Amino acid dipepetide frequency for Actinomadura chibensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.902AlaAla: 23.902 ± 0.176	1.096AlaCys: 1.096 ± 0.022	9.057AlaAsp: 9.057 ± 0.069	9.12AlaGlu: 9.12 ± 0.076	3.817AlaPhe: 3.817 ± 0.045	13.841AlaGly: 13.841 ± 0.087	2.736AlaHis: 2.736 ± 0.03	3.897AlaIle: 3.897 ± 0.039	2.687AlaLys: 2.687 ± 0.035	14.848AlaLeu: 14.848 ± 0.099	2.525AlaMet: 2.525 ± 0.032	1.887AlaAsn: 1.887 ± 0.024	7.225AlaPro: 7.225 ± 0.069	3.071AlaGln: 3.071 ± 0.041	11.705AlaArg: 11.705 ± 0.079	5.859AlaSer: 5.859 ± 0.044	6.416AlaThr: 6.416 ± 0.057	12.577AlaVal: 12.577 ± 0.094	1.963AlaTrp: 1.963 ± 0.027	2.569AlaTyr: 2.569 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	1.11CysAla: 1.11 ± 0.02	0.102CysCys: 0.102 ± 0.007	0.536CysAsp: 0.536 ± 0.015	0.408CysGlu: 0.408 ± 0.012	0.216CysPhe: 0.216 ± 0.009	1.003CysGly: 1.003 ± 0.023	0.189CysHis: 0.189 ± 0.009	0.131CysIle: 0.131 ± 0.007	0.123CysLys: 0.123 ± 0.007	0.702CysLeu: 0.702 ± 0.015	0.122CysMet: 0.122 ± 0.008	0.123CysAsn: 0.123 ± 0.007	0.506CysPro: 0.506 ± 0.014	0.164CysGln: 0.164 ± 0.007	0.64CysArg: 0.64 ± 0.019	0.387CysSer: 0.387 ± 0.012	0.406CysThr: 0.406 ± 0.012	0.713CysVal: 0.713 ± 0.016	0.115CysTrp: 0.115 ± 0.007	0.168CysTyr: 0.168 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.594AspAla: 8.594 ± 0.06	0.38AspCys: 0.38 ± 0.012	4.172AspAsp: 4.172 ± 0.043	4.108AspGlu: 4.108 ± 0.043	1.541AspPhe: 1.541 ± 0.028	6.913AspGly: 6.913 ± 0.058	1.373AspHis: 1.373 ± 0.026	1.673AspIle: 1.673 ± 0.027	0.966AspLys: 0.966 ± 0.024	6.736AspLeu: 6.736 ± 0.06	0.847AspMet: 0.847 ± 0.019	0.811AspAsn: 0.811 ± 0.019	4.881AspPro: 4.881 ± 0.049	1.46AspGln: 1.46 ± 0.025	5.493AspArg: 5.493 ± 0.049	1.975AspSer: 1.975 ± 0.03	2.589AspThr: 2.589 ± 0.032	5.516AspVal: 5.516 ± 0.052	0.944AspTrp: 0.944 ± 0.019	1.132AspTyr: 1.132 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.91GluAla: 6.91 ± 0.061	0.38GluCys: 0.38 ± 0.011	2.627GluAsp: 2.627 ± 0.037	3.095GluGlu: 3.095 ± 0.038	1.601GluPhe: 1.601 ± 0.024	3.853GluGly: 3.853 ± 0.042	1.556GluHis: 1.556 ± 0.026	2.379GluIle: 2.379 ± 0.035	1.193GluLys: 1.193 ± 0.024	6.535GluLeu: 6.535 ± 0.057	0.947GluMet: 0.947 ± 0.022	0.958GluAsn: 0.958 ± 0.019	3.693GluPro: 3.693 ± 0.047	1.698GluGln: 1.698 ± 0.027	6.177GluArg: 6.177 ± 0.056	2.461GluSer: 2.461 ± 0.036	2.867GluThr: 2.867 ± 0.036	4.435GluVal: 4.435 ± 0.042	0.801GluTrp: 0.801 ± 0.017	1.079GluTyr: 1.079 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.983PheAla: 3.983 ± 0.041	0.284PheCys: 0.284 ± 0.012	2.036PheAsp: 2.036 ± 0.029	1.443PheGlu: 1.443 ± 0.028	0.859PhePhe: 0.859 ± 0.022	3.166PheGly: 3.166 ± 0.041	0.618PheHis: 0.618 ± 0.016	0.683PheIle: 0.683 ± 0.016	0.477PheLys: 0.477 ± 0.015	2.606PheLeu: 2.606 ± 0.033	0.425PheMet: 0.425 ± 0.014	0.563PheAsn: 0.563 ± 0.016	1.445PhePro: 1.445 ± 0.023	0.703PheGln: 0.703 ± 0.016	1.903PheArg: 1.903 ± 0.023	1.34PheSer: 1.34 ± 0.028	1.87PheThr: 1.87 ± 0.023	2.363PheVal: 2.363 ± 0.031	0.413PheTrp: 0.413 ± 0.013	0.583PheTyr: 0.583 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.834GlyAla: 11.834 ± 0.089	0.845GlyCys: 0.845 ± 0.017	5.681GlyAsp: 5.681 ± 0.043	5.117GlyGlu: 5.117 ± 0.044	2.936GlyPhe: 2.936 ± 0.036	10.035GlyGly: 10.035 ± 0.084	2.267GlyHis: 2.267 ± 0.034	3.19GlyIle: 3.19 ± 0.039	2.187GlyLys: 2.187 ± 0.034	9.824GlyLeu: 9.824 ± 0.068	2.051GlyMet: 2.051 ± 0.029	1.581GlyAsn: 1.581 ± 0.03	5.804GlyPro: 5.804 ± 0.071	2.329GlyGln: 2.329 ± 0.037	9.094GlyArg: 9.094 ± 0.065	4.651GlySer: 4.651 ± 0.044	6.002GlyThr: 6.002 ± 0.05	8.14GlyVal: 8.14 ± 0.069	1.752GlyTrp: 1.752 ± 0.028	2.227GlyTyr: 2.227 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.662HisAla: 2.662 ± 0.033	0.209HisCys: 0.209 ± 0.009	1.344HisAsp: 1.344 ± 0.018	1.136HisGlu: 1.136 ± 0.023	0.581HisPhe: 0.581 ± 0.014	2.34HisGly: 2.34 ± 0.026	0.583HisHis: 0.583 ± 0.017	0.595HisIle: 0.595 ± 0.014	0.3HisLys: 0.3 ± 0.01	2.254HisLeu: 2.254 ± 0.032	0.332HisMet: 0.332 ± 0.011	0.345HisAsn: 0.345 ± 0.011	1.708HisPro: 1.708 ± 0.028	0.542HisGln: 0.542 ± 0.013	2.092HisArg: 2.092 ± 0.033	0.862HisSer: 0.862 ± 0.018	1.019HisThr: 1.019 ± 0.02	1.852HisVal: 1.852 ± 0.027	0.347HisTrp: 0.347 ± 0.01	0.458HisTyr: 0.458 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.826IleAla: 4.826 ± 0.048	0.281IleCys: 0.281 ± 0.01	2.22IleAsp: 2.22 ± 0.029	1.997IleGlu: 1.997 ± 0.028	0.714IlePhe: 0.714 ± 0.014	3.565IleGly: 3.565 ± 0.042	0.558IleHis: 0.558 ± 0.016	0.905IleIle: 0.905 ± 0.018	0.674IleLys: 0.674 ± 0.018	2.399IleLeu: 2.399 ± 0.032	0.494IleMet: 0.494 ± 0.015	0.645IleAsn: 0.645 ± 0.017	1.68IlePro: 1.68 ± 0.027	0.683IleGln: 0.683 ± 0.016	2.27IleArg: 2.27 ± 0.029	1.558IleSer: 1.558 ± 0.027	2.094IleThr: 2.094 ± 0.028	3.15IleVal: 3.15 ± 0.041	0.371IleTrp: 0.371 ± 0.011	0.526IleTyr: 0.526 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.596LysAla: 2.596 ± 0.036	0.119LysCys: 0.119 ± 0.007	1.124LysAsp: 1.124 ± 0.025	0.998LysGlu: 0.998 ± 0.02	0.418LysPhe: 0.418 ± 0.013	1.702LysGly: 1.702 ± 0.03	0.395LysHis: 0.395 ± 0.012	0.841LysIle: 0.841 ± 0.017	0.647LysLys: 0.647 ± 0.019	1.697LysLeu: 1.697 ± 0.027	0.356LysMet: 0.356 ± 0.012	0.46LysAsn: 0.46 ± 0.015	1.278LysPro: 1.278 ± 0.025	0.545LysGln: 0.545 ± 0.017	1.467LysArg: 1.467 ± 0.028	1.044LysSer: 1.044 ± 0.02	1.138LysThr: 1.138 ± 0.024	1.778LysVal: 1.778 ± 0.029	0.233LysTrp: 0.233 ± 0.009	0.393LysTyr: 0.393 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	16.076LeuAla: 16.076 ± 0.106	0.793LeuCys: 0.793 ± 0.02	7.148LeuAsp: 7.148 ± 0.068	4.55LeuGlu: 4.55 ± 0.048	2.617LeuPhe: 2.617 ± 0.034	9.564LeuGly: 9.564 ± 0.071	2.076LeuHis: 2.076 ± 0.033	3.267LeuIle: 3.267 ± 0.044	1.774LeuLys: 1.774 ± 0.028	10.773LeuLeu: 10.773 ± 0.086	1.576LeuMet: 1.576 ± 0.025	1.749LeuAsn: 1.749 ± 0.028	6.408LeuPro: 6.408 ± 0.046	1.928LeuGln: 1.928 ± 0.029	9.357LeuArg: 9.357 ± 0.059	5.028LeuSer: 5.028 ± 0.044	6.239LeuThr: 6.239 ± 0.048	8.948LeuVal: 8.948 ± 0.061	1.264LeuTrp: 1.264 ± 0.022	1.788LeuTyr: 1.788 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.357MetAla: 2.357 ± 0.033	0.13MetCys: 0.13 ± 0.007	0.972MetAsp: 0.972 ± 0.019	0.742MetGlu: 0.742 ± 0.016	0.495MetPhe: 0.495 ± 0.014	1.331MetGly: 1.331 ± 0.024	0.329MetHis: 0.329 ± 0.011	0.711MetIle: 0.711 ± 0.016	0.381MetLys: 0.381 ± 0.013	1.766MetLeu: 1.766 ± 0.027	0.298MetMet: 0.298 ± 0.011	0.392MetAsn: 0.392 ± 0.012	1.132MetPro: 1.132 ± 0.021	0.384MetGln: 0.384 ± 0.013	1.592MetArg: 1.592 ± 0.023	1.262MetSer: 1.262 ± 0.023	1.5MetThr: 1.5 ± 0.024	1.31MetVal: 1.31 ± 0.023	0.213MetTrp: 0.213 ± 0.008	0.314MetTyr: 0.314 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.178AsnAla: 2.178 ± 0.03	0.18AsnCys: 0.18 ± 0.008	0.929AsnAsp: 0.929 ± 0.018	0.772AsnGlu: 0.772 ± 0.018	0.453AsnPhe: 0.453 ± 0.013	1.883AsnGly: 1.883 ± 0.028	0.352AsnHis: 0.352 ± 0.012	0.552AsnIle: 0.552 ± 0.015	0.351AsnLys: 0.351 ± 0.013	1.675AsnLeu: 1.675 ± 0.026	0.268AsnMet: 0.268 ± 0.009	0.34AsnAsn: 0.34 ± 0.013	1.278AsnPro: 1.278 ± 0.022	0.471AsnGln: 0.471 ± 0.015	1.249AsnArg: 1.249 ± 0.024	0.718AsnSer: 0.718 ± 0.018	0.953AsnThr: 0.953 ± 0.023	1.468AsnVal: 1.468 ± 0.023	0.255AsnTrp: 0.255 ± 0.01	0.391AsnTyr: 0.391 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.91ProAla: 8.91 ± 0.073	0.379ProCys: 0.379 ± 0.012	5.071ProAsp: 5.071 ± 0.052	4.183ProGlu: 4.183 ± 0.045	1.639ProPhe: 1.639 ± 0.024	7.446ProGly: 7.446 ± 0.056	1.27ProHis: 1.27 ± 0.022	1.581ProIle: 1.581 ± 0.024	1.198ProLys: 1.198 ± 0.025	5.298ProLeu: 5.298 ± 0.043	1.098ProMet: 1.098 ± 0.021	0.966ProAsn: 0.966 ± 0.022	4.717ProPro: 4.717 ± 0.072	1.341ProGln: 1.341 ± 0.025	4.566ProArg: 4.566 ± 0.04	3.465ProSer: 3.465 ± 0.038	2.791ProThr: 2.791 ± 0.044	5.446ProVal: 5.446 ± 0.048	0.935ProTrp: 0.935 ± 0.019	1.307ProTyr: 1.307 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.222GlnAla: 3.222 ± 0.046	0.157GlnCys: 0.157 ± 0.008	1.181GlnAsp: 1.181 ± 0.019	1.143GlnGlu: 1.143 ± 0.021	0.64GlnPhe: 0.64 ± 0.016	1.989GlnGly: 1.989 ± 0.033	0.518GlnHis: 0.518 ± 0.014	1.043GlnIle: 1.043 ± 0.024	0.513GlnLys: 0.513 ± 0.017	2.266GlnLeu: 2.266 ± 0.037	0.445GlnMet: 0.445 ± 0.013	0.468GlnAsn: 0.468 ± 0.014	1.407GlnPro: 1.407 ± 0.028	0.872GlnGln: 0.872 ± 0.026	2.238GlnArg: 2.238 ± 0.027	1.044GlnSer: 1.044 ± 0.023	1.163GlnThr: 1.163 ± 0.024	2.212GlnVal: 2.212 ± 0.03	0.365GlnTrp: 0.365 ± 0.012	0.482GlnTyr: 0.482 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	11.477ArgAla: 11.477 ± 0.085	0.659ArgCys: 0.659 ± 0.017	5.383ArgAsp: 5.383 ± 0.054	4.941ArgGlu: 4.941 ± 0.051	2.549ArgPhe: 2.549 ± 0.035	6.632ArgGly: 6.632 ± 0.049	2.191ArgHis: 2.191 ± 0.025	3.076ArgIle: 3.076 ± 0.029	1.538ArgLys: 1.538 ± 0.032	10.021ArgLeu: 10.021 ± 0.074	1.863ArgMet: 1.863 ± 0.032	1.368ArgAsn: 1.368 ± 0.021	5.977ArgPro: 5.977 ± 0.051	2.064ArgGln: 2.064 ± 0.028	9.379ArgArg: 9.379 ± 0.081	3.911ArgSer: 3.911 ± 0.037	5.012ArgThr: 5.012 ± 0.044	6.891ArgVal: 6.891 ± 0.049	1.462ArgTrp: 1.462 ± 0.025	1.897ArgTyr: 1.897 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.301SerAla: 6.301 ± 0.051	0.37SerCys: 0.37 ± 0.013	2.489SerAsp: 2.489 ± 0.033	2.141SerGlu: 2.141 ± 0.033	1.451SerPhe: 1.451 ± 0.023	5.915SerGly: 5.915 ± 0.055	0.868SerHis: 0.868 ± 0.018	1.44SerIle: 1.44 ± 0.023	0.884SerLys: 0.884 ± 0.02	4.437SerLeu: 4.437 ± 0.045	1.057SerMet: 1.057 ± 0.02	0.787SerAsn: 0.787 ± 0.017	3.124SerPro: 3.124 ± 0.034	1.035SerGln: 1.035 ± 0.019	3.712SerArg: 3.712 ± 0.041	2.462SerSer: 2.462 ± 0.037	2.494SerThr: 2.494 ± 0.031	3.918SerVal: 3.918 ± 0.041	0.81SerTrp: 0.81 ± 0.019	1.104SerTyr: 1.104 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	7.933ThrAla: 7.933 ± 0.063	0.415ThrCys: 0.415 ± 0.013	2.979ThrAsp: 2.979 ± 0.035	2.7ThrGlu: 2.7 ± 0.03	1.594ThrPhe: 1.594 ± 0.028	6.456ThrGly: 6.456 ± 0.075	0.983ThrHis: 0.983 ± 0.019	1.788ThrIle: 1.788 ± 0.029	0.982ThrLys: 0.982 ± 0.021	5.376ThrLeu: 5.376 ± 0.044	0.956ThrMet: 0.956 ± 0.017	0.853ThrAsn: 0.853 ± 0.017	3.685ThrPro: 3.685 ± 0.043	1.047ThrGln: 1.047 ± 0.022	4.086ThrArg: 4.086 ± 0.04	2.841ThrSer: 2.841 ± 0.03	3.073ThrThr: 3.073 ± 0.046	5.44ThrVal: 5.44 ± 0.043	0.827ThrTrp: 0.827 ± 0.022	1.142ThrTyr: 1.142 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	11.725ValAla: 11.725 ± 0.079	0.762ValCys: 0.762 ± 0.017	4.953ValAsp: 4.953 ± 0.047	4.791ValGlu: 4.791 ± 0.044	2.554ValPhe: 2.554 ± 0.038	6.693ValGly: 6.693 ± 0.052	1.929ValHis: 1.929 ± 0.026	2.842ValIle: 2.842 ± 0.041	1.653ValLys: 1.653 ± 0.03	9.88ValLeu: 9.88 ± 0.07	1.404ValMet: 1.404 ± 0.021	1.677ValAsn: 1.677 ± 0.025	5.762ValPro: 5.762 ± 0.047	2.039ValGln: 2.039 ± 0.027	7.841ValArg: 7.841 ± 0.062	4.185ValSer: 4.185 ± 0.044	5.345ValThr: 5.345 ± 0.043	8.258ValVal: 8.258 ± 0.073	1.129ValTrp: 1.129 ± 0.022	1.586ValTyr: 1.586 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.632TrpAla: 1.632 ± 0.024	0.142TrpCys: 0.142 ± 0.007	0.856TrpAsp: 0.856 ± 0.022	0.701TrpGlu: 0.701 ± 0.016	0.47TrpPhe: 0.47 ± 0.014	1.058TrpGly: 1.058 ± 0.021	0.354TrpHis: 0.354 ± 0.011	0.533TrpIle: 0.533 ± 0.013	0.324TrpLys: 0.324 ± 0.012	1.72TrpLeu: 1.72 ± 0.025	0.274TrpMet: 0.274 ± 0.01	0.375TrpAsn: 0.375 ± 0.014	0.865TrpPro: 0.865 ± 0.018	0.446TrpGln: 0.446 ± 0.013	1.587TrpArg: 1.587 ± 0.024	0.831TrpSer: 0.831 ± 0.017	1.093TrpThr: 1.093 ± 0.021	0.952TrpVal: 0.952 ± 0.019	0.333TrpTrp: 0.333 ± 0.011	0.337TrpTyr: 0.337 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.571TyrAla: 2.571 ± 0.03	0.18TyrCys: 0.18 ± 0.008	1.344TyrAsp: 1.344 ± 0.027	1.161TyrGlu: 1.161 ± 0.022	0.617TyrPhe: 0.617 ± 0.017	2.166TyrGly: 2.166 ± 0.031	0.418TyrHis: 0.418 ± 0.012	0.483TyrIle: 0.483 ± 0.015	0.375TyrLys: 0.375 ± 0.014	2.108TyrLeu: 2.108 ± 0.027	0.273TyrMet: 0.273 ± 0.01	0.368TyrAsn: 0.368 ± 0.013	1.03TyrPro: 1.03 ± 0.021	0.546TyrGln: 0.546 ± 0.016	1.841TyrArg: 1.841 ± 0.024	0.914TyrSer: 0.914 ± 0.02	1.091TyrThr: 1.091 ± 0.021	1.642TyrVal: 1.642 ± 0.028	0.352TyrTrp: 0.352 ± 0.011	0.435TyrTyr: 0.435 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8099 proteins (2744976 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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