Amino acid dipepetide frequency for Soehngenia longivitae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.541AlaAla: 3.541 ± 0.12
0.569AlaCys: 0.569 ± 0.033
2.838AlaAsp: 2.838 ± 0.076
3.428AlaGlu: 3.428 ± 0.09
2.44AlaPhe: 2.44 ± 0.076
3.804AlaGly: 3.804 ± 0.088
0.866AlaHis: 0.866 ± 0.041
6.181AlaIle: 6.181 ± 0.117
4.814AlaLys: 4.814 ± 0.096
6.023AlaLeu: 6.023 ± 0.131
1.584AlaMet: 1.584 ± 0.061
3.016AlaAsn: 3.016 ± 0.073
1.313AlaPro: 1.313 ± 0.05
1.572AlaGln: 1.572 ± 0.058
2.002AlaArg: 2.002 ± 0.066
3.44AlaSer: 3.44 ± 0.081
2.856AlaThr: 2.856 ± 0.082
4.099AlaVal: 4.099 ± 0.099
0.303AlaTrp: 0.303 ± 0.027
2.162AlaTyr: 2.162 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.539CysAla: 0.539 ± 0.032
0.083CysCys: 0.083 ± 0.011
0.497CysAsp: 0.497 ± 0.031
0.513CysGlu: 0.513 ± 0.037
0.249CysPhe: 0.249 ± 0.02
0.821CysGly: 0.821 ± 0.044
0.151CysHis: 0.151 ± 0.016
0.703CysIle: 0.703 ± 0.038
0.576CysLys: 0.576 ± 0.032
0.621CysLeu: 0.621 ± 0.033
0.19CysMet: 0.19 ± 0.02
0.386CysAsn: 0.386 ± 0.027
0.442CysPro: 0.442 ± 0.035
0.151CysGln: 0.151 ± 0.019
0.263CysArg: 0.263 ± 0.025
0.506CysSer: 0.506 ± 0.034
0.376CysThr: 0.376 ± 0.026
0.534CysVal: 0.534 ± 0.037
0.031CysTrp: 0.031 ± 0.007
0.306CysTyr: 0.306 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
2.816AspAla: 2.816 ± 0.082
0.52AspCys: 0.52 ± 0.033
3.35AspAsp: 3.35 ± 0.085
5.55AspGlu: 5.55 ± 0.114
3.042AspPhe: 3.042 ± 0.069
3.411AspGly: 3.411 ± 0.092
0.677AspHis: 0.677 ± 0.035
6.651AspIle: 6.651 ± 0.118
5.324AspLys: 5.324 ± 0.103
5.819AspLeu: 5.819 ± 0.098
1.579AspMet: 1.579 ± 0.055
3.204AspAsn: 3.204 ± 0.082
1.652AspPro: 1.652 ± 0.059
1.03AspGln: 1.03 ± 0.046
2.108AspArg: 2.108 ± 0.058
3.037AspSer: 3.037 ± 0.069
2.557AspThr: 2.557 ± 0.069
3.823AspVal: 3.823 ± 0.089
0.362AspTrp: 0.362 ± 0.026
2.937AspTyr: 2.937 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
4.195GluAla: 4.195 ± 0.088
0.473GluCys: 0.473 ± 0.028
4.633GluAsp: 4.633 ± 0.096
7.211GluGlu: 7.211 ± 0.147
3.049GluPhe: 3.049 ± 0.085
4.191GluGly: 4.191 ± 0.098
0.908GluHis: 0.908 ± 0.04
8.606GluIle: 8.606 ± 0.145
7.727GluLys: 7.727 ± 0.145
7.564GluLeu: 7.564 ± 0.135
2.054GluMet: 2.054 ± 0.063
5.543GluAsn: 5.543 ± 0.098
1.621GluPro: 1.621 ± 0.061
1.701GluGln: 1.701 ± 0.052
2.842GluArg: 2.842 ± 0.089
3.586GluSer: 3.586 ± 0.081
3.167GluThr: 3.167 ± 0.083
4.955GluVal: 4.955 ± 0.104
0.398GluTrp: 0.398 ± 0.025
3.191GluTyr: 3.191 ± 0.081
0.0GluXaa: 0.0 ± 0.0
Phe
2.348PheAla: 2.348 ± 0.079
0.357PheCys: 0.357 ± 0.026
2.819PheAsp: 2.819 ± 0.078
2.99PheGlu: 2.99 ± 0.083
1.896PhePhe: 1.896 ± 0.063
2.965PheGly: 2.965 ± 0.082
0.51PheHis: 0.51 ± 0.03
4.461PheIle: 4.461 ± 0.106
3.238PheLys: 3.238 ± 0.075
3.96PheLeu: 3.96 ± 0.104
1.068PheMet: 1.068 ± 0.045
2.574PheAsn: 2.574 ± 0.064
1.278PhePro: 1.278 ± 0.045
0.856PheGln: 0.856 ± 0.045
1.409PheArg: 1.409 ± 0.058
3.124PheSer: 3.124 ± 0.078
2.353PheThr: 2.353 ± 0.062
2.558PheVal: 2.558 ± 0.076
0.254PheTrp: 0.254 ± 0.021
1.777PheTyr: 1.777 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.059GlyAla: 4.059 ± 0.114
0.645GlyCys: 0.645 ± 0.039
3.221GlyAsp: 3.221 ± 0.076
4.252GlyGlu: 4.252 ± 0.085
3.082GlyPhe: 3.082 ± 0.074
4.27GlyGly: 4.27 ± 0.11
0.96GlyHis: 0.96 ± 0.041
6.929GlyIle: 6.929 ± 0.123
5.265GlyLys: 5.265 ± 0.101
5.913GlyLeu: 5.913 ± 0.111
1.739GlyMet: 1.739 ± 0.059
3.188GlyAsn: 3.188 ± 0.07
1.365GlyPro: 1.365 ± 0.057
1.499GlyGln: 1.499 ± 0.051
2.306GlyArg: 2.306 ± 0.082
3.64GlySer: 3.64 ± 0.089
3.348GlyThr: 3.348 ± 0.078
4.494GlyVal: 4.494 ± 0.101
0.384GlyTrp: 0.384 ± 0.026
3.056GlyTyr: 3.056 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
0.739HisAla: 0.739 ± 0.037
0.125HisCys: 0.125 ± 0.016
0.73HisAsp: 0.73 ± 0.031
0.878HisGlu: 0.878 ± 0.04
0.701HisPhe: 0.701 ± 0.034
1.012HisGly: 1.012 ± 0.042
0.256HisHis: 0.256 ± 0.022
1.398HisIle: 1.398 ± 0.052
1.017HisLys: 1.017 ± 0.041
1.249HisLeu: 1.249 ± 0.045
0.299HisMet: 0.299 ± 0.025
0.734HisAsn: 0.734 ± 0.035
0.675HisPro: 0.675 ± 0.032
0.386HisGln: 0.386 ± 0.026
0.539HisArg: 0.539 ± 0.031
0.757HisSer: 0.757 ± 0.034
0.689HisThr: 0.689 ± 0.035
0.717HisVal: 0.717 ± 0.033
0.087HisTrp: 0.087 ± 0.012
0.567HisTyr: 0.567 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.303IleAla: 6.303 ± 0.115
0.77IleCys: 0.77 ± 0.034
7.152IleAsp: 7.152 ± 0.128
8.388IleGlu: 8.388 ± 0.134
4.094IlePhe: 4.094 ± 0.102
6.466IleGly: 6.466 ± 0.129
1.355IleHis: 1.355 ± 0.041
9.679IleIle: 9.679 ± 0.162
8.341IleLys: 8.341 ± 0.134
9.061IleLeu: 9.061 ± 0.156
2.317IleMet: 2.317 ± 0.076
6.251IleAsn: 6.251 ± 0.108
3.574IlePro: 3.574 ± 0.084
2.085IleGln: 2.085 ± 0.065
3.506IleArg: 3.506 ± 0.08
7.127IleSer: 7.127 ± 0.13
4.814IleThr: 4.814 ± 0.093
6.779IleVal: 6.779 ± 0.124
0.459IleTrp: 0.459 ± 0.027
3.847IleTyr: 3.847 ± 0.083
0.0IleXaa: 0.0 ± 0.0
Lys
4.818LysAla: 4.818 ± 0.097
0.508LysCys: 0.508 ± 0.037
5.609LysAsp: 5.609 ± 0.104
8.308LysGlu: 8.308 ± 0.153
2.922LysPhe: 2.922 ± 0.08
4.475LysGly: 4.475 ± 0.08
1.026LysHis: 1.026 ± 0.043
8.312LysIle: 8.312 ± 0.132
7.618LysLys: 7.618 ± 0.143
7.724LysLeu: 7.724 ± 0.134
2.336LysMet: 2.336 ± 0.061
5.797LysAsn: 5.797 ± 0.117
2.24LysPro: 2.24 ± 0.072
1.91LysGln: 1.91 ± 0.056
3.118LysArg: 3.118 ± 0.072
4.678LysSer: 4.678 ± 0.106
3.924LysThr: 3.924 ± 0.083
5.409LysVal: 5.409 ± 0.103
0.489LysTrp: 0.489 ± 0.026
3.79LysTyr: 3.79 ± 0.082
0.0LysXaa: 0.0 ± 0.0
Leu
5.645LeuAla: 5.645 ± 0.108
0.654LeuCys: 0.654 ± 0.037
5.903LeuAsp: 5.903 ± 0.114
7.157LeuGlu: 7.157 ± 0.127
3.884LeuPhe: 3.884 ± 0.105
6.198LeuGly: 6.198 ± 0.126
1.129LeuHis: 1.129 ± 0.046
9.131LeuIle: 9.131 ± 0.162
8.138LeuLys: 8.138 ± 0.119
8.399LeuLeu: 8.399 ± 0.151
2.318LeuMet: 2.318 ± 0.076
6.47LeuAsn: 6.47 ± 0.117
3.021LeuPro: 3.021 ± 0.069
1.861LeuGln: 1.861 ± 0.057
3.48LeuArg: 3.48 ± 0.083
6.828LeuSer: 6.828 ± 0.115
4.804LeuThr: 4.804 ± 0.091
5.725LeuVal: 5.725 ± 0.112
0.477LeuTrp: 0.477 ± 0.035
3.313LeuTyr: 3.313 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
1.765MetAla: 1.765 ± 0.057
0.165MetCys: 0.165 ± 0.016
1.466MetAsp: 1.466 ± 0.048
1.779MetGlu: 1.779 ± 0.063
0.861MetPhe: 0.861 ± 0.037
1.751MetGly: 1.751 ± 0.062
0.327MetHis: 0.327 ± 0.022
2.444MetIle: 2.444 ± 0.063
2.251MetLys: 2.251 ± 0.058
2.284MetLeu: 2.284 ± 0.055
0.734MetMet: 0.734 ± 0.035
1.59MetAsn: 1.59 ± 0.049
0.941MetPro: 0.941 ± 0.039
0.65MetGln: 0.65 ± 0.032
0.957MetArg: 0.957 ± 0.042
1.577MetSer: 1.577 ± 0.047
1.35MetThr: 1.35 ± 0.054
1.555MetVal: 1.555 ± 0.057
0.122MetTrp: 0.122 ± 0.013
0.87MetTyr: 0.87 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
2.944AsnAla: 2.944 ± 0.08
0.518AsnCys: 0.518 ± 0.037
3.178AsnAsp: 3.178 ± 0.085
4.461AsnGlu: 4.461 ± 0.091
2.433AsnPhe: 2.433 ± 0.073
3.64AsnGly: 3.64 ± 0.077
0.776AsnHis: 0.776 ± 0.037
6.722AsnIle: 6.722 ± 0.122
5.36AsnLys: 5.36 ± 0.112
6.096AsnLeu: 6.096 ± 0.104
1.546AsnMet: 1.546 ± 0.049
3.736AsnAsn: 3.736 ± 0.104
2.353AsnPro: 2.353 ± 0.057
1.562AsnGln: 1.562 ± 0.062
2.15AsnArg: 2.15 ± 0.067
3.685AsnSer: 3.685 ± 0.087
2.772AsnThr: 2.772 ± 0.068
3.466AsnVal: 3.466 ± 0.073
0.386AsnTrp: 0.386 ± 0.028
2.777AsnTyr: 2.777 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
1.433ProAla: 1.433 ± 0.061
0.242ProCys: 0.242 ± 0.019
1.678ProAsp: 1.678 ± 0.05
2.303ProGlu: 2.303 ± 0.066
1.499ProPhe: 1.499 ± 0.059
1.809ProGly: 1.809 ± 0.051
0.558ProHis: 0.558 ± 0.031
3.118ProIle: 3.118 ± 0.072
2.23ProLys: 2.23 ± 0.069
2.764ProLeu: 2.764 ± 0.071
0.694ProMet: 0.694 ± 0.039
1.72ProAsn: 1.72 ± 0.051
0.736ProPro: 0.736 ± 0.036
0.877ProGln: 0.877 ± 0.04
0.943ProArg: 0.943 ± 0.037
1.851ProSer: 1.851 ± 0.052
1.718ProThr: 1.718 ± 0.055
2.136ProVal: 2.136 ± 0.079
0.207ProTrp: 0.207 ± 0.018
1.424ProTyr: 1.424 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
1.463GlnAla: 1.463 ± 0.053
0.144GlnCys: 0.144 ± 0.015
1.049GlnAsp: 1.049 ± 0.039
1.541GlnGlu: 1.541 ± 0.05
0.948GlnPhe: 0.948 ± 0.048
1.365GlnGly: 1.365 ± 0.044
0.289GlnHis: 0.289 ± 0.023
2.416GlnIle: 2.416 ± 0.069
2.172GlnLys: 2.172 ± 0.062
2.129GlnLeu: 2.129 ± 0.056
0.708GlnMet: 0.708 ± 0.034
1.461GlnAsn: 1.461 ± 0.05
0.64GlnPro: 0.64 ± 0.032
0.567GlnGln: 0.567 ± 0.036
1.141GlnArg: 1.141 ± 0.048
1.233GlnSer: 1.233 ± 0.054
1.219GlnThr: 1.219 ± 0.048
1.379GlnVal: 1.379 ± 0.056
0.163GlnTrp: 0.163 ± 0.016
1.033GlnTyr: 1.033 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.148ArgAla: 2.148 ± 0.065
0.308ArgCys: 0.308 ± 0.023
2.132ArgAsp: 2.132 ± 0.062
3.211ArgGlu: 3.211 ± 0.083
1.511ArgPhe: 1.511 ± 0.054
2.219ArgGly: 2.219 ± 0.068
0.466ArgHis: 0.466 ± 0.03
3.459ArgIle: 3.459 ± 0.082
3.162ArgLys: 3.162 ± 0.064
3.291ArgLeu: 3.291 ± 0.073
0.957ArgMet: 0.957 ± 0.046
2.11ArgAsn: 2.11 ± 0.06
0.991ArgPro: 0.991 ± 0.048
0.991ArgGln: 0.991 ± 0.046
1.475ArgArg: 1.475 ± 0.06
1.644ArgSer: 1.644 ± 0.045
1.732ArgThr: 1.732 ± 0.056
2.478ArgVal: 2.478 ± 0.071
0.224ArgTrp: 0.224 ± 0.024
1.497ArgTyr: 1.497 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
2.958SerAla: 2.958 ± 0.064
0.47SerCys: 0.47 ± 0.032
3.351SerAsp: 3.351 ± 0.076
3.96SerGlu: 3.96 ± 0.092
2.948SerPhe: 2.948 ± 0.075
4.266SerGly: 4.266 ± 0.088
0.957SerHis: 0.957 ± 0.041
6.536SerIle: 6.536 ± 0.119
5.038SerLys: 5.038 ± 0.116
6.038SerLeu: 6.038 ± 0.119
1.6SerMet: 1.6 ± 0.054
3.52SerAsn: 3.52 ± 0.089
1.769SerPro: 1.769 ± 0.051
1.555SerGln: 1.555 ± 0.062
2.091SerArg: 2.091 ± 0.054
3.993SerSer: 3.993 ± 0.102
3.099SerThr: 3.099 ± 0.077
3.515SerVal: 3.515 ± 0.08
0.4SerTrp: 0.4 ± 0.028
2.586SerTyr: 2.586 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
2.868ThrAla: 2.868 ± 0.083
0.376ThrCys: 0.376 ± 0.027
2.534ThrAsp: 2.534 ± 0.066
3.099ThrGlu: 3.099 ± 0.073
2.031ThrPhe: 2.031 ± 0.06
3.671ThrGly: 3.671 ± 0.087
0.828ThrHis: 0.828 ± 0.036
5.08ThrIle: 5.08 ± 0.094
3.842ThrLys: 3.842 ± 0.094
4.814ThrLeu: 4.814 ± 0.09
1.078ThrMet: 1.078 ± 0.035
2.817ThrAsn: 2.817 ± 0.082
1.75ThrPro: 1.75 ± 0.054
1.217ThrGln: 1.217 ± 0.045
1.748ThrArg: 1.748 ± 0.051
2.986ThrSer: 2.986 ± 0.076
2.628ThrThr: 2.628 ± 0.081
3.456ThrVal: 3.456 ± 0.079
0.261ThrTrp: 0.261 ± 0.021
1.807ThrTyr: 1.807 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
3.845ValAla: 3.845 ± 0.092
0.557ValCys: 0.557 ± 0.032
4.284ValAsp: 4.284 ± 0.087
4.96ValGlu: 4.96 ± 0.099
2.927ValPhe: 2.927 ± 0.082
4.386ValGly: 4.386 ± 0.105
0.84ValHis: 0.84 ± 0.041
6.146ValIle: 6.146 ± 0.112
5.049ValLys: 5.049 ± 0.095
6.284ValLeu: 6.284 ± 0.115
1.525ValMet: 1.525 ± 0.047
3.645ValAsn: 3.645 ± 0.076
2.002ValPro: 2.002 ± 0.069
1.287ValGln: 1.287 ± 0.042
2.181ValArg: 2.181 ± 0.073
3.972ValSer: 3.972 ± 0.086
3.181ValThr: 3.181 ± 0.084
4.651ValVal: 4.651 ± 0.12
0.337ValTrp: 0.337 ± 0.021
2.419ValTyr: 2.419 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.397TrpAla: 0.397 ± 0.031
0.038TrpCys: 0.038 ± 0.008
0.365TrpAsp: 0.365 ± 0.023
0.45TrpGlu: 0.45 ± 0.028
0.242TrpPhe: 0.242 ± 0.02
0.393TrpGly: 0.393 ± 0.03
0.099TrpHis: 0.099 ± 0.014
0.529TrpIle: 0.529 ± 0.03
0.393TrpLys: 0.393 ± 0.025
0.473TrpLeu: 0.473 ± 0.029
0.176TrpMet: 0.176 ± 0.021
0.343TrpAsn: 0.343 ± 0.025
0.177TrpPro: 0.177 ± 0.017
0.183TrpGln: 0.183 ± 0.016
0.216TrpArg: 0.216 ± 0.021
0.273TrpSer: 0.273 ± 0.023
0.256TrpThr: 0.256 ± 0.023
0.369TrpVal: 0.369 ± 0.025
0.061TrpTrp: 0.061 ± 0.011
0.226TrpTyr: 0.226 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.026TyrAla: 2.026 ± 0.059
0.416TyrCys: 0.416 ± 0.028
2.656TyrAsp: 2.656 ± 0.075
3.176TyrGlu: 3.176 ± 0.084
2.037TyrPhe: 2.037 ± 0.069
2.501TyrGly: 2.501 ± 0.066
0.579TyrHis: 0.579 ± 0.035
3.87TyrIle: 3.87 ± 0.088
3.456TyrLys: 3.456 ± 0.082
4.03TyrLeu: 4.03 ± 0.087
0.934TyrMet: 0.934 ± 0.043
2.459TyrAsn: 2.459 ± 0.067
1.398TyrPro: 1.398 ± 0.052
1.12TyrGln: 1.12 ± 0.038
1.534TyrArg: 1.534 ± 0.056
2.713TyrSer: 2.713 ± 0.078
2.051TyrThr: 2.051 ± 0.067
2.381TyrVal: 2.381 ± 0.069
0.252TyrTrp: 0.252 ± 0.022
2.002TyrTyr: 2.002 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1787 proteins (574980 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski