Amino acid dipepetide frequency for Pseudoruegeria lutimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.476AlaAla: 15.476 ± 0.123
1.213AlaCys: 1.213 ± 0.03
6.31AlaAsp: 6.31 ± 0.064
8.591AlaGlu: 8.591 ± 0.087
4.359AlaPhe: 4.359 ± 0.063
10.23AlaGly: 10.23 ± 0.094
2.188AlaHis: 2.188 ± 0.038
6.132AlaIle: 6.132 ± 0.066
3.514AlaLys: 3.514 ± 0.054
13.129AlaLeu: 13.129 ± 0.118
3.719AlaMet: 3.719 ± 0.054
2.811AlaAsn: 2.811 ± 0.049
5.445AlaPro: 5.445 ± 0.072
3.726AlaGln: 3.726 ± 0.05
8.377AlaArg: 8.377 ± 0.092
5.922AlaSer: 5.922 ± 0.056
5.892AlaThr: 5.892 ± 0.054
7.925AlaVal: 7.925 ± 0.066
1.461AlaTrp: 1.461 ± 0.032
2.379AlaTyr: 2.379 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.06CysAla: 1.06 ± 0.029
0.109CysCys: 0.109 ± 0.009
0.59CysAsp: 0.59 ± 0.019
0.537CysGlu: 0.537 ± 0.02
0.353CysPhe: 0.353 ± 0.018
1.013CysGly: 1.013 ± 0.026
0.334CysHis: 0.334 ± 0.021
0.449CysIle: 0.449 ± 0.018
0.229CysLys: 0.229 ± 0.013
0.89CysLeu: 0.89 ± 0.025
0.211CysMet: 0.211 ± 0.011
0.27CysAsn: 0.27 ± 0.014
0.519CysPro: 0.519 ± 0.019
0.264CysGln: 0.264 ± 0.013
0.657CysArg: 0.657 ± 0.022
0.553CysSer: 0.553 ± 0.018
0.441CysThr: 0.441 ± 0.019
0.679CysVal: 0.679 ± 0.023
0.161CysTrp: 0.161 ± 0.012
0.214CysTyr: 0.214 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.64AspAla: 6.64 ± 0.063
0.565AspCys: 0.565 ± 0.02
2.859AspAsp: 2.859 ± 0.063
3.545AspGlu: 3.545 ± 0.048
2.398AspPhe: 2.398 ± 0.037
5.43AspGly: 5.43 ± 0.068
1.255AspHis: 1.255 ± 0.031
3.102AspIle: 3.102 ± 0.049
1.623AspLys: 1.623 ± 0.034
6.049AspLeu: 6.049 ± 0.06
1.621AspMet: 1.621 ± 0.034
1.299AspAsn: 1.299 ± 0.028
3.579AspPro: 3.579 ± 0.045
1.566AspGln: 1.566 ± 0.032
4.131AspArg: 4.131 ± 0.052
2.399AspSer: 2.399 ± 0.044
2.668AspThr: 2.668 ± 0.044
3.982AspVal: 3.982 ± 0.051
1.152AspTrp: 1.152 ± 0.029
1.429AspTyr: 1.429 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
8.505GluAla: 8.505 ± 0.076
0.452GluCys: 0.452 ± 0.017
3.438GluAsp: 3.438 ± 0.055
4.149GluGlu: 4.149 ± 0.066
2.018GluPhe: 2.018 ± 0.036
4.916GluGly: 4.916 ± 0.058
1.29GluHis: 1.29 ± 0.032
4.319GluIle: 4.319 ± 0.053
2.371GluLys: 2.371 ± 0.037
5.863GluLeu: 5.863 ± 0.065
2.109GluMet: 2.109 ± 0.038
1.953GluAsn: 1.953 ± 0.034
2.755GluPro: 2.755 ± 0.044
2.239GluGln: 2.239 ± 0.038
4.866GluArg: 4.866 ± 0.057
2.654GluSer: 2.654 ± 0.04
4.116GluThr: 4.116 ± 0.052
4.311GluVal: 4.311 ± 0.058
0.791GluTrp: 0.791 ± 0.022
1.166GluTyr: 1.166 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.3PheAla: 4.3 ± 0.054
0.472PheCys: 0.472 ± 0.018
2.751PheAsp: 2.751 ± 0.042
2.46PheGlu: 2.46 ± 0.039
1.576PhePhe: 1.576 ± 0.032
3.861PheGly: 3.861 ± 0.057
0.798PheHis: 0.798 ± 0.021
1.685PheIle: 1.685 ± 0.035
0.914PheLys: 0.914 ± 0.023
3.84PheLeu: 3.84 ± 0.062
0.877PheMet: 0.877 ± 0.021
1.057PheAsn: 1.057 ± 0.03
1.697PhePro: 1.697 ± 0.033
1.021PheGln: 1.021 ± 0.026
2.41PheArg: 2.41 ± 0.038
2.335PheSer: 2.335 ± 0.04
1.997PheThr: 1.997 ± 0.037
2.884PheVal: 2.884 ± 0.047
0.605PheTrp: 0.605 ± 0.023
0.945PheTyr: 0.945 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
9.369GlyAla: 9.369 ± 0.09
0.94GlyCys: 0.94 ± 0.026
4.437GlyAsp: 4.437 ± 0.076
5.054GlyGlu: 5.054 ± 0.054
3.747GlyPhe: 3.747 ± 0.057
7.2GlyGly: 7.2 ± 0.107
1.908GlyHis: 1.908 ± 0.039
4.758GlyIle: 4.758 ± 0.058
3.293GlyLys: 3.293 ± 0.049
9.092GlyLeu: 9.092 ± 0.081
2.698GlyMet: 2.698 ± 0.045
2.278GlyAsn: 2.278 ± 0.042
3.66GlyPro: 3.66 ± 0.052
2.981GlyGln: 2.981 ± 0.043
5.638GlyArg: 5.638 ± 0.073
4.365GlySer: 4.365 ± 0.054
4.593GlyThr: 4.593 ± 0.056
6.213GlyVal: 6.213 ± 0.062
1.578GlyTrp: 1.578 ± 0.039
2.352GlyTyr: 2.352 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.172HisAla: 2.172 ± 0.038
0.254HisCys: 0.254 ± 0.012
1.226HisAsp: 1.226 ± 0.03
1.19HisGlu: 1.19 ± 0.027
0.891HisPhe: 0.891 ± 0.021
1.953HisGly: 1.953 ± 0.036
0.575HisHis: 0.575 ± 0.022
0.978HisIle: 0.978 ± 0.028
0.559HisLys: 0.559 ± 0.02
2.023HisLeu: 2.023 ± 0.037
0.582HisMet: 0.582 ± 0.018
0.45HisAsn: 0.45 ± 0.019
1.336HisPro: 1.336 ± 0.03
0.552HisGln: 0.552 ± 0.018
1.424HisArg: 1.424 ± 0.031
1.063HisSer: 1.063 ± 0.028
0.839HisThr: 0.839 ± 0.023
1.581HisVal: 1.581 ± 0.027
0.362HisTrp: 0.362 ± 0.016
0.587HisTyr: 0.587 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
7.029IleAla: 7.029 ± 0.07
0.652IleCys: 0.652 ± 0.02
3.517IleAsp: 3.517 ± 0.045
3.694IleGlu: 3.694 ± 0.054
1.875IlePhe: 1.875 ± 0.033
5.038IleGly: 5.038 ± 0.059
0.98IleHis: 0.98 ± 0.025
2.266IleIle: 2.266 ± 0.043
1.309IleLys: 1.309 ± 0.032
5.174IleLeu: 5.174 ± 0.062
1.039IleMet: 1.039 ± 0.027
1.362IleAsn: 1.362 ± 0.03
2.509IlePro: 2.509 ± 0.045
1.146IleGln: 1.146 ± 0.027
3.398IleArg: 3.398 ± 0.048
3.247IleSer: 3.247 ± 0.043
2.679IleThr: 2.679 ± 0.039
4.034IleVal: 4.034 ± 0.058
0.731IleTrp: 0.731 ± 0.021
1.175IleTyr: 1.175 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.905LysAla: 3.905 ± 0.047
0.2LysCys: 0.2 ± 0.012
1.657LysAsp: 1.657 ± 0.034
1.683LysGlu: 1.683 ± 0.035
0.978LysPhe: 0.978 ± 0.026
2.64LysGly: 2.64 ± 0.048
0.604LysHis: 0.604 ± 0.02
1.68LysIle: 1.68 ± 0.031
1.239LysLys: 1.239 ± 0.036
3.213LysLeu: 3.213 ± 0.044
0.879LysMet: 0.879 ± 0.026
0.826LysAsn: 0.826 ± 0.024
1.847LysPro: 1.847 ± 0.04
0.937LysGln: 0.937 ± 0.025
2.273LysArg: 2.273 ± 0.041
1.762LysSer: 1.762 ± 0.033
1.88LysThr: 1.88 ± 0.037
2.401LysVal: 2.401 ± 0.04
0.407LysTrp: 0.407 ± 0.017
0.645LysTyr: 0.645 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
12.923LeuAla: 12.923 ± 0.108
0.969LeuCys: 0.969 ± 0.025
6.051LeuAsp: 6.051 ± 0.07
6.164LeuGlu: 6.164 ± 0.08
3.763LeuPhe: 3.763 ± 0.051
8.415LeuGly: 8.415 ± 0.076
1.956LeuHis: 1.956 ± 0.039
4.879LeuIle: 4.879 ± 0.066
3.369LeuLys: 3.369 ± 0.052
9.592LeuLeu: 9.592 ± 0.11
2.51LeuMet: 2.51 ± 0.042
2.583LeuAsn: 2.583 ± 0.035
5.686LeuPro: 5.686 ± 0.064
2.835LeuGln: 2.835 ± 0.048
6.896LeuArg: 6.896 ± 0.077
6.743LeuSer: 6.743 ± 0.078
5.486LeuThr: 5.486 ± 0.056
7.144LeuVal: 7.144 ± 0.074
1.26LeuTrp: 1.26 ± 0.035
2.015LeuTyr: 2.015 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.383MetAla: 3.383 ± 0.048
0.207MetCys: 0.207 ± 0.012
1.402MetAsp: 1.402 ± 0.033
1.563MetGlu: 1.563 ± 0.037
0.852MetPhe: 0.852 ± 0.025
2.161MetGly: 2.161 ± 0.037
0.478MetHis: 0.478 ± 0.018
1.629MetIle: 1.629 ± 0.033
1.136MetLys: 1.136 ± 0.028
2.667MetLeu: 2.667 ± 0.041
0.766MetMet: 0.766 ± 0.023
0.907MetAsn: 0.907 ± 0.022
1.518MetPro: 1.518 ± 0.031
0.928MetGln: 0.928 ± 0.022
1.853MetArg: 1.853 ± 0.037
1.842MetSer: 1.842 ± 0.034
1.978MetThr: 1.978 ± 0.033
1.949MetVal: 1.949 ± 0.034
0.225MetTrp: 0.225 ± 0.01
0.326MetTyr: 0.326 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.161AsnAla: 3.161 ± 0.041
0.275AsnCys: 0.275 ± 0.014
1.406AsnAsp: 1.406 ± 0.034
1.368AsnGlu: 1.368 ± 0.029
1.02AsnPhe: 1.02 ± 0.025
2.477AsnGly: 2.477 ± 0.042
0.529AsnHis: 0.529 ± 0.017
1.396AsnIle: 1.396 ± 0.031
0.677AsnLys: 0.677 ± 0.022
2.572AsnLeu: 2.572 ± 0.038
0.747AsnMet: 0.747 ± 0.02
0.718AsnAsn: 0.718 ± 0.021
1.918AsnPro: 1.918 ± 0.03
0.739AsnGln: 0.739 ± 0.022
1.859AsnArg: 1.859 ± 0.038
1.334AsnSer: 1.334 ± 0.031
1.311AsnThr: 1.311 ± 0.029
1.949AsnVal: 1.949 ± 0.037
0.474AsnTrp: 0.474 ± 0.017
0.701AsnTyr: 0.701 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
5.496ProAla: 5.496 ± 0.065
0.394ProCys: 0.394 ± 0.014
3.696ProAsp: 3.696 ± 0.051
4.7ProGlu: 4.7 ± 0.057
2.042ProPhe: 2.042 ± 0.034
4.6ProGly: 4.6 ± 0.058
1.049ProHis: 1.049 ± 0.024
2.375ProIle: 2.375 ± 0.038
1.628ProLys: 1.628 ± 0.031
4.61ProLeu: 4.61 ± 0.061
1.323ProMet: 1.323 ± 0.027
1.389ProAsn: 1.389 ± 0.029
2.354ProPro: 2.354 ± 0.047
1.536ProGln: 1.536 ± 0.029
2.82ProArg: 2.82 ± 0.044
2.631ProSer: 2.631 ± 0.039
2.419ProThr: 2.419 ± 0.038
4.235ProVal: 4.235 ± 0.054
0.718ProTrp: 0.718 ± 0.022
1.156ProTyr: 1.156 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.698GlnAla: 3.698 ± 0.057
0.233GlnCys: 0.233 ± 0.011
1.499GlnAsp: 1.499 ± 0.032
1.763GlnGlu: 1.763 ± 0.034
1.054GlnPhe: 1.054 ± 0.026
2.35GlnGly: 2.35 ± 0.041
0.583GlnHis: 0.583 ± 0.018
1.868GlnIle: 1.868 ± 0.033
1.081GlnLys: 1.081 ± 0.026
2.699GlnLeu: 2.699 ± 0.046
1.001GlnMet: 1.001 ± 0.027
0.823GlnAsn: 0.823 ± 0.022
1.606GlnPro: 1.606 ± 0.028
1.102GlnGln: 1.102 ± 0.031
2.138GlnArg: 2.138 ± 0.037
1.71GlnSer: 1.71 ± 0.034
1.629GlnThr: 1.629 ± 0.034
2.298GlnVal: 2.298 ± 0.041
0.416GlnTrp: 0.416 ± 0.015
0.561GlnTyr: 0.561 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
7.526ArgAla: 7.526 ± 0.094
0.548ArgCys: 0.548 ± 0.019
3.921ArgAsp: 3.921 ± 0.049
4.253ArgGlu: 4.253 ± 0.056
2.764ArgPhe: 2.764 ± 0.041
4.566ArgGly: 4.566 ± 0.056
1.603ArgHis: 1.603 ± 0.034
3.952ArgIle: 3.952 ± 0.05
2.502ArgLys: 2.502 ± 0.038
7.333ArgLeu: 7.333 ± 0.084
2.007ArgMet: 2.007 ± 0.033
1.968ArgAsn: 1.968 ± 0.037
3.405ArgPro: 3.405 ± 0.048
2.349ArgGln: 2.349 ± 0.042
5.165ArgArg: 5.165 ± 0.073
3.685ArgSer: 3.685 ± 0.059
3.074ArgThr: 3.074 ± 0.04
4.533ArgVal: 4.533 ± 0.065
0.968ArgTrp: 0.968 ± 0.026
1.623ArgTyr: 1.623 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
5.995SerAla: 5.995 ± 0.062
0.5SerCys: 0.5 ± 0.018
3.309SerAsp: 3.309 ± 0.042
3.466SerGlu: 3.466 ± 0.052
2.341SerPhe: 2.341 ± 0.041
5.576SerGly: 5.576 ± 0.058
1.141SerHis: 1.141 ± 0.024
2.703SerIle: 2.703 ± 0.042
1.618SerLys: 1.618 ± 0.031
5.336SerLeu: 5.336 ± 0.06
1.476SerMet: 1.476 ± 0.027
1.506SerAsn: 1.506 ± 0.03
2.716SerPro: 2.716 ± 0.035
1.615SerGln: 1.615 ± 0.034
3.579SerArg: 3.579 ± 0.056
2.844SerSer: 2.844 ± 0.046
2.656SerThr: 2.656 ± 0.048
4.122SerVal: 4.122 ± 0.046
0.751SerTrp: 0.751 ± 0.018
1.309SerTyr: 1.309 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
5.932ThrAla: 5.932 ± 0.056
0.475ThrCys: 0.475 ± 0.016
2.886ThrAsp: 2.886 ± 0.043
3.155ThrGlu: 3.155 ± 0.051
1.971ThrPhe: 1.971 ± 0.039
5.219ThrGly: 5.219 ± 0.055
1.139ThrHis: 1.139 ± 0.027
2.809ThrIle: 2.809 ± 0.048
1.417ThrLys: 1.417 ± 0.031
5.783ThrLeu: 5.783 ± 0.062
1.267ThrMet: 1.267 ± 0.026
1.312ThrAsn: 1.312 ± 0.029
3.179ThrPro: 3.179 ± 0.042
1.374ThrGln: 1.374 ± 0.026
3.328ThrArg: 3.328 ± 0.049
2.771ThrSer: 2.771 ± 0.044
2.606ThrThr: 2.606 ± 0.041
4.079ThrVal: 4.079 ± 0.057
0.645ThrTrp: 0.645 ± 0.018
1.182ThrTyr: 1.182 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
8.509ValAla: 8.509 ± 0.064
0.679ValCys: 0.679 ± 0.022
4.059ValAsp: 4.059 ± 0.054
4.874ValGlu: 4.874 ± 0.054
2.925ValPhe: 2.925 ± 0.048
5.48ValGly: 5.48 ± 0.07
1.382ValHis: 1.382 ± 0.029
4.186ValIle: 4.186 ± 0.053
2.055ValLys: 2.055 ± 0.041
7.492ValLeu: 7.492 ± 0.07
1.99ValMet: 1.99 ± 0.038
1.981ValAsn: 1.981 ± 0.036
3.687ValPro: 3.687 ± 0.044
1.97ValGln: 1.97 ± 0.035
4.251ValArg: 4.251 ± 0.055
4.521ValSer: 4.521 ± 0.059
4.397ValThr: 4.397 ± 0.053
5.556ValVal: 5.556 ± 0.061
0.867ValTrp: 0.867 ± 0.025
1.465ValTyr: 1.465 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.348TrpAla: 1.348 ± 0.031
0.136TrpCys: 0.136 ± 0.009
0.738TrpAsp: 0.738 ± 0.023
0.774TrpGlu: 0.774 ± 0.022
0.576TrpPhe: 0.576 ± 0.018
0.979TrpGly: 0.979 ± 0.028
0.349TrpHis: 0.349 ± 0.016
0.765TrpIle: 0.765 ± 0.021
0.54TrpLys: 0.54 ± 0.019
1.619TrpLeu: 1.619 ± 0.031
0.45TrpMet: 0.45 ± 0.018
0.512TrpAsn: 0.512 ± 0.017
0.673TrpPro: 0.673 ± 0.023
0.557TrpGln: 0.557 ± 0.019
1.041TrpArg: 1.041 ± 0.027
0.887TrpSer: 0.887 ± 0.025
0.774TrpThr: 0.774 ± 0.021
0.898TrpVal: 0.898 ± 0.021
0.211TrpTrp: 0.211 ± 0.011
0.313TrpTyr: 0.313 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.372TyrAla: 2.372 ± 0.036
0.263TyrCys: 0.263 ± 0.011
1.539TyrAsp: 1.539 ± 0.028
1.296TyrGlu: 1.296 ± 0.028
0.984TyrPhe: 0.984 ± 0.025
2.049TyrGly: 2.049 ± 0.038
0.46TyrHis: 0.46 ± 0.015
0.924TyrIle: 0.924 ± 0.021
0.579TyrLys: 0.579 ± 0.019
2.26TyrLeu: 2.26 ± 0.041
0.496TyrMet: 0.496 ± 0.019
0.626TyrAsn: 0.626 ± 0.021
1.082TyrPro: 1.082 ± 0.025
0.678TyrGln: 0.678 ± 0.02
1.641TyrArg: 1.641 ± 0.032
1.291TyrSer: 1.291 ± 0.028
1.094TyrThr: 1.094 ± 0.029
1.554TyrVal: 1.554 ± 0.031
0.357TyrTrp: 0.357 ± 0.017
0.586TyrTyr: 0.586 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5650 proteins (1678539 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski