Amino acid dipepetide frequency for Geitlerinema sp. PCC 7407

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.61AlaAla: 11.61 ± 0.154
1.029AlaCys: 1.029 ± 0.029
5.178AlaAsp: 5.178 ± 0.078
6.85AlaGlu: 6.85 ± 0.095
3.268AlaPhe: 3.268 ± 0.051
6.996AlaGly: 6.996 ± 0.084
1.846AlaHis: 1.846 ± 0.05
7.967AlaIle: 7.967 ± 0.091
3.004AlaLys: 3.004 ± 0.061
11.905AlaLeu: 11.905 ± 0.134
2.08AlaMet: 2.08 ± 0.043
2.865AlaAsn: 2.865 ± 0.083
5.088AlaPro: 5.088 ± 0.098
5.903AlaGln: 5.903 ± 0.077
5.365AlaArg: 5.365 ± 0.074
5.713AlaSer: 5.713 ± 0.091
5.071AlaThr: 5.071 ± 0.081
6.741AlaVal: 6.741 ± 0.065
1.457AlaTrp: 1.457 ± 0.042
2.501AlaTyr: 2.501 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.75CysAla: 0.75 ± 0.026
0.19CysCys: 0.19 ± 0.012
0.621CysAsp: 0.621 ± 0.022
0.525CysGlu: 0.525 ± 0.021
0.403CysPhe: 0.403 ± 0.019
0.795CysGly: 0.795 ± 0.027
0.285CysHis: 0.285 ± 0.015
0.431CysIle: 0.431 ± 0.02
0.216CysLys: 0.216 ± 0.014
1.097CysLeu: 1.097 ± 0.032
0.147CysMet: 0.147 ± 0.009
0.265CysAsn: 0.265 ± 0.015
0.631CysPro: 0.631 ± 0.027
0.589CysGln: 0.589 ± 0.02
0.649CysArg: 0.649 ± 0.023
0.544CysSer: 0.544 ± 0.022
0.426CysThr: 0.426 ± 0.019
0.623CysVal: 0.623 ± 0.021
0.148CysTrp: 0.148 ± 0.011
0.343CysTyr: 0.343 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.589AspAla: 4.589 ± 0.068
0.546AspCys: 0.546 ± 0.022
2.313AspAsp: 2.313 ± 0.063
2.984AspGlu: 2.984 ± 0.052
2.182AspPhe: 2.182 ± 0.054
3.593AspGly: 3.593 ± 0.085
0.95AspHis: 0.95 ± 0.031
2.521AspIle: 2.521 ± 0.049
1.162AspLys: 1.162 ± 0.039
6.812AspLeu: 6.812 ± 0.101
0.718AspMet: 0.718 ± 0.024
1.283AspAsn: 1.283 ± 0.036
3.263AspPro: 3.263 ± 0.051
2.428AspGln: 2.428 ± 0.044
5.587AspArg: 5.587 ± 0.065
2.753AspSer: 2.753 ± 0.073
2.283AspThr: 2.283 ± 0.064
3.098AspVal: 3.098 ± 0.053
1.009AspTrp: 1.009 ± 0.031
1.649AspTyr: 1.649 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
7.85GluAla: 7.85 ± 0.092
0.419GluCys: 0.419 ± 0.018
2.991GluAsp: 2.991 ± 0.065
3.955GluGlu: 3.955 ± 0.093
2.009GluPhe: 2.009 ± 0.039
3.985GluGly: 3.985 ± 0.057
1.044GluHis: 1.044 ± 0.033
3.53GluIle: 3.53 ± 0.067
2.177GluLys: 2.177 ± 0.046
6.189GluLeu: 6.189 ± 0.076
1.327GluMet: 1.327 ± 0.035
1.773GluAsn: 1.773 ± 0.039
3.104GluPro: 3.104 ± 0.088
3.34GluGln: 3.34 ± 0.058
4.047GluArg: 4.047 ± 0.064
3.314GluSer: 3.314 ± 0.056
3.802GluThr: 3.802 ± 0.062
4.453GluVal: 4.453 ± 0.063
0.759GluTrp: 0.759 ± 0.024
1.391GluTyr: 1.391 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.0PheAla: 3.0 ± 0.053
0.485PheCys: 0.485 ± 0.018
2.099PheAsp: 2.099 ± 0.052
2.249PheGlu: 2.249 ± 0.043
1.505PhePhe: 1.505 ± 0.041
3.017PheGly: 3.017 ± 0.063
0.672PheHis: 0.672 ± 0.028
1.507PheIle: 1.507 ± 0.04
0.948PheLys: 0.948 ± 0.029
3.973PheLeu: 3.973 ± 0.067
0.617PheMet: 0.617 ± 0.02
1.16PheAsn: 1.16 ± 0.034
1.669PhePro: 1.669 ± 0.035
1.792PheGln: 1.792 ± 0.036
2.149PheArg: 2.149 ± 0.043
2.634PheSer: 2.634 ± 0.055
1.798PheThr: 1.798 ± 0.056
2.385PheVal: 2.385 ± 0.051
0.762PheTrp: 0.762 ± 0.026
1.137PheTyr: 1.137 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
6.635GlyAla: 6.635 ± 0.096
0.818GlyCys: 0.818 ± 0.028
4.397GlyAsp: 4.397 ± 0.064
3.97GlyGlu: 3.97 ± 0.066
2.9GlyPhe: 2.9 ± 0.049
5.263GlyGly: 5.263 ± 0.088
1.45GlyHis: 1.45 ± 0.037
4.17GlyIle: 4.17 ± 0.065
2.567GlyLys: 2.567 ± 0.054
8.502GlyLeu: 8.502 ± 0.11
1.506GlyMet: 1.506 ± 0.037
2.227GlyAsn: 2.227 ± 0.072
2.594GlyPro: 2.594 ± 0.05
3.821GlyGln: 3.821 ± 0.057
4.527GlyArg: 4.527 ± 0.073
4.523GlySer: 4.523 ± 0.078
4.093GlyThr: 4.093 ± 0.077
5.199GlyVal: 5.199 ± 0.064
1.338GlyTrp: 1.338 ± 0.037
2.288GlyTyr: 2.288 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.453HisAla: 1.453 ± 0.036
0.311HisCys: 0.311 ± 0.018
0.777HisAsp: 0.777 ± 0.025
0.957HisGlu: 0.957 ± 0.026
0.817HisPhe: 0.817 ± 0.028
1.355HisGly: 1.355 ± 0.039
0.668HisHis: 0.668 ± 0.028
0.839HisIle: 0.839 ± 0.026
0.449HisLys: 0.449 ± 0.019
2.515HisLeu: 2.515 ± 0.048
0.258HisMet: 0.258 ± 0.015
0.528HisAsn: 0.528 ± 0.024
1.498HisPro: 1.498 ± 0.038
1.244HisGln: 1.244 ± 0.037
1.431HisArg: 1.431 ± 0.034
1.112HisSer: 1.112 ± 0.029
0.908HisThr: 0.908 ± 0.026
0.963HisVal: 0.963 ± 0.027
0.429HisTrp: 0.429 ± 0.017
0.757HisTyr: 0.757 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
7.967IleAla: 7.967 ± 0.091
0.576IleCys: 0.576 ± 0.022
2.874IleAsp: 2.874 ± 0.052
3.21IleGlu: 3.21 ± 0.051
1.87IlePhe: 1.87 ± 0.043
3.763IleGly: 3.763 ± 0.066
1.084IleHis: 1.084 ± 0.031
1.896IleIle: 1.896 ± 0.045
1.412IleLys: 1.412 ± 0.034
5.38IleLeu: 5.38 ± 0.077
0.588IleMet: 0.588 ± 0.023
1.639IleAsn: 1.639 ± 0.037
2.767IlePro: 2.767 ± 0.047
2.604IleGln: 2.604 ± 0.052
3.041IleArg: 3.041 ± 0.048
3.03IleSer: 3.03 ± 0.055
2.639IleThr: 2.639 ± 0.055
3.613IleVal: 3.613 ± 0.059
0.688IleTrp: 0.688 ± 0.027
1.37IleTyr: 1.37 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.234LysAla: 3.234 ± 0.058
0.17LysCys: 0.17 ± 0.013
1.326LysAsp: 1.326 ± 0.04
1.59LysGlu: 1.59 ± 0.044
0.941LysPhe: 0.941 ± 0.03
1.93LysGly: 1.93 ± 0.044
0.538LysHis: 0.538 ± 0.024
1.704LysIle: 1.704 ± 0.045
1.04LysLys: 1.04 ± 0.042
3.344LysLeu: 3.344 ± 0.057
0.555LysMet: 0.555 ± 0.025
0.918LysAsn: 0.918 ± 0.03
1.796LysPro: 1.796 ± 0.038
1.53LysGln: 1.53 ± 0.032
1.919LysArg: 1.919 ± 0.043
1.677LysSer: 1.677 ± 0.04
1.896LysThr: 1.896 ± 0.041
2.172LysVal: 2.172 ± 0.05
0.233LysTrp: 0.233 ± 0.014
0.714LysTyr: 0.714 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
11.629LeuAla: 11.629 ± 0.105
1.077LeuCys: 1.077 ± 0.031
5.866LeuAsp: 5.866 ± 0.09
7.674LeuGlu: 7.674 ± 0.092
3.522LeuPhe: 3.522 ± 0.066
9.219LeuGly: 9.219 ± 0.125
2.042LeuHis: 2.042 ± 0.041
5.452LeuIle: 5.452 ± 0.073
3.872LeuLys: 3.872 ± 0.065
12.363LeuLeu: 12.363 ± 0.147
2.35LeuMet: 2.35 ± 0.042
3.416LeuAsn: 3.416 ± 0.056
6.485LeuPro: 6.485 ± 0.078
6.116LeuGln: 6.116 ± 0.078
7.658LeuArg: 7.658 ± 0.091
7.636LeuSer: 7.636 ± 0.091
6.318LeuThr: 6.318 ± 0.073
7.971LeuVal: 7.971 ± 0.082
1.702LeuTrp: 1.702 ± 0.045
2.685LeuTyr: 2.685 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.243MetAla: 2.243 ± 0.04
0.108MetCys: 0.108 ± 0.008
0.887MetAsp: 0.887 ± 0.027
0.967MetGlu: 0.967 ± 0.029
0.471MetPhe: 0.471 ± 0.021
1.496MetGly: 1.496 ± 0.035
0.31MetHis: 0.31 ± 0.014
0.867MetIle: 0.867 ± 0.03
0.634MetLys: 0.634 ± 0.021
1.903MetLeu: 1.903 ± 0.045
0.473MetMet: 0.473 ± 0.022
0.653MetAsn: 0.653 ± 0.021
1.08MetPro: 1.08 ± 0.024
0.874MetGln: 0.874 ± 0.026
1.079MetArg: 1.079 ± 0.03
1.204MetSer: 1.204 ± 0.028
1.353MetThr: 1.353 ± 0.031
1.498MetVal: 1.498 ± 0.039
0.136MetTrp: 0.136 ± 0.011
0.278MetTyr: 0.278 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.649AsnAla: 2.649 ± 0.047
0.312AsnCys: 0.312 ± 0.018
1.353AsnAsp: 1.353 ± 0.106
1.216AsnGlu: 1.216 ± 0.031
1.237AsnPhe: 1.237 ± 0.037
2.145AsnGly: 2.145 ± 0.073
0.602AsnHis: 0.602 ± 0.021
1.288AsnIle: 1.288 ± 0.031
0.668AsnLys: 0.668 ± 0.024
4.092AsnLeu: 4.092 ± 0.084
0.366AsnMet: 0.366 ± 0.014
0.924AsnAsn: 0.924 ± 0.038
2.362AsnPro: 2.362 ± 0.052
1.736AsnGln: 1.736 ± 0.041
2.021AsnArg: 2.021 ± 0.04
1.651AsnSer: 1.651 ± 0.042
1.378AsnThr: 1.378 ± 0.038
1.785AsnVal: 1.785 ± 0.049
0.471AsnTrp: 0.471 ± 0.02
0.83AsnTyr: 0.83 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
5.729ProAla: 5.729 ± 0.098
0.415ProCys: 0.415 ± 0.018
3.604ProAsp: 3.604 ± 0.064
4.951ProGlu: 4.951 ± 0.084
1.808ProPhe: 1.808 ± 0.037
3.883ProGly: 3.883 ± 0.061
1.007ProHis: 1.007 ± 0.035
2.585ProIle: 2.585 ± 0.046
1.669ProLys: 1.669 ± 0.044
5.684ProLeu: 5.684 ± 0.072
1.054ProMet: 1.054 ± 0.029
1.673ProAsn: 1.673 ± 0.036
3.267ProPro: 3.267 ± 0.069
2.823ProGln: 2.823 ± 0.049
2.691ProArg: 2.691 ± 0.049
3.66ProSer: 3.66 ± 0.073
3.116ProThr: 3.116 ± 0.052
4.119ProVal: 4.119 ± 0.067
0.879ProTrp: 0.879 ± 0.029
1.315ProTyr: 1.315 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
6.551GlnAla: 6.551 ± 0.087
0.387GlnCys: 0.387 ± 0.016
2.297GlnAsp: 2.297 ± 0.039
3.354GlnGlu: 3.354 ± 0.061
1.736GlnPhe: 1.736 ± 0.039
3.95GlnGly: 3.95 ± 0.063
1.004GlnHis: 1.004 ± 0.032
3.084GlnIle: 3.084 ± 0.054
1.663GlnLys: 1.663 ± 0.038
5.369GlnLeu: 5.369 ± 0.073
1.095GlnMet: 1.095 ± 0.031
1.389GlnAsn: 1.389 ± 0.041
3.089GlnPro: 3.089 ± 0.055
3.639GlnGln: 3.639 ± 0.071
4.276GlnArg: 4.276 ± 0.064
3.123GlnSer: 3.123 ± 0.057
3.015GlnThr: 3.015 ± 0.05
4.156GlnVal: 4.156 ± 0.059
0.807GlnTrp: 0.807 ± 0.025
1.112GlnTyr: 1.112 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
5.205ArgAla: 5.205 ± 0.071
0.674ArgCys: 0.674 ± 0.022
3.594ArgAsp: 3.594 ± 0.064
3.727ArgGlu: 3.727 ± 0.065
2.608ArgPhe: 2.608 ± 0.048
3.817ArgGly: 3.817 ± 0.054
1.367ArgHis: 1.367 ± 0.037
3.222ArgIle: 3.222 ± 0.058
1.782ArgLys: 1.782 ± 0.041
7.853ArgLeu: 7.853 ± 0.092
1.247ArgMet: 1.247 ± 0.033
1.758ArgAsn: 1.758 ± 0.037
3.487ArgPro: 3.487 ± 0.053
4.359ArgGln: 4.359 ± 0.069
4.649ArgArg: 4.649 ± 0.075
4.932ArgSer: 4.932 ± 0.057
3.046ArgThr: 3.046 ± 0.049
4.315ArgVal: 4.315 ± 0.06
1.319ArgTrp: 1.319 ± 0.037
2.282ArgTyr: 2.282 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
5.68SerAla: 5.68 ± 0.074
0.509SerCys: 0.509 ± 0.019
3.231SerAsp: 3.231 ± 0.05
3.477SerGlu: 3.477 ± 0.066
2.292SerPhe: 2.292 ± 0.051
4.844SerGly: 4.844 ± 0.072
1.257SerHis: 1.257 ± 0.032
2.805SerIle: 2.805 ± 0.051
1.506SerLys: 1.506 ± 0.041
7.773SerLeu: 7.773 ± 0.091
1.198SerMet: 1.198 ± 0.03
1.708SerAsn: 1.708 ± 0.058
4.301SerPro: 4.301 ± 0.071
3.272SerGln: 3.272 ± 0.058
3.798SerArg: 3.798 ± 0.058
4.152SerSer: 4.152 ± 0.07
3.186SerThr: 3.186 ± 0.057
4.208SerVal: 4.208 ± 0.072
0.875SerTrp: 0.875 ± 0.027
1.517SerTyr: 1.517 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
5.275ThrAla: 5.275 ± 0.074
0.478ThrCys: 0.478 ± 0.02
2.575ThrAsp: 2.575 ± 0.055
3.004ThrGlu: 3.004 ± 0.053
1.896ThrPhe: 1.896 ± 0.036
4.186ThrGly: 4.186 ± 0.064
1.047ThrHis: 1.047 ± 0.031
2.568ThrIle: 2.568 ± 0.051
1.283ThrLys: 1.283 ± 0.036
7.061ThrLeu: 7.061 ± 0.088
0.773ThrMet: 0.773 ± 0.027
1.417ThrAsn: 1.417 ± 0.042
3.767ThrPro: 3.767 ± 0.068
2.653ThrGln: 2.653 ± 0.051
2.748ThrArg: 2.748 ± 0.055
3.015ThrSer: 3.015 ± 0.06
2.858ThrThr: 2.858 ± 0.063
4.266ThrVal: 4.266 ± 0.11
0.814ThrTrp: 0.814 ± 0.025
1.579ThrTyr: 1.579 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
7.019ValAla: 7.019 ± 0.092
0.702ValCys: 0.702 ± 0.022
3.65ValAsp: 3.65 ± 0.068
4.363ValGlu: 4.363 ± 0.066
2.452ValPhe: 2.452 ± 0.047
5.235ValGly: 5.235 ± 0.079
1.156ValHis: 1.156 ± 0.035
3.658ValIle: 3.658 ± 0.053
2.082ValLys: 2.082 ± 0.044
7.831ValLeu: 7.831 ± 0.082
1.468ValMet: 1.468 ± 0.039
2.235ValAsn: 2.235 ± 0.076
3.652ValPro: 3.652 ± 0.062
3.357ValGln: 3.357 ± 0.056
4.199ValArg: 4.199 ± 0.057
4.415ValSer: 4.415 ± 0.064
4.117ValThr: 4.117 ± 0.074
5.421ValVal: 5.421 ± 0.075
0.944ValTrp: 0.944 ± 0.032
1.795ValTyr: 1.795 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.214TrpAla: 1.214 ± 0.032
0.138TrpCys: 0.138 ± 0.011
0.674TrpAsp: 0.674 ± 0.024
0.796TrpGlu: 0.796 ± 0.025
0.562TrpPhe: 0.562 ± 0.022
1.101TrpGly: 1.101 ± 0.029
0.348TrpHis: 0.348 ± 0.017
0.818TrpIle: 0.818 ± 0.029
0.428TrpLys: 0.428 ± 0.019
2.244TrpLeu: 2.244 ± 0.056
0.342TrpMet: 0.342 ± 0.017
0.469TrpAsn: 0.469 ± 0.018
0.583TrpPro: 0.583 ± 0.025
1.263TrpGln: 1.263 ± 0.034
1.117TrpArg: 1.117 ± 0.031
0.953TrpSer: 0.953 ± 0.03
0.639TrpThr: 0.639 ± 0.024
1.171TrpVal: 1.171 ± 0.031
0.271TrpTrp: 0.271 ± 0.015
0.409TrpTyr: 0.409 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.154TyrAla: 2.154 ± 0.048
0.331TyrCys: 0.331 ± 0.016
1.419TyrAsp: 1.419 ± 0.036
1.64TyrGlu: 1.64 ± 0.045
1.08TyrPhe: 1.08 ± 0.032
2.214TyrGly: 2.214 ± 0.049
0.593TyrHis: 0.593 ± 0.021
1.098TyrIle: 1.098 ± 0.027
0.664TyrLys: 0.664 ± 0.027
3.164TyrLeu: 3.164 ± 0.052
0.351TyrMet: 0.351 ± 0.017
0.784TyrAsn: 0.784 ± 0.026
1.453TyrPro: 1.453 ± 0.034
1.754TyrGln: 1.754 ± 0.039
2.293TyrArg: 2.293 ± 0.04
1.549TyrSer: 1.549 ± 0.037
1.318TyrThr: 1.318 ± 0.063
1.594TyrVal: 1.594 ± 0.035
0.501TyrTrp: 0.501 ± 0.019
0.825TyrTyr: 0.825 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3813 proteins (1300425 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski