Amino acid dipepetide frequency for Kudzu mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.344AlaAla: 7.344 ± 2.087
2.448AlaCys: 2.448 ± 1.226
1.836AlaAsp: 1.836 ± 1.097
4.896AlaGlu: 4.896 ± 1.271
3.672AlaPhe: 3.672 ± 1.069
0.612AlaGly: 0.612 ± 0.48
0.612AlaHis: 0.612 ± 0.48
2.448AlaIle: 2.448 ± 0.996
4.896AlaLys: 4.896 ± 1.309
4.896AlaLeu: 4.896 ± 1.645
0.612AlaMet: 0.612 ± 0.511
1.836AlaAsn: 1.836 ± 1.054
1.224AlaPro: 1.224 ± 0.643
4.896AlaGln: 4.896 ± 1.376
3.06AlaArg: 3.06 ± 0.976
4.896AlaSer: 4.896 ± 1.503
4.896AlaThr: 4.896 ± 1.396
1.836AlaVal: 1.836 ± 0.843
0.612AlaTrp: 0.612 ± 0.48
1.224AlaTyr: 1.224 ± 0.572
0.0AlaXaa: 0.0 ± 0.0
Cys
0.612CysAla: 0.612 ± 0.48
0.612CysCys: 0.612 ± 0.668
0.0CysAsp: 0.0 ± 0.0
1.836CysGlu: 1.836 ± 0.74
0.612CysPhe: 0.612 ± 0.861
3.06CysGly: 3.06 ± 0.971
0.0CysHis: 0.0 ± 0.0
0.612CysIle: 0.612 ± 0.519
1.224CysLys: 1.224 ± 1.039
1.224CysLeu: 1.224 ± 0.706
1.224CysMet: 1.224 ± 0.845
1.836CysAsn: 1.836 ± 0.917
1.224CysPro: 1.224 ± 0.776
0.612CysGln: 0.612 ± 0.668
1.224CysArg: 1.224 ± 0.96
3.672CysSer: 3.672 ± 2.503
1.224CysThr: 1.224 ± 0.803
1.224CysVal: 1.224 ± 0.609
0.0CysTrp: 0.0 ± 0.0
0.612CysTyr: 0.612 ± 0.683
0.0CysXaa: 0.0 ± 0.0
Asp
3.06AspAla: 3.06 ± 1.067
0.612AspCys: 0.612 ± 0.53
2.448AspAsp: 2.448 ± 0.89
1.836AspGlu: 1.836 ± 0.577
3.06AspPhe: 3.06 ± 0.832
4.896AspGly: 4.896 ± 1.425
2.448AspHis: 2.448 ± 1.133
3.672AspIle: 3.672 ± 1.315
1.224AspLys: 1.224 ± 1.335
6.732AspLeu: 6.732 ± 2.053
0.612AspMet: 0.612 ± 0.511
1.836AspAsn: 1.836 ± 0.741
2.448AspPro: 2.448 ± 0.722
1.224AspGln: 1.224 ± 0.706
2.448AspArg: 2.448 ± 1.226
2.448AspSer: 2.448 ± 1.08
1.836AspThr: 1.836 ± 0.694
4.284AspVal: 4.284 ± 1.6
0.612AspTrp: 0.612 ± 0.48
1.224AspTyr: 1.224 ± 0.706
0.0AspXaa: 0.0 ± 0.0
Glu
2.448GluAla: 2.448 ± 1.115
0.0GluCys: 0.0 ± 0.0
0.612GluAsp: 0.612 ± 0.53
1.836GluGlu: 1.836 ± 0.767
3.06GluPhe: 3.06 ± 1.083
2.448GluGly: 2.448 ± 0.952
1.836GluHis: 1.836 ± 0.978
0.0GluIle: 0.0 ± 0.0
1.224GluLys: 1.224 ± 0.96
3.06GluLeu: 3.06 ± 1.478
0.0GluMet: 0.0 ± 0.0
5.508GluAsn: 5.508 ± 1.845
2.448GluPro: 2.448 ± 0.952
2.448GluGln: 2.448 ± 0.936
1.836GluArg: 1.836 ± 0.619
3.06GluSer: 3.06 ± 1.076
7.344GluThr: 7.344 ± 2.508
0.612GluVal: 0.612 ± 0.61
1.836GluTrp: 1.836 ± 1.361
1.836GluTyr: 1.836 ± 1.139
0.0GluXaa: 0.0 ± 0.0
Phe
1.224PheAla: 1.224 ± 0.575
1.224PheCys: 1.224 ± 0.896
0.612PheAsp: 0.612 ± 0.48
3.06PheGlu: 3.06 ± 1.098
1.836PhePhe: 1.836 ± 0.917
2.448PheGly: 2.448 ± 1.072
1.836PheHis: 1.836 ± 1.069
1.836PheIle: 1.836 ± 1.054
3.672PheLys: 3.672 ± 1.675
4.284PheLeu: 4.284 ± 1.731
1.224PheMet: 1.224 ± 0.739
2.448PheAsn: 2.448 ± 1.022
2.448PhePro: 2.448 ± 1.714
1.836PheGln: 1.836 ± 1.069
4.284PheArg: 4.284 ± 1.614
3.672PheSer: 3.672 ± 0.927
3.06PheThr: 3.06 ± 1.428
3.06PheVal: 3.06 ± 2.557
1.224PheTrp: 1.224 ± 0.609
1.836PheTyr: 1.836 ± 1.066
0.0PheXaa: 0.0 ± 0.0
Gly
2.448GlyAla: 2.448 ± 1.345
2.448GlyCys: 2.448 ± 1.01
3.06GlyAsp: 3.06 ± 0.821
2.448GlyGlu: 2.448 ± 0.933
1.836GlyPhe: 1.836 ± 0.982
5.508GlyGly: 5.508 ± 1.873
0.612GlyHis: 0.612 ± 0.48
3.06GlyIle: 3.06 ± 0.967
4.896GlyLys: 4.896 ± 1.636
3.672GlyLeu: 3.672 ± 1.659
0.612GlyMet: 0.612 ± 0.49
1.836GlyAsn: 1.836 ± 1.339
3.06GlyPro: 3.06 ± 0.564
3.06GlyGln: 3.06 ± 1.151
3.672GlyArg: 3.672 ± 1.006
4.896GlySer: 4.896 ± 2.004
3.06GlyThr: 3.06 ± 1.545
4.284GlyVal: 4.284 ± 2.056
0.0GlyTrp: 0.0 ± 0.0
0.612GlyTyr: 0.612 ± 0.668
0.0GlyXaa: 0.0 ± 0.0
His
0.612HisAla: 0.612 ± 0.519
0.612HisCys: 0.612 ± 0.683
1.836HisAsp: 1.836 ± 0.911
0.612HisGlu: 0.612 ± 0.48
1.224HisPhe: 1.224 ± 0.96
2.448HisGly: 2.448 ± 1.491
0.612HisHis: 0.612 ± 0.683
1.836HisIle: 1.836 ± 1.104
1.836HisLys: 1.836 ± 0.808
3.672HisLeu: 3.672 ± 1.381
1.224HisMet: 1.224 ± 0.706
3.672HisAsn: 3.672 ± 1.489
1.836HisPro: 1.836 ± 0.982
0.612HisGln: 0.612 ± 0.519
3.672HisArg: 3.672 ± 1.59
1.836HisSer: 1.836 ± 0.808
1.836HisThr: 1.836 ± 1.165
3.06HisVal: 3.06 ± 1.479
0.0HisTrp: 0.0 ± 0.0
1.224HisTyr: 1.224 ± 0.575
0.0HisXaa: 0.0 ± 0.0
Ile
0.612IleAla: 0.612 ± 0.511
0.612IleCys: 0.612 ± 0.61
2.448IleAsp: 2.448 ± 1.474
3.06IleGlu: 3.06 ± 2.001
1.836IlePhe: 1.836 ± 1.439
1.224IleGly: 1.224 ± 1.061
1.224IleHis: 1.224 ± 0.715
1.836IleIle: 1.836 ± 0.619
5.508IleLys: 5.508 ± 1.615
2.448IleLeu: 2.448 ± 0.722
2.448IleMet: 2.448 ± 1.309
4.284IleAsn: 4.284 ± 1.405
1.224IlePro: 1.224 ± 0.572
3.672IleGln: 3.672 ± 1.327
5.508IleArg: 5.508 ± 0.969
4.284IleSer: 4.284 ± 1.391
2.448IleThr: 2.448 ± 0.799
2.448IleVal: 2.448 ± 1.001
0.0IleTrp: 0.0 ± 0.0
1.836IleTyr: 1.836 ± 1.151
0.0IleXaa: 0.0 ± 0.0
Lys
3.672LysAla: 3.672 ± 2.029
1.836LysCys: 1.836 ± 0.829
3.672LysAsp: 3.672 ± 1.103
3.672LysGlu: 3.672 ± 1.877
2.448LysPhe: 2.448 ± 0.972
2.448LysGly: 2.448 ± 1.132
2.448LysHis: 2.448 ± 1.017
1.836LysIle: 1.836 ± 0.748
3.06LysLys: 3.06 ± 1.11
6.732LysLeu: 6.732 ± 3.162
1.836LysMet: 1.836 ± 0.962
3.672LysAsn: 3.672 ± 1.211
5.508LysPro: 5.508 ± 1.888
0.612LysGln: 0.612 ± 0.511
3.06LysArg: 3.06 ± 1.066
3.06LysSer: 3.06 ± 1.215
1.836LysThr: 1.836 ± 1.178
5.508LysVal: 5.508 ± 1.692
0.0LysTrp: 0.0 ± 0.0
3.672LysTyr: 3.672 ± 1.122
0.0LysXaa: 0.0 ± 0.0
Leu
2.448LeuAla: 2.448 ± 0.975
1.836LeuCys: 1.836 ± 1.008
5.508LeuAsp: 5.508 ± 1.624
1.836LeuGlu: 1.836 ± 0.701
3.06LeuPhe: 3.06 ± 0.967
4.896LeuGly: 4.896 ± 1.266
5.508LeuHis: 5.508 ± 1.101
1.836LeuIle: 1.836 ± 0.911
10.404LeuLys: 10.404 ± 1.796
7.344LeuLeu: 7.344 ± 1.287
0.612LeuMet: 0.612 ± 0.748
2.448LeuAsn: 2.448 ± 0.963
4.284LeuPro: 4.284 ± 1.47
3.672LeuGln: 3.672 ± 1.471
6.12LeuArg: 6.12 ± 2.354
7.956LeuSer: 7.956 ± 1.607
4.896LeuThr: 4.896 ± 1.296
3.06LeuVal: 3.06 ± 1.061
0.612LeuTrp: 0.612 ± 0.511
3.06LeuTyr: 3.06 ± 1.166
0.0LeuXaa: 0.0 ± 0.0
Met
0.612MetAla: 0.612 ± 0.519
0.612MetCys: 0.612 ± 0.511
3.06MetAsp: 3.06 ± 1.249
1.224MetGlu: 1.224 ± 0.575
2.448MetPhe: 2.448 ± 1.064
2.448MetGly: 2.448 ± 0.99
1.224MetHis: 1.224 ± 0.706
0.0MetIle: 0.0 ± 0.0
1.836MetLys: 1.836 ± 1.118
3.672MetLeu: 3.672 ± 1.545
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
0.612MetArg: 0.612 ± 0.53
0.612MetSer: 0.612 ± 0.48
1.224MetThr: 1.224 ± 0.7
0.612MetVal: 0.612 ± 0.683
1.224MetTrp: 1.224 ± 0.776
1.836MetTyr: 1.836 ± 1.558
0.0MetXaa: 0.0 ± 0.0
Asn
5.508AsnAla: 5.508 ± 1.585
1.224AsnCys: 1.224 ± 0.803
2.448AsnAsp: 2.448 ± 0.87
1.836AsnGlu: 1.836 ± 0.577
1.836AsnPhe: 1.836 ± 1.008
3.672AsnGly: 3.672 ± 1.909
3.672AsnHis: 3.672 ± 2.162
4.284AsnIle: 4.284 ± 1.581
1.224AsnLys: 1.224 ± 0.575
3.06AsnLeu: 3.06 ± 2.08
2.448AsnMet: 2.448 ± 1.029
3.672AsnAsn: 3.672 ± 1.122
3.672AsnPro: 3.672 ± 1.557
1.836AsnGln: 1.836 ± 0.701
1.836AsnArg: 1.836 ± 0.577
3.672AsnSer: 3.672 ± 1.245
1.836AsnThr: 1.836 ± 1.025
6.732AsnVal: 6.732 ± 1.918
0.0AsnTrp: 0.0 ± 0.0
1.836AsnTyr: 1.836 ± 0.973
0.0AsnXaa: 0.0 ± 0.0
Pro
1.836ProAla: 1.836 ± 1.066
1.224ProCys: 1.224 ± 0.801
3.672ProAsp: 3.672 ± 1.103
2.448ProGlu: 2.448 ± 0.927
4.284ProPhe: 4.284 ± 1.928
3.06ProGly: 3.06 ± 1.76
2.448ProHis: 2.448 ± 1.516
3.672ProIle: 3.672 ± 1.237
3.06ProLys: 3.06 ± 1.247
4.896ProLeu: 4.896 ± 0.736
1.836ProMet: 1.836 ± 1.0
0.612ProAsn: 0.612 ± 0.48
3.672ProPro: 3.672 ± 1.468
0.612ProGln: 0.612 ± 0.683
6.732ProArg: 6.732 ± 1.939
3.672ProSer: 3.672 ± 0.958
4.284ProThr: 4.284 ± 1.329
3.06ProVal: 3.06 ± 0.896
0.612ProTrp: 0.612 ± 0.53
1.836ProTyr: 1.836 ± 1.113
0.0ProXaa: 0.0 ± 0.0
Gln
3.06GlnAla: 3.06 ± 2.012
1.836GlnCys: 1.836 ± 1.104
1.224GlnAsp: 1.224 ± 0.803
1.836GlnGlu: 1.836 ± 0.845
2.448GlnPhe: 2.448 ± 0.979
2.448GlnGly: 2.448 ± 1.071
1.836GlnHis: 1.836 ± 1.142
1.836GlnIle: 1.836 ± 0.917
0.612GlnLys: 0.612 ± 0.48
1.836GlnLeu: 1.836 ± 1.239
0.612GlnMet: 0.612 ± 0.861
1.224GlnAsn: 1.224 ± 0.758
2.448GlnPro: 2.448 ± 1.52
0.0GlnGln: 0.0 ± 0.0
3.06GlnArg: 3.06 ± 1.532
2.448GlnSer: 2.448 ± 0.625
1.836GlnThr: 1.836 ± 0.917
3.672GlnVal: 3.672 ± 0.917
0.612GlnTrp: 0.612 ± 0.61
1.224GlnTyr: 1.224 ± 0.761
0.0GlnXaa: 0.0 ± 0.0
Arg
3.06ArgAla: 3.06 ± 0.982
2.448ArgCys: 2.448 ± 1.157
4.284ArgAsp: 4.284 ± 1.314
1.836ArgGlu: 1.836 ± 1.038
3.06ArgPhe: 3.06 ± 1.098
3.06ArgGly: 3.06 ± 1.106
2.448ArgHis: 2.448 ± 0.74
3.06ArgIle: 3.06 ± 1.498
3.06ArgLys: 3.06 ± 1.744
5.508ArgLeu: 5.508 ± 2.087
0.612ArgMet: 0.612 ± 0.519
3.672ArgAsn: 3.672 ± 0.851
6.12ArgPro: 6.12 ± 1.13
1.836ArgGln: 1.836 ± 0.829
7.956ArgArg: 7.956 ± 3.65
7.344ArgSer: 7.344 ± 1.276
3.06ArgThr: 3.06 ± 1.435
3.672ArgVal: 3.672 ± 1.118
0.612ArgTrp: 0.612 ± 0.519
3.06ArgTyr: 3.06 ± 1.113
0.0ArgXaa: 0.0 ± 0.0
Ser
6.12SerAla: 6.12 ± 1.075
0.612SerCys: 0.612 ± 0.511
4.896SerAsp: 4.896 ± 1.353
1.224SerGlu: 1.224 ± 0.758
4.284SerPhe: 4.284 ± 0.906
3.672SerGly: 3.672 ± 0.883
2.448SerHis: 2.448 ± 1.16
6.12SerIle: 6.12 ± 1.192
4.284SerLys: 4.284 ± 1.892
5.508SerLeu: 5.508 ± 1.631
2.448SerMet: 2.448 ± 1.771
5.508SerAsn: 5.508 ± 1.29
2.448SerPro: 2.448 ± 1.602
1.836SerGln: 1.836 ± 0.694
3.06SerArg: 3.06 ± 1.459
10.404SerSer: 10.404 ± 2.016
6.732SerThr: 6.732 ± 2.0
5.508SerVal: 5.508 ± 1.817
1.224SerTrp: 1.224 ± 0.643
4.284SerTyr: 4.284 ± 1.227
0.0SerXaa: 0.0 ± 0.0
Thr
4.284ThrAla: 4.284 ± 1.305
1.224ThrCys: 1.224 ± 0.776
0.612ThrAsp: 0.612 ± 0.53
2.448ThrGlu: 2.448 ± 1.137
1.836ThrPhe: 1.836 ± 1.147
2.448ThrGly: 2.448 ± 0.657
1.836ThrHis: 1.836 ± 1.165
5.508ThrIle: 5.508 ± 2.554
1.224ThrLys: 1.224 ± 0.896
4.284ThrLeu: 4.284 ± 0.884
0.612ThrMet: 0.612 ± 0.48
4.896ThrAsn: 4.896 ± 1.566
5.508ThrPro: 5.508 ± 1.915
3.06ThrGln: 3.06 ± 1.311
4.896ThrArg: 4.896 ± 1.499
4.284ThrSer: 4.284 ± 2.55
3.06ThrThr: 3.06 ± 1.035
3.672ThrVal: 3.672 ± 1.473
1.836ThrTrp: 1.836 ± 1.147
3.06ThrTyr: 3.06 ± 0.936
0.0ThrXaa: 0.0 ± 0.0
Val
3.06ValAla: 3.06 ± 1.253
1.224ValCys: 1.224 ± 0.96
4.284ValAsp: 4.284 ± 1.243
3.06ValGlu: 3.06 ± 1.238
2.448ValPhe: 2.448 ± 1.287
3.06ValGly: 3.06 ± 1.241
0.0ValHis: 0.0 ± 0.0
3.672ValIle: 3.672 ± 1.009
4.284ValLys: 4.284 ± 0.862
5.508ValLeu: 5.508 ± 2.393
1.224ValMet: 1.224 ± 1.023
3.06ValAsn: 3.06 ± 1.067
3.06ValPro: 3.06 ± 1.175
3.06ValGln: 3.06 ± 1.09
1.224ValArg: 1.224 ± 1.023
7.956ValSer: 7.956 ± 1.95
4.284ValThr: 4.284 ± 1.976
1.836ValVal: 1.836 ± 1.008
1.224ValTrp: 1.224 ± 0.761
3.06ValTyr: 3.06 ± 1.681
0.0ValXaa: 0.0 ± 0.0
Trp
3.672TrpAla: 3.672 ± 1.165
0.0TrpCys: 0.0 ± 0.0
0.612TrpAsp: 0.612 ± 0.668
1.224TrpGlu: 1.224 ± 0.73
0.612TrpPhe: 0.612 ± 0.668
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.612TrpLeu: 0.612 ± 0.519
0.0TrpMet: 0.0 ± 0.0
0.612TrpAsn: 0.612 ± 0.519
0.612TrpPro: 0.612 ± 0.61
0.612TrpGln: 0.612 ± 0.48
1.224TrpArg: 1.224 ± 1.06
0.612TrpSer: 0.612 ± 0.53
0.612TrpThr: 0.612 ± 0.519
0.612TrpVal: 0.612 ± 0.519
0.0TrpTrp: 0.0 ± 0.0
1.224TrpTyr: 1.224 ± 0.715
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.06TyrAla: 3.06 ± 1.298
0.0TyrCys: 0.0 ± 0.0
1.836TyrAsp: 1.836 ± 1.121
1.224TyrGlu: 1.224 ± 0.643
1.224TyrPhe: 1.224 ± 0.609
1.224TyrGly: 1.224 ± 0.643
1.224TyrHis: 1.224 ± 1.22
1.836TyrIle: 1.836 ± 0.808
3.06TyrLys: 3.06 ± 0.891
3.06TyrLeu: 3.06 ± 1.623
2.448TyrMet: 2.448 ± 0.751
3.672TyrAsn: 3.672 ± 0.851
4.284TyrPro: 4.284 ± 1.598
0.612TyrGln: 0.612 ± 0.519
4.284TyrArg: 4.284 ± 1.759
1.836TyrSer: 1.836 ± 0.619
1.224TyrThr: 1.224 ± 0.575
1.836TyrVal: 1.836 ± 0.802
0.612TyrTrp: 0.612 ± 0.668
0.612TyrTyr: 0.612 ± 0.683
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (1635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski