Amino acid dipepetide frequency for Symmachiella dynata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.299AlaAla: 12.299 ± 0.097	1.093AlaCys: 1.093 ± 0.023	6.186AlaAsp: 6.186 ± 0.063	7.057AlaGlu: 7.057 ± 0.076	3.217AlaPhe: 3.217 ± 0.047	7.979AlaGly: 7.979 ± 0.071	1.808AlaHis: 1.808 ± 0.032	5.265AlaIle: 5.265 ± 0.051	3.856AlaLys: 3.856 ± 0.059	8.632AlaLeu: 8.632 ± 0.081	2.334AlaMet: 2.334 ± 0.034	2.89AlaAsn: 2.89 ± 0.038	4.013AlaPro: 4.013 ± 0.053	3.718AlaGln: 3.718 ± 0.051	5.337AlaArg: 5.337 ± 0.058	4.719AlaSer: 4.719 ± 0.048	5.711AlaThr: 5.711 ± 0.056	7.353AlaVal: 7.353 ± 0.068	1.289AlaTrp: 1.289 ± 0.026	2.194AlaTyr: 2.194 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.965CysAla: 0.965 ± 0.027	0.291CysCys: 0.291 ± 0.024	0.729CysAsp: 0.729 ± 0.022	0.673CysGlu: 0.673 ± 0.018	0.463CysPhe: 0.463 ± 0.014	1.152CysGly: 1.152 ± 0.025	0.424CysHis: 0.424 ± 0.015	0.466CysIle: 0.466 ± 0.016	0.313CysLys: 0.313 ± 0.013	1.236CysLeu: 1.236 ± 0.026	0.217CysMet: 0.217 ± 0.01	0.331CysAsn: 0.331 ± 0.012	0.617CysPro: 0.617 ± 0.018	0.381CysGln: 0.381 ± 0.013	0.855CysArg: 0.855 ± 0.023	0.617CysSer: 0.617 ± 0.02	0.541CysThr: 0.541 ± 0.018	0.792CysVal: 0.792 ± 0.022	0.203CysTrp: 0.203 ± 0.011	0.339CysTyr: 0.339 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.911AspAla: 5.911 ± 0.059	0.649AspCys: 0.649 ± 0.018	4.165AspAsp: 4.165 ± 0.071	4.495AspGlu: 4.495 ± 0.046	2.505AspPhe: 2.505 ± 0.033	5.262AspGly: 5.262 ± 0.08	1.408AspHis: 1.408 ± 0.027	2.904AspIle: 2.904 ± 0.041	2.15AspLys: 2.15 ± 0.034	5.693AspLeu: 5.693 ± 0.059	1.125AspMet: 1.125 ± 0.024	1.814AspAsn: 1.814 ± 0.033	3.52AspPro: 3.52 ± 0.048	2.333AspGln: 2.333 ± 0.033	3.742AspArg: 3.742 ± 0.05	3.228AspSer: 3.228 ± 0.042	2.623AspThr: 2.623 ± 0.052	4.549AspVal: 4.549 ± 0.067	1.098AspTrp: 1.098 ± 0.026	1.746AspTyr: 1.746 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.648GluAla: 5.648 ± 0.057	0.518GluCys: 0.518 ± 0.015	2.954GluAsp: 2.954 ± 0.045	4.088GluGlu: 4.088 ± 0.049	2.728GluPhe: 2.728 ± 0.039	3.636GluGly: 3.636 ± 0.04	1.478GluHis: 1.478 ± 0.029	3.919GluIle: 3.919 ± 0.047	2.936GluLys: 2.936 ± 0.045	6.891GluLeu: 6.891 ± 0.069	1.711GluMet: 1.711 ± 0.027	2.212GluAsn: 2.212 ± 0.032	2.822GluPro: 2.822 ± 0.042	3.276GluGln: 3.276 ± 0.043	3.986GluArg: 3.986 ± 0.051	3.839GluSer: 3.839 ± 0.044	4.078GluThr: 4.078 ± 0.047	4.069GluVal: 4.069 ± 0.044	0.853GluTrp: 0.853 ± 0.02	1.598GluTyr: 1.598 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.794PheAla: 3.794 ± 0.046	0.54PheCys: 0.54 ± 0.017	2.804PheAsp: 2.804 ± 0.035	2.349PheGlu: 2.349 ± 0.034	1.496PhePhe: 1.496 ± 0.028	3.147PheGly: 3.147 ± 0.038	0.92PheHis: 0.92 ± 0.022	1.609PheIle: 1.609 ± 0.029	1.043PheLys: 1.043 ± 0.024	3.679PheLeu: 3.679 ± 0.055	0.709PheMet: 0.709 ± 0.019	1.214PheAsn: 1.214 ± 0.025	1.839PhePro: 1.839 ± 0.03	1.515PheGln: 1.515 ± 0.027	2.408PheArg: 2.408 ± 0.036	2.511PheSer: 2.511 ± 0.037	2.101PheThr: 2.101 ± 0.044	2.975PheVal: 2.975 ± 0.037	0.605PheTrp: 0.605 ± 0.018	1.028PheTyr: 1.028 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	5.74GlyAla: 5.74 ± 0.065	1.02GlyCys: 1.02 ± 0.026	4.663GlyAsp: 4.663 ± 0.067	4.83GlyGlu: 4.83 ± 0.052	3.03GlyPhe: 3.03 ± 0.04	6.431GlyGly: 6.431 ± 0.09	1.786GlyHis: 1.786 ± 0.031	4.265GlyIle: 4.265 ± 0.056	3.681GlyLys: 3.681 ± 0.054	7.263GlyLeu: 7.263 ± 0.067	2.021GlyMet: 2.021 ± 0.029	2.669GlyAsn: 2.669 ± 0.044	3.115GlyPro: 3.115 ± 0.046	3.066GlyGln: 3.066 ± 0.034	5.033GlyArg: 5.033 ± 0.049	4.268GlySer: 4.268 ± 0.056	4.391GlyThr: 4.391 ± 0.067	5.128GlyVal: 5.128 ± 0.058	1.331GlyTrp: 1.331 ± 0.026	2.244GlyTyr: 2.244 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.031HisAla: 2.031 ± 0.032	0.328HisCys: 0.328 ± 0.012	1.403HisAsp: 1.403 ± 0.03	1.367HisGlu: 1.367 ± 0.026	0.973HisPhe: 0.973 ± 0.021	1.853HisGly: 1.853 ± 0.038	0.652HisHis: 0.652 ± 0.019	1.014HisIle: 1.014 ± 0.023	0.753HisLys: 0.753 ± 0.019	2.303HisLeu: 2.303 ± 0.037	0.424HisMet: 0.424 ± 0.015	0.765HisAsn: 0.765 ± 0.018	1.511HisPro: 1.511 ± 0.03	0.838HisGln: 0.838 ± 0.024	1.588HisArg: 1.588 ± 0.028	1.243HisSer: 1.243 ± 0.024	1.084HisThr: 1.084 ± 0.024	1.631HisVal: 1.631 ± 0.036	0.487HisTrp: 0.487 ± 0.018	0.66HisTyr: 0.66 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.807IleAla: 5.807 ± 0.058	0.721IleCys: 0.721 ± 0.019	3.817IleAsp: 3.817 ± 0.056	3.567IleGlu: 3.567 ± 0.045	1.713IlePhe: 1.713 ± 0.031	4.14IleGly: 4.14 ± 0.047	1.156IleHis: 1.156 ± 0.025	2.214IleIle: 2.214 ± 0.035	1.698IleLys: 1.698 ± 0.026	4.523IleLeu: 4.523 ± 0.05	0.834IleMet: 0.834 ± 0.022	1.644IleAsn: 1.644 ± 0.03	2.841IlePro: 2.841 ± 0.039	1.801IleGln: 1.801 ± 0.029	3.307IleArg: 3.307 ± 0.038	3.198IleSer: 3.198 ± 0.04	2.937IleThr: 2.937 ± 0.043	4.204IleVal: 4.204 ± 0.045	0.679IleTrp: 0.679 ± 0.016	1.28IleTyr: 1.28 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.16LysAla: 3.16 ± 0.046	0.32LysCys: 0.32 ± 0.012	1.795LysAsp: 1.795 ± 0.035	1.966LysGlu: 1.966 ± 0.031	1.394LysPhe: 1.394 ± 0.025	2.033LysGly: 2.033 ± 0.033	0.923LysHis: 0.923 ± 0.022	2.241LysIle: 2.241 ± 0.035	2.142LysLys: 2.142 ± 0.049	4.162LysLeu: 4.162 ± 0.049	1.033LysMet: 1.033 ± 0.024	1.421LysAsn: 1.421 ± 0.032	2.524LysPro: 2.524 ± 0.044	2.014LysGln: 2.014 ± 0.038	2.57LysArg: 2.57 ± 0.038	2.549LysSer: 2.549 ± 0.04	2.592LysThr: 2.592 ± 0.038	2.375LysVal: 2.375 ± 0.038	0.533LysTrp: 0.533 ± 0.016	1.068LysTyr: 1.068 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	10.455LeuAla: 10.455 ± 0.078	1.213LeuCys: 1.213 ± 0.029	5.78LeuAsp: 5.78 ± 0.063	5.884LeuGlu: 5.884 ± 0.069	3.819LeuPhe: 3.819 ± 0.048	7.008LeuGly: 7.008 ± 0.062	2.024LeuHis: 2.024 ± 0.032	4.911LeuIle: 4.911 ± 0.05	4.243LeuLys: 4.243 ± 0.054	10.086LeuLeu: 10.086 ± 0.09	2.084LeuMet: 2.084 ± 0.034	3.184LeuAsn: 3.184 ± 0.04	5.433LeuPro: 5.433 ± 0.056	3.849LeuGln: 3.849 ± 0.054	6.36LeuArg: 6.36 ± 0.069	6.288LeuSer: 6.288 ± 0.057	5.694LeuThr: 5.694 ± 0.058	6.705LeuVal: 6.705 ± 0.06	1.402LeuTrp: 1.402 ± 0.027	2.158LeuTyr: 2.158 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.202MetAla: 2.202 ± 0.029	0.22MetCys: 0.22 ± 0.01	1.053MetAsp: 1.053 ± 0.022	1.06MetGlu: 1.06 ± 0.024	0.834MetPhe: 0.834 ± 0.019	1.484MetGly: 1.484 ± 0.028	0.519MetHis: 0.519 ± 0.016	1.238MetIle: 1.238 ± 0.021	0.905MetLys: 0.905 ± 0.02	2.373MetLeu: 2.373 ± 0.033	0.542MetMet: 0.542 ± 0.016	0.807MetAsn: 0.807 ± 0.02	1.296MetPro: 1.296 ± 0.026	0.979MetGln: 0.979 ± 0.021	1.448MetArg: 1.448 ± 0.026	1.562MetSer: 1.562 ± 0.027	1.567MetThr: 1.567 ± 0.027	1.475MetVal: 1.475 ± 0.028	0.289MetTrp: 0.289 ± 0.013	0.465MetTyr: 0.465 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.791AsnAla: 2.791 ± 0.046	0.451AsnCys: 0.451 ± 0.015	2.134AsnAsp: 2.134 ± 0.041	1.851AsnGlu: 1.851 ± 0.032	1.188AsnPhe: 1.188 ± 0.023	2.718AsnGly: 2.718 ± 0.052	0.775AsnHis: 0.775 ± 0.019	1.53AsnIle: 1.53 ± 0.027	1.004AsnLys: 1.004 ± 0.025	3.135AsnLeu: 3.135 ± 0.043	0.68AsnMet: 0.68 ± 0.017	1.117AsnAsn: 1.117 ± 0.026	2.104AsnPro: 2.104 ± 0.032	1.252AsnGln: 1.252 ± 0.024	2.234AsnArg: 2.234 ± 0.035	2.0AsnSer: 2.0 ± 0.03	1.67AsnThr: 1.67 ± 0.032	2.341AsnVal: 2.341 ± 0.035	0.587AsnTrp: 0.587 ± 0.017	0.945AsnTyr: 0.945 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.281ProAla: 5.281 ± 0.057	0.405ProCys: 0.405 ± 0.015	3.545ProAsp: 3.545 ± 0.046	3.934ProGlu: 3.934 ± 0.042	1.855ProPhe: 1.855 ± 0.03	3.928ProGly: 3.928 ± 0.05	1.328ProHis: 1.328 ± 0.026	2.464ProIle: 2.464 ± 0.035	1.934ProLys: 1.934 ± 0.038	4.857ProLeu: 4.857 ± 0.056	1.01ProMet: 1.01 ± 0.022	1.785ProAsn: 1.785 ± 0.028	3.097ProPro: 3.097 ± 0.042	2.544ProGln: 2.544 ± 0.04	2.852ProArg: 2.852 ± 0.036	2.848ProSer: 2.848 ± 0.041	3.019ProThr: 3.019 ± 0.045	3.85ProVal: 3.85 ± 0.05	0.7ProTrp: 0.7 ± 0.018	1.222ProTyr: 1.222 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.002GlnAla: 4.002 ± 0.047	0.407GlnCys: 0.407 ± 0.015	1.832GlnAsp: 1.832 ± 0.03	2.271GlnGlu: 2.271 ± 0.039	1.757GlnPhe: 1.757 ± 0.029	2.542GlnGly: 2.542 ± 0.035	1.056GlnHis: 1.056 ± 0.02	2.278GlnIle: 2.278 ± 0.031	1.59GlnLys: 1.59 ± 0.033	4.634GlnLeu: 4.634 ± 0.05	0.976GlnMet: 0.976 ± 0.023	1.253GlnAsn: 1.253 ± 0.025	2.454GlnPro: 2.454 ± 0.042	2.522GlnGln: 2.522 ± 0.05	3.078GlnArg: 3.078 ± 0.041	2.453GlnSer: 2.453 ± 0.041	2.409GlnThr: 2.409 ± 0.04	2.701GlnVal: 2.701 ± 0.037	0.674GlnTrp: 0.674 ± 0.016	0.967GlnTyr: 0.967 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.993ArgAla: 4.993 ± 0.054	0.696ArgCys: 0.696 ± 0.017	3.856ArgAsp: 3.856 ± 0.049	4.103ArgGlu: 4.103 ± 0.049	2.722ArgPhe: 2.722 ± 0.037	4.259ArgGly: 4.259 ± 0.057	1.499ArgHis: 1.499 ± 0.029	3.729ArgIle: 3.729 ± 0.042	2.619ArgLys: 2.619 ± 0.04	6.637ArgLeu: 6.637 ± 0.066	1.634ArgMet: 1.634 ± 0.026	2.158ArgAsn: 2.158 ± 0.028	3.032ArgPro: 3.032 ± 0.043	2.871ArgGln: 2.871 ± 0.035	5.168ArgArg: 5.168 ± 0.067	3.635ArgSer: 3.635 ± 0.038	3.296ArgThr: 3.296 ± 0.036	4.165ArgVal: 4.165 ± 0.048	1.169ArgTrp: 1.169 ± 0.025	1.817ArgTyr: 1.817 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	5.304SerAla: 5.304 ± 0.058	0.637SerCys: 0.637 ± 0.017	3.568SerAsp: 3.568 ± 0.047	3.489SerGlu: 3.489 ± 0.04	2.136SerPhe: 2.136 ± 0.036	5.123SerGly: 5.123 ± 0.062	1.365SerHis: 1.365 ± 0.026	2.905SerIle: 2.905 ± 0.041	2.084SerLys: 2.084 ± 0.032	5.769SerLeu: 5.769 ± 0.056	1.356SerMet: 1.356 ± 0.024	1.872SerAsn: 1.872 ± 0.032	3.381SerPro: 3.381 ± 0.041	2.519SerGln: 2.519 ± 0.038	3.716SerArg: 3.716 ± 0.042	3.644SerSer: 3.644 ± 0.049	3.295SerThr: 3.295 ± 0.043	3.911SerVal: 3.911 ± 0.044	0.922SerTrp: 0.922 ± 0.023	1.417SerTyr: 1.417 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.065ThrAla: 6.065 ± 0.066	0.59ThrCys: 0.59 ± 0.017	3.503ThrAsp: 3.503 ± 0.054	3.21ThrGlu: 3.21 ± 0.042	2.091ThrPhe: 2.091 ± 0.031	4.845ThrGly: 4.845 ± 0.055	1.251ThrHis: 1.251 ± 0.024	3.335ThrIle: 3.335 ± 0.052	1.931ThrLys: 1.931 ± 0.028	5.395ThrLeu: 5.395 ± 0.064	1.15ThrMet: 1.15 ± 0.023	1.765ThrAsn: 1.765 ± 0.029	3.427ThrPro: 3.427 ± 0.051	2.046ThrGln: 2.046 ± 0.033	2.94ThrArg: 2.94 ± 0.041	3.204ThrSer: 3.204 ± 0.045	3.478ThrThr: 3.478 ± 0.056	4.42ThrVal: 4.42 ± 0.059	0.828ThrTrp: 0.828 ± 0.024	1.433ThrTyr: 1.433 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.27ValAla: 7.27 ± 0.058	0.917ValCys: 0.917 ± 0.022	4.511ValAsp: 4.511 ± 0.052	4.678ValGlu: 4.678 ± 0.058	2.62ValPhe: 2.62 ± 0.039	5.127ValGly: 5.127 ± 0.049	1.453ValHis: 1.453 ± 0.026	3.957ValIle: 3.957 ± 0.05	2.439ValLys: 2.439 ± 0.034	6.946ValLeu: 6.946 ± 0.062	1.581ValMet: 1.581 ± 0.03	2.219ValAsn: 2.219 ± 0.049	3.496ValPro: 3.496 ± 0.043	2.474ValGln: 2.474 ± 0.039	4.365ValArg: 4.365 ± 0.048	4.221ValSer: 4.221 ± 0.046	4.281ValThr: 4.281 ± 0.061	5.72ValVal: 5.72 ± 0.054	1.0ValTrp: 1.0 ± 0.023	1.778ValTyr: 1.778 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.094TrpAla: 1.094 ± 0.022	0.205TrpCys: 0.205 ± 0.009	0.907TrpAsp: 0.907 ± 0.023	0.818TrpGlu: 0.818 ± 0.02	0.579TrpPhe: 0.579 ± 0.016	1.132TrpGly: 1.132 ± 0.026	0.401TrpHis: 0.401 ± 0.014	0.842TrpIle: 0.842 ± 0.02	0.734TrpLys: 0.734 ± 0.019	1.676TrpLeu: 1.676 ± 0.035	0.454TrpMet: 0.454 ± 0.016	0.606TrpAsn: 0.606 ± 0.018	0.712TrpPro: 0.712 ± 0.018	0.769TrpGln: 0.769 ± 0.019	1.031TrpArg: 1.031 ± 0.022	0.942TrpSer: 0.942 ± 0.025	0.886TrpThr: 0.886 ± 0.022	0.932TrpVal: 0.932 ± 0.024	0.302TrpTrp: 0.302 ± 0.012	0.406TrpTyr: 0.406 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.138TyrAla: 2.138 ± 0.033	0.384TyrCys: 0.384 ± 0.015	1.716TyrAsp: 1.716 ± 0.039	1.55TyrGlu: 1.55 ± 0.024	1.164TyrPhe: 1.164 ± 0.025	2.174TyrGly: 2.174 ± 0.037	0.681TyrHis: 0.681 ± 0.018	0.997TyrIle: 0.997 ± 0.021	0.759TyrLys: 0.759 ± 0.02	2.689TyrLeu: 2.689 ± 0.037	0.442TyrMet: 0.442 ± 0.014	0.782TyrAsn: 0.782 ± 0.025	1.223TyrPro: 1.223 ± 0.026	1.091TyrGln: 1.091 ± 0.024	2.042TyrArg: 2.042 ± 0.032	1.443TyrSer: 1.443 ± 0.027	1.253TyrThr: 1.253 ± 0.031	1.757TyrVal: 1.757 ± 0.03	0.479TyrTrp: 0.479 ± 0.016	0.877TyrTyr: 0.877 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6115 proteins (2198892 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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