ± 0.042	3.045GlyPhe: 3.045 ± 0.036	7.824GlyGly: 7.824 ± 0.075	1.924GlyHis: 1.924 ± 0.029	3.843GlyIle: 3.843 ± 0.04	2.59GlyLys: 2.59 ± 0.039	9.716GlyLeu: 9.716 ± 0.076	1.763GlyMet: 1.763 ± 0.029	2.015GlyAsn: 2.015 ± 0.031	4.737GlyPro: 4.737 ± 0.048	2.942GlyGln: 2.942 ± 0.039	6.872GlyArg: 6.872 ± 0.058	5.348GlySer: 5.348 ± 0.055	6.031GlyThr: 6.031 ± 0.059	7.551GlyVal: 7.551 ± 0.059	1.909GlyTrp: 1.909 ± 0.036	2.483GlyTyr: 2.483 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.176HisAla: 2.176 ± 0.034	0.165HisCys: 0.165 ± 0.007	1.208HisAsp: 1.208 ± 0.022	1.088HisGlu: 1.088 ± 0.023	0.58HisPhe: 0.58 ± 0.015	2.052HisGly: 2.052 ± 0.03	0.605HisHis: 0.605 ± 0.017	0.505HisIle: 0.505 ± 0.014	0.359HisLys: 0.359 ± 0.012	2.384HisLeu: 2.384 ± 0.032	0.231HisMet: 0.231 ± 0.009	0.382HisAsn: 0.382 ± 0.014	1.583HisPro: 1.583 ± 0.03	0.736HisGln: 0.736 ± 0.018	1.921HisArg: 1.921 ± 0.03	0.903HisSer: 0.903 ± 0.017	1.046HisThr: 1.046 ± 0.025	1.581HisVal: 1.581 ± 0.027	0.371HisTrp: 0.371 ± 0.012	0.444HisTyr: 0.444 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.425IleAla: 5.425 ± 0.048	0.299IleCys: 0.299 ± 0.011	2.62IleAsp: 2.62 ± 0.032	2.251IleGlu: 2.251 ± 0.029	0.918IlePhe: 0.918 ± 0.024	4.151IleGly: 4.151 ± 0.047	0.651IleHis: 0.651 ± 0.018	0.942IleIle: 0.942 ± 0.02	0.733IleLys: 0.733 ± 0.018	2.938IleLeu: 2.938 ± 0.039	0.415IleMet: 0.415 ± 0.013	0.73IleAsn: 0.73 ± 0.021	2.012IlePro: 2.012 ± 0.037	0.911IleGln: 0.911 ± 0.02	2.58IleArg: 2.58 ± 0.03	1.953IleSer: 1.953 ± 0.029	2.555IleThr: 2.555 ± 0.035	3.307IleVal: 3.307 ± 0.043	0.485IleTrp: 0.485 ± 0.014	0.683IleTyr: 0.683 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.099LysAla: 3.099 ± 0.046	0.1LysCys: 0.1 ± 0.007	1.299LysAsp: 1.299 ± 0.025	1.006LysGlu: 1.006 ± 0.023	0.591LysPhe: 0.591 ± 0.018	1.589LysGly: 1.589 ± 0.026	0.446LysHis: 0.446 ± 0.013	0.887LysIle: 0.887 ± 0.02	0.778LysLys: 0.778 ± 0.029	2.548LysLeu: 2.548 ± 0.037	0.383LysMet: 0.383 ± 0.013	0.572LysAsn: 0.572 ± 0.018	1.629LysPro: 1.629 ± 0.029	0.8LysGln: 0.8 ± 0.021	1.367LysArg: 1.367 ± 0.023	1.273LysSer: 1.273 ± 0.026	1.425LysThr: 1.425 ± 0.027	2.273LysVal: 2.273 ± 0.038	0.303LysTrp: 0.303 ± 0.012	0.622LysTyr: 0.622 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.092LeuAla: 15.092 ± 0.098	0.693LeuCys: 0.693 ± 0.019	7.0LeuAsp: 7.0 ± 0.051	4.816LeuGlu: 4.816 ± 0.052	2.78LeuPhe: 2.78 ± 0.045	9.522LeuGly: 9.522 ± 0.074	2.076LeuHis: 2.076 ± 0.033	3.946LeuIle: 3.946 ± 0.05	2.051LeuLys: 2.051 ± 0.034	11.071LeuLeu: 11.071 ± 0.105	1.538LeuMet: 1.538 ± 0.023	1.872LeuAsn: 1.872 ± 0.028	6.153LeuPro: 6.153 ± 0.055	2.688LeuGln: 2.688 ± 0.035	8.215LeuArg: 8.215 ± 0.069	5.396LeuSer: 5.396 ± 0.058	7.332LeuThr: 7.332 ± 0.064	9.786LeuVal: 9.786 ± 0.071	1.361LeuTrp: 1.361 ± 0.026	1.906LeuTyr: 1.906 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.996MetAla: 1.996 ± 0.032	0.083MetCys: 0.083 ± 0.006	0.751MetAsp: 0.751 ± 0.017	0.614MetGlu: 0.614 ± 0.015	0.483MetPhe: 0.483 ± 0.017	1.091MetGly: 1.091 ± 0.02	0.294MetHis: 0.294 ± 0.012	0.724MetIle: 0.724 ± 0.018	0.423MetLys: 0.423 ± 0.013	1.755MetLeu: 1.755 ± 0.03	0.273MetMet: 0.273 ± 0.011	0.414MetAsn: 0.414 ± 0.013	1.012MetPro: 1.012 ± 0.019	0.406MetGln: 0.406 ± 0.012	1.231MetArg: 1.231 ± 0.022	1.269MetSer: 1.269 ± 0.024	1.619MetThr: 1.619 ± 0.027	1.353MetVal: 1.353 ± 0.023	0.166MetTrp: 0.166 ± 0.009	0.295MetTyr: 0.295 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.35AsnAla: 2.35 ± 0.036	0.158AsnCys: 0.158 ± 0.008	1.169AsnAsp: 1.169 ± 0.025	0.914AsnGlu: 0.914 ± 0.02	0.597AsnPhe: 0.597 ± 0.017	2.163AsnGly: 2.163 ± 0.039	0.484AsnHis: 0.484 ± 0.015	0.62AsnIle: 0.62 ± 0.017	0.448AsnLys: 0.448 ± 0.017	2.077AsnLeu: 2.077 ± 0.031	0.275AsnMet: 0.275 ± 0.012	0.534AsnAsn: 0.534 ± 0.019	1.59AsnPro: 1.59 ± 0.03	0.75AsnGln: 0.75 ± 0.02	1.435AsnArg: 1.435 ± 0.027	1.049AsnSer: 1.049 ± 0.026	1.142AsnThr: 1.142 ± 0.025	1.572AsnVal: 1.572 ± 0.024	0.391AsnTrp: 0.391 ± 0.014	0.528AsnTyr: 0.528 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.048ProAla: 8.048 ± 0.07	0.282ProCys: 0.282 ± 0.012	4.474ProAsp: 4.474 ± 0.052	3.801ProGlu: 3.801 ± 0.039	1.493ProPhe: 1.493 ± 0.027	5.873ProGly: 5.873 ± 0.052	1.113ProHis: 1.113 ± 0.029	1.889ProIle: 1.889 ± 0.028	1.329ProLys: 1.329 ± 0.023	4.961ProLeu: 4.961 ± 0.047	0.946ProMet: 0.946 ± 0.023	1.192ProAsn: 1.192 ± 0.028	3.237ProPro: 3.237 ± 0.058	1.652ProGln: 1.652 ± 0.03	3.549ProArg: 3.549 ± 0.042	3.217ProSer: 3.217 ± 0.041	3.75ProThr: 3.75 ± 0.057	5.098ProVal: 5.098 ± 0.043	0.987ProTrp: 0.987 ± 0.022	1.327ProTyr: 1.327 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.097GlnAla: 4.097 ± 0.044	0.146GlnCys: 0.146 ± 0.008	1.399GlnAsp: 1.399 ± 0.026	1.343GlnGlu: 1.343 ± 0.026	0.864GlnPhe: 0.864 ± 0.018	2.195GlnGly: 2.195 ± 0.033	0.666GlnHis: 0.666 ± 0.016	1.187GlnIle: 1.187 ± 0.023	0.612GlnLys: 0.612 ± 0.017	3.731GlnLeu: 3.731 ± 0.037	0.448GlnMet: 0.448 ± 0.014	0.618GlnAsn: 0.618 ± 0.017	2.082GlnPro: 2.082 ± 0.035	1.503GlnGln: 1.503 ± 0.035	2.586GlnArg: 2.586 ± 0.035	1.438GlnSer: 1.438 ± 0.026	1.644GlnThr: 1.644 ± 0.026	2.936GlnVal: 2.936 ± 0.037	0.516GlnTrp: 0.516 ± 0.014	0.855GlnTyr: 0.855 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.178ArgAla: 8.178 ± 0.068	0.474ArgCys: 0.474 ± 0.014	4.151ArgAsp: 4.151 ± 0.045	4.004ArgGlu: 4.004 ± 0.046	2.313ArgPhe: 2.313 ± 0.029	5.236ArgGly: 5.236 ± 0.052	1.62ArgHis: 1.62 ± 0.029	3.467ArgIle: 3.467 ± 0.043	1.73ArgLys: 1.73 ± 0.03	8.116ArgLeu: 8.116 ± 0.074	1.66ArgMet: 1.66 ± 0.027	1.499ArgAsn: 1.499 ± 0.024	4.451ArgPro: 4.451 ± 0.045	2.433ArgGln: 2.433 ± 0.034	7.124ArgArg: 7.124 ± 0.08	4.184ArgSer: 4.184 ± 0.042	5.131ArgThr: 5.131 ± 0.043	5.487ArgVal: 5.487 ± 0.054	1.454ArgTrp: 1.454 ± 0.027	1.931ArgTyr: 1.931 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.517SerAla: 6.517 ± 0.059	0.375SerCys: 0.375 ± 0.014	2.69SerAsp: 2.69 ± 0.033	2.436SerGlu: 2.436 ± 0.037	1.639SerPhe: 1.639 ± 0.032	5.661SerGly: 5.661 ± 0.056	0.949SerHis: 0.949 ± 0.021	1.873SerIle: 1.873 ± 0.029	1.175SerLys: 1.175 ± 0.024	5.024SerLeu: 5.024 ± 0.048	1.115SerMet: 1.115 ± 0.023	1.093SerAsn: 1.093 ± 0.023	3.095SerPro: 3.095 ± 0.039	1.374SerGln: 1.374 ± 0.024	3.617SerArg: 3.617 ± 0.037	3.132SerSer: 3.132 ± 0.044	3.722SerThr: 3.722 ± 0.044	4.466SerVal: 4.466 ± 0.042	1.053SerTrp: 1.053 ± 0.023	1.294SerTyr: 1.294 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.54ThrAla: 8.54 ± 0.07	0.398ThrCys: 0.398 ± 0.013	3.847ThrAsp: 3.847 ± 0.039	3.543ThrGlu: 3.543 ± 0.043	1.897ThrPhe: 1.897 ± 0.03	6.475ThrGly: 6.475 ± 0.055	1.104ThrHis: 1.104 ± 0.024	2.269ThrIle: 2.269 ± 0.03	1.499ThrLys: 1.499 ± 0.025	5.909ThrLeu: 5.909 ± 0.055	1.024ThrMet: 1.024 ± 0.019	1.253ThrAsn: 1.253 ± 0.025	4.056ThrPro: 4.056 ± 0.046	1.57ThrGln: 1.57 ± 0.026	3.885ThrArg: 3.885 ± 0.035	3.465ThrSer: 3.465 ± 0.039	4.556ThrThr: 4.556 ± 0.058	6.155ThrVal: 6.155 ± 0.057	1.062ThrTrp: 1.062 ± 0.02	1.465ThrTyr: 1.465 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	11.316ValAla: 11.316 ± 0.077	0.611ValCys: 0.611 ± 0.017	5.633ValAsp: 5.633 ± 0.048	5.023ValGlu: 5.023 ± 0.048	2.517ValPhe: 2.517 ± 0.032	7.056ValGly: 7.056 ± 0.061	1.733ValHis: 1.733 ± 0.028	3.432ValIle: 3.432 ± 0.04	1.875ValLys: 1.875 ± 0.032	9.974ValLeu: 9.974 ± 0.077	1.402ValMet: 1.402 ± 0.026	1.813ValAsn: 1.813 ± 0.03	5.13ValPro: 5.13 ± 0.048	2.365ValGln: 2.365 ± 0.03	6.525ValArg: 6.525 ± 0.051	4.43ValSer: 4.43 ± 0.044	5.869ValThr: 5.869 ± 0.05	9.074ValVal: 9.074 ± 0.078	1.154ValTrp: 1.154 ± 0.021	1.606ValTyr: 1.606 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.625TrpAla: 1.625 ± 0.026	0.138TrpCys: 0.138 ± 0.008	0.864TrpAsp: 0.864 ± 0.024	0.637TrpGlu: 0.637 ± 0.017	0.598TrpPhe: 0.598 ± 0.017	1.087TrpGly: 1.087 ± 0.028	0.391TrpHis: 0.391 ± 0.013	0.738TrpIle: 0.738 ± 0.019	0.417TrpLys: 0.417 ± 0.013	1.964TrpLeu: 1.964 ± 0.034	0.328TrpMet: 0.328 ± 0.013	0.462TrpAsn: 0.462 ± 0.014	0.907TrpPro: 0.907 ± 0.019	0.69TrpGln: 0.69 ± 0.019	1.297TrpArg: 1.297 ± 0.025	1.142TrpSer: 1.142 ± 0.023	1.165TrpThr: 1.165 ± 0.024	1.146TrpVal: 1.146 ± 0.022	0.411TrpTrp: 0.411 ± 0.014	0.405TrpTyr: 0.405 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.694TyrAla: 2.694 ± 0.035	0.198TyrCys: 0.198 ± 0.009	1.691TyrAsp: 1.691 ± 0.031	1.199TyrGlu: 1.199 ± 0.019	0.732TyrPhe: 0.732 ± 0.018	2.248TyrGly: 2.248 ± 0.033	0.43TyrHis: 0.43 ± 0.015	0.503TyrIle: 0.503 ± 0.015	0.414TyrLys: 0.414 ± 0.013	2.438TyrLeu: 2.438 ± 0.03	0.223TyrMet: 0.223 ± 0.01	0.489TyrAsn: 0.489 ± 0.016	1.217TyrPro: 1.217 ± 0.025	0.794TyrGln: 0.794 ± 0.021	1.92TyrArg: 1.92 ± 0.028	1.164TyrSer: 1.164 ± 0.023	1.187TyrThr: 1.187 ± 0.023	1.896TyrVal: 1.896 ± 0.031	0.419TyrTrp: 0.419 ± 0.013	0.554TyrTyr: 0.554 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7393 proteins (2439600 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---