Amino acid dipepetide frequency for Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.741AlaAla: 12.741 ± 0.166	1.129AlaCys: 1.129 ± 0.035	5.786AlaAsp: 5.786 ± 0.088	7.485AlaGlu: 7.485 ± 0.103	3.467AlaPhe: 3.467 ± 0.066	9.596AlaGly: 9.596 ± 0.143	2.587AlaHis: 2.587 ± 0.054	4.792AlaIle: 4.792 ± 0.071	2.388AlaLys: 2.388 ± 0.063	13.668AlaLeu: 13.668 ± 0.152	3.017AlaMet: 3.017 ± 0.063	2.343AlaAsn: 2.343 ± 0.051	4.815AlaPro: 4.815 ± 0.089	4.113AlaGln: 4.113 ± 0.066	9.709AlaArg: 9.709 ± 0.13	5.252AlaSer: 5.252 ± 0.084	4.557AlaThr: 4.557 ± 0.067	8.208AlaVal: 8.208 ± 0.119	1.713AlaTrp: 1.713 ± 0.045	2.467AlaTyr: 2.467 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.895CysAla: 0.895 ± 0.032	0.104CysCys: 0.104 ± 0.01	0.502CysAsp: 0.502 ± 0.024	0.567CysGlu: 0.567 ± 0.025	0.291CysPhe: 0.291 ± 0.015	0.927CysGly: 0.927 ± 0.037	0.326CysHis: 0.326 ± 0.023	0.357CysIle: 0.357 ± 0.019	0.182CysLys: 0.182 ± 0.014	0.962CysLeu: 0.962 ± 0.036	0.158CysMet: 0.158 ± 0.013	0.213CysAsn: 0.213 ± 0.014	0.545CysPro: 0.545 ± 0.029	0.314CysGln: 0.314 ± 0.019	0.71CysArg: 0.71 ± 0.024	0.396CysSer: 0.396 ± 0.022	0.398CysThr: 0.398 ± 0.017	0.617CysVal: 0.617 ± 0.026	0.1CysTrp: 0.1 ± 0.01	0.229CysTyr: 0.229 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.403AspAla: 6.403 ± 0.09	0.473AspCys: 0.473 ± 0.024	2.983AspAsp: 2.983 ± 0.061	4.103AspGlu: 4.103 ± 0.074	2.065AspPhe: 2.065 ± 0.046	4.533AspGly: 4.533 ± 0.074	1.369AspHis: 1.369 ± 0.043	2.59AspIle: 2.59 ± 0.049	1.514AspLys: 1.514 ± 0.052	6.496AspLeu: 6.496 ± 0.085	1.454AspMet: 1.454 ± 0.039	1.361AspAsn: 1.361 ± 0.038	3.527AspPro: 3.527 ± 0.074	1.947AspGln: 1.947 ± 0.046	4.178AspArg: 4.178 ± 0.066	2.507AspSer: 2.507 ± 0.052	2.901AspThr: 2.901 ± 0.052	3.893AspVal: 3.893 ± 0.058	1.057AspTrp: 1.057 ± 0.032	1.672AspTyr: 1.672 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.547GluAla: 8.547 ± 0.117	0.398GluCys: 0.398 ± 0.022	3.383GluAsp: 3.383 ± 0.061	3.757GluGlu: 3.757 ± 0.076	1.945GluPhe: 1.945 ± 0.046	5.057GluGly: 5.057 ± 0.074	1.843GluHis: 1.843 ± 0.046	3.333GluIle: 3.333 ± 0.051	1.864GluLys: 1.864 ± 0.051	6.678GluLeu: 6.678 ± 0.077	1.684GluMet: 1.684 ± 0.043	1.5GluAsn: 1.5 ± 0.04	3.155GluPro: 3.155 ± 0.084	3.303GluGln: 3.303 ± 0.066	6.221GluArg: 6.221 ± 0.102	3.185GluSer: 3.185 ± 0.062	3.578GluThr: 3.578 ± 0.062	4.673GluVal: 4.673 ± 0.072	0.736GluTrp: 0.736 ± 0.029	1.354GluTyr: 1.354 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.346PheAla: 3.346 ± 0.057	0.362PheCys: 0.362 ± 0.02	2.228PheAsp: 2.228 ± 0.048	2.271PheGlu: 2.271 ± 0.056	1.315PhePhe: 1.315 ± 0.04	2.952PheGly: 2.952 ± 0.056	0.821PheHis: 0.821 ± 0.026	1.574PheIle: 1.574 ± 0.046	0.939PheLys: 0.939 ± 0.033	3.391PheLeu: 3.391 ± 0.067	0.884PheMet: 0.884 ± 0.028	1.058PheAsn: 1.058 ± 0.039	1.483PhePro: 1.483 ± 0.041	1.108PheGln: 1.108 ± 0.033	2.366PheArg: 2.366 ± 0.05	2.014PheSer: 2.014 ± 0.048	1.829PheThr: 1.829 ± 0.043	2.464PheVal: 2.464 ± 0.053	0.454PheTrp: 0.454 ± 0.022	0.945PheTyr: 0.945 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.681GlyAla: 7.681 ± 0.119	0.848GlyCys: 0.848 ± 0.034	4.631GlyAsp: 4.631 ± 0.084	5.74GlyGlu: 5.74 ± 0.08	3.286GlyPhe: 3.286 ± 0.062	6.524GlyGly: 6.524 ± 0.11	2.164GlyHis: 2.164 ± 0.053	4.346GlyIle: 4.346 ± 0.068	2.576GlyLys: 2.576 ± 0.059	9.501GlyLeu: 9.501 ± 0.121	2.433GlyMet: 2.433 ± 0.061	2.141GlyAsn: 2.141 ± 0.058	3.067GlyPro: 3.067 ± 0.062	3.2GlyGln: 3.2 ± 0.061	6.561GlyArg: 6.561 ± 0.091	4.034GlySer: 4.034 ± 0.072	3.875GlyThr: 3.875 ± 0.073	6.568GlyVal: 6.568 ± 0.097	1.297GlyTrp: 1.297 ± 0.04	2.374GlyTyr: 2.374 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.561HisAla: 2.561 ± 0.051	0.295HisCys: 0.295 ± 0.017	1.321HisAsp: 1.321 ± 0.038	1.458HisGlu: 1.458 ± 0.042	0.936HisPhe: 0.936 ± 0.032	2.392HisGly: 2.392 ± 0.057	0.832HisHis: 0.832 ± 0.033	1.057HisIle: 1.057 ± 0.027	0.594HisLys: 0.594 ± 0.026	2.701HisLeu: 2.701 ± 0.056	0.626HisMet: 0.626 ± 0.024	0.57HisAsn: 0.57 ± 0.024	1.752HisPro: 1.752 ± 0.048	0.896HisGln: 0.896 ± 0.03	1.965HisArg: 1.965 ± 0.045	1.06HisSer: 1.06 ± 0.038	1.119HisThr: 1.119 ± 0.033	1.771HisVal: 1.771 ± 0.048	0.477HisTrp: 0.477 ± 0.02	0.776HisTyr: 0.776 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.182IleAla: 5.182 ± 0.081	0.41IleCys: 0.41 ± 0.02	2.846IleAsp: 2.846 ± 0.058	3.427IleGlu: 3.427 ± 0.063	1.309IlePhe: 1.309 ± 0.04	3.832IleGly: 3.832 ± 0.079	1.25IleHis: 1.25 ± 0.038	2.047IleIle: 2.047 ± 0.059	1.315IleLys: 1.315 ± 0.041	4.571IleLeu: 4.571 ± 0.081	0.927IleMet: 0.927 ± 0.028	1.569IleAsn: 1.569 ± 0.039	2.51IlePro: 2.51 ± 0.053	1.683IleGln: 1.683 ± 0.044	3.696IleArg: 3.696 ± 0.058	2.477IleSer: 2.477 ± 0.056	2.714IleThr: 2.714 ± 0.047	3.002IleVal: 3.002 ± 0.059	0.472IleTrp: 0.472 ± 0.022	1.125IleTyr: 1.125 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.185LysAla: 3.185 ± 0.095	0.149LysCys: 0.149 ± 0.012	1.571LysAsp: 1.571 ± 0.047	1.512LysGlu: 1.512 ± 0.05	0.644LysPhe: 0.644 ± 0.027	2.252LysGly: 2.252 ± 0.056	0.668LysHis: 0.668 ± 0.026	1.166LysIle: 1.166 ± 0.041	1.139LysLys: 1.139 ± 0.068	2.683LysLeu: 2.683 ± 0.059	0.596LysMet: 0.596 ± 0.028	0.704LysAsn: 0.704 ± 0.024	1.59LysPro: 1.59 ± 0.046	1.023LysGln: 1.023 ± 0.034	2.146LysArg: 2.146 ± 0.056	1.358LysSer: 1.358 ± 0.04	1.473LysThr: 1.473 ± 0.044	2.032LysVal: 2.032 ± 0.051	0.266LysTrp: 0.266 ± 0.016	0.565LysTyr: 0.565 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.428LeuAla: 13.428 ± 0.147	0.917LeuCys: 0.917 ± 0.034	7.031LeuAsp: 7.031 ± 0.098	7.653LeuGlu: 7.653 ± 0.102	3.811LeuPhe: 3.811 ± 0.087	9.153LeuGly: 9.153 ± 0.108	2.507LeuHis: 2.507 ± 0.059	5.09LeuIle: 5.09 ± 0.08	3.395LeuLys: 3.395 ± 0.075	12.057LeuLeu: 12.057 ± 0.154	2.826LeuMet: 2.826 ± 0.056	2.953LeuAsn: 2.953 ± 0.057	6.031LeuPro: 6.031 ± 0.093	3.254LeuGln: 3.254 ± 0.063	8.581LeuArg: 8.581 ± 0.108	6.48LeuSer: 6.48 ± 0.09	5.31LeuThr: 5.31 ± 0.074	8.22LeuVal: 8.22 ± 0.114	1.461LeuTrp: 1.461 ± 0.043	2.417LeuTyr: 2.417 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.089MetAla: 3.089 ± 0.061	0.149MetCys: 0.149 ± 0.013	1.612MetAsp: 1.612 ± 0.041	1.516MetGlu: 1.516 ± 0.036	0.647MetPhe: 0.647 ± 0.028	1.997MetGly: 1.997 ± 0.047	0.566MetHis: 0.566 ± 0.025	1.153MetIle: 1.153 ± 0.038	0.969MetLys: 0.969 ± 0.029	2.522MetLeu: 2.522 ± 0.056	0.602MetMet: 0.602 ± 0.028	0.873MetAsn: 0.873 ± 0.032	1.431MetPro: 1.431 ± 0.04	1.006MetGln: 1.006 ± 0.033	1.789MetArg: 1.789 ± 0.044	1.754MetSer: 1.754 ± 0.041	1.421MetThr: 1.421 ± 0.041	1.7MetVal: 1.7 ± 0.05	0.171MetTrp: 0.171 ± 0.014	0.382MetTyr: 0.382 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.616AsnAla: 2.616 ± 0.051	0.253AsnCys: 0.253 ± 0.018	1.362AsnAsp: 1.362 ± 0.042	1.341AsnGlu: 1.341 ± 0.04	0.814AsnPhe: 0.814 ± 0.029	2.015AsnGly: 2.015 ± 0.052	0.604AsnHis: 0.604 ± 0.024	1.372AsnIle: 1.372 ± 0.039	0.662AsnLys: 0.662 ± 0.034	2.882AsnLeu: 2.882 ± 0.064	0.617AsnMet: 0.617 ± 0.028	0.733AsnAsn: 0.733 ± 0.036	1.806AsnPro: 1.806 ± 0.044	0.928AsnGln: 0.928 ± 0.032	2.119AsnArg: 2.119 ± 0.058	1.014AsnSer: 1.014 ± 0.034	1.368AsnThr: 1.368 ± 0.042	1.855AsnVal: 1.855 ± 0.05	0.31AsnTrp: 0.31 ± 0.021	0.607AsnTyr: 0.607 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.871ProAla: 5.871 ± 0.107	0.387ProCys: 0.387 ± 0.019	3.497ProAsp: 3.497 ± 0.064	4.619ProGlu: 4.619 ± 0.092	1.647ProPhe: 1.647 ± 0.044	5.099ProGly: 5.099 ± 0.087	1.148ProHis: 1.148 ± 0.035	1.806ProIle: 1.806 ± 0.05	1.157ProLys: 1.157 ± 0.037	5.024ProLeu: 5.024 ± 0.092	1.344ProMet: 1.344 ± 0.036	1.087ProAsn: 1.087 ± 0.028	2.452ProPro: 2.452 ± 0.068	1.57ProGln: 1.57 ± 0.042	3.368ProArg: 3.368 ± 0.07	2.403ProSer: 2.403 ± 0.053	1.98ProThr: 1.98 ± 0.049	4.647ProVal: 4.647 ± 0.074	0.86ProTrp: 0.86 ± 0.031	1.171ProTyr: 1.171 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	5.051GlnAla: 5.051 ± 0.078	0.268GlnCys: 0.268 ± 0.017	1.824GlnAsp: 1.824 ± 0.041	2.112GlnGlu: 2.112 ± 0.051	1.083GlnPhe: 1.083 ± 0.03	3.269GlnGly: 3.269 ± 0.06	0.883GlnHis: 0.883 ± 0.032	1.632GlnIle: 1.632 ± 0.04	0.878GlnLys: 0.878 ± 0.029	3.652GlnLeu: 3.652 ± 0.069	0.894GlnMet: 0.894 ± 0.028	0.726GlnAsn: 0.726 ± 0.026	1.797GlnPro: 1.797 ± 0.04	1.58GlnGln: 1.58 ± 0.042	3.188GlnArg: 3.188 ± 0.06	1.743GlnSer: 1.743 ± 0.045	1.767GlnThr: 1.767 ± 0.047	3.345GlnVal: 3.345 ± 0.053	0.567GlnTrp: 0.567 ± 0.024	0.73GlnTyr: 0.73 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.891ArgAla: 7.891 ± 0.113	0.69ArgCys: 0.69 ± 0.029	4.668ArgAsp: 4.668 ± 0.074	5.877ArgGlu: 5.877 ± 0.088	3.204ArgPhe: 3.204 ± 0.054	5.275ArgGly: 5.275 ± 0.082	2.358ArgHis: 2.358 ± 0.049	4.232ArgIle: 4.232 ± 0.058	2.096ArgLys: 2.096 ± 0.047	9.937ArgLeu: 9.937 ± 0.12	2.249ArgMet: 2.249 ± 0.045	2.037ArgAsn: 2.037 ± 0.049	3.736ArgPro: 3.736 ± 0.066	3.317ArgGln: 3.317 ± 0.063	6.474ArgArg: 6.474 ± 0.097	3.517ArgSer: 3.517 ± 0.06	3.341ArgThr: 3.341 ± 0.064	6.118ArgVal: 6.118 ± 0.072	1.122ArgTrp: 1.122 ± 0.037	2.201ArgTyr: 2.201 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.138SerAla: 5.138 ± 0.086	0.43SerCys: 0.43 ± 0.026	2.694SerAsp: 2.694 ± 0.055	2.932SerGlu: 2.932 ± 0.062	1.736SerPhe: 1.736 ± 0.046	4.946SerGly: 4.946 ± 0.078	1.309SerHis: 1.309 ± 0.039	2.177SerIle: 2.177 ± 0.046	1.204SerLys: 1.204 ± 0.033	6.079SerLeu: 6.079 ± 0.091	1.286SerMet: 1.286 ± 0.036	1.225SerAsn: 1.225 ± 0.037	2.75SerPro: 2.75 ± 0.054	1.737SerGln: 1.737 ± 0.051	4.15SerArg: 4.15 ± 0.074	2.467SerSer: 2.467 ± 0.068	2.431SerThr: 2.431 ± 0.057	3.611SerVal: 3.611 ± 0.061	0.617SerTrp: 0.617 ± 0.022	1.157SerTyr: 1.157 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.977ThrAla: 4.977 ± 0.075	0.429ThrCys: 0.429 ± 0.021	2.649ThrAsp: 2.649 ± 0.053	2.73ThrGlu: 2.73 ± 0.056	1.422ThrPhe: 1.422 ± 0.041	4.829ThrGly: 4.829 ± 0.069	1.176ThrHis: 1.176 ± 0.032	1.965ThrIle: 1.965 ± 0.049	0.871ThrLys: 0.871 ± 0.034	6.396ThrLeu: 6.396 ± 0.085	0.834ThrMet: 0.834 ± 0.028	0.969ThrAsn: 0.969 ± 0.03	3.162ThrPro: 3.162 ± 0.058	1.729ThrGln: 1.729 ± 0.043	3.986ThrArg: 3.986 ± 0.065	2.048ThrSer: 2.048 ± 0.053	2.341ThrThr: 2.341 ± 0.056	3.927ThrVal: 3.927 ± 0.077	0.61ThrTrp: 0.61 ± 0.028	1.088ThrTyr: 1.088 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.866ValAla: 7.866 ± 0.118	0.702ValCys: 0.702 ± 0.027	4.482ValAsp: 4.482 ± 0.063	4.985ValGlu: 4.985 ± 0.075	2.73ValPhe: 2.73 ± 0.057	5.259ValGly: 5.259 ± 0.089	1.754ValHis: 1.754 ± 0.036	4.088ValIle: 4.088 ± 0.077	2.053ValLys: 2.053 ± 0.061	8.423ValLeu: 8.423 ± 0.112	2.066ValMet: 2.066 ± 0.048	2.243ValAsn: 2.243 ± 0.058	3.574ValPro: 3.574 ± 0.061	2.556ValGln: 2.556 ± 0.054	5.65ValArg: 5.65 ± 0.08	4.447ValSer: 4.447 ± 0.079	3.944ValThr: 3.944 ± 0.069	6.169ValVal: 6.169 ± 0.103	0.863ValTrp: 0.863 ± 0.034	1.698ValTyr: 1.698 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.111TrpAla: 1.111 ± 0.034	0.162TrpCys: 0.162 ± 0.012	0.635TrpAsp: 0.635 ± 0.027	0.694TrpGlu: 0.694 ± 0.026	0.566TrpPhe: 0.566 ± 0.029	0.861TrpGly: 0.861 ± 0.03	0.365TrpHis: 0.365 ± 0.02	0.7TrpIle: 0.7 ± 0.027	0.344TrpLys: 0.344 ± 0.016	2.04TrpLeu: 2.04 ± 0.052	0.355TrpMet: 0.355 ± 0.02	0.362TrpAsn: 0.362 ± 0.02	0.692TrpPro: 0.692 ± 0.03	0.691TrpGln: 0.691 ± 0.028	1.222TrpArg: 1.222 ± 0.04	0.752TrpSer: 0.752 ± 0.026	0.568TrpThr: 0.568 ± 0.026	1.067TrpVal: 1.067 ± 0.035	0.274TrpTrp: 0.274 ± 0.02	0.36TrpTyr: 0.36 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.256TyrAla: 2.256 ± 0.045	0.235TyrCys: 0.235 ± 0.015	1.321TyrAsp: 1.321 ± 0.039	1.414TyrGlu: 1.414 ± 0.04	0.888TyrPhe: 0.888 ± 0.028	2.079TyrGly: 2.079 ± 0.048	0.626TyrHis: 0.626 ± 0.023	0.889TyrIle: 0.889 ± 0.031	0.583TyrLys: 0.583 ± 0.025	2.912TyrLeu: 2.912 ± 0.058	0.496TyrMet: 0.496 ± 0.024	0.61TyrAsn: 0.61 ± 0.028	1.261TyrPro: 1.261 ± 0.036	1.036TyrGln: 1.036 ± 0.038	2.26TyrArg: 2.26 ± 0.049	1.167TyrSer: 1.167 ± 0.038	1.223TyrThr: 1.223 ± 0.036	1.667TyrVal: 1.667 ± 0.046	0.396TyrTrp: 0.396 ± 0.023	0.677TyrTyr: 0.677 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3272 proteins (1002246 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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