Amino acid dipepetide frequency for Halorhabdus tiamatea SARL4B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.753AlaAla: 11.753 ± 0.195
0.618AlaCys: 0.618 ± 0.034
9.745AlaAsp: 9.745 ± 0.124
8.993AlaGlu: 8.993 ± 0.137
3.749AlaPhe: 3.749 ± 0.074
9.062AlaGly: 9.062 ± 0.137
1.886AlaHis: 1.886 ± 0.049
5.577AlaIle: 5.577 ± 0.086
1.949AlaLys: 1.949 ± 0.051
9.691AlaLeu: 9.691 ± 0.155
2.137AlaMet: 2.137 ± 0.054
2.459AlaAsn: 2.459 ± 0.056
3.433AlaPro: 3.433 ± 0.069
2.226AlaGln: 2.226 ± 0.056
5.928AlaArg: 5.928 ± 0.086
5.181AlaSer: 5.181 ± 0.077
6.89AlaThr: 6.89 ± 0.104
9.824AlaVal: 9.824 ± 0.137
1.161AlaTrp: 1.161 ± 0.04
2.748AlaTyr: 2.748 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.475CysAla: 0.475 ± 0.029
0.06CysCys: 0.06 ± 0.007
0.539CysAsp: 0.539 ± 0.034
0.576CysGlu: 0.576 ± 0.031
0.126CysPhe: 0.126 ± 0.013
0.872CysGly: 0.872 ± 0.046
0.166CysHis: 0.166 ± 0.016
0.198CysIle: 0.198 ± 0.015
0.112CysLys: 0.112 ± 0.012
0.497CysLeu: 0.497 ± 0.026
0.095CysMet: 0.095 ± 0.009
0.161CysAsn: 0.161 ± 0.015
0.547CysPro: 0.547 ± 0.033
0.187CysGln: 0.187 ± 0.014
0.372CysArg: 0.372 ± 0.019
0.394CysSer: 0.394 ± 0.029
0.364CysThr: 0.364 ± 0.024
0.392CysVal: 0.392 ± 0.024
0.095CysTrp: 0.095 ± 0.011
0.16CysTyr: 0.16 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
9.978AspAla: 9.978 ± 0.136
0.558AspCys: 0.558 ± 0.027
7.867AspAsp: 7.867 ± 0.138
7.972AspGlu: 7.972 ± 0.12
2.446AspPhe: 2.446 ± 0.06
8.182AspGly: 8.182 ± 0.14
1.983AspHis: 1.983 ± 0.052
3.28AspIle: 3.28 ± 0.067
0.898AspLys: 0.898 ± 0.036
7.533AspLeu: 7.533 ± 0.102
1.167AspMet: 1.167 ± 0.04
1.439AspAsn: 1.439 ± 0.048
4.895AspPro: 4.895 ± 0.08
2.009AspGln: 2.009 ± 0.045
7.102AspArg: 7.102 ± 0.109
3.946AspSer: 3.946 ± 0.088
4.222AspThr: 4.222 ± 0.074
8.568AspVal: 8.568 ± 0.116
1.063AspTrp: 1.063 ± 0.038
1.864AspTyr: 1.864 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
8.914GluAla: 8.914 ± 0.139
0.571GluCys: 0.571 ± 0.03
6.708GluAsp: 6.708 ± 0.107
7.064GluGlu: 7.064 ± 0.127
2.861GluPhe: 2.861 ± 0.065
5.464GluGly: 5.464 ± 0.081
2.17GluHis: 2.17 ± 0.052
4.404GluIle: 4.404 ± 0.08
2.028GluLys: 2.028 ± 0.054
7.272GluLeu: 7.272 ± 0.107
2.037GluMet: 2.037 ± 0.054
2.702GluAsn: 2.702 ± 0.064
4.044GluPro: 4.044 ± 0.077
3.103GluGln: 3.103 ± 0.063
7.364GluArg: 7.364 ± 0.119
5.636GluSer: 5.636 ± 0.1
7.455GluThr: 7.455 ± 0.124
5.432GluVal: 5.432 ± 0.092
1.294GluTrp: 1.294 ± 0.041
3.035GluTyr: 3.035 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.389PheAla: 3.389 ± 0.074
0.237PheCys: 0.237 ± 0.019
3.295PheAsp: 3.295 ± 0.061
3.636PheGlu: 3.636 ± 0.069
1.013PhePhe: 1.013 ± 0.043
3.139PheGly: 3.139 ± 0.062
0.629PheHis: 0.629 ± 0.025
1.047PheIle: 1.047 ± 0.035
0.506PheLys: 0.506 ± 0.026
2.76PheLeu: 2.76 ± 0.071
0.48PheMet: 0.48 ± 0.022
0.719PheAsn: 0.719 ± 0.033
1.336PhePro: 1.336 ± 0.039
0.804PheGln: 0.804 ± 0.03
1.807PheArg: 1.807 ± 0.043
1.63PheSer: 1.63 ± 0.042
1.828PheThr: 1.828 ± 0.051
3.138PheVal: 3.138 ± 0.07
0.42PheTrp: 0.42 ± 0.025
0.873PheTyr: 0.873 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
7.209GlyAla: 7.209 ± 0.119
0.575GlyCys: 0.575 ± 0.03
6.715GlyAsp: 6.715 ± 0.095
7.547GlyGlu: 7.547 ± 0.118
2.956GlyPhe: 2.956 ± 0.06
6.861GlyGly: 6.861 ± 0.124
1.719GlyHis: 1.719 ± 0.051
4.161GlyIle: 4.161 ± 0.071
1.762GlyLys: 1.762 ± 0.051
7.098GlyLeu: 7.098 ± 0.12
1.624GlyMet: 1.624 ± 0.051
2.051GlyAsn: 2.051 ± 0.056
3.124GlyPro: 3.124 ± 0.068
2.23GlyGln: 2.23 ± 0.05
4.683GlyArg: 4.683 ± 0.082
5.051GlySer: 5.051 ± 0.096
5.669GlyThr: 5.669 ± 0.091
7.367GlyVal: 7.367 ± 0.113
1.079GlyTrp: 1.079 ± 0.039
2.53GlyTyr: 2.53 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
2.068HisAla: 2.068 ± 0.05
0.186HisCys: 0.186 ± 0.019
1.969HisAsp: 1.969 ± 0.043
1.719HisGlu: 1.719 ± 0.049
0.606HisPhe: 0.606 ± 0.027
1.75HisGly: 1.75 ± 0.048
0.503HisHis: 0.503 ± 0.025
0.744HisIle: 0.744 ± 0.029
0.26HisLys: 0.26 ± 0.017
1.834HisLeu: 1.834 ± 0.054
0.314HisMet: 0.314 ± 0.022
0.513HisAsn: 0.513 ± 0.027
1.282HisPro: 1.282 ± 0.046
0.522HisGln: 0.522 ± 0.028
1.38HisArg: 1.38 ± 0.041
0.891HisSer: 0.891 ± 0.03
1.125HisThr: 1.125 ± 0.041
1.916HisVal: 1.916 ± 0.054
0.254HisTrp: 0.254 ± 0.018
0.652HisTyr: 0.652 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.105IleAla: 5.105 ± 0.093
0.243IleCys: 0.243 ± 0.018
4.725IleAsp: 4.725 ± 0.092
5.133IleGlu: 5.133 ± 0.085
0.985IlePhe: 0.985 ± 0.038
3.997IleGly: 3.997 ± 0.074
0.881IleHis: 0.881 ± 0.029
1.229IleIle: 1.229 ± 0.038
0.807IleLys: 0.807 ± 0.03
3.092IleLeu: 3.092 ± 0.066
0.548IleMet: 0.548 ± 0.024
1.025IleAsn: 1.025 ± 0.04
2.154IlePro: 2.154 ± 0.053
1.233IleGln: 1.233 ± 0.041
2.608IleArg: 2.608 ± 0.062
2.163IleSer: 2.163 ± 0.06
2.643IleThr: 2.643 ± 0.062
4.013IleVal: 4.013 ± 0.088
0.354IleTrp: 0.354 ± 0.02
0.993IleTyr: 0.993 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
1.751LysAla: 1.751 ± 0.045
0.141LysCys: 0.141 ± 0.013
1.212LysAsp: 1.212 ± 0.047
1.385LysGlu: 1.385 ± 0.043
0.512LysPhe: 0.512 ± 0.027
1.253LysGly: 1.253 ± 0.046
0.492LysHis: 0.492 ± 0.026
0.816LysIle: 0.816 ± 0.033
0.484LysLys: 0.484 ± 0.024
1.719LysLeu: 1.719 ± 0.049
0.37LysMet: 0.37 ± 0.021
0.552LysAsn: 0.552 ± 0.028
0.889LysPro: 0.889 ± 0.034
0.867LysGln: 0.867 ± 0.037
1.687LysArg: 1.687 ± 0.047
1.119LysSer: 1.119 ± 0.041
1.365LysThr: 1.365 ± 0.043
1.144LysVal: 1.144 ± 0.04
0.228LysTrp: 0.228 ± 0.017
0.581LysTyr: 0.581 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
10.997LeuAla: 10.997 ± 0.165
0.445LeuCys: 0.445 ± 0.025
7.775LeuAsp: 7.775 ± 0.105
7.767LeuGlu: 7.767 ± 0.107
2.922LeuPhe: 2.922 ± 0.063
7.275LeuGly: 7.275 ± 0.123
1.452LeuHis: 1.452 ± 0.041
3.078LeuIle: 3.078 ± 0.075
1.558LeuLys: 1.558 ± 0.047
8.233LeuLeu: 8.233 ± 0.135
1.211LeuMet: 1.211 ± 0.042
1.811LeuAsn: 1.811 ± 0.054
4.09LeuPro: 4.09 ± 0.071
2.373LeuGln: 2.373 ± 0.059
5.397LeuArg: 5.397 ± 0.084
5.617LeuSer: 5.617 ± 0.073
5.284LeuThr: 5.284 ± 0.09
7.689LeuVal: 7.689 ± 0.119
0.877LeuTrp: 0.877 ± 0.031
2.17LeuTyr: 2.17 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
1.876MetAla: 1.876 ± 0.048
0.074MetCys: 0.074 ± 0.009
1.446MetAsp: 1.446 ± 0.05
1.144MetGlu: 1.144 ± 0.039
0.477MetPhe: 0.477 ± 0.024
1.372MetGly: 1.372 ± 0.043
0.39MetHis: 0.39 ± 0.022
0.701MetIle: 0.701 ± 0.033
0.408MetLys: 0.408 ± 0.02
1.42MetLeu: 1.42 ± 0.043
0.317MetMet: 0.317 ± 0.02
0.603MetAsn: 0.603 ± 0.026
0.806MetPro: 0.806 ± 0.034
0.523MetGln: 0.523 ± 0.023
1.044MetArg: 1.044 ± 0.033
1.467MetSer: 1.467 ± 0.039
1.561MetThr: 1.561 ± 0.046
1.225MetVal: 1.225 ± 0.04
0.128MetTrp: 0.128 ± 0.012
0.383MetTyr: 0.383 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.545AsnAla: 2.545 ± 0.058
0.16AsnCys: 0.16 ± 0.013
1.889AsnAsp: 1.889 ± 0.055
1.869AsnGlu: 1.869 ± 0.057
0.741AsnPhe: 0.741 ± 0.032
2.041AsnGly: 2.041 ± 0.061
0.552AsnHis: 0.552 ± 0.024
0.912AsnIle: 0.912 ± 0.034
0.441AsnLys: 0.441 ± 0.025
2.156AsnLeu: 2.156 ± 0.054
0.433AsnMet: 0.433 ± 0.025
0.597AsnAsn: 0.597 ± 0.031
1.576AsnPro: 1.576 ± 0.043
0.736AsnGln: 0.736 ± 0.035
1.578AsnArg: 1.578 ± 0.039
1.064AsnSer: 1.064 ± 0.037
1.319AsnThr: 1.319 ± 0.044
2.341AsnVal: 2.341 ± 0.056
0.329AsnTrp: 0.329 ± 0.019
0.709AsnTyr: 0.709 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
4.771ProAla: 4.771 ± 0.083
0.208ProCys: 0.208 ± 0.016
4.913ProAsp: 4.913 ± 0.081
4.568ProGlu: 4.568 ± 0.076
1.515ProPhe: 1.515 ± 0.049
3.713ProGly: 3.713 ± 0.074
0.844ProHis: 0.844 ± 0.034
2.162ProIle: 2.162 ± 0.05
0.813ProLys: 0.813 ± 0.033
3.618ProLeu: 3.618 ± 0.068
0.802ProMet: 0.802 ± 0.027
1.117ProAsn: 1.117 ± 0.037
2.214ProPro: 2.214 ± 0.057
1.009ProGln: 1.009 ± 0.034
2.153ProArg: 2.153 ± 0.053
2.581ProSer: 2.581 ± 0.055
3.264ProThr: 3.264 ± 0.072
3.878ProVal: 3.878 ± 0.067
0.531ProTrp: 0.531 ± 0.028
1.25ProTyr: 1.25 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
2.841GlnAla: 2.841 ± 0.062
0.223GlnCys: 0.223 ± 0.02
1.672GlnAsp: 1.672 ± 0.049
1.852GlnGlu: 1.852 ± 0.048
1.092GlnPhe: 1.092 ± 0.035
1.648GlnGly: 1.648 ± 0.046
0.611GlnHis: 0.611 ± 0.025
1.263GlnIle: 1.263 ± 0.037
0.629GlnLys: 0.629 ± 0.035
2.625GlnLeu: 2.625 ± 0.054
0.578GlnMet: 0.578 ± 0.024
0.743GlnAsn: 0.743 ± 0.031
1.265GlnPro: 1.265 ± 0.038
1.165GlnGln: 1.165 ± 0.044
2.177GlnArg: 2.177 ± 0.056
1.847GlnSer: 1.847 ± 0.056
1.888GlnThr: 1.888 ± 0.047
1.806GlnVal: 1.806 ± 0.046
0.404GlnTrp: 0.404 ± 0.022
0.956GlnTyr: 0.956 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
5.997ArgAla: 5.997 ± 0.102
0.469ArgCys: 0.469 ± 0.029
5.209ArgAsp: 5.209 ± 0.084
7.0ArgGlu: 7.0 ± 0.115
2.349ArgPhe: 2.349 ± 0.053
4.151ArgGly: 4.151 ± 0.076
1.314ArgHis: 1.314 ± 0.046
3.169ArgIle: 3.169 ± 0.063
1.496ArgLys: 1.496 ± 0.046
6.17ArgLeu: 6.17 ± 0.102
1.224ArgMet: 1.224 ± 0.035
1.579ArgAsn: 1.579 ± 0.041
2.495ArgPro: 2.495 ± 0.063
2.009ArgGln: 2.009 ± 0.052
4.777ArgArg: 4.777 ± 0.084
3.581ArgSer: 3.581 ± 0.068
4.013ArgThr: 4.013 ± 0.077
4.881ArgVal: 4.881 ± 0.086
0.83ArgTrp: 0.83 ± 0.03
1.957ArgTyr: 1.957 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
5.382SerAla: 5.382 ± 0.09
0.313SerCys: 0.313 ± 0.022
4.334SerAsp: 4.334 ± 0.078
4.372SerGlu: 4.372 ± 0.092
1.854SerPhe: 1.854 ± 0.046
5.127SerGly: 5.127 ± 0.081
1.039SerHis: 1.039 ± 0.035
2.925SerIle: 2.925 ± 0.064
1.175SerLys: 1.175 ± 0.037
4.868SerLeu: 4.868 ± 0.09
1.11SerMet: 1.11 ± 0.039
1.363SerAsn: 1.363 ± 0.048
2.69SerPro: 2.69 ± 0.059
1.608SerGln: 1.608 ± 0.043
3.235SerArg: 3.235 ± 0.061
2.825SerSer: 2.825 ± 0.07
3.67SerThr: 3.67 ± 0.077
5.025SerVal: 5.025 ± 0.073
0.651SerTrp: 0.651 ± 0.031
1.366SerTyr: 1.366 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
6.896ThrAla: 6.896 ± 0.094
0.407ThrCys: 0.407 ± 0.031
6.169ThrAsp: 6.169 ± 0.105
4.887ThrGlu: 4.887 ± 0.086
2.25ThrPhe: 2.25 ± 0.054
5.578ThrGly: 5.578 ± 0.088
1.287ThrHis: 1.287 ± 0.042
3.44ThrIle: 3.44 ± 0.059
1.086ThrLys: 1.086 ± 0.04
5.869ThrLeu: 5.869 ± 0.078
0.992ThrMet: 0.992 ± 0.037
1.517ThrAsn: 1.517 ± 0.045
3.3ThrPro: 3.3 ± 0.06
1.441ThrGln: 1.441 ± 0.044
3.28ThrArg: 3.28 ± 0.063
2.937ThrSer: 2.937 ± 0.065
4.615ThrThr: 4.615 ± 0.102
7.088ThrVal: 7.088 ± 0.108
0.711ThrTrp: 0.711 ± 0.032
1.91ThrTyr: 1.91 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
9.319ValAla: 9.319 ± 0.14
0.572ValCys: 0.572 ± 0.032
7.1ValAsp: 7.1 ± 0.106
8.649ValGlu: 8.649 ± 0.12
2.899ValPhe: 2.899 ± 0.067
7.391ValGly: 7.391 ± 0.126
1.645ValHis: 1.645 ± 0.055
3.541ValIle: 3.541 ± 0.068
1.365ValLys: 1.365 ± 0.046
7.773ValLeu: 7.773 ± 0.125
1.368ValMet: 1.368 ± 0.045
1.906ValAsn: 1.906 ± 0.043
4.062ValPro: 4.062 ± 0.069
1.96ValGln: 1.96 ± 0.051
5.097ValArg: 5.097 ± 0.089
5.091ValSer: 5.091 ± 0.079
6.187ValThr: 6.187 ± 0.101
8.16ValVal: 8.16 ± 0.146
0.855ValTrp: 0.855 ± 0.031
2.153ValTyr: 2.153 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.986TrpAla: 0.986 ± 0.035
0.078TrpCys: 0.078 ± 0.01
0.909TrpAsp: 0.909 ± 0.033
0.91TrpGlu: 0.91 ± 0.035
0.481TrpPhe: 0.481 ± 0.026
0.834TrpGly: 0.834 ± 0.029
0.242TrpHis: 0.242 ± 0.018
0.564TrpIle: 0.564 ± 0.027
0.301TrpLys: 0.301 ± 0.019
1.307TrpLeu: 1.307 ± 0.045
0.204TrpMet: 0.204 ± 0.019
0.414TrpAsn: 0.414 ± 0.026
0.441TrpPro: 0.441 ± 0.021
0.406TrpGln: 0.406 ± 0.023
0.889TrpArg: 0.889 ± 0.036
0.674TrpSer: 0.674 ± 0.029
0.8TrpThr: 0.8 ± 0.032
0.799TrpVal: 0.799 ± 0.031
0.215TrpTrp: 0.215 ± 0.017
0.4TrpTyr: 0.4 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.757TyrAla: 2.757 ± 0.057
0.252TyrCys: 0.252 ± 0.021
2.781TyrAsp: 2.781 ± 0.062
2.516TyrGlu: 2.516 ± 0.069
0.853TyrPhe: 0.853 ± 0.034
2.301TyrGly: 2.301 ± 0.047
0.686TyrHis: 0.686 ± 0.03
0.719TyrIle: 0.719 ± 0.032
0.488TyrLys: 0.488 ± 0.027
2.483TyrLeu: 2.483 ± 0.055
0.356TyrMet: 0.356 ± 0.02
0.719TyrAsn: 0.719 ± 0.031
1.279TyrPro: 1.279 ± 0.045
0.873TyrGln: 0.873 ± 0.033
2.111TyrArg: 2.111 ± 0.05
1.233TyrSer: 1.233 ± 0.037
1.498TyrThr: 1.498 ± 0.042
2.408TyrVal: 2.408 ± 0.054
0.377TyrTrp: 0.377 ± 0.022
0.902TyrTyr: 0.902 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2988 proteins (856988 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski