Amino acid dipepetide frequency for Larkinella punicea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.382AlaAla: 6.382 ± 0.075	0.684AlaCys: 0.684 ± 0.021	4.699AlaAsp: 4.699 ± 0.049	4.702AlaGlu: 4.702 ± 0.049	3.802AlaPhe: 3.802 ± 0.044	6.325AlaGly: 6.325 ± 0.058	1.301AlaHis: 1.301 ± 0.026	4.866AlaIle: 4.866 ± 0.059	3.911AlaLys: 3.911 ± 0.05	8.052AlaLeu: 8.052 ± 0.066	1.689AlaMet: 1.689 ± 0.026	3.511AlaAsn: 3.511 ± 0.043	2.978AlaPro: 2.978 ± 0.044	3.335AlaGln: 3.335 ± 0.033	3.748AlaArg: 3.748 ± 0.043	4.765AlaSer: 4.765 ± 0.056	4.937AlaThr: 4.937 ± 0.054	5.811AlaVal: 5.811 ± 0.049	0.967AlaTrp: 0.967 ± 0.021	2.944AlaTyr: 2.944 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.481CysAla: 0.481 ± 0.016	0.11CysCys: 0.11 ± 0.007	0.351CysAsp: 0.351 ± 0.015	0.367CysGlu: 0.367 ± 0.015	0.353CysPhe: 0.353 ± 0.013	0.553CysGly: 0.553 ± 0.018	0.215CysHis: 0.215 ± 0.01	0.428CysIle: 0.428 ± 0.015	0.294CysLys: 0.294 ± 0.013	0.805CysLeu: 0.805 ± 0.019	0.139CysMet: 0.139 ± 0.008	0.281CysAsn: 0.281 ± 0.01	0.34CysPro: 0.34 ± 0.012	0.337CysGln: 0.337 ± 0.012	0.397CysArg: 0.397 ± 0.013	0.466CysSer: 0.466 ± 0.017	0.415CysThr: 0.415 ± 0.015	0.464CysVal: 0.464 ± 0.013	0.117CysTrp: 0.117 ± 0.008	0.258CysTyr: 0.258 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.192AspAla: 4.192 ± 0.05	0.366AspCys: 0.366 ± 0.014	2.604AspAsp: 2.604 ± 0.034	3.261AspGlu: 3.261 ± 0.045	2.769AspPhe: 2.769 ± 0.034	4.212AspGly: 4.212 ± 0.059	0.979AspHis: 0.979 ± 0.021	2.88AspIle: 2.88 ± 0.039	2.697AspLys: 2.697 ± 0.039	5.383AspLeu: 5.383 ± 0.057	0.924AspMet: 0.924 ± 0.02	2.149AspAsn: 2.149 ± 0.036	2.625AspPro: 2.625 ± 0.034	2.286AspGln: 2.286 ± 0.032	3.012AspArg: 3.012 ± 0.038	2.8AspSer: 2.8 ± 0.041	2.397AspThr: 2.397 ± 0.039	3.519AspVal: 3.519 ± 0.04	0.935AspTrp: 0.935 ± 0.018	2.369AspTyr: 2.369 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	4.489GluAla: 4.489 ± 0.053	0.285GluCys: 0.285 ± 0.011	2.358GluAsp: 2.358 ± 0.036	3.277GluGlu: 3.277 ± 0.051	2.137GluPhe: 2.137 ± 0.028	3.435GluGly: 3.435 ± 0.037	0.988GluHis: 0.988 ± 0.021	3.537GluIle: 3.537 ± 0.044	4.047GluLys: 4.047 ± 0.052	5.577GluLeu: 5.577 ± 0.059	1.336GluMet: 1.336 ± 0.026	2.796GluAsn: 2.796 ± 0.038	2.23GluPro: 2.23 ± 0.035	2.591GluGln: 2.591 ± 0.039	3.101GluArg: 3.101 ± 0.044	3.046GluSer: 3.046 ± 0.038	3.569GluThr: 3.569 ± 0.041	3.843GluVal: 3.843 ± 0.044	0.702GluTrp: 0.702 ± 0.018	1.754GluTyr: 1.754 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.344PheAla: 3.344 ± 0.034	0.441PheCys: 0.441 ± 0.014	2.854PheAsp: 2.854 ± 0.036	2.497PheGlu: 2.497 ± 0.035	2.328PhePhe: 2.328 ± 0.04	3.471PheGly: 3.471 ± 0.042	0.787PheHis: 0.787 ± 0.017	2.567PheIle: 2.567 ± 0.039	2.142PheLys: 2.142 ± 0.029	4.635PheLeu: 4.635 ± 0.054	0.967PheMet: 0.967 ± 0.022	2.198PheAsn: 2.198 ± 0.032	1.967PhePro: 1.967 ± 0.03	1.798PheGln: 1.798 ± 0.03	2.728PheArg: 2.728 ± 0.036	3.409PheSer: 3.409 ± 0.034	2.908PheThr: 2.908 ± 0.035	3.103PheVal: 3.103 ± 0.042	0.723PheTrp: 0.723 ± 0.019	1.847PheTyr: 1.847 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	4.964GlyAla: 4.964 ± 0.054	0.676GlyCys: 0.676 ± 0.021	3.407GlyAsp: 3.407 ± 0.042	3.399GlyGlu: 3.399 ± 0.045	3.814GlyPhe: 3.814 ± 0.043	5.337GlyGly: 5.337 ± 0.073	1.309GlyHis: 1.309 ± 0.028	4.812GlyIle: 4.812 ± 0.047	4.726GlyLys: 4.726 ± 0.055	7.29GlyLeu: 7.29 ± 0.071	1.669GlyMet: 1.669 ± 0.028	3.474GlyAsn: 3.474 ± 0.05	2.149GlyPro: 2.149 ± 0.036	3.07GlyGln: 3.07 ± 0.04	3.606GlyArg: 3.606 ± 0.046	4.725GlySer: 4.725 ± 0.07	4.72GlyThr: 4.72 ± 0.066	4.837GlyVal: 4.837 ± 0.05	1.185GlyTrp: 1.185 ± 0.026	3.056GlyTyr: 3.056 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.187HisAla: 1.187 ± 0.024	0.165HisCys: 0.165 ± 0.009	0.865HisAsp: 0.865 ± 0.019	0.972HisGlu: 0.972 ± 0.02	1.065HisPhe: 1.065 ± 0.024	1.198HisGly: 1.198 ± 0.024	0.532HisHis: 0.532 ± 0.016	1.047HisIle: 1.047 ± 0.023	0.724HisLys: 0.724 ± 0.021	1.93HisLeu: 1.93 ± 0.034	0.303HisMet: 0.303 ± 0.012	0.74HisAsn: 0.74 ± 0.021	1.189HisPro: 1.189 ± 0.026	0.913HisGln: 0.913 ± 0.02	1.071HisArg: 1.071 ± 0.021	1.066HisSer: 1.066 ± 0.021	1.037HisThr: 1.037 ± 0.02	0.97HisVal: 0.97 ± 0.018	0.33HisTrp: 0.33 ± 0.013	0.852HisTyr: 0.852 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.824IleAla: 4.824 ± 0.054	0.514IleCys: 0.514 ± 0.018	3.635IleAsp: 3.635 ± 0.046	3.418IleGlu: 3.418 ± 0.043	2.225IlePhe: 2.225 ± 0.036	4.594IleGly: 4.594 ± 0.052	1.174IleHis: 1.174 ± 0.024	3.108IleIle: 3.108 ± 0.042	2.825IleLys: 2.825 ± 0.034	5.24IleLeu: 5.24 ± 0.053	0.959IleMet: 0.959 ± 0.021	2.804IleAsn: 2.804 ± 0.037	3.048IlePro: 3.048 ± 0.039	2.442IleGln: 2.442 ± 0.037	3.836IleArg: 3.836 ± 0.043	3.84IleSer: 3.84 ± 0.042	3.7IleThr: 3.7 ± 0.048	3.688IleVal: 3.688 ± 0.049	0.751IleTrp: 0.751 ± 0.021	1.996IleTyr: 1.996 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.664LysAla: 4.664 ± 0.052	0.207LysCys: 0.207 ± 0.009	2.818LysAsp: 2.818 ± 0.04	3.262LysGlu: 3.262 ± 0.042	1.715LysPhe: 1.715 ± 0.029	3.749LysGly: 3.749 ± 0.04	0.907LysHis: 0.907 ± 0.019	3.183LysIle: 3.183 ± 0.045	3.593LysLys: 3.593 ± 0.045	4.958LysLeu: 4.958 ± 0.055	1.355LysMet: 1.355 ± 0.021	2.867LysAsn: 2.867 ± 0.035	3.263LysPro: 3.263 ± 0.04	2.21LysGln: 2.21 ± 0.036	2.665LysArg: 2.665 ± 0.036	2.994LysSer: 2.994 ± 0.037	4.058LysThr: 4.058 ± 0.045	3.535LysVal: 3.535 ± 0.039	0.638LysTrp: 0.638 ± 0.016	1.85LysTyr: 1.85 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	8.518LeuAla: 8.518 ± 0.068	0.742LeuCys: 0.742 ± 0.018	4.771LeuAsp: 4.771 ± 0.053	5.081LeuGlu: 5.081 ± 0.054	4.751LeuPhe: 4.751 ± 0.05	6.333LeuGly: 6.333 ± 0.06	1.743LeuHis: 1.743 ± 0.031	5.967LeuIle: 5.967 ± 0.066	6.054LeuLys: 6.054 ± 0.053	10.551LeuLeu: 10.551 ± 0.097	2.173LeuMet: 2.173 ± 0.036	4.875LeuAsn: 4.875 ± 0.053	4.992LeuPro: 4.992 ± 0.047	3.839LeuGln: 3.839 ± 0.042	5.011LeuArg: 5.011 ± 0.051	6.814LeuSer: 6.814 ± 0.057	7.066LeuThr: 7.066 ± 0.059	6.732LeuVal: 6.732 ± 0.062	1.173LeuTrp: 1.173 ± 0.026	3.392LeuTyr: 3.392 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.912MetAla: 1.912 ± 0.028	0.101MetCys: 0.101 ± 0.007	1.021MetAsp: 1.021 ± 0.026	1.121MetGlu: 1.121 ± 0.024	0.586MetPhe: 0.586 ± 0.016	1.499MetGly: 1.499 ± 0.032	0.388MetHis: 0.388 ± 0.014	1.181MetIle: 1.181 ± 0.025	1.636MetLys: 1.636 ± 0.024	2.011MetLeu: 2.011 ± 0.035	0.542MetMet: 0.542 ± 0.016	1.153MetAsn: 1.153 ± 0.023	1.105MetPro: 1.105 ± 0.02	0.856MetGln: 0.856 ± 0.021	1.073MetArg: 1.073 ± 0.021	1.142MetSer: 1.142 ± 0.019	1.328MetThr: 1.328 ± 0.026	1.32MetVal: 1.32 ± 0.023	0.183MetTrp: 0.183 ± 0.009	0.55MetTyr: 0.55 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.655AsnAla: 3.655 ± 0.045	0.33AsnCys: 0.33 ± 0.012	2.343AsnAsp: 2.343 ± 0.036	2.421AsnGlu: 2.421 ± 0.032	2.022AsnPhe: 2.022 ± 0.034	3.871AsnGly: 3.871 ± 0.047	0.908AsnHis: 0.908 ± 0.022	2.393AsnIle: 2.393 ± 0.041	2.031AsnLys: 2.031 ± 0.034	4.599AsnLeu: 4.599 ± 0.06	0.81AsnMet: 0.81 ± 0.018	2.183AsnAsn: 2.183 ± 0.048	3.062AsnPro: 3.062 ± 0.042	2.343AsnGln: 2.343 ± 0.034	3.245AsnArg: 3.245 ± 0.038	2.704AsnSer: 2.704 ± 0.043	2.854AsnThr: 2.854 ± 0.04	2.868AsnVal: 2.868 ± 0.043	0.708AsnTrp: 0.708 ± 0.019	1.96AsnTyr: 1.96 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	4.349ProAla: 4.349 ± 0.053	0.213ProCys: 0.213 ± 0.01	3.201ProAsp: 3.201 ± 0.039	3.293ProGlu: 3.293 ± 0.041	2.168ProPhe: 2.168 ± 0.031	3.462ProGly: 3.462 ± 0.039	0.793ProHis: 0.793 ± 0.018	2.51ProIle: 2.51 ± 0.031	2.292ProLys: 2.292 ± 0.035	4.123ProLeu: 4.123 ± 0.044	0.917ProMet: 0.917 ± 0.02	2.321ProAsn: 2.321 ± 0.04	1.626ProPro: 1.626 ± 0.034	1.627ProGln: 1.627 ± 0.025	1.653ProArg: 1.653 ± 0.031	2.582ProSer: 2.582 ± 0.034	3.016ProThr: 3.016 ± 0.041	4.107ProVal: 4.107 ± 0.049	0.488ProTrp: 0.488 ± 0.016	1.655ProTyr: 1.655 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.405GlnAla: 3.405 ± 0.04	0.227GlnCys: 0.227 ± 0.011	1.638GlnAsp: 1.638 ± 0.024	2.24GlnGlu: 2.24 ± 0.029	1.936GlnPhe: 1.936 ± 0.027	2.404GlnGly: 2.404 ± 0.035	0.855GlnHis: 0.855 ± 0.02	2.464GlnIle: 2.464 ± 0.036	2.684GlnLys: 2.684 ± 0.036	4.564GlnLeu: 4.564 ± 0.052	0.87GlnMet: 0.87 ± 0.019	2.108GlnAsn: 2.108 ± 0.034	2.31GlnPro: 2.31 ± 0.033	2.419GlnGln: 2.419 ± 0.042	2.261GlnArg: 2.261 ± 0.032	2.426GlnSer: 2.426 ± 0.026	3.025GlnThr: 3.025 ± 0.04	2.703GlnVal: 2.703 ± 0.032	0.565GlnTrp: 0.565 ± 0.016	1.61GlnTyr: 1.61 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.489ArgAla: 3.489 ± 0.04	0.294ArgCys: 0.294 ± 0.013	2.548ArgAsp: 2.548 ± 0.033	2.943ArgGlu: 2.943 ± 0.036	2.991ArgPhe: 2.991 ± 0.039	2.841ArgGly: 2.841 ± 0.039	0.972ArgHis: 0.972 ± 0.021	3.641ArgIle: 3.641 ± 0.041	3.097ArgLys: 3.097 ± 0.035	5.631ArgLeu: 5.631 ± 0.058	1.309ArgMet: 1.309 ± 0.027	2.679ArgAsn: 2.679 ± 0.035	2.259ArgPro: 2.259 ± 0.032	2.787ArgGln: 2.787 ± 0.041	2.804ArgArg: 2.804 ± 0.043	3.084ArgSer: 3.084 ± 0.041	3.009ArgThr: 3.009 ± 0.038	3.456ArgVal: 3.456 ± 0.037	0.869ArgTrp: 0.869 ± 0.021	2.297ArgTyr: 2.297 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.728SerAla: 4.728 ± 0.055	0.466SerCys: 0.466 ± 0.014	3.188SerAsp: 3.188 ± 0.036	3.081SerGlu: 3.081 ± 0.036	3.183SerPhe: 3.183 ± 0.038	5.002SerGly: 5.002 ± 0.064	1.08SerHis: 1.08 ± 0.022	3.659SerIle: 3.659 ± 0.042	2.781SerLys: 2.781 ± 0.039	6.587SerLeu: 6.587 ± 0.063	1.237SerMet: 1.237 ± 0.022	2.572SerAsn: 2.572 ± 0.037	2.879SerPro: 2.879 ± 0.039	2.399SerGln: 2.399 ± 0.029	3.103SerArg: 3.103 ± 0.037	3.839SerSer: 3.839 ± 0.06	3.722SerThr: 3.722 ± 0.046	4.512SerVal: 4.512 ± 0.048	0.805SerTrp: 0.805 ± 0.019	2.478SerTyr: 2.478 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.392ThrAla: 5.392 ± 0.055	0.37ThrCys: 0.37 ± 0.016	3.689ThrAsp: 3.689 ± 0.04	3.193ThrGlu: 3.193 ± 0.041	2.845ThrPhe: 2.845 ± 0.036	5.444ThrGly: 5.444 ± 0.05	1.098ThrHis: 1.098 ± 0.022	3.812ThrIle: 3.812 ± 0.049	2.788ThrLys: 2.788 ± 0.039	6.362ThrLeu: 6.362 ± 0.054	1.052ThrMet: 1.052 ± 0.023	2.857ThrAsn: 2.857 ± 0.039	3.253ThrPro: 3.253 ± 0.043	2.261ThrGln: 2.261 ± 0.035	2.772ThrArg: 2.772 ± 0.032	3.503ThrSer: 3.503 ± 0.045	4.096ThrThr: 4.096 ± 0.06	5.119ThrVal: 5.119 ± 0.058	0.747ThrTrp: 0.747 ± 0.022	2.475ThrTyr: 2.475 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	5.627ValAla: 5.627 ± 0.053	0.573ValCys: 0.573 ± 0.016	3.541ValAsp: 3.541 ± 0.041	3.827ValGlu: 3.827 ± 0.043	3.406ValPhe: 3.406 ± 0.041	4.77ValGly: 4.77 ± 0.052	1.058ValHis: 1.058 ± 0.023	4.023ValIle: 4.023 ± 0.048	3.555ValLys: 3.555 ± 0.036	6.912ValLeu: 6.912 ± 0.062	1.484ValMet: 1.484 ± 0.031	3.203ValAsn: 3.203 ± 0.039	2.992ValPro: 2.992 ± 0.039	2.535ValGln: 2.535 ± 0.034	3.695ValArg: 3.695 ± 0.042	4.924ValSer: 4.924 ± 0.055	4.275ValThr: 4.275 ± 0.055	5.326ValVal: 5.326 ± 0.055	0.951ValTrp: 0.951 ± 0.022	2.449ValTyr: 2.449 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	0.974TrpAla: 0.974 ± 0.023	0.094TrpCys: 0.094 ± 0.006	0.693TrpAsp: 0.693 ± 0.02	0.713TrpGlu: 0.713 ± 0.019	0.64TrpPhe: 0.64 ± 0.019	0.916TrpGly: 0.916 ± 0.022	0.291TrpHis: 0.291 ± 0.011	0.749TrpIle: 0.749 ± 0.021	0.799TrpLys: 0.799 ± 0.019	1.535TrpLeu: 1.535 ± 0.029	0.374TrpMet: 0.374 ± 0.013	0.687TrpAsn: 0.687 ± 0.019	0.455TrpPro: 0.455 ± 0.015	0.758TrpGln: 0.758 ± 0.018	0.73TrpArg: 0.73 ± 0.017	0.789TrpSer: 0.789 ± 0.022	0.761TrpThr: 0.761 ± 0.018	0.942TrpVal: 0.942 ± 0.019	0.244TrpTrp: 0.244 ± 0.01	0.489TrpTyr: 0.489 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.835TyrAla: 2.835 ± 0.036	0.312TyrCys: 0.312 ± 0.012	2.135TyrAsp: 2.135 ± 0.034	2.033TyrGlu: 2.033 ± 0.033	1.98TyrPhe: 1.98 ± 0.029	2.811TyrGly: 2.811 ± 0.04	0.776TyrHis: 0.776 ± 0.018	1.794TyrIle: 1.794 ± 0.027	1.812TyrLys: 1.812 ± 0.033	3.831TyrLeu: 3.831 ± 0.04	0.602TyrMet: 0.602 ± 0.016	1.853TyrAsn: 1.853 ± 0.036	1.671TyrPro: 1.671 ± 0.028	1.906TyrGln: 1.906 ± 0.029	2.488TyrArg: 2.488 ± 0.03	2.382TyrSer: 2.382 ± 0.035	2.236TyrThr: 2.236 ± 0.035	2.27TyrVal: 2.27 ± 0.029	0.554TyrTrp: 0.554 ± 0.015	1.585TyrTyr: 1.585 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6294 proteins (2371370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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