Amino acid dipepetide frequency for Rhizobium phage vB_RleM_PPF1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.213AlaAla: 18.213 ± 1.149
1.724AlaCys: 1.724 ± 0.383
8.503AlaAsp: 8.503 ± 0.646
7.124AlaGlu: 7.124 ± 0.658
4.022AlaPhe: 4.022 ± 0.573
9.94AlaGly: 9.94 ± 0.761
1.551AlaHis: 1.551 ± 0.299
6.55AlaIle: 6.55 ± 0.509
5.056AlaLys: 5.056 ± 0.471
9.767AlaLeu: 9.767 ± 0.809
3.907AlaMet: 3.907 ± 0.493
3.964AlaAsn: 3.964 ± 0.598
5.343AlaPro: 5.343 ± 0.439
3.045AlaGln: 3.045 ± 0.397
7.354AlaArg: 7.354 ± 0.636
5.918AlaSer: 5.918 ± 0.599
6.722AlaThr: 6.722 ± 0.743
7.297AlaVal: 7.297 ± 0.725
2.241AlaTrp: 2.241 ± 0.351
2.011AlaTyr: 2.011 ± 0.263
0.0AlaXaa: 0.0 ± 0.0
Cys
0.919CysAla: 0.919 ± 0.19
0.402CysCys: 0.402 ± 0.204
0.862CysAsp: 0.862 ± 0.236
0.632CysGlu: 0.632 ± 0.233
0.46CysPhe: 0.46 ± 0.166
1.264CysGly: 1.264 ± 0.319
0.575CysHis: 0.575 ± 0.24
0.23CysIle: 0.23 ± 0.102
0.287CysLys: 0.287 ± 0.13
0.747CysLeu: 0.747 ± 0.197
0.402CysMet: 0.402 ± 0.135
0.46CysAsn: 0.46 ± 0.148
0.747CysPro: 0.747 ± 0.205
0.115CysGln: 0.115 ± 0.085
1.207CysArg: 1.207 ± 0.355
0.575CysSer: 0.575 ± 0.217
0.517CysThr: 0.517 ± 0.163
0.689CysVal: 0.689 ± 0.193
0.23CysTrp: 0.23 ± 0.121
0.46CysTyr: 0.46 ± 0.153
0.0CysXaa: 0.0 ± 0.0
Asp
7.871AspAla: 7.871 ± 0.647
0.517AspCys: 0.517 ± 0.176
4.022AspAsp: 4.022 ± 0.489
4.137AspGlu: 4.137 ± 0.586
2.356AspPhe: 2.356 ± 0.352
6.722AspGly: 6.722 ± 0.686
0.919AspHis: 0.919 ± 0.223
2.815AspIle: 2.815 ± 0.419
2.413AspLys: 2.413 ± 0.359
6.09AspLeu: 6.09 ± 0.645
0.919AspMet: 0.919 ± 0.242
1.379AspAsn: 1.379 ± 0.255
4.079AspPro: 4.079 ± 0.557
1.953AspGln: 1.953 ± 0.43
5.171AspArg: 5.171 ± 0.465
2.643AspSer: 2.643 ± 0.341
3.562AspThr: 3.562 ± 0.41
3.907AspVal: 3.907 ± 0.465
0.862AspTrp: 0.862 ± 0.249
1.953AspTyr: 1.953 ± 0.328
0.0AspXaa: 0.0 ± 0.0
Glu
6.665GluAla: 6.665 ± 0.523
1.149GluCys: 1.149 ± 0.327
3.045GluAsp: 3.045 ± 0.319
3.677GluGlu: 3.677 ± 0.466
2.183GluPhe: 2.183 ± 0.323
3.792GluGly: 3.792 ± 0.388
1.264GluHis: 1.264 ± 0.241
4.424GluIle: 4.424 ± 0.57
2.585GluLys: 2.585 ± 0.394
4.884GluLeu: 4.884 ± 0.452
1.724GluMet: 1.724 ± 0.3
2.011GluAsn: 2.011 ± 0.311
3.332GluPro: 3.332 ± 0.414
1.953GluGln: 1.953 ± 0.363
4.194GluArg: 4.194 ± 0.49
1.724GluSer: 1.724 ± 0.284
3.62GluThr: 3.62 ± 0.514
3.505GluVal: 3.505 ± 0.426
1.264GluTrp: 1.264 ± 0.261
1.034GluTyr: 1.034 ± 0.214
0.0GluXaa: 0.0 ± 0.0
Phe
3.217PheAla: 3.217 ± 0.409
0.402PheCys: 0.402 ± 0.162
2.93PheAsp: 2.93 ± 0.326
2.413PheGlu: 2.413 ± 0.333
1.149PhePhe: 1.149 ± 0.269
2.585PheGly: 2.585 ± 0.406
0.575PheHis: 0.575 ± 0.161
1.494PheIle: 1.494 ± 0.265
1.207PheLys: 1.207 ± 0.279
2.585PheLeu: 2.585 ± 0.358
0.689PheMet: 0.689 ± 0.188
0.977PheAsn: 0.977 ± 0.264
1.666PhePro: 1.666 ± 0.283
0.919PheGln: 0.919 ± 0.199
2.7PheArg: 2.7 ± 0.34
1.896PheSer: 1.896 ± 0.307
1.494PheThr: 1.494 ± 0.282
2.471PheVal: 2.471 ± 0.356
0.172PheTrp: 0.172 ± 0.123
0.517PheTyr: 0.517 ± 0.171
0.0PheXaa: 0.0 ± 0.0
Gly
7.986GlyAla: 7.986 ± 0.748
0.977GlyCys: 0.977 ± 0.236
5.516GlyAsp: 5.516 ± 0.601
5.113GlyGlu: 5.113 ± 0.524
2.93GlyPhe: 2.93 ± 0.399
7.469GlyGly: 7.469 ± 0.626
1.724GlyHis: 1.724 ± 0.341
4.769GlyIle: 4.769 ± 0.488
3.39GlyLys: 3.39 ± 0.38
6.148GlyLeu: 6.148 ± 0.566
2.183GlyMet: 2.183 ± 0.314
2.585GlyAsn: 2.585 ± 0.394
2.241GlyPro: 2.241 ± 0.353
3.045GlyGln: 3.045 ± 0.512
6.492GlyArg: 6.492 ± 0.676
4.711GlySer: 4.711 ± 0.578
4.941GlyThr: 4.941 ± 0.517
4.769GlyVal: 4.769 ± 0.581
1.149GlyTrp: 1.149 ± 0.268
2.413GlyTyr: 2.413 ± 0.336
0.0GlyXaa: 0.0 ± 0.0
His
1.724HisAla: 1.724 ± 0.325
0.402HisCys: 0.402 ± 0.187
0.862HisAsp: 0.862 ± 0.22
1.149HisGlu: 1.149 ± 0.249
0.919HisPhe: 0.919 ± 0.214
1.379HisGly: 1.379 ± 0.341
0.689HisHis: 0.689 ± 0.219
1.207HisIle: 1.207 ± 0.214
1.034HisLys: 1.034 ± 0.231
1.666HisLeu: 1.666 ± 0.313
0.402HisMet: 0.402 ± 0.178
0.517HisAsn: 0.517 ± 0.205
1.264HisPro: 1.264 ± 0.335
0.689HisGln: 0.689 ± 0.21
2.068HisArg: 2.068 ± 0.37
1.034HisSer: 1.034 ± 0.254
1.149HisThr: 1.149 ± 0.28
1.321HisVal: 1.321 ± 0.225
0.115HisTrp: 0.115 ± 0.076
0.689HisTyr: 0.689 ± 0.196
0.0HisXaa: 0.0 ± 0.0
Ile
7.182IleAla: 7.182 ± 0.674
0.689IleCys: 0.689 ± 0.18
4.367IleAsp: 4.367 ± 0.557
4.137IleGlu: 4.137 ± 0.487
1.494IlePhe: 1.494 ± 0.258
4.194IleGly: 4.194 ± 0.544
0.804IleHis: 0.804 ± 0.259
2.241IleIle: 2.241 ± 0.331
2.873IleLys: 2.873 ± 0.386
3.39IleLeu: 3.39 ± 0.416
1.207IleMet: 1.207 ± 0.279
1.551IleAsn: 1.551 ± 0.243
2.241IlePro: 2.241 ± 0.353
1.321IleGln: 1.321 ± 0.229
3.275IleArg: 3.275 ± 0.434
3.275IleSer: 3.275 ± 0.518
3.275IleThr: 3.275 ± 0.559
3.16IleVal: 3.16 ± 0.33
0.977IleTrp: 0.977 ± 0.251
1.551IleTyr: 1.551 ± 0.324
0.0IleXaa: 0.0 ± 0.0
Lys
5.803LysAla: 5.803 ± 0.571
0.402LysCys: 0.402 ± 0.156
2.183LysAsp: 2.183 ± 0.284
1.896LysGlu: 1.896 ± 0.378
1.034LysPhe: 1.034 ± 0.215
2.93LysGly: 2.93 ± 0.518
0.575LysHis: 0.575 ± 0.163
2.126LysIle: 2.126 ± 0.369
1.953LysLys: 1.953 ± 0.354
3.62LysLeu: 3.62 ± 0.459
1.207LysMet: 1.207 ± 0.262
0.747LysAsn: 0.747 ± 0.166
2.758LysPro: 2.758 ± 0.388
1.379LysGln: 1.379 ± 0.284
3.792LysArg: 3.792 ± 0.48
2.93LysSer: 2.93 ± 0.413
2.241LysThr: 2.241 ± 0.481
2.471LysVal: 2.471 ± 0.411
0.632LysTrp: 0.632 ± 0.199
0.345LysTyr: 0.345 ± 0.154
0.0LysXaa: 0.0 ± 0.0
Leu
11.548LeuAla: 11.548 ± 0.808
0.804LeuCys: 0.804 ± 0.201
4.711LeuAsp: 4.711 ± 0.509
4.079LeuGlu: 4.079 ± 0.387
2.7LeuPhe: 2.7 ± 0.438
5.113LeuGly: 5.113 ± 0.417
1.494LeuHis: 1.494 ± 0.296
4.424LeuIle: 4.424 ± 0.493
2.758LeuLys: 2.758 ± 0.393
6.435LeuLeu: 6.435 ± 0.716
2.241LeuMet: 2.241 ± 0.359
2.241LeuAsn: 2.241 ± 0.375
4.999LeuPro: 4.999 ± 0.533
2.471LeuGln: 2.471 ± 0.334
6.55LeuArg: 6.55 ± 0.637
4.999LeuSer: 4.999 ± 0.534
4.769LeuThr: 4.769 ± 0.537
5.056LeuVal: 5.056 ± 0.488
1.494LeuTrp: 1.494 ± 0.322
2.183LeuTyr: 2.183 ± 0.389
0.0LeuXaa: 0.0 ± 0.0
Met
4.309MetAla: 4.309 ± 0.418
0.0MetCys: 0.0 ± 0.0
1.379MetAsp: 1.379 ± 0.299
1.321MetGlu: 1.321 ± 0.268
0.804MetPhe: 0.804 ± 0.211
1.379MetGly: 1.379 ± 0.25
0.517MetHis: 0.517 ± 0.151
1.034MetIle: 1.034 ± 0.205
1.207MetLys: 1.207 ± 0.251
2.298MetLeu: 2.298 ± 0.335
0.804MetMet: 0.804 ± 0.243
0.862MetAsn: 0.862 ± 0.208
1.436MetPro: 1.436 ± 0.294
0.632MetGln: 0.632 ± 0.206
2.528MetArg: 2.528 ± 0.414
2.126MetSer: 2.126 ± 0.356
1.953MetThr: 1.953 ± 0.312
1.896MetVal: 1.896 ± 0.338
0.287MetTrp: 0.287 ± 0.119
0.115MetTyr: 0.115 ± 0.092
0.0MetXaa: 0.0 ± 0.0
Asn
3.677AsnAla: 3.677 ± 0.487
0.287AsnCys: 0.287 ± 0.145
1.781AsnAsp: 1.781 ± 0.296
1.149AsnGlu: 1.149 ± 0.218
1.092AsnPhe: 1.092 ± 0.244
3.217AsnGly: 3.217 ± 0.41
0.632AsnHis: 0.632 ± 0.241
1.666AsnIle: 1.666 ± 0.318
0.747AsnLys: 0.747 ± 0.224
2.93AsnLeu: 2.93 ± 0.361
0.919AsnMet: 0.919 ± 0.253
0.862AsnAsn: 0.862 ± 0.242
2.413AsnPro: 2.413 ± 0.346
1.034AsnGln: 1.034 ± 0.247
1.953AsnArg: 1.953 ± 0.31
2.126AsnSer: 2.126 ± 0.44
1.551AsnThr: 1.551 ± 0.386
1.609AsnVal: 1.609 ± 0.298
0.632AsnTrp: 0.632 ± 0.206
0.517AsnTyr: 0.517 ± 0.18
0.0AsnXaa: 0.0 ± 0.0
Pro
5.401ProAla: 5.401 ± 0.582
0.517ProCys: 0.517 ± 0.157
4.079ProAsp: 4.079 ± 0.523
3.045ProGlu: 3.045 ± 0.406
2.126ProPhe: 2.126 ± 0.354
3.849ProGly: 3.849 ± 0.535
1.149ProHis: 1.149 ± 0.272
3.16ProIle: 3.16 ± 0.462
2.413ProLys: 2.413 ± 0.365
3.332ProLeu: 3.332 ± 0.647
1.436ProMet: 1.436 ± 0.292
1.666ProAsn: 1.666 ± 0.322
2.471ProPro: 2.471 ± 0.415
1.379ProGln: 1.379 ± 0.297
2.873ProArg: 2.873 ± 0.362
3.735ProSer: 3.735 ± 0.569
2.758ProThr: 2.758 ± 0.41
4.022ProVal: 4.022 ± 0.46
0.46ProTrp: 0.46 ± 0.158
1.724ProTyr: 1.724 ± 0.34
0.0ProXaa: 0.0 ± 0.0
Gln
3.39GlnAla: 3.39 ± 0.444
0.23GlnCys: 0.23 ± 0.125
1.379GlnAsp: 1.379 ± 0.249
1.551GlnGlu: 1.551 ± 0.297
0.862GlnPhe: 0.862 ± 0.194
2.7GlnGly: 2.7 ± 0.347
0.804GlnHis: 0.804 ± 0.177
1.551GlnIle: 1.551 ± 0.274
1.321GlnLys: 1.321 ± 0.302
2.356GlnLeu: 2.356 ± 0.393
1.092GlnMet: 1.092 ± 0.23
0.804GlnAsn: 0.804 ± 0.224
1.666GlnPro: 1.666 ± 0.313
2.011GlnGln: 2.011 ± 0.351
2.068GlnArg: 2.068 ± 0.426
2.126GlnSer: 2.126 ± 0.282
1.839GlnThr: 1.839 ± 0.298
1.839GlnVal: 1.839 ± 0.336
0.689GlnTrp: 0.689 ± 0.192
0.804GlnTyr: 0.804 ± 0.227
0.0GlnXaa: 0.0 ± 0.0
Arg
7.699ArgAla: 7.699 ± 0.603
1.034ArgCys: 1.034 ± 0.224
4.999ArgAsp: 4.999 ± 0.591
4.711ArgGlu: 4.711 ± 0.549
1.724ArgPhe: 1.724 ± 0.278
5.286ArgGly: 5.286 ± 0.657
2.241ArgHis: 2.241 ± 0.405
3.907ArgIle: 3.907 ± 0.457
3.045ArgLys: 3.045 ± 0.427
6.033ArgLeu: 6.033 ± 0.57
2.356ArgMet: 2.356 ± 0.353
2.298ArgAsn: 2.298 ± 0.377
3.562ArgPro: 3.562 ± 0.381
2.815ArgGln: 2.815 ± 0.393
5.688ArgArg: 5.688 ± 0.585
4.711ArgSer: 4.711 ± 0.509
3.217ArgThr: 3.217 ± 0.395
4.194ArgVal: 4.194 ± 0.466
1.781ArgTrp: 1.781 ± 0.282
1.781ArgTyr: 1.781 ± 0.291
0.0ArgXaa: 0.0 ± 0.0
Ser
7.412SerAla: 7.412 ± 0.791
0.689SerCys: 0.689 ± 0.186
3.677SerAsp: 3.677 ± 0.524
3.16SerGlu: 3.16 ± 0.397
1.781SerPhe: 1.781 ± 0.309
5.86SerGly: 5.86 ± 0.602
1.034SerHis: 1.034 ± 0.262
2.988SerIle: 2.988 ± 0.349
2.471SerLys: 2.471 ± 0.487
4.309SerLeu: 4.309 ± 0.545
2.011SerMet: 2.011 ± 0.297
1.896SerAsn: 1.896 ± 0.393
2.7SerPro: 2.7 ± 0.405
1.149SerGln: 1.149 ± 0.253
4.022SerArg: 4.022 ± 0.456
3.735SerSer: 3.735 ± 0.549
2.585SerThr: 2.585 ± 0.401
5.113SerVal: 5.113 ± 0.655
1.149SerTrp: 1.149 ± 0.224
1.666SerTyr: 1.666 ± 0.284
0.0SerXaa: 0.0 ± 0.0
Thr
6.09ThrAla: 6.09 ± 0.666
0.345ThrCys: 0.345 ± 0.124
3.332ThrAsp: 3.332 ± 0.423
2.643ThrGlu: 2.643 ± 0.487
1.494ThrPhe: 1.494 ± 0.311
5.343ThrGly: 5.343 ± 0.541
1.207ThrHis: 1.207 ± 0.264
3.39ThrIle: 3.39 ± 0.382
2.471ThrLys: 2.471 ± 0.5
5.056ThrLeu: 5.056 ± 0.471
1.264ThrMet: 1.264 ± 0.317
2.068ThrAsn: 2.068 ± 0.354
4.022ThrPro: 4.022 ± 0.443
1.321ThrGln: 1.321 ± 0.302
2.93ThrArg: 2.93 ± 0.425
2.815ThrSer: 2.815 ± 0.382
3.562ThrThr: 3.562 ± 0.469
5.516ThrVal: 5.516 ± 0.557
1.321ThrTrp: 1.321 ± 0.265
1.896ThrTyr: 1.896 ± 0.327
0.0ThrXaa: 0.0 ± 0.0
Val
6.895ValAla: 6.895 ± 0.689
0.517ValCys: 0.517 ± 0.149
4.367ValAsp: 4.367 ± 0.463
3.792ValGlu: 3.792 ± 0.423
1.781ValPhe: 1.781 ± 0.276
4.424ValGly: 4.424 ± 0.574
1.379ValHis: 1.379 ± 0.276
3.332ValIle: 3.332 ± 0.4
2.413ValLys: 2.413 ± 0.393
5.286ValLeu: 5.286 ± 0.485
1.379ValMet: 1.379 ± 0.236
2.643ValAsn: 2.643 ± 0.38
2.93ValPro: 2.93 ± 0.322
1.551ValGln: 1.551 ± 0.267
4.481ValArg: 4.481 ± 0.475
5.516ValSer: 5.516 ± 0.584
6.148ValThr: 6.148 ± 0.591
4.367ValVal: 4.367 ± 0.503
0.977ValTrp: 0.977 ± 0.215
1.494ValTyr: 1.494 ± 0.331
0.0ValXaa: 0.0 ± 0.0
Trp
1.724TrpAla: 1.724 ± 0.331
0.287TrpCys: 0.287 ± 0.123
0.689TrpAsp: 0.689 ± 0.175
0.575TrpGlu: 0.575 ± 0.166
0.632TrpPhe: 0.632 ± 0.209
0.862TrpGly: 0.862 ± 0.245
0.517TrpHis: 0.517 ± 0.155
0.862TrpIle: 0.862 ± 0.236
0.862TrpLys: 0.862 ± 0.216
2.356TrpLeu: 2.356 ± 0.324
0.46TrpMet: 0.46 ± 0.166
0.517TrpAsn: 0.517 ± 0.169
0.804TrpPro: 0.804 ± 0.219
1.034TrpGln: 1.034 ± 0.224
1.321TrpArg: 1.321 ± 0.329
1.264TrpSer: 1.264 ± 0.256
1.092TrpThr: 1.092 ± 0.293
1.034TrpVal: 1.034 ± 0.224
0.115TrpTrp: 0.115 ± 0.073
0.057TrpTyr: 0.057 ± 0.054
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.528TyrAla: 2.528 ± 0.371
0.402TyrCys: 0.402 ± 0.156
1.609TyrAsp: 1.609 ± 0.284
1.724TyrGlu: 1.724 ± 0.317
0.517TyrPhe: 0.517 ± 0.137
2.241TyrGly: 2.241 ± 0.333
0.632TyrHis: 0.632 ± 0.182
1.034TyrIle: 1.034 ± 0.242
0.517TyrLys: 0.517 ± 0.184
1.781TyrLeu: 1.781 ± 0.307
0.23TyrMet: 0.23 ± 0.112
0.747TyrAsn: 0.747 ± 0.25
0.919TyrPro: 0.919 ± 0.199
1.264TyrGln: 1.264 ± 0.246
2.471TyrArg: 2.471 ± 0.357
1.551TyrSer: 1.551 ± 0.333
1.092TyrThr: 1.092 ± 0.256
1.436TyrVal: 1.436 ± 0.307
0.517TyrTrp: 0.517 ± 0.177
0.575TyrTyr: 0.575 ± 0.167
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 94 proteins (17406 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski