Amino acid dipepetide frequency for Megamonas hypermegale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.645AlaAla: 5.645 ± 0.132
0.976AlaCys: 0.976 ± 0.039
4.361AlaAsp: 4.361 ± 0.093
4.232AlaGlu: 4.232 ± 0.09
2.925AlaPhe: 2.925 ± 0.074
5.426AlaGly: 5.426 ± 0.106
1.414AlaHis: 1.414 ± 0.047
6.625AlaIle: 6.625 ± 0.104
5.998AlaLys: 5.998 ± 0.116
6.84AlaLeu: 6.84 ± 0.114
2.382AlaMet: 2.382 ± 0.07
3.235AlaAsn: 3.235 ± 0.075
2.149AlaPro: 2.149 ± 0.062
2.924AlaGln: 2.924 ± 0.075
2.582AlaArg: 2.582 ± 0.065
3.838AlaSer: 3.838 ± 0.07
3.921AlaThr: 3.921 ± 0.11
5.803AlaVal: 5.803 ± 0.109
0.534AlaTrp: 0.534 ± 0.026
2.622AlaTyr: 2.622 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.9CysAla: 0.9 ± 0.036
0.198CysCys: 0.198 ± 0.017
0.715CysAsp: 0.715 ± 0.032
0.673CysGlu: 0.673 ± 0.032
0.603CysPhe: 0.603 ± 0.034
1.262CysGly: 1.262 ± 0.048
0.327CysHis: 0.327 ± 0.023
1.066CysIle: 1.066 ± 0.047
0.773CysLys: 0.773 ± 0.036
1.229CysLeu: 1.229 ± 0.045
0.344CysMet: 0.344 ± 0.028
0.601CysAsn: 0.601 ± 0.031
0.611CysPro: 0.611 ± 0.032
0.41CysGln: 0.41 ± 0.029
0.497CysArg: 0.497 ± 0.031
0.816CysSer: 0.816 ± 0.032
0.629CysThr: 0.629 ± 0.033
0.811CysVal: 0.811 ± 0.038
0.112CysTrp: 0.112 ± 0.012
0.479CysTyr: 0.479 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.415AspAla: 3.415 ± 0.078
0.704AspCys: 0.704 ± 0.041
3.409AspAsp: 3.409 ± 0.092
4.387AspGlu: 4.387 ± 0.094
3.077AspPhe: 3.077 ± 0.065
3.662AspGly: 3.662 ± 0.115
0.624AspHis: 0.624 ± 0.033
5.828AspIle: 5.828 ± 0.099
5.289AspLys: 5.289 ± 0.106
5.047AspLeu: 5.047 ± 0.112
1.902AspMet: 1.902 ± 0.055
3.177AspAsn: 3.177 ± 0.074
1.427AspPro: 1.427 ± 0.055
0.765AspGln: 0.765 ± 0.034
1.856AspArg: 1.856 ± 0.055
2.427AspSer: 2.427 ± 0.071
2.981AspThr: 2.981 ± 0.088
4.099AspVal: 4.099 ± 0.086
0.518AspTrp: 0.518 ± 0.031
2.617AspTyr: 2.617 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.791GluAla: 4.791 ± 0.101
0.592GluCys: 0.592 ± 0.034
3.587GluAsp: 3.587 ± 0.083
4.38GluGlu: 4.38 ± 0.105
2.385GluPhe: 2.385 ± 0.067
3.366GluGly: 3.366 ± 0.073
1.273GluHis: 1.273 ± 0.047
5.438GluIle: 5.438 ± 0.095
5.918GluLys: 5.918 ± 0.117
5.565GluLeu: 5.565 ± 0.092
1.914GluMet: 1.914 ± 0.049
4.404GluAsn: 4.404 ± 0.088
1.574GluPro: 1.574 ± 0.052
2.543GluGln: 2.543 ± 0.069
2.399GluArg: 2.399 ± 0.068
2.08GluSer: 2.08 ± 0.06
2.942GluThr: 2.942 ± 0.077
3.847GluVal: 3.847 ± 0.077
0.396GluTrp: 0.396 ± 0.025
2.504GluTyr: 2.504 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
3.373PheAla: 3.373 ± 0.082
0.758PheCys: 0.758 ± 0.035
2.533PheAsp: 2.533 ± 0.068
1.997PheGlu: 1.997 ± 0.072
2.103PhePhe: 2.103 ± 0.07
3.162PheGly: 3.162 ± 0.087
0.693PheHis: 0.693 ± 0.03
4.185PheIle: 4.185 ± 0.122
2.866PheLys: 2.866 ± 0.085
3.86PheLeu: 3.86 ± 0.091
1.318PheMet: 1.318 ± 0.043
2.384PheAsn: 2.384 ± 0.067
1.279PhePro: 1.279 ± 0.045
0.887PheGln: 0.887 ± 0.037
1.232PheArg: 1.232 ± 0.042
3.134PheSer: 3.134 ± 0.075
2.482PheThr: 2.482 ± 0.071
2.861PheVal: 2.861 ± 0.081
0.393PheTrp: 0.393 ± 0.026
1.779PheTyr: 1.779 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
4.907GlyAla: 4.907 ± 0.107
1.031GlyCys: 1.031 ± 0.041
3.307GlyAsp: 3.307 ± 0.095
3.633GlyGlu: 3.633 ± 0.081
3.148GlyPhe: 3.148 ± 0.078
4.611GlyGly: 4.611 ± 0.111
1.298GlyHis: 1.298 ± 0.047
6.385GlyIle: 6.385 ± 0.11
5.279GlyLys: 5.279 ± 0.088
5.731GlyLeu: 5.731 ± 0.099
2.069GlyMet: 2.069 ± 0.062
2.978GlyAsn: 2.978 ± 0.094
1.393GlyPro: 1.393 ± 0.05
1.936GlyGln: 1.936 ± 0.058
2.648GlyArg: 2.648 ± 0.066
3.611GlySer: 3.611 ± 0.067
3.978GlyThr: 3.978 ± 0.111
4.489GlyVal: 4.489 ± 0.1
0.646GlyTrp: 0.646 ± 0.039
2.683GlyTyr: 2.683 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.218HisAla: 1.218 ± 0.037
0.313HisCys: 0.313 ± 0.025
1.089HisAsp: 1.089 ± 0.044
1.098HisGlu: 1.098 ± 0.047
0.848HisPhe: 0.848 ± 0.034
1.298HisGly: 1.298 ± 0.052
0.512HisHis: 0.512 ± 0.03
1.568HisIle: 1.568 ± 0.053
1.301HisLys: 1.301 ± 0.049
1.686HisLeu: 1.686 ± 0.052
0.499HisMet: 0.499 ± 0.025
0.977HisAsn: 0.977 ± 0.039
0.796HisPro: 0.796 ± 0.037
0.561HisGln: 0.561 ± 0.028
0.713HisArg: 0.713 ± 0.033
0.98HisSer: 0.98 ± 0.041
0.917HisThr: 0.917 ± 0.035
1.051HisVal: 1.051 ± 0.038
0.155HisTrp: 0.155 ± 0.015
0.71HisTyr: 0.71 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.971IleAla: 6.971 ± 0.137
1.44IleCys: 1.44 ± 0.051
5.314IleAsp: 5.314 ± 0.102
5.24IleGlu: 5.24 ± 0.092
3.909IlePhe: 3.909 ± 0.113
6.127IleGly: 6.127 ± 0.132
1.336IleHis: 1.336 ± 0.049
7.627IleIle: 7.627 ± 0.167
6.495IleLys: 6.495 ± 0.091
8.049IleLeu: 8.049 ± 0.153
2.329IleMet: 2.329 ± 0.068
4.851IleAsn: 4.851 ± 0.109
3.234IlePro: 3.234 ± 0.068
2.149IleGln: 2.149 ± 0.061
3.028IleArg: 3.028 ± 0.07
5.486IleSer: 5.486 ± 0.108
4.824IleThr: 4.824 ± 0.103
5.799IleVal: 5.799 ± 0.113
0.657IleTrp: 0.657 ± 0.031
3.119IleTyr: 3.119 ± 0.087
0.0IleXaa: 0.0 ± 0.0
Lys
5.616LysAla: 5.616 ± 0.107
0.7LysCys: 0.7 ± 0.034
4.769LysAsp: 4.769 ± 0.088
5.788LysGlu: 5.788 ± 0.104
2.672LysPhe: 2.672 ± 0.07
3.86LysGly: 3.86 ± 0.083
1.249LysHis: 1.249 ± 0.038
6.868LysIle: 6.868 ± 0.115
6.199LysLys: 6.199 ± 0.112
6.805LysLeu: 6.805 ± 0.112
2.629LysMet: 2.629 ± 0.06
4.958LysAsn: 4.958 ± 0.086
2.448LysPro: 2.448 ± 0.092
2.876LysGln: 2.876 ± 0.074
2.812LysArg: 2.812 ± 0.06
3.83LysSer: 3.83 ± 0.078
4.084LysThr: 4.084 ± 0.073
4.901LysVal: 4.901 ± 0.086
0.726LysTrp: 0.726 ± 0.038
3.491LysTyr: 3.491 ± 0.091
0.0LysXaa: 0.0 ± 0.0
Leu
7.322LeuAla: 7.322 ± 0.11
1.284LeuCys: 1.284 ± 0.048
5.076LeuAsp: 5.076 ± 0.091
5.144LeuGlu: 5.144 ± 0.104
3.817LeuPhe: 3.817 ± 0.1
5.842LeuGly: 5.842 ± 0.112
1.802LeuHis: 1.802 ± 0.057
7.167LeuIle: 7.167 ± 0.147
7.221LeuLys: 7.221 ± 0.126
8.198LeuLeu: 8.198 ± 0.147
2.608LeuMet: 2.608 ± 0.08
5.34LeuAsn: 5.34 ± 0.104
3.766LeuPro: 3.766 ± 0.079
3.116LeuGln: 3.116 ± 0.08
3.297LeuArg: 3.297 ± 0.068
6.217LeuSer: 6.217 ± 0.126
4.952LeuThr: 4.952 ± 0.083
5.412LeuVal: 5.412 ± 0.096
0.658LeuTrp: 0.658 ± 0.029
3.102LeuTyr: 3.102 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.611MetAla: 2.611 ± 0.068
0.299MetCys: 0.299 ± 0.02
1.569MetAsp: 1.569 ± 0.044
1.77MetGlu: 1.77 ± 0.051
1.048MetPhe: 1.048 ± 0.043
1.974MetGly: 1.974 ± 0.06
0.476MetHis: 0.476 ± 0.029
2.235MetIle: 2.235 ± 0.069
2.258MetLys: 2.258 ± 0.055
2.648MetLeu: 2.648 ± 0.065
0.844MetMet: 0.844 ± 0.044
1.631MetAsn: 1.631 ± 0.05
1.367MetPro: 1.367 ± 0.045
1.339MetGln: 1.339 ± 0.047
1.213MetArg: 1.213 ± 0.04
1.675MetSer: 1.675 ± 0.05
1.632MetThr: 1.632 ± 0.047
1.821MetVal: 1.821 ± 0.057
0.16MetTrp: 0.16 ± 0.016
0.982MetTyr: 0.982 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.619AsnAla: 3.619 ± 0.079
0.77AsnCys: 0.77 ± 0.037
3.002AsnAsp: 3.002 ± 0.09
3.399AsnGlu: 3.399 ± 0.064
2.333AsnPhe: 2.333 ± 0.067
3.36AsnGly: 3.36 ± 0.115
1.042AsnHis: 1.042 ± 0.04
5.401AsnIle: 5.401 ± 0.107
4.245AsnLys: 4.245 ± 0.088
5.208AsnLeu: 5.208 ± 0.102
1.609AsnMet: 1.609 ± 0.055
3.272AsnAsn: 3.272 ± 0.102
2.261AsnPro: 2.261 ± 0.059
1.467AsnGln: 1.467 ± 0.05
1.962AsnArg: 1.962 ± 0.056
2.909AsnSer: 2.909 ± 0.087
2.987AsnThr: 2.987 ± 0.092
3.473AsnVal: 3.473 ± 0.097
0.534AsnTrp: 0.534 ± 0.027
2.229AsnTyr: 2.229 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
2.45ProAla: 2.45 ± 0.059
0.393ProCys: 0.393 ± 0.026
1.979ProAsp: 1.979 ± 0.059
2.651ProGlu: 2.651 ± 0.075
1.6ProPhe: 1.6 ± 0.052
2.023ProGly: 2.023 ± 0.065
0.689ProHis: 0.689 ± 0.035
2.843ProIle: 2.843 ± 0.063
2.237ProLys: 2.237 ± 0.061
2.967ProLeu: 2.967 ± 0.075
0.922ProMet: 0.922 ± 0.043
1.821ProAsn: 1.821 ± 0.051
1.003ProPro: 1.003 ± 0.069
1.304ProGln: 1.304 ± 0.05
1.065ProArg: 1.065 ± 0.042
1.767ProSer: 1.767 ± 0.055
1.79ProThr: 1.79 ± 0.058
2.642ProVal: 2.642 ± 0.08
0.31ProTrp: 0.31 ± 0.023
1.414ProTyr: 1.414 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.477GlnAla: 2.477 ± 0.073
0.25GlnCys: 0.25 ± 0.02
1.594GlnAsp: 1.594 ± 0.048
2.255GlnGlu: 2.255 ± 0.063
1.253GlnPhe: 1.253 ± 0.048
1.789GlnGly: 1.789 ± 0.055
0.549GlnHis: 0.549 ± 0.03
2.968GlnIle: 2.968 ± 0.066
2.881GlnLys: 2.881 ± 0.08
2.93GlnLeu: 2.93 ± 0.068
1.035GlnMet: 1.035 ± 0.037
2.154GlnAsn: 2.154 ± 0.067
0.937GlnPro: 0.937 ± 0.042
1.5GlnGln: 1.5 ± 0.069
1.332GlnArg: 1.332 ± 0.049
1.623GlnSer: 1.623 ± 0.05
1.606GlnThr: 1.606 ± 0.057
1.821GlnVal: 1.821 ± 0.052
0.265GlnTrp: 0.265 ± 0.022
1.321GlnTyr: 1.321 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.453ArgAla: 2.453 ± 0.075
0.434ArgCys: 0.434 ± 0.027
1.93ArgAsp: 1.93 ± 0.061
2.53ArgGlu: 2.53 ± 0.058
1.618ArgPhe: 1.618 ± 0.058
2.172ArgGly: 2.172 ± 0.061
0.747ArgHis: 0.747 ± 0.033
3.063ArgIle: 3.063 ± 0.074
2.835ArgLys: 2.835 ± 0.078
3.501ArgLeu: 3.501 ± 0.074
1.124ArgMet: 1.124 ± 0.04
1.824ArgAsn: 1.824 ± 0.064
1.35ArgPro: 1.35 ± 0.048
1.615ArgGln: 1.615 ± 0.051
1.885ArgArg: 1.885 ± 0.062
1.651ArgSer: 1.651 ± 0.045
1.737ArgThr: 1.737 ± 0.048
2.257ArgVal: 2.257 ± 0.069
0.356ArgTrp: 0.356 ± 0.028
1.606ArgTyr: 1.606 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
3.978SerAla: 3.978 ± 0.085
0.723SerCys: 0.723 ± 0.041
2.961SerAsp: 2.961 ± 0.075
2.973SerGlu: 2.973 ± 0.071
2.573SerPhe: 2.573 ± 0.072
4.157SerGly: 4.157 ± 0.091
1.077SerHis: 1.077 ± 0.041
4.693SerIle: 4.693 ± 0.098
3.406SerLys: 3.406 ± 0.084
5.481SerLeu: 5.481 ± 0.095
1.617SerMet: 1.617 ± 0.048
2.596SerAsn: 2.596 ± 0.078
1.85SerPro: 1.85 ± 0.066
1.709SerGln: 1.709 ± 0.054
2.157SerArg: 2.157 ± 0.056
3.413SerSer: 3.413 ± 0.087
2.81SerThr: 2.81 ± 0.069
3.755SerVal: 3.755 ± 0.086
0.492SerTrp: 0.492 ± 0.028
2.183SerTyr: 2.183 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
4.423ThrAla: 4.423 ± 0.088
0.634ThrCys: 0.634 ± 0.03
3.191ThrAsp: 3.191 ± 0.096
2.902ThrGlu: 2.902 ± 0.082
2.269ThrPhe: 2.269 ± 0.065
4.047ThrGly: 4.047 ± 0.083
0.965ThrHis: 0.965 ± 0.041
4.423ThrIle: 4.423 ± 0.101
3.807ThrLys: 3.807 ± 0.082
4.936ThrLeu: 4.936 ± 0.087
1.355ThrMet: 1.355 ± 0.042
2.557ThrAsn: 2.557 ± 0.098
2.232ThrPro: 2.232 ± 0.052
1.617ThrGln: 1.617 ± 0.055
1.772ThrArg: 1.772 ± 0.048
2.893ThrSer: 2.893 ± 0.071
3.096ThrThr: 3.096 ± 0.126
3.999ThrVal: 3.999 ± 0.1
0.46ThrTrp: 0.46 ± 0.026
1.773ThrTyr: 1.773 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
5.194ValAla: 5.194 ± 0.102
0.914ValCys: 0.914 ± 0.038
3.979ValAsp: 3.979 ± 0.085
4.013ValGlu: 4.013 ± 0.079
2.878ValPhe: 2.878 ± 0.08
4.412ValGly: 4.412 ± 0.102
1.135ValHis: 1.135 ± 0.044
5.765ValIle: 5.765 ± 0.108
4.84ValLys: 4.84 ± 0.099
5.987ValLeu: 5.987 ± 0.11
1.855ValMet: 1.855 ± 0.06
3.531ValAsn: 3.531 ± 0.075
2.523ValPro: 2.523 ± 0.067
1.997ValGln: 1.997 ± 0.05
2.341ValArg: 2.341 ± 0.061
3.844ValSer: 3.844 ± 0.1
3.456ValThr: 3.456 ± 0.087
4.696ValVal: 4.696 ± 0.113
0.508ValTrp: 0.508 ± 0.025
2.453ValTyr: 2.453 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.554TrpAla: 0.554 ± 0.03
0.121TrpCys: 0.121 ± 0.012
0.463TrpAsp: 0.463 ± 0.031
0.535TrpGlu: 0.535 ± 0.029
0.379TrpPhe: 0.379 ± 0.023
0.56TrpGly: 0.56 ± 0.035
0.238TrpHis: 0.238 ± 0.018
0.655TrpIle: 0.655 ± 0.035
0.509TrpLys: 0.509 ± 0.03
0.824TrpLeu: 0.824 ± 0.036
0.23TrpMet: 0.23 ± 0.019
0.483TrpAsn: 0.483 ± 0.028
0.202TrpPro: 0.202 ± 0.018
0.565TrpGln: 0.565 ± 0.029
0.416TrpArg: 0.416 ± 0.027
0.439TrpSer: 0.439 ± 0.028
0.341TrpThr: 0.341 ± 0.023
0.414TrpVal: 0.414 ± 0.027
0.097TrpTrp: 0.097 ± 0.012
0.316TrpTyr: 0.316 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.517TyrAla: 2.517 ± 0.07
0.523TyrCys: 0.523 ± 0.03
2.384TyrAsp: 2.384 ± 0.069
2.298TyrGlu: 2.298 ± 0.063
1.839TyrPhe: 1.839 ± 0.06
2.651TyrGly: 2.651 ± 0.066
0.845TyrHis: 0.845 ± 0.044
3.18TyrIle: 3.18 ± 0.073
2.925TyrLys: 2.925 ± 0.083
3.847TyrLeu: 3.847 ± 0.088
0.965TyrMet: 0.965 ± 0.038
2.307TyrAsn: 2.307 ± 0.067
1.465TyrPro: 1.465 ± 0.051
1.261TyrGln: 1.261 ± 0.051
1.482TyrArg: 1.482 ± 0.045
1.968TyrSer: 1.968 ± 0.066
2.186TyrThr: 2.186 ± 0.05
2.372TyrVal: 2.372 ± 0.064
0.367TyrTrp: 0.367 ± 0.022
1.744TyrTyr: 1.744 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2073 proteins (651883 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski