Amino acid dipepetide frequency for Candidatus Nasuia deltocephalinicola str. NAS-ALF

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.906AlaAla: 0.906 ± 0.248
0.205AlaCys: 0.205 ± 0.081
0.409AlaAsp: 0.409 ± 0.134
0.526AlaGlu: 0.526 ± 0.203
0.672AlaPhe: 0.672 ± 0.12
1.082AlaGly: 1.082 ± 0.229
0.205AlaHis: 0.205 ± 0.067
1.549AlaIle: 1.549 ± 0.309
1.198AlaLys: 1.198 ± 0.221
1.549AlaLeu: 1.549 ± 0.242
0.234AlaMet: 0.234 ± 0.077
0.935AlaAsn: 0.935 ± 0.19
0.409AlaPro: 0.409 ± 0.102
0.322AlaGln: 0.322 ± 0.1
0.409AlaArg: 0.409 ± 0.104
0.965AlaSer: 0.965 ± 0.218
0.702AlaThr: 0.702 ± 0.229
0.906AlaVal: 0.906 ± 0.18
0.029AlaTrp: 0.029 ± 0.031
0.438AlaTyr: 0.438 ± 0.116
0.0AlaXaa: 0.0 ± 0.0
Cys
0.263CysAla: 0.263 ± 0.129
0.205CysCys: 0.205 ± 0.078
0.614CysAsp: 0.614 ± 0.113
0.643CysGlu: 0.643 ± 0.159
1.374CysPhe: 1.374 ± 0.256
0.818CysGly: 0.818 ± 0.154
0.351CysHis: 0.351 ± 0.124
1.257CysIle: 1.257 ± 0.17
1.725CysLys: 1.725 ± 0.191
1.608CysLeu: 1.608 ± 0.202
0.117CysMet: 0.117 ± 0.06
0.935CysAsn: 0.935 ± 0.167
0.322CysPro: 0.322 ± 0.108
0.234CysGln: 0.234 ± 0.086
0.322CysArg: 0.322 ± 0.084
0.965CysSer: 0.965 ± 0.152
0.38CysThr: 0.38 ± 0.105
0.643CysVal: 0.643 ± 0.14
0.146CysTrp: 0.146 ± 0.063
0.848CysTyr: 0.848 ± 0.153
0.0CysXaa: 0.0 ± 0.0
Asp
0.731AspAla: 0.731 ± 0.167
0.497AspCys: 0.497 ± 0.124
1.169AspAsp: 1.169 ± 0.249
1.345AspGlu: 1.345 ± 0.279
3.917AspPhe: 3.917 ± 0.356
0.818AspGly: 0.818 ± 0.186
0.322AspHis: 0.322 ± 0.102
4.443AspIle: 4.443 ± 0.39
2.806AspLys: 2.806 ± 0.24
4.063AspLeu: 4.063 ± 0.441
0.585AspMet: 0.585 ± 0.13
2.923AspAsn: 2.923 ± 0.435
0.526AspPro: 0.526 ± 0.125
0.38AspGln: 0.38 ± 0.095
0.468AspArg: 0.468 ± 0.107
1.958AspSer: 1.958 ± 0.228
1.023AspThr: 1.023 ± 0.174
1.198AspVal: 1.198 ± 0.19
0.117AspTrp: 0.117 ± 0.083
1.783AspTyr: 1.783 ± 0.225
0.0AspXaa: 0.0 ± 0.0
Glu
0.585GluAla: 0.585 ± 0.193
0.526GluCys: 0.526 ± 0.14
1.608GluAsp: 1.608 ± 0.278
1.666GluGlu: 1.666 ± 0.327
2.28GluPhe: 2.28 ± 0.291
1.491GluGly: 1.491 ± 0.262
0.322GluHis: 0.322 ± 0.106
5.554GluIle: 5.554 ± 0.515
4.502GluLys: 4.502 ± 0.459
2.631GluLeu: 2.631 ± 0.361
0.877GluMet: 0.877 ± 0.173
4.151GluAsn: 4.151 ± 0.453
0.438GluPro: 0.438 ± 0.123
0.322GluGln: 0.322 ± 0.113
0.994GluArg: 0.994 ± 0.244
2.397GluSer: 2.397 ± 0.304
0.906GluThr: 0.906 ± 0.156
1.082GluVal: 1.082 ± 0.212
0.058GluTrp: 0.058 ± 0.037
1.52GluTyr: 1.52 ± 0.209
0.0GluXaa: 0.0 ± 0.0
Phe
0.409PheAla: 0.409 ± 0.12
0.994PheCys: 0.994 ± 0.158
2.923PheAsp: 2.923 ± 0.3
2.28PheGlu: 2.28 ± 0.258
14.469PhePhe: 14.469 ± 1.853
2.309PheGly: 2.309 ± 0.352
0.555PheHis: 0.555 ± 0.113
12.716PheIle: 12.716 ± 0.916
14.966PheLys: 14.966 ± 1.132
15.463PheLeu: 15.463 ± 1.344
1.198PheMet: 1.198 ± 0.198
11.722PheAsn: 11.722 ± 0.805
0.848PhePro: 0.848 ± 0.235
0.731PheGln: 0.731 ± 0.128
1.257PheArg: 1.257 ± 0.224
6.051PheSer: 6.051 ± 0.512
1.286PheThr: 1.286 ± 0.194
1.52PheVal: 1.52 ± 0.217
0.614PheTrp: 0.614 ± 0.171
8.214PheTyr: 8.214 ± 0.767
0.0PheXaa: 0.0 ± 0.0
Gly
0.818GlyAla: 0.818 ± 0.168
0.614GlyCys: 0.614 ± 0.141
1.958GlyAsp: 1.958 ± 0.236
1.929GlyGlu: 1.929 ± 0.29
3.274GlyPhe: 3.274 ± 0.35
2.952GlyGly: 2.952 ± 0.414
0.585GlyHis: 0.585 ± 0.149
4.034GlyIle: 4.034 ± 0.393
3.595GlyLys: 3.595 ± 0.346
3.42GlyLeu: 3.42 ± 0.308
0.38GlyMet: 0.38 ± 0.098
2.163GlyAsn: 2.163 ± 0.231
0.643GlyPro: 0.643 ± 0.124
0.877GlyGln: 0.877 ± 0.149
1.695GlyArg: 1.695 ± 0.234
2.748GlySer: 2.748 ± 0.372
1.169GlyThr: 1.169 ± 0.21
1.871GlyVal: 1.871 ± 0.269
0.351GlyTrp: 0.351 ± 0.096
1.14GlyTyr: 1.14 ± 0.177
0.0GlyXaa: 0.0 ± 0.0
His
0.263HisAla: 0.263 ± 0.097
0.322HisCys: 0.322 ± 0.093
0.263HisAsp: 0.263 ± 0.085
0.088HisGlu: 0.088 ± 0.044
0.731HisPhe: 0.731 ± 0.173
0.468HisGly: 0.468 ± 0.127
0.322HisHis: 0.322 ± 0.119
1.345HisIle: 1.345 ± 0.23
1.082HisLys: 1.082 ± 0.176
0.789HisLeu: 0.789 ± 0.153
0.205HisMet: 0.205 ± 0.078
1.052HisAsn: 1.052 ± 0.195
0.322HisPro: 0.322 ± 0.107
0.058HisGln: 0.058 ± 0.047
0.234HisArg: 0.234 ± 0.089
0.906HisSer: 0.906 ± 0.17
0.292HisThr: 0.292 ± 0.11
0.438HisVal: 0.438 ± 0.127
0.058HisTrp: 0.058 ± 0.044
0.585HisTyr: 0.585 ± 0.134
0.0HisXaa: 0.0 ± 0.0
Ile
1.491IleAla: 1.491 ± 0.232
2.338IleCys: 2.338 ± 0.269
4.969IleAsp: 4.969 ± 0.431
5.203IleGlu: 5.203 ± 0.505
15.726IlePhe: 15.726 ± 1.441
3.975IleGly: 3.975 ± 0.336
1.374IleHis: 1.374 ± 0.197
20.52IleIle: 20.52 ± 0.971
22.479IleLys: 22.479 ± 1.267
16.749IleLeu: 16.749 ± 0.771
2.046IleMet: 2.046 ± 0.186
16.983IleAsn: 16.983 ± 0.79
2.368IlePro: 2.368 ± 0.292
1.695IleGln: 1.695 ± 0.217
2.66IleArg: 2.66 ± 0.288
10.085IleSer: 10.085 ± 0.535
3.245IleThr: 3.245 ± 0.325
3.274IleVal: 3.274 ± 0.378
0.585IleTrp: 0.585 ± 0.152
9.091IleTyr: 9.091 ± 0.602
0.0IleXaa: 0.0 ± 0.0
Lys
1.082LysAla: 1.082 ± 0.218
1.666LysCys: 1.666 ± 0.246
3.595LysAsp: 3.595 ± 0.374
4.268LysGlu: 4.268 ± 0.543
11.196LysPhe: 11.196 ± 0.806
4.18LysGly: 4.18 ± 0.371
0.965LysHis: 0.965 ± 0.19
27.74LysIle: 27.74 ± 1.229
26.776LysLys: 26.776 ± 1.695
10.143LysLeu: 10.143 ± 0.535
1.491LysMet: 1.491 ± 0.259
24.905LysAsn: 24.905 ± 1.148
1.812LysPro: 1.812 ± 0.222
1.52LysGln: 1.52 ± 0.218
3.303LysArg: 3.303 ± 0.397
7.571LysSer: 7.571 ± 0.497
2.982LysThr: 2.982 ± 0.306
2.952LysVal: 2.952 ± 0.328
0.702LysTrp: 0.702 ± 0.161
8.302LysTyr: 8.302 ± 0.564
0.0LysXaa: 0.0 ± 0.0
Leu
1.257LeuAla: 1.257 ± 0.213
0.877LeuCys: 0.877 ± 0.141
3.128LeuAsp: 3.128 ± 0.343
3.946LeuGlu: 3.946 ± 0.428
8.916LeuPhe: 8.916 ± 0.834
3.537LeuGly: 3.537 ± 0.329
0.877LeuHis: 0.877 ± 0.154
13.768LeuIle: 13.768 ± 0.782
21.426LeuLys: 21.426 ± 1.138
8.126LeuLeu: 8.126 ± 0.516
1.023LeuMet: 1.023 ± 0.175
16.077LeuAsn: 16.077 ± 0.668
1.695LeuPro: 1.695 ± 0.199
1.111LeuGln: 1.111 ± 0.18
2.602LeuArg: 2.602 ± 0.285
6.255LeuSer: 6.255 ± 0.486
2.543LeuThr: 2.543 ± 0.206
1.842LeuVal: 1.842 ± 0.221
0.526LeuTrp: 0.526 ± 0.124
5.057LeuTyr: 5.057 ± 0.392
0.0LeuXaa: 0.0 ± 0.0
Met
0.438MetAla: 0.438 ± 0.117
0.234MetCys: 0.234 ± 0.072
0.438MetAsp: 0.438 ± 0.176
0.585MetGlu: 0.585 ± 0.122
1.14MetPhe: 1.14 ± 0.166
0.555MetGly: 0.555 ± 0.118
0.205MetHis: 0.205 ± 0.094
1.871MetIle: 1.871 ± 0.197
1.52MetLys: 1.52 ± 0.221
1.52MetLeu: 1.52 ± 0.231
0.058MetMet: 0.058 ± 0.04
1.169MetAsn: 1.169 ± 0.18
0.438MetPro: 0.438 ± 0.116
0.322MetGln: 0.322 ± 0.1
0.234MetArg: 0.234 ± 0.08
0.877MetSer: 0.877 ± 0.154
0.322MetThr: 0.322 ± 0.092
0.497MetVal: 0.497 ± 0.139
0.058MetTrp: 0.058 ± 0.044
0.614MetTyr: 0.614 ± 0.169
0.0MetXaa: 0.0 ± 0.0
Asn
1.023AsnAla: 1.023 ± 0.187
1.52AsnCys: 1.52 ± 0.209
2.543AsnAsp: 2.543 ± 0.331
2.865AsnGlu: 2.865 ± 0.324
15.668AsnPhe: 15.668 ± 1.148
2.192AsnGly: 2.192 ± 0.291
0.965AsnHis: 0.965 ± 0.152
20.988AsnIle: 20.988 ± 0.954
16.399AsnLys: 16.399 ± 0.782
13.563AsnLeu: 13.563 ± 0.69
1.286AsnMet: 1.286 ± 0.176
13.008AsnAsn: 13.008 ± 0.696
1.462AsnPro: 1.462 ± 0.178
1.228AsnGln: 1.228 ± 0.169
2.514AsnArg: 2.514 ± 0.251
6.986AsnSer: 6.986 ± 0.485
2.134AsnThr: 2.134 ± 0.254
2.631AsnVal: 2.631 ± 0.268
0.643AsnTrp: 0.643 ± 0.148
9.588AsnTyr: 9.588 ± 0.53
0.0AsnXaa: 0.0 ± 0.0
Pro
0.38ProAla: 0.38 ± 0.112
0.117ProCys: 0.117 ± 0.058
0.585ProAsp: 0.585 ± 0.12
0.848ProGlu: 0.848 ± 0.203
1.169ProPhe: 1.169 ± 0.158
0.935ProGly: 0.935 ± 0.213
0.234ProHis: 0.234 ± 0.082
2.046ProIle: 2.046 ± 0.261
1.286ProLys: 1.286 ± 0.226
1.842ProLeu: 1.842 ± 0.232
0.234ProMet: 0.234 ± 0.071
1.403ProAsn: 1.403 ± 0.201
0.234ProPro: 0.234 ± 0.08
0.234ProGln: 0.234 ± 0.084
0.38ProArg: 0.38 ± 0.13
1.286ProSer: 1.286 ± 0.2
0.76ProThr: 0.76 ± 0.165
0.731ProVal: 0.731 ± 0.151
0.029ProTrp: 0.029 ± 0.036
0.906ProTyr: 0.906 ± 0.143
0.0ProXaa: 0.0 ± 0.0
Gln
0.526GlnAla: 0.526 ± 0.133
0.234GlnCys: 0.234 ± 0.082
0.38GlnAsp: 0.38 ± 0.084
0.468GlnGlu: 0.468 ± 0.134
0.585GlnPhe: 0.585 ± 0.121
0.643GlnGly: 0.643 ± 0.157
0.117GlnHis: 0.117 ± 0.064
2.251GlnIle: 2.251 ± 0.285
1.491GlnLys: 1.491 ± 0.211
0.848GlnLeu: 0.848 ± 0.152
0.351GlnMet: 0.351 ± 0.101
1.14GlnAsn: 1.14 ± 0.208
0.263GlnPro: 0.263 ± 0.084
0.175GlnGln: 0.175 ± 0.069
0.438GlnArg: 0.438 ± 0.145
0.818GlnSer: 0.818 ± 0.157
0.322GlnThr: 0.322 ± 0.101
0.555GlnVal: 0.555 ± 0.126
0.117GlnTrp: 0.117 ± 0.062
0.526GlnTyr: 0.526 ± 0.123
0.0GlnXaa: 0.0 ± 0.0
Arg
0.38ArgAla: 0.38 ± 0.11
0.234ArgCys: 0.234 ± 0.075
0.702ArgAsp: 0.702 ± 0.131
0.848ArgGlu: 0.848 ± 0.137
1.842ArgPhe: 1.842 ± 0.167
1.608ArgGly: 1.608 ± 0.281
0.409ArgHis: 0.409 ± 0.122
2.952ArgIle: 2.952 ± 0.28
3.303ArgLys: 3.303 ± 0.425
1.929ArgLeu: 1.929 ± 0.307
0.205ArgMet: 0.205 ± 0.094
2.485ArgAsn: 2.485 ± 0.322
0.292ArgPro: 0.292 ± 0.102
0.497ArgGln: 0.497 ± 0.121
0.614ArgArg: 0.614 ± 0.116
1.725ArgSer: 1.725 ± 0.226
0.614ArgThr: 0.614 ± 0.155
1.169ArgVal: 1.169 ± 0.193
0.088ArgTrp: 0.088 ± 0.047
1.286ArgTyr: 1.286 ± 0.186
0.0ArgXaa: 0.0 ± 0.0
Ser
1.14SerAla: 1.14 ± 0.217
1.082SerCys: 1.082 ± 0.177
2.163SerAsp: 2.163 ± 0.26
2.426SerGlu: 2.426 ± 0.293
5.554SerPhe: 5.554 ± 0.562
3.449SerGly: 3.449 ± 0.371
0.848SerHis: 0.848 ± 0.155
8.565SerIle: 8.565 ± 0.474
8.039SerLys: 8.039 ± 0.419
7.308SerLeu: 7.308 ± 0.523
0.614SerMet: 0.614 ± 0.164
6.109SerAsn: 6.109 ± 0.365
1.169SerPro: 1.169 ± 0.174
1.023SerGln: 1.023 ± 0.159
1.695SerArg: 1.695 ± 0.248
4.18SerSer: 4.18 ± 0.457
1.52SerThr: 1.52 ± 0.237
1.812SerVal: 1.812 ± 0.264
0.438SerTrp: 0.438 ± 0.128
3.888SerTyr: 3.888 ± 0.388
0.0SerXaa: 0.0 ± 0.0
Thr
0.468ThrAla: 0.468 ± 0.142
0.322ThrCys: 0.322 ± 0.094
0.789ThrAsp: 0.789 ± 0.14
1.052ThrGlu: 1.052 ± 0.237
1.403ThrPhe: 1.403 ± 0.202
1.403ThrGly: 1.403 ± 0.191
0.322ThrHis: 0.322 ± 0.105
3.508ThrIle: 3.508 ± 0.301
1.988ThrLys: 1.988 ± 0.24
2.777ThrLeu: 2.777 ± 0.28
0.351ThrMet: 0.351 ± 0.147
2.075ThrAsn: 2.075 ± 0.257
0.965ThrPro: 0.965 ± 0.162
0.234ThrGln: 0.234 ± 0.075
0.994ThrArg: 0.994 ± 0.193
1.491ThrSer: 1.491 ± 0.187
1.023ThrThr: 1.023 ± 0.206
0.965ThrVal: 0.965 ± 0.19
0.058ThrTrp: 0.058 ± 0.046
1.257ThrTyr: 1.257 ± 0.165
0.0ThrXaa: 0.0 ± 0.0
Val
0.672ValAla: 0.672 ± 0.205
0.555ValCys: 0.555 ± 0.132
0.994ValAsp: 0.994 ± 0.17
1.491ValGlu: 1.491 ± 0.233
2.222ValPhe: 2.222 ± 0.251
1.812ValGly: 1.812 ± 0.225
0.438ValHis: 0.438 ± 0.123
3.245ValIle: 3.245 ± 0.336
2.806ValLys: 2.806 ± 0.31
2.806ValLeu: 2.806 ± 0.283
0.614ValMet: 0.614 ± 0.11
2.017ValAsn: 2.017 ± 0.253
0.555ValPro: 0.555 ± 0.109
0.438ValGln: 0.438 ± 0.128
0.789ValArg: 0.789 ± 0.157
1.432ValSer: 1.432 ± 0.247
0.877ValThr: 0.877 ± 0.216
0.789ValVal: 0.789 ± 0.139
0.175ValTrp: 0.175 ± 0.074
1.432ValTyr: 1.432 ± 0.191
0.0ValXaa: 0.0 ± 0.0
Trp
0.146TrpAla: 0.146 ± 0.065
0.029TrpCys: 0.029 ± 0.026
0.205TrpAsp: 0.205 ± 0.092
0.175TrpGlu: 0.175 ± 0.072
0.497TrpPhe: 0.497 ± 0.142
0.322TrpGly: 0.322 ± 0.093
0.029TrpHis: 0.029 ± 0.032
0.643TrpIle: 0.643 ± 0.136
0.614TrpLys: 0.614 ± 0.131
0.497TrpLeu: 0.497 ± 0.118
0.263TrpMet: 0.263 ± 0.102
0.438TrpAsn: 0.438 ± 0.111
0.088TrpPro: 0.088 ± 0.049
0.029TrpGln: 0.029 ± 0.034
0.234TrpArg: 0.234 ± 0.105
0.38TrpSer: 0.38 ± 0.116
0.117TrpThr: 0.117 ± 0.075
0.117TrpVal: 0.117 ± 0.061
0.117TrpTrp: 0.117 ± 0.066
0.234TrpTyr: 0.234 ± 0.084
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.672TyrAla: 0.672 ± 0.136
1.198TyrCys: 1.198 ± 0.165
1.637TyrAsp: 1.637 ± 0.215
1.257TyrGlu: 1.257 ± 0.185
7.892TyrPhe: 7.892 ± 0.705
1.666TyrGly: 1.666 ± 0.23
0.38TyrHis: 0.38 ± 0.11
7.863TyrIle: 7.863 ± 0.571
9.149TyrLys: 9.149 ± 0.546
6.957TyrLeu: 6.957 ± 0.483
0.935TyrMet: 0.935 ± 0.185
7.542TyrAsn: 7.542 ± 0.575
0.789TyrPro: 0.789 ± 0.15
0.818TyrGln: 0.818 ± 0.111
1.345TyrArg: 1.345 ± 0.204
3.946TyrSer: 3.946 ± 0.286
1.228TyrThr: 1.228 ± 0.18
1.169TyrVal: 1.169 ± 0.211
0.263TyrTrp: 0.263 ± 0.073
4.56TyrTyr: 4.56 ± 0.433
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 137 proteins (34211 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski