Amino acid dipepetide frequency for Rhodotorula diobovata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.054AlaAla: 18.054 ± 0.155	1.23AlaCys: 1.23 ± 0.02	5.581AlaAsp: 5.581 ± 0.038	6.075AlaGlu: 6.075 ± 0.048	3.642AlaPhe: 3.642 ± 0.037	9.439AlaGly: 9.439 ± 0.066	2.921AlaHis: 2.921 ± 0.029	3.107AlaIle: 3.107 ± 0.033	4.242AlaLys: 4.242 ± 0.051	11.487AlaLeu: 11.487 ± 0.076	1.838AlaMet: 1.838 ± 0.024	2.318AlaAsn: 2.318 ± 0.028	9.932AlaPro: 9.932 ± 0.105	4.689AlaGln: 4.689 ± 0.046	8.825AlaArg: 8.825 ± 0.065	11.445AlaSer: 11.445 ± 0.084	6.534AlaThr: 6.534 ± 0.045	6.925AlaVal: 6.925 ± 0.041	1.385AlaTrp: 1.385 ± 0.02	2.221AlaTyr: 2.221 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	1.278CysAla: 1.278 ± 0.023	0.224CysCys: 0.224 ± 0.009	0.56CysAsp: 0.56 ± 0.014	0.533CysGlu: 0.533 ± 0.012	0.406CysPhe: 0.406 ± 0.011	0.928CysGly: 0.928 ± 0.019	0.233CysHis: 0.233 ± 0.009	0.409CysIle: 0.409 ± 0.011	0.333CysLys: 0.333 ± 0.01	1.053CysLeu: 1.053 ± 0.019	0.185CysMet: 0.185 ± 0.007	0.236CysAsn: 0.236 ± 0.007	0.696CysPro: 0.696 ± 0.018	0.302CysGln: 0.302 ± 0.009	0.769CysArg: 0.769 ± 0.017	0.858CysSer: 0.858 ± 0.019	0.644CysThr: 0.644 ± 0.016	0.806CysVal: 0.806 ± 0.014	0.166CysTrp: 0.166 ± 0.006	0.24CysTyr: 0.24 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.669AspAla: 6.669 ± 0.044	0.473AspCys: 0.473 ± 0.01	5.397AspAsp: 5.397 ± 0.071	5.628AspGlu: 5.628 ± 0.048	1.752AspPhe: 1.752 ± 0.021	4.429AspGly: 4.429 ± 0.039	1.014AspHis: 1.014 ± 0.015	1.549AspIle: 1.549 ± 0.025	2.323AspLys: 2.323 ± 0.033	5.109AspLeu: 5.109 ± 0.043	0.84AspMet: 0.84 ± 0.016	1.104AspAsn: 1.104 ± 0.018	3.632AspPro: 3.632 ± 0.037	1.448AspGln: 1.448 ± 0.019	3.049AspArg: 3.049 ± 0.031	3.671AspSer: 3.671 ± 0.033	2.243AspThr: 2.243 ± 0.025	3.797AspVal: 3.797 ± 0.035	0.766AspTrp: 0.766 ± 0.015	1.119AspTyr: 1.119 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	6.517GluAla: 6.517 ± 0.054	0.537GluCys: 0.537 ± 0.013	3.985GluAsp: 3.985 ± 0.043	5.183GluGlu: 5.183 ± 0.058	1.413GluPhe: 1.413 ± 0.021	5.317GluGly: 5.317 ± 0.044	1.398GluHis: 1.398 ± 0.021	1.69GluIle: 1.69 ± 0.024	2.27GluLys: 2.27 ± 0.032	5.366GluLeu: 5.366 ± 0.047	1.074GluMet: 1.074 ± 0.018	1.054GluAsn: 1.054 ± 0.017	2.916GluPro: 2.916 ± 0.034	2.389GluGln: 2.389 ± 0.027	5.413GluArg: 5.413 ± 0.045	3.199GluSer: 3.199 ± 0.033	2.672GluThr: 2.672 ± 0.03	3.887GluVal: 3.887 ± 0.034	0.903GluTrp: 0.903 ± 0.015	1.178GluTyr: 1.178 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.694PheAla: 3.694 ± 0.037	0.444PheCys: 0.444 ± 0.012	2.059PheAsp: 2.059 ± 0.026	1.844PheGlu: 1.844 ± 0.024	1.288PhePhe: 1.288 ± 0.024	2.566PheGly: 2.566 ± 0.035	0.707PheHis: 0.707 ± 0.013	1.025PheIle: 1.025 ± 0.017	1.05PheLys: 1.05 ± 0.018	3.143PheLeu: 3.143 ± 0.037	0.434PheMet: 0.434 ± 0.012	0.849PheAsn: 0.849 ± 0.015	1.855PhePro: 1.855 ± 0.024	0.854PheGln: 0.854 ± 0.015	1.756PheArg: 1.756 ± 0.022	2.591PheSer: 2.591 ± 0.03	1.62PheThr: 1.62 ± 0.022	2.385PheVal: 2.385 ± 0.027	0.429PheTrp: 0.429 ± 0.013	0.758PheTyr: 0.758 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	9.982GlyAla: 9.982 ± 0.083	0.778GlyCys: 0.778 ± 0.017	4.225GlyAsp: 4.225 ± 0.036	4.843GlyGlu: 4.843 ± 0.037	2.412GlyPhe: 2.412 ± 0.027	9.654GlyGly: 9.654 ± 0.119	1.644GlyHis: 1.644 ± 0.022	2.33GlyIle: 2.33 ± 0.027	3.411GlyLys: 3.411 ± 0.04	6.091GlyLeu: 6.091 ± 0.045	1.334GlyMet: 1.334 ± 0.022	1.559GlyAsn: 1.559 ± 0.024	4.108GlyPro: 4.108 ± 0.04	2.508GlyGln: 2.508 ± 0.029	5.403GlyArg: 5.403 ± 0.05	6.225GlySer: 6.225 ± 0.055	4.164GlyThr: 4.164 ± 0.031	4.868GlyVal: 4.868 ± 0.037	1.199GlyTrp: 1.199 ± 0.019	1.656GlyTyr: 1.656 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	2.777HisAla: 2.777 ± 0.034	0.268HisCys: 0.268 ± 0.009	1.298HisAsp: 1.298 ± 0.02	1.227HisGlu: 1.227 ± 0.02	0.79HisPhe: 0.79 ± 0.013	1.753HisGly: 1.753 ± 0.026	0.888HisHis: 0.888 ± 0.022	0.692HisIle: 0.692 ± 0.013	0.741HisLys: 0.741 ± 0.014	2.557HisLeu: 2.557 ± 0.026	0.3HisMet: 0.3 ± 0.01	0.493HisAsn: 0.493 ± 0.013	2.039HisPro: 2.039 ± 0.027	0.817HisGln: 0.817 ± 0.016	1.608HisArg: 1.608 ± 0.024	1.854HisSer: 1.854 ± 0.024	1.117HisThr: 1.117 ± 0.017	1.493HisVal: 1.493 ± 0.018	0.285HisTrp: 0.285 ± 0.008	0.512HisTyr: 0.512 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.175IleAla: 3.175 ± 0.034	0.404IleCys: 0.404 ± 0.011	1.875IleAsp: 1.875 ± 0.023	1.869IleGlu: 1.869 ± 0.024	1.039IlePhe: 1.039 ± 0.017	2.058IleGly: 2.058 ± 0.031	0.634IleHis: 0.634 ± 0.013	1.062IleIle: 1.062 ± 0.02	1.245IleLys: 1.245 ± 0.021	2.818IleLeu: 2.818 ± 0.036	0.482IleMet: 0.482 ± 0.011	0.836IleAsn: 0.836 ± 0.016	1.838IlePro: 1.838 ± 0.019	0.937IleGln: 0.937 ± 0.018	1.871IleArg: 1.871 ± 0.026	2.107IleSer: 2.107 ± 0.027	1.486IleThr: 1.486 ± 0.023	2.292IleVal: 2.292 ± 0.028	0.362IleTrp: 0.362 ± 0.01	0.69IleTyr: 0.69 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.261LysAla: 4.261 ± 0.048	0.326LysCys: 0.326 ± 0.009	2.007LysAsp: 2.007 ± 0.03	2.469LysGlu: 2.469 ± 0.032	0.865LysPhe: 0.865 ± 0.017	3.09LysGly: 3.09 ± 0.04	0.818LysHis: 0.818 ± 0.015	1.124LysIle: 1.124 ± 0.02	2.458LysLys: 2.458 ± 0.046	3.191LysLeu: 3.191 ± 0.037	0.636LysMet: 0.636 ± 0.014	0.859LysAsn: 0.859 ± 0.018	2.177LysPro: 2.177 ± 0.032	1.336LysGln: 1.336 ± 0.023	3.244LysArg: 3.244 ± 0.039	2.182LysSer: 2.182 ± 0.027	1.889LysThr: 1.889 ± 0.028	2.507LysVal: 2.507 ± 0.03	0.465LysTrp: 0.465 ± 0.011	0.744LysTyr: 0.744 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	11.588LeuAla: 11.588 ± 0.062	1.176LeuCys: 1.176 ± 0.019	5.703LeuAsp: 5.703 ± 0.042	5.558LeuGlu: 5.558 ± 0.047	3.165LeuPhe: 3.165 ± 0.033	6.39LeuGly: 6.39 ± 0.042	2.244LeuHis: 2.244 ± 0.026	2.587LeuIle: 2.587 ± 0.032	3.172LeuLys: 3.172 ± 0.034	9.124LeuLeu: 9.124 ± 0.078	1.263LeuMet: 1.263 ± 0.021	2.166LeuAsn: 2.166 ± 0.026	6.959LeuPro: 6.959 ± 0.051	2.962LeuGln: 2.962 ± 0.029	6.889LeuArg: 6.889 ± 0.057	8.299LeuSer: 8.299 ± 0.053	4.656LeuThr: 4.656 ± 0.039	7.062LeuVal: 7.062 ± 0.057	1.066LeuTrp: 1.066 ± 0.017	1.963LeuTyr: 1.963 ± 0.025	0.002LeuXaa: 0.002 ± 0.001
Met	1.719MetAla: 1.719 ± 0.021	0.181MetCys: 0.181 ± 0.006	0.828MetAsp: 0.828 ± 0.015	0.717MetGlu: 0.717 ± 0.013	0.428MetPhe: 0.428 ± 0.012	1.14MetGly: 1.14 ± 0.02	0.374MetHis: 0.374 ± 0.01	0.453MetIle: 0.453 ± 0.011	0.488MetLys: 0.488 ± 0.013	1.468MetLeu: 1.468 ± 0.02	0.305MetMet: 0.305 ± 0.01	0.358MetAsn: 0.358 ± 0.009	1.023MetPro: 1.023 ± 0.016	0.624MetGln: 0.624 ± 0.014	1.223MetArg: 1.223 ± 0.019	1.436MetSer: 1.436 ± 0.02	0.837MetThr: 0.837 ± 0.013	0.886MetVal: 0.886 ± 0.016	0.199MetTrp: 0.199 ± 0.008	0.339MetTyr: 0.339 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.452AsnAla: 2.452 ± 0.026	0.258AsnCys: 0.258 ± 0.008	1.192AsnAsp: 1.192 ± 0.018	1.213AsnGlu: 1.213 ± 0.021	0.723AsnPhe: 0.723 ± 0.015	1.917AsnGly: 1.917 ± 0.024	0.431AsnHis: 0.431 ± 0.012	0.795AsnIle: 0.795 ± 0.015	0.912AsnLys: 0.912 ± 0.015	2.154AsnLeu: 2.154 ± 0.027	0.336AsnMet: 0.336 ± 0.01	0.591AsnAsn: 0.591 ± 0.014	1.659AsnPro: 1.659 ± 0.023	0.633AsnGln: 0.633 ± 0.012	1.237AsnArg: 1.237 ± 0.019	1.46AsnSer: 1.46 ± 0.021	1.034AsnThr: 1.034 ± 0.018	1.548AsnVal: 1.548 ± 0.024	0.311AsnTrp: 0.311 ± 0.009	0.54AsnTyr: 0.54 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	9.868ProAla: 9.868 ± 0.098	0.588ProCys: 0.588 ± 0.012	3.167ProAsp: 3.167 ± 0.028	3.078ProGlu: 3.078 ± 0.032	2.198ProPhe: 2.198 ± 0.025	4.552ProGly: 4.552 ± 0.042	1.95ProHis: 1.95 ± 0.029	1.678ProIle: 1.678 ± 0.023	1.924ProLys: 1.924 ± 0.027	6.614ProLeu: 6.614 ± 0.051	0.738ProMet: 0.738 ± 0.013	1.387ProAsn: 1.387 ± 0.019	9.416ProPro: 9.416 ± 0.13	2.435ProGln: 2.435 ± 0.036	5.164ProArg: 5.164 ± 0.048	9.168ProSer: 9.168 ± 0.081	4.721ProThr: 4.721 ± 0.045	4.154ProVal: 4.154 ± 0.035	0.638ProTrp: 0.638 ± 0.014	1.369ProTyr: 1.369 ± 0.023	0.001ProXaa: 0.001 ± 0.001
Gln	3.973GlnAla: 3.973 ± 0.045	0.342GlnCys: 0.342 ± 0.011	1.636GlnAsp: 1.636 ± 0.023	1.778GlnGlu: 1.778 ± 0.022	0.885GlnPhe: 0.885 ± 0.016	2.618GlnGly: 2.618 ± 0.033	1.091GlnHis: 1.091 ± 0.021	1.02GlnIle: 1.02 ± 0.02	1.098GlnLys: 1.098 ± 0.018	3.457GlnLeu: 3.457 ± 0.035	0.56GlnMet: 0.56 ± 0.013	0.69GlnAsn: 0.69 ± 0.013	2.569GlnPro: 2.569 ± 0.037	2.792GlnGln: 2.792 ± 0.084	2.872GlnArg: 2.872 ± 0.031	2.217GlnSer: 2.217 ± 0.027	1.633GlnThr: 1.633 ± 0.022	2.089GlnVal: 2.089 ± 0.024	0.414GlnTrp: 0.414 ± 0.011	0.722GlnTyr: 0.722 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	8.666ArgAla: 8.666 ± 0.064	0.817ArgCys: 0.817 ± 0.017	3.962ArgAsp: 3.962 ± 0.036	4.701ArgGlu: 4.701 ± 0.047	2.207ArgPhe: 2.207 ± 0.023	5.242ArgGly: 5.242 ± 0.045	1.62ArgHis: 1.62 ± 0.024	2.248ArgIle: 2.248 ± 0.024	2.998ArgLys: 2.998 ± 0.034	6.691ArgLeu: 6.691 ± 0.051	1.211ArgMet: 1.211 ± 0.019	1.563ArgAsn: 1.563 ± 0.019	5.03ArgPro: 5.03 ± 0.047	2.461ArgGln: 2.461 ± 0.029	7.916ArgArg: 7.916 ± 0.089	5.849ArgSer: 5.849 ± 0.056	4.048ArgThr: 4.048 ± 0.036	4.36ArgVal: 4.36 ± 0.038	1.047ArgTrp: 1.047 ± 0.019	1.38ArgTyr: 1.38 ± 0.021	0.001ArgXaa: 0.001 ± 0.0
Ser	10.255SerAla: 10.255 ± 0.076	0.877SerCys: 0.877 ± 0.019	3.876SerAsp: 3.876 ± 0.041	3.206SerGlu: 3.206 ± 0.03	2.847SerPhe: 2.847 ± 0.029	6.016SerGly: 6.016 ± 0.049	1.987SerHis: 1.987 ± 0.023	2.435SerIle: 2.435 ± 0.028	2.392SerLys: 2.392 ± 0.03	8.504SerLeu: 8.504 ± 0.057	1.176SerMet: 1.176 ± 0.019	1.759SerAsn: 1.759 ± 0.025	8.04SerPro: 8.04 ± 0.081	2.372SerGln: 2.372 ± 0.03	5.926SerArg: 5.926 ± 0.056	12.876SerSer: 12.876 ± 0.124	6.393SerThr: 6.393 ± 0.056	4.507SerVal: 4.507 ± 0.044	0.934SerTrp: 0.934 ± 0.015	1.646SerTyr: 1.646 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	6.338ThrAla: 6.338 ± 0.041	0.689ThrCys: 0.689 ± 0.019	2.393ThrAsp: 2.393 ± 0.021	2.2ThrGlu: 2.2 ± 0.027	1.886ThrPhe: 1.886 ± 0.021	4.047ThrGly: 4.047 ± 0.036	1.237ThrHis: 1.237 ± 0.016	1.753ThrIle: 1.753 ± 0.029	1.796ThrLys: 1.796 ± 0.026	5.548ThrLeu: 5.548 ± 0.04	0.758ThrMet: 0.758 ± 0.015	1.141ThrAsn: 1.141 ± 0.018	4.768ThrPro: 4.768 ± 0.046	1.576ThrGln: 1.576 ± 0.021	3.686ThrArg: 3.686 ± 0.036	5.658ThrSer: 5.658 ± 0.051	3.918ThrThr: 3.918 ± 0.045	3.371ThrVal: 3.371 ± 0.033	0.721ThrTrp: 0.721 ± 0.014	1.187ThrTyr: 1.187 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	7.127ValAla: 7.127 ± 0.046	0.787ValCys: 0.787 ± 0.016	4.154ValAsp: 4.154 ± 0.039	4.369ValGlu: 4.369 ± 0.036	2.182ValPhe: 2.182 ± 0.025	4.694ValGly: 4.694 ± 0.041	1.496ValHis: 1.496 ± 0.02	1.939ValIle: 1.939 ± 0.026	2.606ValLys: 2.606 ± 0.031	6.215ValLeu: 6.215 ± 0.048	0.969ValMet: 0.969 ± 0.018	1.512ValAsn: 1.512 ± 0.02	4.38ValPro: 4.38 ± 0.044	2.215ValGln: 2.215 ± 0.025	4.697ValArg: 4.697 ± 0.04	4.411ValSer: 4.411 ± 0.033	3.103ValThr: 3.103 ± 0.029	5.169ValVal: 5.169 ± 0.038	0.903ValTrp: 0.903 ± 0.016	1.338ValTyr: 1.338 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.261TrpAla: 1.261 ± 0.02	0.183TrpCys: 0.183 ± 0.008	0.814TrpAsp: 0.814 ± 0.016	0.746TrpGlu: 0.746 ± 0.013	0.417TrpPhe: 0.417 ± 0.01	0.839TrpGly: 0.839 ± 0.015	0.307TrpHis: 0.307 ± 0.008	0.489TrpIle: 0.489 ± 0.012	0.481TrpLys: 0.481 ± 0.013	1.236TrpLeu: 1.236 ± 0.016	0.263TrpMet: 0.263 ± 0.008	0.348TrpAsn: 0.348 ± 0.01	0.556TrpPro: 0.556 ± 0.014	0.442TrpGln: 0.442 ± 0.01	1.108TrpArg: 1.108 ± 0.017	0.987TrpSer: 0.987 ± 0.015	0.853TrpThr: 0.853 ± 0.017	0.857TrpVal: 0.857 ± 0.015	0.259TrpTrp: 0.259 ± 0.01	0.295TrpTyr: 0.295 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.24TyrAla: 2.24 ± 0.025	0.277TyrCys: 0.277 ± 0.009	1.3TyrAsp: 1.3 ± 0.019	1.123TyrGlu: 1.123 ± 0.017	0.803TyrPhe: 0.803 ± 0.015	1.704TyrGly: 1.704 ± 0.028	0.512TyrHis: 0.512 ± 0.012	0.694TyrIle: 0.694 ± 0.015	0.71TyrLys: 0.71 ± 0.013	2.17TyrLeu: 2.17 ± 0.027	0.32TyrMet: 0.32 ± 0.009	0.576TyrAsn: 0.576 ± 0.013	1.215TyrPro: 1.215 ± 0.018	0.664TyrGln: 0.664 ± 0.014	1.363TyrArg: 1.363 ± 0.018	1.53TyrSer: 1.53 ± 0.022	1.107TyrThr: 1.107 ± 0.017	1.299TyrVal: 1.299 ± 0.019	0.291TyrTrp: 0.291 ± 0.008	0.574TyrTyr: 0.574 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.02XaaXaa: 0.02 ± 0.008

Statistics based on 7905 proteins (4044272 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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